give me simplified version of this figure which is easy to represent i

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give me simplified version of this figure which is easy to represent in university theory exam

Generating Image

Clean simplified university exam diagram showing Pattern Recognition Receptor (PRR) signaling pathways. Black and white line art style, clear labels, minimal detail. Three main pathways shown as vertical columns with arrows: LEFT COLUMN - "TLR/NOD Pathway (MyD88-dependent)": Box at top: "MAMPs (LPS, peptidoglycan)" → TLR2/TLR4 (membrane receptor) or NOD1/NOD2 (cytosolic) → MyD88 adaptor → IRAK1 + TRAF6 → TAK1 → two branches: (1) IKK complex → IκB degradation → NF-κB activation, (2) MKK → MAPK (p38/ERK) → AP-1 activation → OUTCOME BOX: "Inflammatory genes: TNF, IL-1, IL-6, chemokines, adhesion molecules" MIDDLE COLUMN - "TLR3/TLR4 Pathway (TRIF-dependent)": Box at top: "dsRNA / LPS (endosome)" → TLR3/TLR4 → TRIF adaptor → IRF3/IRF7 → OUTCOME BOX: "Type I Interferons (IFN-α/β)" RIGHT COLUMN - "NLRP3 Inflammasome": Box at top: "Signal 1: NF-κB → NLRP3 expression" then "Signal 2: DAMPs (ATP, ROS, crystals)" → NLRP3 + ASC + Pro-Caspase-1 assembly → Caspase-1 cleavage → OUTCOME BOX: "IL-1β / IL-18 secretion + Pyroptosis (Gasdermin-D pores)" Clean layout, bold headers for each pathway, simple arrows, no color fills except light gray boxes, suitable for hand-drawing in exam

Here's how to read and reproduce this in an exam:

Three Core Pathways to Know

1. MyD88-Dependent Pathway (Most TLRs + NOD1/NOD2)

Trigger: MAMPs (LPS, peptidoglycan, flagellin) Receptors: TLR2, TLR4 (membrane) | NOD1/NOD2 (cytosolic, signals via Rip2)

MAMP → TLR/NOD → MyD88 → IRAK1/TRAF6 → TAK1
                                              ↓           ↓
                                          IKK → NF-κB   MKK → MAPK → AP-1
                                              ↓
                          Cytokines (TNF, IL-1, IL-6), Chemokines, Adhesion molecules

2. TRIF-Dependent Pathway (TLR3, endosomal TLR4)

Trigger: Bacterial/viral dsRNA, LPS in endosomes

dsRNA/LPS → TLR3/TLR4 (endosome) → TRIF → IRF3/IRF7 → Type I IFNs (IFN-α/β)

TLR9 (bacterial DNA) also uses MyD88 but activates IRFs - a hybrid pathway.

3. NLRP3 Inflammasome (Two-Signal Model)

Signal 1 (Priming): NF-κB activation → NLRP3 protein expression Signal 2 (Activation): DAMPs - ATP, ROS, cathepsins, crystals

Signal 1 + Signal 2 → NLRP3 + ASC + Pro-Caspase-1 (complex assembly)
                                          ↓
                                   Cleaved Caspase-1
                                     ↙           ↘
                            IL-1β / IL-18      Gasdermin-D cleavage
                            (secreted)          → pores → Pyroptosis

Quick Exam Memory Aid

Pathway	Receptor	Adaptor	Outcome
Most TLRs	TLR2/4, NOD1/2	MyD88	NF-κB + AP-1 → Inflammation
Antiviral	TLR3/endosomal TLR4	TRIF	IRF3/7 → IFN-α/β
Danger signals	NLRP3 (cytosolic)	ASC	Caspase-1 → IL-1β + Pyroptosis

Key rule: TLR3 is the ONLY TLR that uses TRIF exclusively (not MyD88). All others use MyD88 (some use both).

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