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Pharmacology on discuss first pass metabolism as pptx
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First Pass Metabolism
Presentation · PPTX
What's inside (10 slides, dark navy theme with colour-coded sections):
| Slide | Content |
|---|---|
| 1 | Title slide |
| 2 | Definition - what first-pass metabolism is (Lippincott + Goldman-Cecil) |
| 3 | Mechanism & Pathway - step-by-step diagram (GI tract → portal vein → liver → systemic circulation), key enzymes (CYP450, MAO, UGT), sites |
| 4 | Bioavailability & Extraction Ratio - formula F = AUC(oral)/AUC(IV), high/intermediate/low ER drug table |
| 5 | Classic Clinical Examples - Nitroglycerin, Morphine, Lidocaine, Propranolol, Verapamil, Naloxone |
| 6 | Routes that Bypass First-Pass - IV, sublingual, transdermal, inhalation, rectal, IM/SC with bypass extent |
| 7 | Factors Affecting It - liver disease, hepatic blood flow, enzyme induction/inhibition, genetic polymorphisms, age, CKD |
| 8 | Clinical Implications - pro-drugs (codeine→morphine, enalapril→enalaprilat) + dosing adjustments |
| 9 | Summary table - all key concepts at a glance |
| 10 | Key Takeaways - 5 exam-ready bullet points |
Sources: Lippincott Illustrated Reviews Pharmacology, Katzung Basic & Clinical Pharmacology 16E, Goodman & Gilman 14E, Goldman-Cecil Medicine.
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