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Examination of Liposarcoma
What is Liposarcoma?
Liposarcoma is a malignant tumour with adipocytic differentiation and is the most common soft tissue sarcoma of adulthood (second most common in some orthopaedic series). It occurs predominantly in people in their 50s-60s, arising in the deep soft tissues and retroperitoneum. Three distinct histological subtypes exist, each with different genetics, behaviour, and prognosis.
Subtypes at a Glance
| Subtype | Location | Genetics | Behaviour |
|---|
| Well-differentiated (ALT/WDL) | Deep extremity, retroperitoneum | MDM2 amplification (12q13-q15) | Indolent; excellent prognosis if resected; retroperitoneal WDL frequently recurs |
| Myxoid liposarcoma | Thigh, lower extremity | t(12;16) fusion gene | Intermediate; metastasises to soft tissue (retroperitoneum, extremities) |
| Pleomorphic liposarcoma | Extremities | Complex karyotype | Aggressive; frequent metastases |
| Dedifferentiated liposarcoma | Retroperitoneum | MDM2 amplification + high-grade component | High-grade; risk of dedifferentiation highest in retroperitoneum |
(ALT = Atypical Lipomatous Tumour; WDL = Well-Differentiated Liposarcoma - histologically identical but differ by anatomic location and clinical outcome)
Clinical Presentation
The classic presentation is a large, painless, deep-seated mass located proximally in the extremities (most commonly the thigh) in a patient over 50 years old. Key features:
- Asymptomatic mass - the most common presentation; often noticed incidentally or after minor trauma draws attention to a pre-existing lesion
- Size: tumours in distal extremities tend to be smaller at presentation; proximal extremity and retroperitoneal tumours can grow very large before becoming apparent
- Retroperitoneal liposarcoma: typically presents as a mass >10 cm; symptoms arise late when the tumour compresses surrounding structures - pain, early satiety, obstructive GI symptoms, or neurological symptoms from lumbar/pelvic nerve compression
- Pain: occurs with impingement on bone or neurovascular bundles; more typical of high-grade or large tumours
- Tumour growth: centrifugal - compresses but initially does not invade surrounding normal structures
- Lower extremity DVT may occasionally be the presenting feature (tumour compressing venous outflow)
History Taking
A thorough history should document:
| Parameter | Detail |
|---|
| Location | Extremity vs. truncal vs. retroperitoneal |
| Time frame | How long the mass has been present; rate of growth |
| Size change | Enlarging masses are more concerning |
| Pain | Noncyclical pain raises suspicion for malignancy |
| Bowel/urinary symptoms | Compression effects in retroperitoneal disease |
| Family history | Li-Fraumeni syndrome (p53 mutation), Neurofibromatosis Type 1 (3-15% lifetime risk of malignant tumours including MPNST) |
| Previous cancer | Prior history raises concern for metastasis to abdominal wall |
| Prior surgery/radiation | Radiation-induced sarcoma; port-site recurrence after laparoscopy (<1% risk) |
Physical Examination
General Examination
- Overall appearance: look for signs of anaemia (chronic bleeding retroperitoneally), weight loss, cachexia
- Lymph nodes: a complete nodal examination of all nodal basins is mandatory - though lymph node metastasis is rare in liposarcoma (<5% of soft tissue sarcomas overall), it must be excluded
- Testicular examination in men: retroperitoneal mass differential includes testicular primaries (germ cell tumours) - elevated AFP/beta-HCG should be checked
Local Examination of the Mass
The physical examination should systematically document:
| Parameter | Findings and Significance |
|---|
| Location | Anatomic site; superficial vs. deep to fascia |
| Size | Measured in three dimensions; >5 cm is high-risk |
| Depth | Superficial (above investing fascia) vs. deep (below fascia) - deep lesions are higher grade |
| Consistency | Soft and fluctuant (lipomatous) vs. firm/hard (dedifferentiated or pleomorphic) |
| Mobility | Mobile vs. fixed - fixation to underlying bone, neurovascular bundles, or overlying skin suggests invasion |
| Surface | Smooth vs. lobulated |
| Tenderness | Pain on palpation - suggests high-grade or rapidly enlarging tumour |
| Skin involvement | Overlying skin changes, induration, ulceration (rare) |
| Transillumination | Liposarcoma does NOT transilluminate (unlike lipoma which may partially do so) |
| Regional neurovascular status | Assess distal pulses, sensation, and motor function for neurovascular compromise |
A key clinical rule: any soft tissue mass that is >5 cm, deep to the fascia, or enlarging must be evaluated with imaging and biopsy - it should NOT be assumed benign.
"Enlarging masses and masses larger than 5 cm or deep to the fascia should be evaluated with a history, imaging, and biopsy." - Schwartz's Principles of Surgery, 11th Ed.
Distinguishing Features from Lipoma (Differential)
Lipoma is 100 times more common than sarcoma. Clinical features that raise suspicion for liposarcoma over lipoma:
- Deep location (beneath investing fascia)
- Size >5-10 cm
- Firmness or heterogeneity on palpation
- Fixed or non-mobile
- Rapid growth
- Pain (lipomas are typically painless)
- Age >50 years with retroperitoneal location
Investigations
Imaging
MRI is the preferred modality for extremity soft tissue sarcomas:
- Shows fat signal in well-differentiated subtypes
- Features favouring malignancy over a benign lipoma:
- Size >10 cm
- Thick, nodular septa
- Globular or nodular non-adipose areas
- Fat content <75%
- Septal enhancement on contrast
- Incomplete fat suppression
CT is preferred for retroperitoneal, intra-abdominal, and truncal sarcomas; can often distinguish WDL from dedifferentiated liposarcoma.
Chest CT for lung metastasis staging in:
- High-grade tumours >5 cm
- Myxoid liposarcoma (also CT abdomen/pelvis - metastasises to soft tissues)
Well-differentiated liposarcoma can be diagnosed by CT imaging alone - negative biopsy should not delay operative intervention if CT is diagnostic.
Histopathology
Fig. 19.43 - Robbins & Kumar Basic Pathology: (A) Well-differentiated liposarcoma - mature adipocytes with rare atypical stromal cells; (B) Myxoid liposarcoma - myxoid matrix, arborising "chicken wire" capillaries, and scattered lipoblasts.
Sarcoma is diagnosed by morphologic assessment of histologic sections by an experienced sarcoma pathologist. Even expert pathologists disagree on subtype and grade in 25-40% of cases, highlighting the need for a specialist sarcoma centre.
Ancillary techniques:
- Immunohistochemistry (MDM2, CDK4 for WDL/dedifferentiated)
- Conventional cytogenetics
- FISH for MDM2 amplification (12q13-q15)
- PCR for t(12;16) in myxoid liposarcoma
Biopsy
- Core needle biopsy - preferred for extremity and truncal lesions; performed by the operating surgeon at a sarcoma centre; incision oriented longitudinally along the extremity
- Incisional biopsy - for lesions where core needle is inadequate
- Excisional biopsy - only for superficial lesions <3 cm
- FNA - generally inadequate; only at institutions with specialist cytopathology expertise
- Important: diagnostic imaging should be performed before biopsy to avoid swelling/haemorrhage artefact
Pathological Staging (AJCC)
Soft tissue sarcoma staging includes:
- Histologic grade (most important prognostic factor)
- Tumour size (≤5 cm vs. >5 cm; retroperitoneal: most are >10 cm at diagnosis)
- Depth (superficial vs. deep)
- Nodal/distant metastasis
Poor prognostic indicators: high grade, large size (>5 cm), deep/proximal location, presence of metastasis.
Complications of Liposarcoma
| Complication | Notes |
|---|
| Local recurrence | Most common cause of treatment failure, especially retroperitoneal WDL |
| Lung metastases | Primary haematogenous spread (especially high-grade) |
| Soft tissue metastases | Unique to myxoid liposarcoma (retroperitoneum, contralateral extremity) |
| Dedifferentiation | WDL in the retroperitoneum may transform to high-grade dedifferentiated liposarcoma (up to 10%) |
| Portal pyaemia | Rare |
Summary: Examination Checklist
- History - duration, growth rate, pain, systemic symptoms, family/cancer history
- General - anaemia, weight loss, lymphadenopathy, testicular exam (in men with retroperitoneal mass)
- Local mass - site, size, depth, consistency, mobility, skin involvement, neurovascular status
- Imaging before biopsy - MRI for extremity; CT for retroperitoneal
- Core needle biopsy at a sarcoma centre, longitudinal incision
- Chest CT for staging (high-grade or >5 cm)
- Staging workup - CT chest/abdomen/pelvis for myxoid liposarcoma specifically
- Multidisciplinary team - radiologist, pathologist, surgical oncologist, medical and radiation oncologist
Sources: Schwartz's Principles of Surgery 11th Edition, Ch. 36; Campbell's Operative Orthopaedics 15th Ed 2026, Ch. 30; Robbins & Kumar Basic Pathology; Grainger & Allison's Diagnostic Radiology; Fischer's Mastery of Surgery 8th Ed