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Interpret and treatment as the fever is not subsiding

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dengue management

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WHO dengue clinical management warning signs paracetamol NSAIDs fluid advice

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The report is strongly positive for dengue NS1 antigen: 400 AU/mL. The lab’s positive cutoff is ≥10 AU/mL. This supports acute dengue infection, usually during the first 1 to 9 days of fever.
A fever can continue for about 2 to 7 days in dengue. However, because it is not settling, she should be reviewed by a doctor today, particularly to assess hydration and obtain a baseline/trend blood count.

What should be checked today

Ask for:
  • CBC with platelet count, hematocrit, and white-cell count
  • Repeat CBC/hematocrit daily or as the clinician advises, especially around illness days 3 to 7
  • Kidney function, liver tests, and electrolytes if unwell, vomiting, dehydrated, or if liver involvement is suspected
  • Evaluation for another concurrent cause of fever if clinically indicated, such as malaria, urinary infection, or respiratory infection
Platelets can fall during dengue, commonly around days 3 to 7. The trend plus symptoms and hematocrit matter more than one platelet result alone.

Home care if she is alert, drinking, passing urine, and has no danger signs

  • Use paracetamol/acetaminophen only for discomfort or high fever. Adults commonly use 500-650 mg every 6 hours as needed. Do not exceed the labeled maximum, and use a lower limit or medical advice if she has liver disease, low body weight, or uses alcohol regularly.
  • Take frequent fluids: water, ORS, soup, coconut water, or other non-alcoholic fluids. Aim for regular urination with light-colored urine.
  • Rest and monitor temperature, fluid intake, vomiting, urine output, bleeding, and abdominal pain.
  • Do not use aspirin, ibuprofen, diclofenac, naproxen, or other NSAID painkillers, because they can increase bleeding risk in dengue.
  • Do not start antibiotics, steroids, platelet transfusions, or IV fluids at home unless a clinician specifically directs this.

Go to an emergency department now if any of these occur

  • Severe or persistent abdominal pain
  • Repeated vomiting or inability to keep fluids down
  • Bleeding from gums/nose, blood in vomit or stool, black stools, unusually heavy periods, or widespread bruising
  • Drowsiness, confusion, marked weakness, restlessness, fainting, cold hands/feet
  • Breathing difficulty
  • Very little urine, dark urine, or no urine for 6 hours or more
  • Severe headache with persistent vomiting, chest pain, or a rapidly worsening condition
Be particularly watchful when the fever starts coming down. In dengue, the potentially dangerous leakage/dehydration phase often begins around days 3 to 7 as temperature falls, not necessarily while fever is highest. Warning signs need prompt hospital assessment. Park’s Textbook of Preventive and Social Medicine, section “Critical phase,” lines 2887-2917.
There is no specific antiviral treatment for routine dengue. Care is mainly careful hydration, fever relief with paracetamol, and monitoring for warning signs. A recent systematic review of dengue management also supports this supportive-care approach.
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