You are answering a USMLE-style medical question. Question: A 40-year-old man presents to the physician with progressive weight loss for the last 3 months. He also says he frequently sweats profusely at night and has a recurring low-grade fever, for which he takes acetaminophen. The patient denies any symptoms like cough, breathlessness, or gastrointestinal symptoms. His temperature is 37.1ºC (98.8ºF), pulse is 76/min, blood pressure is 116/78 mm Hg, and respiratory rate is 13/min. On physical examination, he has generalized pallor. Bilateral cervical lymphadenopathy is present. Examination of his abdomen reveals non-tender hepatosplenomegaly in the right upper quadrant. Laboratory evaluation confirms the diagnosis of Hodgkin’s lymphoma. Which of the following viral infections is most likely to have played a role in the pathogenesis of this patient’s malignancy? Options: A) Epstein-Barr virus B) Human T-cell leukemia virus type 1 C) Human herpesvirus-8 D) Human papillomavirus type 16 Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.

A
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