50 mark university post graduate theory exam , Question : On the basis of available data critically elucidate your views on " periodontal disease is considered to act as septic focus in the body influencing condition in distant parts of the body. Prepare answer using all uploaded references , provide long form of abbrevation if used
| Section | Content | Marks (Approx.) |
|---|---|---|
| Introduction | Definition, Periodontal Medicine, burden | 3 |
| Part I | Historical evolution: Miller → Hunter → demise → revival (1996) | 6 |
| Part II | Pathophysiology: pocket as reservoir, ulcerated epithelium gateway, 3 mechanisms (metastatic infection/injury/inflammation) + molecular mimicry | 8 |
| Part III | CVD: epidemiology (De Stefano, Beck, Genco, Wu), atherosclerosis mechanisms, infective endocarditis, current consensus | 9 |
| Part IV | Diabetes: bidirectional relationship, key studies (Grossi, Engebretson, Williams), mechanisms | 6 |
| Part V | Adverse pregnancy outcomes: preterm/LBW, pre-eclampsia, miscarriage, IUGR, Offenbacher 7.5× risk, animal models | 7 |
| Part VI | Pulmonary diseases: COPD + pneumonia, Scannapieco-Genco 4 mechanisms, MICU evidence, 40% CHX reduction | 5 |
| Part VII | Other associations: RA (P. gingivalis-ACPA), Alzheimer's, CKD, metabolic syndrome | 3 |
| Part VIII | Critical evaluation: intervention studies (strengths + 6 limitations), Engebretson controversy, RCT inconsistencies | 6 |
| Part IX + Conclusion | Clinical implications, interdisciplinary care, evidence-based practice, conclusion | 3 |
| Abbreviations + References | All 10 uploaded sources cited | Bonus |