I have all the content needed. Here is the complete 4-mark answer directly from Park's Textbook of Preventive and Social Medicine:
Screening Test - Criteria for Selection and Use
(Park's Textbook of Preventive and Social Medicine)
Definition
Before a screening programme is initiated, a decision must be made whether it is worthwhile, which requires ethical, scientific, and financial justification. The criteria for screening are based on two considerations:
- The DISEASE to be screened
- The TEST to be applied
A. Criteria Related to the DISEASE
The disease should fulfil the following before it is suitable for screening:
- The condition should be an important health problem (prevalence should be high)
- There should be a recognizable latent or early asymptomatic stage
- The natural history of the condition (latent to declared disease) should be adequately understood
- There is a test that can detect the disease prior to onset of signs and symptoms
- Facilities should be available for confirmation of the diagnosis
- There is an effective treatment available
- There should be an agreed-on policy concerning whom to treat (e.g., borderline diabetes, lower ranges of BP)
- There is good evidence that early detection and treatment reduces morbidity and mortality
- The expected benefits exceed the risks and costs
B. Criteria Related to the SCREENING TEST
The test must satisfy the following criteria:
1. Acceptability
- The test must be acceptable to the target population
- Tests that are painful, discomforting or embarrassing (e.g., rectal/vaginal examinations) are less likely to be accepted in mass campaigns
2. Repeatability (Reliability/Reproducibility)
- The test must give consistent results when repeated on the same individual under the same conditions
- Depends on three factors:
- Observer variation (intra-observer and inter-observer)
- Biological (subject) variation
- Errors in technical methods
3. Validity (Most Important)
The ability of a test to correctly classify individuals as diseased or not. It has two components:
| Component | Definition | Formula |
|---|
| Sensitivity | Ability to identify TRUE POSITIVES (correctly identifying diseased persons) | a / (a+c) x 100 |
| Specificity | Ability to identify TRUE NEGATIVES (correctly identifying non-diseased persons) | d / (b+d) x 100 |
- A test cannot be both highly sensitive and highly specific simultaneously - there is a trade-off
- Sensitivity is prioritized when missing a case is dangerous (e.g., cancer)
- Specificity is prioritized when false positives carry serious consequences
4. Yield
- The amount of previously unrecognized disease detected and brought to treatment as a result of screening
- Depends on: sensitivity of the test, prevalence of disease, and proportion of population accepting screening
5. Other Criteria
- Simplicity - can be performed by paramedical staff
- Safety - should not harm the subject
- Rapidity - quick to perform
- Cost - should be reasonably low for community-wide application
Source: Park's Textbook of Preventive and Social Medicine, Chapter on Epidemiology - Screening Test section
Exam Tip (4-mark answer): Focus on the 2-part structure (Disease criteria + Test criteria), enumerate the 9 disease criteria, and for the test - cover Acceptability, Repeatability, Validity (sensitivity/specificity), and Yield. That covers a complete 4-mark answer.