Hepa B vaccine dose
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Hepatitis B vaccine dose schedule adults children WHO 2025
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Here is a full summary of Hepatitis B vaccine dosing:
Hepatitis B Vaccine - Dosing & Schedule
Standard Formulations & Doses
| Vaccine | Age Group | Dose | Volume | # Doses | Schedule |
|---|---|---|---|---|---|
| Engerix-B (GSK) | 0-19 years | 10 mcg | 0.5 mL | 3 | 0, 1-2, 6-18 months |
| Engerix-B (GSK) | ≥20 years | 20 mcg | 1.0 mL | 3 | 0, 1-2, 4-6 months |
| Recombivax HB (Merck) | 0-19 years | 5 mcg | 0.5 mL | 3 | 0, 1-2, 6-18 months |
| Recombivax HB (Merck) | 11-15 years | 10 mcg | 1.0 mL | 2 | 0, 4-6 months |
| Recombivax HB (Merck) | ≥20 years | 10 mcg | 1.0 mL | 3 | 0, 1-2, 4-6 months |
| Heplisav-B (Dynavax) | ≥18 years | 20 mcg | 0.5 mL | 2 | 0, 1 month (4 weeks apart) |
| Twinrix (HepA+HepB, GSK) | ≥18 years | 20 mcg | 1.0 mL | 3 | 0, 1, 6 months |
| Twinrix (accelerated) | ≥18 years | 20 mcg | 1.0 mL | 4 | 0, 7, 21-30 days, then 12 months |
Note (CDC 2025): For infants born to HBsAg-negative mothers, birth-dose timing is now subject to shared clinical decision-making between parents and provider. For infants born to HBsAg-positive or unknown-status mothers, the birth dose (within 24 hours) + HBIG remains unchanged.
Route & Site
- Intramuscular (IM) only - intradermal is NOT recommended (less reliable immune response)
- Adults/older children: Deltoid muscle (preferred for reliable antibody conversion; gluteal injection risks fat deposition)
- Infants/children <2 years: Anterolateral thigh
Special Populations
| Population | Regimen |
|---|---|
| Newborns (birth dose) | Monovalent vaccine only, within 24 hours of birth |
| Premature (<2000 g) | Delay first dose to 1 month of chronological age |
| Hemodialysis / immunocompromised | High-dose Recombivax HB (40 mcg/mL) x3 doses at 0, 1, 6 months; OR Engerix-B as four 2 mL injections at 0, 1, 2, 6 months |
| Post-exposure (unvaccinated) | HBIG 0.06 mL/kg IM within 24 hours + begin vaccine series |
India National Immunization Program
A 4-dose schedule is used:
- Birth dose (within 24 hours) - monovalent
- Then 3 doses at 6, 10, and 14 weeks as Pentavalent vaccine (DPT + HepB + Hib)
Minimum Dose Intervals
- Dose 1 to Dose 2: 4 weeks
- Dose 2 to Dose 3: 8 weeks
- Dose 1 to Dose 3: 16 weeks
If a series is interrupted, it does NOT need to be restarted - simply resume from where it left off.
Efficacy & Duration
- Induces protective anti-HBs (≥10 mIU/mL) in >95% of infants, children, and young adults
- Protection drops below 90% after age 40, and to 65-75% by age 60
- Duration: at least 15 years, and likely lifelong based on current evidence
Sources: Park's Textbook of Preventive and Social Medicine; Washington Manual of Medical Therapeutics; CDC Immunization Schedules 2025; Immunize.org HepB reference
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