Tau, a Microtubule-associated protein, was identified in 1975 by Weingarten et al.[1], encoded by 16 exons comprising the MAPT gene. Tau is an intrinsically disordered, natively unfolded, highly soluble protein found on chromosome 17q21.31. It promotes the assembly and stabilisation of microtubules [2]. It is a single-chain isoform produced by alternative splicing of 6 isoforms, ranging from 352 to 441 amino acids, that contains either {0N,1N or 2N} amino-terminal inserts and {3R or 4R} MTB (Microtubule binding repeats) [1] Specific tau isoforms are expressed in the peripheral nervous system. Tau is predominantly expressed in the CNS, where it is augmented in neuronal axons to maintain the axonal cytoskeleton and microtubule stability; low levels of tau expression have been detected in the salivary gland, testes, pancreas, and adipose tissue mark citation