Most acute tonsillitis is viral and improves within about a week without antibiotics. Treatment is mainly to relieve pain, maintain fluids, and identify the smaller group with likely streptococcal infection or complications.
Textbooks describe analgesia, hydration, and saline gargles as the main initial care. Antibiotics are not needed for most cases. Bailey and Love's Short Practice of Surgery, p. 807.
A clinician may use examination, a rapid strep test or throat swab, and a score such as Centor or FeverPAIN to decide. Features favoring group A streptococcal infection include:
For confirmed or strongly suspected streptococcal tonsillitis,
penicillin V (phenoxymethylpenicillin) is commonly first choice. The exact drug, dose, and duration depend on age, pregnancy, allergies, local resistance patterns, and severity. For adults, the NICE guideline lists penicillin V 500 mg four times daily or 1 g twice daily for 5-10 days; avoid self-starting antibiotics and get a prescription tailored to you.
NICE acute sore-throat guidance recommends no antibiotic or a delayed prescription for many lower-risk cases.
These signs can indicate abscess or deeper neck infection, which may need urgent drainage and intravenous treatment.
NICE guidance specifically flags quinsy, parapharyngeal/retropharyngeal abscess, and severe systemic infection as complications needing urgent assessment.