• Sequence Alignment/Map (SAM) - a file format in bioinformatics for storing biological sequences aligned to a reference
• Surface-to-Air Missile - a missile designed to be launched from the ground to destroy aircraft
• Software Asset Management - the practice of managing and optimizing software licenses
• SAM (name) - a given name, short for Samuel or Samantha

SAM - Common Definitions

Military

• Surface-to-Air Missile - a missile launched from the ground (or a ship) to intercept and destroy aircraft or other aerial targets

Business / Marketing

• Serviceable Available Market - the portion of the Total Addressable Market (TAM) that a company can realistically target with its products or services. Used in the TAM-SAM-SOM framework for market sizing.
• Software Asset Management - the practice of managing, controlling, and optimizing software licenses within an organization
• Strategic Account Management - managing key/high-value customer relationships
• Senior Account Manager - a job title in sales or client services

Computing / IT

• Security Account Manager - a Windows database that stores user credentials
• System Administration Manager - a general computing role
• Sequential Access Method - a data access technique in computing
• Sequence Alignment/Map - a standard file format in bioinformatics for storing DNA/RNA sequence alignments

Government

• System for Award Management (SAM.gov) - the official U.S. government database where businesses must register to do federal contracting

Name

• Samuel (male) or Samantha (female) - a common given name; Samuel originates from Hebrew meaning "name of God" or "God has heard"