Quick answer: Crohn's disease management is step-wise and depends on disease location, severity, and behavior. Mild-to-moderate disease typically starts with aminosalicylates or budesonide; moderate-to-severe disease uses corticosteroids for induction, then azathioprine/6-MP or methotrexate for maintenance; biologics (anti-TNF agents like infliximab/adalimumab, vedolizumab, ustekinumab) are used for refractory or complicated disease. Surgery is reserved for complications.

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