TH2 cell release which type of IL
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The diagram perfectly illustrates the TH2 cytokine network:
Summary
TH2 cells release primarily IL-4, IL-5, and IL-13 as their hallmark cytokines, with IL-10 also being a significant product:
| IL | Quick Mnemonic | Main Effect |
|---|---|---|
| IL-4 | "4-ward TH2 differentiation" | IgE switching, TH2 amplification |
| IL-5 | "5 fingers of an eosinophil" | Eosinophil activation |
| IL-13 | "13 = mucosal/mucus" | Mucus secretion, gut motility, macrophage M2 polarization |
| IL-10 | "Anti-10flammation" | Suppresses TH1 and innate inflammation |
Source: Cellular and Molecular Immunology (Abbas & Lichtman), Chapter 10 - Functions of TH2 cells.
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