const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Iodine: Function, Deficiency & Public Health Management";

// ─── COLOUR PALETTE ─────────────────────────────────────────────────────────
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const TEAL   = "1A7F74";   // supporting accent
const AMBER  = "E8A020";   // highlight/accent
const WHITE  = "FFFFFF";
const LIGHT  = "EAF4F2";   // pale teal bg
const GRAY   = "4A5568";   // body text
const LGRAY  = "D1E8E4";   // divider / muted

// ─── HELPER: accent bar on left ─────────────────────────────────────────────
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    x: 0, y: 0, w: 0.18, h: 5.625,
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}

// ─── HELPER: footer ─────────────────────────────────────────────────────────
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    fontSize: 7.5, color: LGRAY, fontFace: "Calibri", valign: "middle", margin: 0
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}

// ─── HELPER: stat box ────────────────────────────────────────────────────────
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
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    x: 0, y: 5.0, w: 10, h: 0.3,
    fill: { color: AMBER },
    line: { color: AMBER, width: 0 }
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  // iodine symbol badge
  s.addShape(pres.ShapeType.ellipse, {
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    fontSize: 18, color: AMBER, fontFace: "Calibri",
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  s.addText("IODINE", {
    x: 0.8, y: 0.7, w: 6.2, h: 1.05,
    fontSize: 52, bold: true, color: WHITE, fontFace: "Calibri",
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  s.addText("Function · Deficiency · Public Health", {
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  s.addText([
    { text: "An essential trace mineral for thyroid hormone synthesis and global health", options: {} }
  ], {
    x: 0.8, y: 2.5, w: 8.9, h: 0.7,
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  });

  // stat chips
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  statBox(s, 3.1, 3.35, 2.1, 1.15, "130+", "Countries affected", AMBER);
  statBox(s, 5.4, 3.35, 2.1, 1.15, "71 M+", "Affected in India alone", TEAL);
  statBox(s, 7.7, 3.35, 2.1, 1.15, "150 µg", "Daily RDA (adult)", "346E6F");
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 2 — WHY IODINE? (Functions)
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: LIGHT };
  leftBar(s, TEAL);
  headerBand(s, "Functions of Iodine", "The only known role: synthesis of thyroid hormones");
  footer(s);

  // Left column: thyroid hormone box
  s.addShape(pres.ShapeType.rect, {
    x: 0.3, y: 1.45, w: 4.3, h: 3.6,
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    fontSize: 13, bold: true, color: AMBER, fontFace: "Calibri",
    align: "center", valign: "middle", margin: 0
  });

  const hormones = [
    { h: "T3  (Triiodothyronine)", d: "Active form · 3 iodine atoms · potent metabolic effect" },
    { h: "T4  (Thyroxine)", d: "Storage form · 4 iodine atoms · converted to T3 in tissues" },
    { h: "Feedback Axis", d: "TSH from pituitary regulates thyroid iodine uptake via NIS" },
  ];
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      fontSize: 10, color: LGRAY, fontFace: "Calibri", italic: true, margin: 0
    });
  });

  // Right column: function list
  const fns = [
    ["Basal Metabolic Rate", "Regulates oxygen consumption and energy metabolism in all cells"],
    ["Growth & Development", "Essential for normal skeletal growth and organ maturation"],
    ["Brain Development", "Foetal neurodevelopment — critical in 1st trimester"],
    ["Cardiovascular", "Maintains heart rate, myocardial contractility, cardiac output"],
    ["Thermogenesis", "Controls body temperature through calorigenic action"],
    ["Reproductive Health", "Normal menstrual cycles, fertility, and pregnancy outcome"],
  ];
  fns.forEach(([title, desc], i) => {
    const yPos = 1.42 + i * 0.67;
    s.addShape(pres.ShapeType.rect, {
      x: 4.85, y: yPos, w: 0.06, h: 0.52,
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      line: { color: AMBER, width: 0 }
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    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 3 — IODINE DEFICIENCY DISORDERS (IDD) SPECTRUM
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: WHITE };
  leftBar(s, AMBER);
  headerBand(s, "Iodine Deficiency Disorders (IDD)", "A spectrum from foetal life through adulthood");
  footer(s, "Source: Park's Preventive & Social Medicine | WHO Classification");

  // Spectrum arrow
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    x: 0.3, y: 1.38, w: 9.4, h: 0.32,
    fill: { color: LGRAY },
    line: { color: LGRAY, width: 0 }
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  s.addText("▶  SEVERITY SPECTRUM: MILD  ─────────────────────────────────────────  SEVERE  ◀", {
    x: 0.3, y: 1.38, w: 9.4, h: 0.32,
    fontSize: 9, color: NAVY, fontFace: "Calibri", align: "center", valign: "middle", margin: 0
  });

  const stages = [
    {
      stage: "Foetal / Neonatal",
      color: "C0392B",
      items: ["Spontaneous abortion", "Stillbirth", "Congenital anomalies", "Cretinism", "Neonatal hypothyroidism", "Psychomotor defects"]
    },
    {
      stage: "Infant / Child",
      color: "E67E22",
      items: ["Endemic goitre", "Impaired mental function", "Retarded growth", "Increased susceptibility to radiation", "Hypothyroidism"]
    },
    {
      stage: "Adolescent",
      color: TEAL,
      items: ["Goitre", "Hypothyroidism", "Retarded mental/physical development", "Impaired school performance"]
    },
    {
      stage: "Adult",
      color: NAVY,
      items: ["Goitre + complications", "Hypothyroidism", "Impaired work capacity", "Iodine-induced hyperthyroidism"]
    }
  ];

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      x, y: 1.78, w: 2.2, h: 0.44,
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      x, y: 1.78, w: 2.2, h: 0.44,
      fontSize: 10.5, bold: true, color: WHITE, fontFace: "Calibri",
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    s.addShape(pres.ShapeType.rect, {
      x, y: 2.22, w: 2.2, h: 3.0,
      fill: { color: "F7F9FC" },
      line: { color: st.color, width: 1 }
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    s.addText(st.items.map(it => ({ text: it, options: { bullet: true, breakLine: true } })), {
      x: x + 0.08, y: 2.28, w: 2.05, h: 2.88,
      fontSize: 9, color: GRAY, fontFace: "Calibri", valign: "top", margin: 0
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 4 — GOITRE: THE HALLMARK SIGN
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: LIGHT };
  leftBar(s, NAVY);
  headerBand(s, "Goitre: The Hallmark of Iodine Deficiency", "Enlarged thyroid gland — visible sign of chronic iodine insufficiency");
  footer(s, "Source: Scott-Brown's ORL & Head and Neck Surgery Vol 1 | Bailey & Love's Surgery");

  // WHO grading table
  s.addText("WHO Grading of Goitre", {
    x: 0.35, y: 1.35, w: 4.5, h: 0.38,
    fontSize: 13, bold: true, color: NAVY, fontFace: "Calibri", margin: 0
  });

  const grades = [
    ["Grade", "Definition", "#FFFFFF"],
    ["0", "No palpable or visible goitre", LIGHT],
    ["1a", "Goitre palpable but not visible with neck extended", "EAF4F2"],
    ["1b", "Goitre palpable, visible only with neck extended", LIGHT],
    ["2", "Goitre visible with neck in normal position", "EAF4F2"],
    ["3", "Very large goitre, visible at distance", LIGHT],
  ];
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    });
    s.addText(g, {
      x: 0.35, y: 1.73 + i * 0.41, w: 0.7, h: 0.41,
      fontSize: i === 0 ? 10 : 12, bold: true, color: WHITE, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
    s.addShape(pres.ShapeType.rect, {
      x: 1.05, y: 1.73 + i * 0.41, w: 3.75, h: 0.41,
      fill: { color: i === 0 ? NAVY : bg },
      line: { color: LGRAY, width: 0.5 }
    });
    s.addText(def, {
      x: 1.1, y: 1.73 + i * 0.41, w: 3.65, h: 0.41,
      fontSize: i === 0 ? 10 : 9.5,
      bold: i === 0, color: i === 0 ? WHITE : GRAY,
      fontFace: "Calibri", valign: "middle", margin: 0
    });
  });

  // Right: Urinary Iodine classification
  s.addText("Urinary Iodine Concentration (UIC) Classification", {
    x: 5.3, y: 1.35, w: 4.5, h: 0.38,
    fontSize: 12, bold: true, color: NAVY, fontFace: "Calibri", margin: 0
  });

  const uicData = [
    ["< 20 µg/L", "Severe Deficiency", "C0392B"],
    ["20-49 µg/L", "Moderate Deficiency", "E67E22"],
    ["50-99 µg/L", "Mild Deficiency", "F39C12"],
    ["100-199 µg/L", "Adequate", "27AE60"],
    ["200-299 µg/L", "More than adequate", "2980B9"],
    ["> 300 µg/L", "Excessive", "8E44AD"],
  ];
  uicData.forEach(([val, label, clr], i) => {
    s.addShape(pres.ShapeType.rect, {
      x: 5.3, y: 1.78 + i * 0.41, w: 1.65, h: 0.41,
      fill: { color: clr },
      line: { color: WHITE, width: 0.5 }
    });
    s.addText(val, {
      x: 5.3, y: 1.78 + i * 0.41, w: 1.65, h: 0.41,
      fontSize: 9.5, bold: true, color: WHITE, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
    s.addShape(pres.ShapeType.rect, {
      x: 6.95, y: 1.78 + i * 0.41, w: 2.85, h: 0.41,
      fill: { color: i % 2 === 0 ? LIGHT : WHITE },
      line: { color: LGRAY, width: 0.5 }
    });
    s.addText(label, {
      x: 7.0, y: 1.78 + i * 0.41, w: 2.75, h: 0.41,
      fontSize: 10, color: GRAY, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
  });

  // key note
  s.addShape(pres.ShapeType.rect, {
    x: 0.35, y: 4.9, w: 9.45, h: 0.38,
    fill: { color: AMBER },
    line: { color: AMBER, width: 0 }
  });
  s.addText("Dietary sources: fish, dairy products, seafood — balanced diet provides ~150 µg/day for non-pregnant adults (Scott-Brown's ORL)", {
    x: 0.35, y: 4.9, w: 9.45, h: 0.38,
    fontSize: 9.5, color: NAVY, fontFace: "Calibri", bold: true,
    align: "center", valign: "middle", margin: 0
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 5 — CRETINISM & NEUROLOGICAL IMPACT
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: WHITE };
  leftBar(s, TEAL);
  headerBand(s, "Severe Deficiency: Cretinism & Brain Damage", "Irreversible consequences when deficiency occurs in foetal/neonatal period");
  footer(s, "Source: Robbins & Cotran Pathologic Basis of Disease | Medical Physiology (Boron & Boulpaep)");

  // Two types box
  const types = [
    {
      title: "Neurological Cretinism",
      color: "C0392B",
      features: [
        "Mental retardation (most prominent)",
        "Deaf-mutism",
        "Spastic diplegia / motor deficits",
        "Squint (strabismus)",
        "Goitre present",
        "Thyroid function near normal",
        "Endemic — due to severe iodine deficiency"
      ]
    },
    {
      title: "Myxedematous Cretinism",
      color: TEAL,
      features: [
        "Stunted growth (dwarfism)",
        "Severe hypothyroidism",
        "Myxedema (puffy features)",
        "Mild intellectual impairment",
        "Absent or atrophied thyroid",
        "Delayed bone age",
        "More responsive to iodine/T4 treatment"
      ]
    }
  ];

  types.forEach((t, i) => {
    const x = 0.28 + i * 4.85;
    s.addShape(pres.ShapeType.rect, {
      x, y: 1.38, w: 4.6, h: 0.5,
      fill: { color: t.color },
      line: { color: t.color, width: 0 }
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    s.addText(t.title, {
      x, y: 1.38, w: 4.6, h: 0.5,
      fontSize: 13.5, bold: true, color: WHITE, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
    s.addShape(pres.ShapeType.rect, {
      x, y: 1.88, w: 4.6, h: 3.35,
      fill: { color: i === 0 ? "FEF9F9" : LIGHT },
      line: { color: t.color, width: 1 }
    });
    s.addText(t.features.map(f => ({ text: f, options: { bullet: true, breakLine: true } })), {
      x: x + 0.15, y: 1.95, w: 4.3, h: 3.2,
      fontSize: 10.5, color: GRAY, fontFace: "Calibri", valign: "top", margin: 0
    });
  });

  // Cognitive impact banner
  s.addShape(pres.ShapeType.rect, {
    x: 0.28, y: 5.25, w: 9.44, h: 0.28,
    fill: { color: NAVY },
    line: { color: NAVY, width: 0 }
  });
  s.addText("Even MILD iodine deficiency in early pregnancy is associated with lower IQ scores, reading accuracy and comprehension in children at age 8 (UK Study, Scott-Brown's)", {
    x: 0.28, y: 5.25, w: 9.44, h: 0.28,
    fontSize: 8.5, color: AMBER, fontFace: "Calibri", italic: true,
    align: "center", valign: "middle", margin: 0
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 6 — HYPOTHYROIDISM SYMPTOMS
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: LIGHT };
  leftBar(s, AMBER);
  headerBand(s, "Hypothyroidism: Clinical Symptoms of Iodine Deficiency", "Low T3/T4 → multi-system manifestations");
  footer(s, "Source: Park's Preventive & Social Medicine | Cleveland Clinic | NIH ODS");

  const systems = [
    { sys: "General", icon: "⚡", items: ["Fatigue, weakness", "Weight gain", "Cold intolerance", "Slowed metabolism"] },
    { sys: "Skin & Hair", icon: "🔬", items: ["Dry, coarse skin", "Hair thinning/loss", "Puffy face (myxedema)", "Brittle nails"] },
    { sys: "Neurological", icon: "🧠", items: ["Poor memory", "Slowed thinking", "Depression", "Carpal tunnel"] },
    { sys: "Cardiovascular", icon: "❤", items: ["Bradycardia", "Raised diastolic BP", "Pericardial effusion", "Reduced cardiac output"] },
    { sys: "GI", icon: "🔵", items: ["Constipation", "Decreased bowel motility", "Enlarged tongue", "Abdominal bloating"] },
    { sys: "Reproductive", icon: "⚕", items: ["Menstrual irregularity", "Infertility", "Reduced libido", "Miscarriage risk ↑"] },
  ];

  systems.forEach((item, i) => {
    const col = i % 3;
    const row = Math.floor(i / 3);
    const x = 0.28 + col * 3.22;
    const y = 1.42 + row * 1.97;

    s.addShape(pres.ShapeType.rect, {
      x, y, w: 3.05, h: 0.44,
      fill: { color: col === 0 ? NAVY : col === 1 ? TEAL : AMBER },
      line: { color: WHITE, width: 0 }
    });
    s.addText(`${item.icon}  ${item.sys}`, {
      x: x + 0.08, y, w: 2.9, h: 0.44,
      fontSize: 12, bold: true, color: WHITE, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
    s.addShape(pres.ShapeType.rect, {
      x, y: y + 0.44, w: 3.05, h: 1.48,
      fill: { color: WHITE },
      line: { color: LGRAY, width: 0.8 }
    });
    s.addText(item.items.map(it => ({ text: it, options: { bullet: true, breakLine: true } })), {
      x: x + 0.1, y: y + 0.5, w: 2.85, h: 1.36,
      fontSize: 9.5, color: GRAY, fontFace: "Calibri", valign: "top", margin: 0
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 7 — AT-RISK POPULATIONS & GLOBAL BURDEN
// ═══════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: WHITE };
  leftBar(s, TEAL);
  headerBand(s, "At-Risk Populations & Global Burden", "29% of world's population lives in iodine-deficient areas");
  footer(s, "Source: WHO 2004 | Medscape | Park's Preventive Medicine | Scott-Brown's ORL");

  // risk groups
  const groups = [
    { grp: "Pregnant Women", why: "2× iodine demand; foetal brain development requires sustained supply; UIC target ≥ 150 µg/L", clr: "C0392B" },
    { grp: "Infants & Neonates", why: "Dependent on maternal iodine stores; neonatal hypothyroidism → permanent brain damage if untreated", clr: "E67E22" },
    { grp: "School-Age Children", why: "Growing brain needs sustained T3/T4; 285 M school children affected globally (WHO 2004)", clr: TEAL },
    { grp: "Mountain/Inland Populations", why: "Iodine-poor soils — Himalayan belt, Sub-Saharan Africa, SE Asia plateaus; crop iodine reflects soil levels", clr: NAVY },
  ];

  groups.forEach((g, i) => {
    s.addShape(pres.ShapeType.rect, {
      x: 0.28, y: 1.42 + i * 0.95, w: 2.65, h: 0.88,
      fill: { color: g.clr },
      line: { color: g.clr, width: 0 }
    });
    s.addText(g.grp, {
      x: 0.28, y: 1.42 + i * 0.95, w: 2.65, h: 0.88,
      fontSize: 10.5, bold: true, color: WHITE, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0, wrap: true
    });
    s.addShape(pres.ShapeType.rect, {
      x: 2.93, y: 1.42 + i * 0.95, w: 6.8, h: 0.88,
      fill: { color: i % 2 === 0 ? LIGHT : WHITE },
      line: { color: LGRAY, width: 0.8 }
    });
    s.addText(g.why, {
      x: 3.05, y: 1.42 + i * 0.95, w: 6.6, h: 0.88,
      fontSize: 10, color: GRAY, fontFace: "Calibri",
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    align: "center", valign: "middle", margin: 0
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 8 — PUBLIC HEALTH MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════
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  footer(s, "Source: Park's Preventive & Social Medicine | WHO/UNICEF/ICCIDD Guidelines");

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      num: "01",
      title: "Universal Salt Iodization (USI)",
      clr: NAVY,
      points: [
        "Fortify ALL edible salt — not just 'iodized salt' programmes",
        "India: ≥ 15 ppm iodine at production level; ≥ 15 ppm at consumer level",
        "Cost-effective: ~ US$ 0.05 per person per year",
        "India banned non-iodized salt under FSSAI 2006/2011"
      ]
    },
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      num: "02",
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      clr: TEAL,
      points: [
        "Urinary iodine concentration (UIC) surveys every 5 years",
        "School-age children: target UIC ≥ 100 µg/L",
        "Pregnant women: target UIC ≥ 150 µg/L",
        "India: IDD Control Cells in 34 States/UTs established",
        "Salt iodine content testing at production and consumer level"
      ]
    },
    {
      num: "03",
      title: "Supplementation Programmes",
      clr: AMBER,
      points: [
        "Iodized oil (oral/IM) in severely deficient, remote areas",
        "Iodine tablets for pregnant/lactating women where salt USI not reached",
        "Iodine supplementation for refugees and conflict-zone populations",
        "Daily iodine supplements: 150 µg (adults), 220-290 µg (pregnancy/lactation)"
      ]
    },
    {
      num: "04",
      title: "Health Education & Communication",
      clr: "346E6F",
      points: [
        "Promote consumption of iodine-rich foods: fish, dairy, eggs",
        "Community awareness on correct salt storage (airtight, away from heat/light)",
        "School health education programmes",
        "Behavioral change communication (BCC) campaigns"
      ]
    }
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 9 — INDIA: NATIONAL IDD CONTROL PROGRAMME
// ═══════════════════════════════════════════════════════════════════════════
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  footer(s, "Source: Park's Preventive & Social Medicine, 26th Edition");

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    { yr: "1962", event: "Goitre Control Programme launched — area-specific iodized salt distribution" },
    { yr: "1986", event: "National IDD Control Programme (NIDDCP) initiated — nationwide rather than area-specific" },
    { yr: "1992", event: "Prevention of Food Adulteration (PFA) Act amended — ban on non-iodized salt in endemic areas" },
    { yr: "2000", event: "Iodized salt mandatory in all states; PFA amended to include all areas" },
    { yr: "2006", event: "Food Safety & Standards Act enacted — nationwide ban on non-iodized salt for human consumption" },
    { yr: "2011", event: "FSSAI Regulations 2011 — enforceable nationwide ban on sale of non-iodized salt" },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 10 — KEY TAKEAWAYS & RECOMMENDATIONS
// ═══════════════════════════════════════════════════════════════════════════
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    { n: "1", t: "Iodine's ONLY known role is thyroid hormone (T3/T4) synthesis — deficiency impairs every system they regulate." },
    { n: "2", t: "IDD is a spectrum: from subclinical hypothyroidism in adults to irreversible cretinism in foetal life." },
    { n: "3", t: "Universal Salt Iodization (USI) is the most cost-effective, scalable public health solution." },
    { n: "4", t: "Pregnant and lactating women and young children are highest-risk — targeted supplementation is essential where USI gaps exist." },
    { n: "5", t: "Surveillance using UIC every 5 years is necessary to monitor programme effectiveness and guide policy." },
    { n: "6", t: "Excess iodine can also cause harm (iodism, Hashimoto's thyroiditis, iodine-induced hyperthyroidism) — programmes must monitor upper limits." },
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  s.addText("Sources: Park's Preventive & Social Medicine | Robbins & Cotran Pathology | Scott-Brown's ORL | Medical Physiology | WHO/UNICEF/ICCIDD", {
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// ─── WRITE FILE ──────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/iodine-ppt/Iodine_Function_Deficiency_Public_Health.pptx" })
  .then(() => console.log("DONE"))
  .catch(e => { console.error(e); process.exit(1); });