Convert into visual form flow chart diagrammatic way
A clean medical flowchart titled "Normal Pregnancy: Blood Pressure Regulation & Spiral Arteriole Changes" with two parallel pathways merging. TOP BOX (wide, blue): "Physiological Changes in Spiral Arterioles" → Arrow down → Box: "Endothelial lining + muscular arterial wall replaced by fibrinoid formation" → Arrow down → Box: "Spiral arterioles become distended, tortuous, funnel-shaped" → Arrow down → Highlighted green box: "LOW RESISTANCE | LOW PRESSURE | HIGH FLOW SYSTEM" Then below, label: "In Normal Pregnancy — Blood Pressure Stabilization" TWO PARALLEL PATHWAYS side by side: LEFT PATHWAY (orange header): "Mechanism 1: Angiotensin-II Destruction" → Box: "Angiotensin-II (part of α2-globulin) present" → Arrow down: "Angiotensinase liberated from placenta" → Arrow down: "Angiotensin-II destroyed" → Arrow down: "Blood Pressure Stabilized" RIGHT PATHWAY (purple header): "Mechanism 2: Vascular Refractoriness" → Box: "Vascular system becomes refractory to Angiotensin-II (pressor agent)" → Arrow down: "Vascular synthesis of Prostaglandin I2 + Nitric Oxide (NO)" → Arrow down: "Vasodilator Effect" → Arrow down: "Blood Pressure Stabilized" BOTH LEFT AND RIGHT arrows converge into a CENTRAL BLUE BOX: "Interaction of both systems → Blood Pressure Stabilized in Normal Pregnancy" FINAL BOX below (green): "↑ VEGF (Vascular Endothelial Growth Factor — mitogenic glycoprotein) → Restores Uteroplacental Blood Flow to Normal Level" Use arrows, rounded boxes, pastel colors, medical diagram style, clean white background, readable fonts

| Mechanism 1 | Mechanism 2 |
|---|---|
| Angiotensin-II (α2-globulin) destroyed by angiotensinase from placenta | Vascular system becomes refractory to Angiotensin-II |
| BP stabilized via removal of pressor agent | Prostaglandin I2 + Nitric Oxide (NO) synthesis causes vasodilation |
Make a presentation comparing normal vs pre-eclampsia pathophysiology
ls /home/daytona/workspace/ 2>/dev/null && echo "---" && ls /home/daytona/skills/pptx/
mkdir -p /home/daytona/workspace/preeclampsia-ppt
~/preeclampsia-ppt/build.js
const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Normal Pregnancy vs Pre-eclampsia: Pathophysiology";
pres.author = "Medical Education";
// ─── Color Palette ───────────────────────────────────────────────
const C = {
darkBg: "0D1B2A", // deep navy – title / section covers
midBg: "1B2A3B", // mid-navy – content background
normal: "1A936F", // teal-green for Normal Pregnancy
pre: "C0392B", // crimson for Pre-eclampsia
accent: "F4A261", // amber – highlights
white: "FFFFFF",
lightGray:"E8EDF2",
textDark: "0D1B2A",
subtext: "7F8C8D",
border: "2C3E50",
};
// ─── Helper: add a dark-background header bar ─────────────────────
function addHeader(slide, title, subtitle) {
slide.addShape(pres.shapes.RECTANGLE, {
x: 0, y: 0, w: "100%", h: 1.1,
fill: { color: C.darkBg },
});
slide.addText(title, {
x: 0.35, y: 0.08, w: 9.3, h: 0.55,
fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", margin: 0,
});
if (subtitle) {
slide.addText(subtitle, {
x: 0.35, y: 0.62, w: 9.3, h: 0.38,
fontSize: 12, color: C.accent, fontFace: "Calibri", italic: true, margin: 0,
});
}
}
// ─── Helper: tag pill ─────────────────────────────────────────────
function addTag(slide, label, x, y, color) {
slide.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x, y, w: 2.1, h: 0.32,
fill: { color }, rectRadius: 0.08,
});
slide.addText(label, {
x, y, w: 2.1, h: 0.32,
fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle",
fontFace: "Calibri", margin: 0,
});
}
// ─── Helper: section card ─────────────────────────────────────────
function addCard(slide, x, y, w, h, headText, headColor, bodyItems) {
// header stripe
slide.addShape(pres.shapes.RECTANGLE, {
x, y, w, h: 0.38,
fill: { color: headColor },
});
slide.addText(headText, {
x: x + 0.08, y, w: w - 0.16, h: 0.38,
fontSize: 11, bold: true, color: C.white, valign: "middle", fontFace: "Calibri", margin: 0,
});
// body
slide.addShape(pres.shapes.RECTANGLE, {
x, y: y + 0.38, w, h: h - 0.38,
fill: { color: C.white },
line: { color: headColor, width: 1.5 },
});
const bullets = bodyItems.map((item, i) => ({
text: item,
options: { bullet: true, breakLine: i < bodyItems.length - 1, fontSize: 10, color: C.textDark, fontFace: "Calibri" },
}));
slide.addText(bullets, {
x: x + 0.12, y: y + 0.42, w: w - 0.24, h: h - 0.52,
valign: "top", fontFace: "Calibri",
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 1 – TITLE
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: C.darkBg } });
// accent left stripe
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.18, h: "100%", fill: { color: C.normal } });
sl.addText("Normal Pregnancy", {
x: 0.5, y: 1.2, w: 9, h: 0.65,
fontSize: 32, bold: true, color: C.normal, fontFace: "Calibri", margin: 0,
});
sl.addText("vs", {
x: 0.5, y: 1.85, w: 9, h: 0.5,
fontSize: 22, color: C.white, fontFace: "Calibri", italic: true, margin: 0,
});
sl.addText("Pre-eclampsia", {
x: 0.5, y: 2.3, w: 9, h: 0.65,
fontSize: 32, bold: true, color: C.pre, fontFace: "Calibri", margin: 0,
});
sl.addText("Pathophysiology — A Comparative Overview", {
x: 0.5, y: 3.1, w: 9, h: 0.45,
fontSize: 16, color: C.accent, fontFace: "Calibri", italic: true, margin: 0,
});
sl.addShape(pres.shapes.RECTANGLE, {
x: 0.5, y: 3.62, w: 5, h: 0.04,
fill: { color: C.accent },
});
sl.addText("Sources: Robbins & Kumar Basic Pathology | DC Dutta's Textbook of Obstetrics", {
x: 0.5, y: 4.8, w: 9, h: 0.35,
fontSize: 9, color: C.subtext, fontFace: "Calibri", italic: true, margin: 0,
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 2 – OVERVIEW TABLE
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: C.lightGray } });
addHeader(sl, "At a Glance: Key Differences", "A side-by-side snapshot");
const rows = [
["Feature", "Normal Pregnancy", "Pre-eclampsia"],
["Spiral artery remodeling", "Complete — dilated sinusoids", "Impaired — narrow channels"],
["Trophoblast invasion", "Full (musculoelastic wall replaced)", "Partial / absent"],
["Blood pressure", "Stabilized / normal", "Hypertension (>140/90)"],
["Angiotensin-II", "Destroyed by angiotensinase", "Vascular hyper-reactivity"],
["Prostacyclin / PGI2", "Increased — vasodilation", "Decreased"],
["Thromboxane A2", "Low", "Increased — vasoconstriction"],
["Nitric Oxide (NO)", "Produced — vasodilator", "Reduced production"],
["VEGF", "Increased — restores blood flow", "Antagonized by sFlt-1 & endoglin"],
["Proteinuria", "Absent", "Present (hallmark)"],
["Outcome", "Normal uteroplacental flow", "Placental hypoxia / end-organ damage"],
];
const colW = [2.6, 3.2, 3.2];
const rowH = 0.33;
const startX = 0.3;
const startY = 1.2;
rows.forEach((row, ri) => {
row.forEach((cell, ci) => {
const x = startX + colW.slice(0, ci).reduce((a, b) => a + b, 0);
const y = startY + ri * rowH;
let bg = ri === 0 ? C.darkBg : (ri % 2 === 0 ? "DDEEFF" : C.white);
if (ri > 0 && ci === 1) bg = ri % 2 === 0 ? "D5F5E8" : "EAF9F2";
if (ri > 0 && ci === 2) bg = ri % 2 === 0 ? "FADBD8" : "FDEDEC";
sl.addShape(pres.shapes.RECTANGLE, {
x, y, w: colW[ci], h: rowH,
fill: { color: bg },
line: { color: "C8D6E5", width: 0.5 },
});
sl.addText(cell, {
x: x + 0.06, y, w: colW[ci] - 0.12, h: rowH,
fontSize: ri === 0 ? 10 : 9,
bold: ri === 0 || ci === 0,
color: ri === 0 ? C.white : C.textDark,
valign: "middle", fontFace: "Calibri", margin: 0,
});
});
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 3 – SPIRAL ARTERY REMODELING
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Spiral Artery Remodeling", "The central divergence in normal vs pre-eclamptic pregnancy");
addTag(sl, "NORMAL PREGNANCY", 0.3, 1.25, C.normal);
addTag(sl, "PRE-ECLAMPSIA", 5.3, 1.25, C.pre);
// Normal side
const normalSteps = [
"Trophoblasts invade spiral artery walls",
"Musculoelastic wall replaced by fibrinoid formation",
"Arterioles become distended, tortuous & funnel-shaped",
"Low resistance · Low pressure · High flow system",
"Adequate uteroplacental perfusion",
];
addCard(sl, 0.3, 1.65, 4.3, 3.5, "Normal Remodeling Pathway", C.normal, normalSteps);
// Pre-eclampsia side
const preSteps = [
"Second wave of endovascular trophoblast migration FAILS",
"Musculoelastic walls are RETAINED",
"Channels remain narrow — vascular remodeling impaired",
"Decreased uteroplacental blood flow",
"Placental hypoxia & dysfunction",
];
addCard(sl, 5.3, 1.65, 4.3, 3.5, "Impaired Remodeling in Pre-eclampsia", C.pre, preSteps);
// Arrow in middle
sl.addShape(pres.shapes.LEFT_RIGHT_ARROW, {
x: 4.65, y: 2.8, w: 0.65, h: 0.4,
fill: { color: C.accent },
});
sl.addText("vs", {
x: 4.65, y: 3.28, w: 0.65, h: 0.28,
fontSize: 10, bold: true, color: C.border, align: "center", fontFace: "Calibri", margin: 0,
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 4 – BLOOD PRESSURE MECHANISMS
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Blood Pressure Regulation", "Vasoactive mediator balance in normal pregnancy vs pre-eclampsia");
// Normal mechanisms
addCard(sl, 0.3, 1.25, 4.3, 1.7, "Normal: Angiotensin-II Control", C.normal, [
"Angiotensin-II (part of α2-globulin) present",
"Angiotensinase liberated from placenta destroys it",
"Result: Blood pressure stabilized",
]);
addCard(sl, 0.3, 3.05, 4.3, 1.7, "Normal: Prostaglandin I2 & NO", C.normal, [
"Vascular synthesis of PGI2 and Nitric Oxide (NO)",
"Vasodilator effect — blunts pressor response to Ang-II",
"Both systems together maintain normal BP",
]);
// Pre-eclampsia mechanisms
addCard(sl, 5.3, 1.25, 4.3, 1.7, "Pre-eclampsia: Vascular Hyper-reactivity", C.pre, [
"Loss of vascular refractoriness to Angiotensin-II",
"Increased thromboxane A2 (vasoconstrictor)",
"Result: Severe hypertension",
]);
addCard(sl, 5.3, 3.05, 4.3, 1.7, "Pre-eclampsia: Vasodilator Deficiency", C.pre, [
"Reduced prostacyclin (PGI2) production",
"Reduced endothelial Nitric Oxide (NO)",
"Net effect: Unopposed vasoconstriction → ↑ BP",
]);
// divider line
sl.addShape(pres.shapes.LINE, {
x: 4.95, y: 1.2, w: 0, h: 3.6,
line: { color: C.accent, width: 1.5, dashType: "dash" },
});
sl.addText("vs", {
x: 4.68, y: 2.85, w: 0.6, h: 0.35,
fontSize: 11, bold: true, color: C.border, align: "center", fontFace: "Calibri",
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 5 – ANGIOGENIC FACTORS (VEGF / sFlt-1 / Endoglin)
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Angiogenic Factor Imbalance", "VEGF, sFlt-1, endoglin, TGF-β in normal vs pre-eclampsia");
// VEGF normal
addCard(sl, 0.3, 1.25, 4.3, 2.0, "Normal Pregnancy: Pro-angiogenic State", C.normal, [
"VEGF (Vascular Endothelial Growth Factor) — a mitogenic glycoprotein",
"Increased VEGF restores uteroplacental blood flow to normal",
"TGF-β supports normal endothelial function",
"Balance maintained — healthy vascular remodeling",
]);
// VEGF preeclampsia
addCard(sl, 5.3, 1.25, 4.3, 2.0, "Pre-eclampsia: Anti-angiogenic Shift", C.pre, [
"↑ Soluble FMS-like tyrosine kinase-1 (sFlt-1) — antagonizes VEGF",
"↑ Soluble endoglin — antagonizes TGF-β",
"Net result: VEGF & TGF-β activity suppressed",
"Endothelial dysfunction & vascular hyper-reactivity",
]);
// Consequences box
sl.addShape(pres.shapes.RECTANGLE, {
x: 0.3, y: 3.35, w: 9.3, h: 1.8,
fill: { color: C.pre }, line: { color: C.pre, width: 0 },
});
sl.addText("Consequences of Endothelial Dysfunction in Pre-eclampsia", {
x: 0.45, y: 3.4, w: 9, h: 0.35,
fontSize: 11, bold: true, color: C.white, fontFace: "Calibri", margin: 0,
});
const consequences = [
{ text: "Placental infarction", options: { bullet: true, breakLine: true, fontSize: 10, color: C.white, fontFace: "Calibri" } },
{ text: "Vascular hyperreactivity → hypertension", options: { bullet: true, breakLine: true, fontSize: 10, color: C.white, fontFace: "Calibri" } },
{ text: "Hypercoagulability → ↑ thrombus risk", options: { bullet: true, breakLine: true, fontSize: 10, color: C.white, fontFace: "Calibri" } },
{ text: "End-organ failure — kidney, liver (HELLP syndrome in ~10% severe cases)", options: { bullet: true, fontSize: 10, color: C.white, fontFace: "Calibri" } },
];
sl.addText(consequences, {
x: 0.45, y: 3.78, w: 9, h: 1.3, valign: "top", fontFace: "Calibri",
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 6 – PATHOGENESIS FLOWCHART
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Pre-eclampsia: Pathogenesis Cascade", "Step-by-step mechanism from impaired remodeling to end-organ damage");
const boxes = [
{ x: 3.5, y: 1.15, w: 3.0, h: 0.45, text: "Inadequate trophoblast invasion", color: C.darkBg },
{ x: 3.5, y: 1.85, w: 3.0, h: 0.45, text: "Retained narrow spiral arteries", color: C.border },
{ x: 3.5, y: 2.55, w: 3.0, h: 0.45, text: "Reduced uteroplacental blood flow", color: C.border },
{ x: 3.5, y: 3.25, w: 3.0, h: 0.45, text: "Placental hypoxia & dysfunction", color: C.pre },
{ x: 3.5, y: 3.95, w: 3.0, h: 0.45, text: "↑ sFlt-1 & Endoglin → endothelial dysfunction", color: C.pre },
{ x: 3.5, y: 4.65, w: 3.0, h: 0.45, text: "Hypertension · Proteinuria · End-organ damage", color: "7D3C98" },
];
boxes.forEach((b, i) => {
sl.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x: b.x, y: b.y, w: b.w, h: b.h,
fill: { color: b.color }, rectRadius: 0.08,
});
sl.addText(b.text, {
x: b.x, y: b.y, w: b.w, h: b.h,
fontSize: 9.5, bold: true, color: C.white,
align: "center", valign: "middle", fontFace: "Calibri", margin: 0,
});
// downward arrow
if (i < boxes.length - 1) {
sl.addShape(pres.shapes.DOWN_ARROW, {
x: 4.7, y: b.y + b.h, w: 0.6, h: 0.28,
fill: { color: C.accent },
});
}
});
// side note: HELLP
sl.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x: 0.2, y: 4.55, w: 2.9, h: 0.65,
fill: { color: "7D3C98" }, rectRadius: 0.08,
});
sl.addText("HELLP Syndrome\n(~10% severe cases)\nHemolysis · Elevated liver enzymes · Low platelets", {
x: 0.3, y: 4.57, w: 2.7, h: 0.62,
fontSize: 8, color: C.white, fontFace: "Calibri", valign: "middle", margin: 0,
});
// side note: DIC
sl.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x: 6.9, y: 4.55, w: 2.8, h: 0.65,
fill: { color: "7D3C98" }, rectRadius: 0.08,
});
sl.addText("DIC possible\n(Disseminated Intravascular\nCoagulation)", {
x: 7.0, y: 4.57, w: 2.6, h: 0.62,
fontSize: 8, color: C.white, fontFace: "Calibri", valign: "middle", margin: 0,
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 7 – CLINICAL FEATURES & MORPHOLOGY
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Clinical Features & Morphological Changes", "Pre-eclampsia presentation and tissue pathology");
addCard(sl, 0.3, 1.25, 4.55, 3.7, "Clinical Presentation", C.pre, [
"Onset: usually after 34 weeks gestation",
"Earlier if: hydatidiform mole, pre-existing renal disease, hypertension, coagulopathy",
"Triad: Hypertension + Oedema + Proteinuria",
"Convulsions / coma → eclampsia",
"BP and proteinuria resolve within 1–2 weeks post-delivery",
"Most effective treatment: prompt delivery",
]);
addCard(sl, 5.15, 1.25, 4.45, 3.7, "Morphological Changes (Placenta)", C.pre, [
"Multiple placental infarcts (more numerous than normal)",
"Retroplacental haemorrhage",
"Ischaemic changes of placental villi",
"Increased syncytial epithelial knots",
"Fibrinoid necrosis of decidual vessels",
"Focal lipid-laden macrophages (acute atherosis)",
]);
sl.addText("Incidence: 3–5% of pregnancies | More common in primigravidae", {
x: 0.3, y: 5.1, w: 9.3, h: 0.3,
fontSize: 10, italic: true, color: C.subtext, fontFace: "Calibri", margin: 0,
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 8 – MEDIATOR BALANCE VISUAL
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: "F0F4F8" } });
addHeader(sl, "Vasoactive Mediator Balance", "The tipping point between normal BP and hypertension");
// Vasodilators column
sl.addShape(pres.shapes.RECTANGLE, {
x: 0.3, y: 1.2, w: 3.5, h: 0.4,
fill: { color: C.normal },
});
sl.addText("VASODILATORS", {
x: 0.3, y: 1.2, w: 3.5, h: 0.4,
fontSize: 12, bold: true, color: C.white, align: "center", valign: "middle", fontFace: "Calibri", margin: 0,
});
const dilators = [
["Prostacyclin (PGI2)", "Normal ↑", "Pre-eclampsia ↓"],
["Nitric Oxide (NO)", "Normal ↑", "Pre-eclampsia ↓"],
["VEGF", "Normal ↑", "Pre-eclampsia ↓ (blocked by sFlt-1)"],
["Prostaglandin E2", "Normal ↑", "Pre-eclampsia ↓"],
];
dilators.forEach((d, i) => {
const y = 1.7 + i * 0.65;
sl.addShape(pres.shapes.RECTANGLE, {
x: 0.3, y, w: 3.5, h: 0.55,
fill: { color: i % 2 === 0 ? "D5F5E8" : "EAF9F2" },
line: { color: C.normal, width: 1 },
});
sl.addText([
{ text: d[0] + "\n", options: { bold: true, fontSize: 9.5, color: C.textDark, fontFace: "Calibri" } },
{ text: d[1] + " | " + d[2], options: { fontSize: 8.5, color: C.subtext, fontFace: "Calibri" } },
], { x: 0.4, y, w: 3.3, h: 0.55, valign: "middle", margin: 0 });
});
// Vasoconstrictors column
sl.addShape(pres.shapes.RECTANGLE, {
x: 6.2, y: 1.2, w: 3.5, h: 0.4,
fill: { color: C.pre },
});
sl.addText("VASOCONSTRICTORS", {
x: 6.2, y: 1.2, w: 3.5, h: 0.4,
fontSize: 12, bold: true, color: C.white, align: "center", valign: "middle", fontFace: "Calibri", margin: 0,
});
const constrictors = [
["Thromboxane A2", "Normal ↓", "Pre-eclampsia ↑"],
["Angiotensin-II", "Normal — destroyed", "Pre-eclampsia — hyper-reactivity"],
["Endothelin", "Normal low", "Pre-eclampsia ↑"],
["sFlt-1 / Endoglin", "Normal absent", "Pre-eclampsia ↑↑ (anti-VEGF)"],
];
constrictors.forEach((d, i) => {
const y = 1.7 + i * 0.65;
sl.addShape(pres.shapes.RECTANGLE, {
x: 6.2, y, w: 3.5, h: 0.55,
fill: { color: i % 2 === 0 ? "FADBD8" : "FDEDEC" },
line: { color: C.pre, width: 1 },
});
sl.addText([
{ text: d[0] + "\n", options: { bold: true, fontSize: 9.5, color: C.textDark, fontFace: "Calibri" } },
{ text: d[1] + " | " + d[2], options: { fontSize: 8.5, color: C.subtext, fontFace: "Calibri" } },
], { x: 6.3, y, w: 3.3, h: 0.55, valign: "middle", margin: 0 });
});
// Balance scale divider
sl.addShape(pres.shapes.RECTANGLE, {
x: 4.6, y: 1.1, w: 0.8, h: 3.9,
fill: { color: C.lightGray },
line: { color: C.accent, width: 1.5 },
});
sl.addText("⚖", {
x: 4.6, y: 2.7, w: 0.8, h: 0.5,
fontSize: 22, align: "center", fontFace: "Calibri", margin: 0,
});
sl.addText("BALANCE", {
x: 4.6, y: 3.25, w: 0.8, h: 0.35,
fontSize: 7, bold: true, color: C.border, align: "center", fontFace: "Calibri", margin: 0,
});
}
// ─────────────────────────────────────────────────────────────────
// SLIDE 9 – SUMMARY / CONCLUSION
// ─────────────────────────────────────────────────────────────────
{
const sl = pres.addSlide();
sl.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: "100%", h: "100%", fill: { color: C.darkBg } });
sl.addText("Key Takeaways", {
x: 0.5, y: 0.25, w: 9, h: 0.6,
fontSize: 28, bold: true, color: C.white, fontFace: "Calibri", margin: 0,
});
sl.addShape(pres.shapes.RECTANGLE, {
x: 0.5, y: 0.88, w: 4, h: 0.05,
fill: { color: C.accent },
});
const points = [
{ num: "01", title: "Trophoblast invasion is the crux", body: "Successful invasion → low resistance flow. Failure → placental hypoxia — the root of pre-eclampsia." },
{ num: "02", title: "Vasodilators vs Vasoconstrictors", body: "Normal pregnancy balances PGI2, NO, VEGF against constrictors. Pre-eclampsia tips this balance toward constriction and hypertension." },
{ num: "03", title: "VEGF / sFlt-1 imbalance", body: "Anti-angiogenic factors (sFlt-1, endoglin) suppress VEGF/TGF-β — this drives endothelial dysfunction systemically." },
{ num: "04", title: "HELLP & DIC — severe end", body: "~10% of severe pre-eclampsia → HELLP (haemolysis, elevated LFTs, low platelets). Convulsions = eclampsia." },
];
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// ─────────────────────────────────────────────────────────────────
// WRITE FILE
// ─────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/preeclampsia-ppt/Normal_vs_Preeclampsia_Pathophysiology.pptx" })
.then(() => console.log("DONE"))
.catch(e => { console.error("ERROR:", e); process.exit(1); });
cd /home/daytona/workspace/preeclampsia-ppt && node build.js 2>&1
ls -lh /home/daytona/workspace/preeclampsia-ppt/
Normal vs Preeclampsia Pathophysiology
Presentation · PPTX
| Slide | Content |
|---|---|
| 1 | Title slide - dark navy with color-coded branding |
| 2 | At a Glance comparison table (11 features side-by-side) |
| 3 | Spiral Artery Remodeling - normal vs impaired (two-column cards) |
| 4 | Blood Pressure Regulation - Angiotensin-II, PGI2, NO mechanisms |
| 5 | Angiogenic Factor Imbalance - VEGF / sFlt-1 / Endoglin / TGF-β |
| 6 | Pre-eclampsia Pathogenesis Cascade (step-by-step flowchart with HELLP/DIC boxes) |
| 7 | Clinical Features + Morphological placental changes |
| 8 | Vasoactive Mediator Balance - visual scale of dilators vs constrictors |
| 9 | Key Takeaways (4-point summary cards) |