Maximum dose of arkamine
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arkamine clonidine maximum dose mg/day
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Here is a complete summary on Arkamine (Clonidine) dosing:
Arkamine (Clonidine HCl) - Dosage Summary
Arkamine is the brand name for Clonidine hydrochloride (marketed by Torrent Pharmaceuticals in India).
Oral Tablet Dosing (for Hypertension)
| Parameter | Dose |
|---|---|
| Starting dose | 0.1 mg twice daily (morning + bedtime) |
| Dose titration | Increase by 0.1 mg/day at weekly intervals as needed |
| Usual therapeutic range | 0.2 to 0.6 mg/day in divided doses |
| Maximum effective daily dose | 2.4 mg/day |
The maximum dose commonly cited in Indian pharmacology exams and the Arkamine prescribing information is 0.9 mg/day in divided doses, though the absolute pharmacological maximum is 2.4 mg/day per the Kaplan & Sadock Comprehensive Textbook of Psychiatry and international prescribing references.
Important Practical Notes
- Take the larger portion at bedtime to minimize daytime sedation and dry mouth.
- Do not stop abruptly - especially at doses >1 mg/day, sudden withdrawal can cause life-threatening hypertensive crisis with rebound sympathetic overactivity (tachycardia, sweating, severe hypertension). Taper by 0.05 mg every other day if used >1 week.
- Withdrawal risk is higher with concurrent beta-blocker use.
Transdermal Patch (TTS)
- TTS-1/2/3 deliver 0.1/0.2/0.3 mg/day respectively
- Changed every 7 days (every 5 days in children)
- Maximum: two 0.3 mg patches per week (0.6 mg/day)
- Remove before MRI (contains aluminum)
Formulations Available
- Tablets: 0.1 mg, 0.2 mg, 0.3 mg
- Extended-release tablets: 0.1 mg, 0.2 mg (swallow whole - do not crush/chew)
Sources: Kaplan & Sadock's Comprehensive Textbook of Psychiatry; Katzung's Basic and Clinical Pharmacology 16e; Arkamine 100 prescribing information (Torrent Pharma)
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