The dose and frequency must be individualized using
12-hour blood lithium levels, kidney function, age, other medicines, and side effects. Do
not change the schedule, skip doses, double a missed dose, or switch between immediate- and extended-release products without the prescriber’s direction. The
FDA prescribing information lists usual adult regimens as divided doses, while
DailyMed labeling emphasizes serum-level guided dosing.
Seek urgent medical advice for possible toxicity symptoms: worsening tremor, vomiting/diarrhea, marked drowsiness, confusion, unsteady walking, or slurred speech. Dehydration and medicines such as NSAID painkillers, ACE inhibitors, ARBs, and some diuretics can raise lithium levels.