Assuming you mean medication for acute tooth and gum pain:
First-line analgesia for adults
Inflammatory odontogenic pain, post-extraction pain, pericoronitis, gingival inflammation
- Ibuprofen 400 mg orally every 6 hours as needed, with food.
- For moderate to severe pain: ibuprofen 400 mg plus paracetamol (acetaminophen) 500-1,000 mg together every 6 hours as needed.
This NSAID plus paracetamol combination is generally more effective than opioid-containing regimens for acute dental pain and should be first line. See the
ADA acute dental analgesia guidance. The 2024 ADA guideline is indexed at PMID: 38325969.
Maximums
- Paracetamol: do not exceed 4 g/day in a healthy adult. Use a lower maximum, often 2-3 g/day, in liver disease, heavy alcohol use, frailty, or low body weight.
- Ibuprofen: respect local prescribing limits. Avoid prolonged self-treatment and avoid combining with another NSAID.
If NSAIDs are unsuitable
- Paracetamol alone: 500-1,000 mg every 6 hours as needed, within the appropriate daily maximum.
- Consider avoiding NSAIDs with active peptic ulcer or GI bleed, significant renal impairment, decompensated heart failure, NSAID hypersensitivity, anticoagulation/high bleeding risk, or pregnancy, especially after 20 weeks and particularly in the third trimester.
Local adjuncts
- Warm saline mouth rinse and gentle plaque removal for uncomplicated sore/bleeding gums.
- Chlorhexidine mouth rinse can be a short-term adjunct for plaque-related gingival inflammation or pericoronitis, but it is not a replacement for debridement. Counsel about staining, taste disturbance, and avoid long unsupervised courses.
- For a focal dental source, a dental nerve block or local infiltration can provide temporary relief while arranging definitive care. Definitive management is drainage, endodontic treatment, extraction, debridement, or periodontal care as indicated.
Avoid placing aspirin directly on gingiva or tooth. It can cause a chemical burn.
Antibiotics: not routine for pain alone
Do not use antibiotics for uncomplicated irreversible pulpitis, apical periodontitis, or a localized abscess when definitive dental treatment is available. Provide source control plus analgesia. The emergency medicine text similarly notes antibiotics do not benefit pulpitis alone, while analgesia and dental referral are needed - ROSEN's Emergency Medicine, 10e, lines 2608-2612.
Use antibiotics as an adjunct when there is systemic involvement or spread, for example fever, malaise, diffuse cellulitis, lymphadenopathy, progressive swelling, or immunocompromise, while arranging urgent dental source control. This aligns with
ADA antibiotic guidance.
Urgent referral or emergency assessment
Arrange urgent dental or ED assessment for:
- Facial, submandibular, or neck swelling
- Trismus, dysphagia, drooling, voice change, dyspnea
- Fever/systemic toxicity
- Rapidly progressive infection, orbital symptoms, or suspected deep-space infection
- Severe pain not controlled by appropriate non-opioid analgesia
For necrotizing ulcerative gingivitis, prioritize urgent dental assessment, debridement, oral hygiene measures, analgesia, and antimicrobial therapy only when clinically indicated. It presents with pain, bleeding, papillary necrosis, and sometimes fever or malaise.
If you actually meant meditation rather than medication, it can be used as an adjunct for pain distress but will not treat pulpitis, abscess, or periodontal infection.