Creatine is stored in muscles as phosphocreatine, which rapidly regenerates ATP (your cells' primary energy currency). Your body makes ~1-2g/day naturally from arginine, glycine, and methionine. Supplementing raises muscle creatine stores by 20-40%.
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Cognitive function - Creatine supports brain ATP production. Studies show it can improve memory, mental fatigue resistance, and processing speed - particularly useful during sleep deprivation or mental stress. This is one of the more compelling reasons for non-exercisers to use it.
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Aging and muscle preservation - In older adults, creatine can help slow sarcopenia (age-related muscle loss) even with minimal exercise, by supporting muscle protein synthesis pathways.
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Recovery from illness or injury - If you're sedentary due to injury or illness, creatine may help preserve muscle mass during immobilization.
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Vegetarians/vegans - People who don't eat red meat or fish have naturally lower creatine stores, so supplementing provides a meaningful baseline top-up even without exercise.
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General cellular energy - Tissues beyond muscle (heart, brain, kidney) also use phosphocreatine, so there is a mild systemic energy benefit.
Creatine monohydrate is one of the most well-studied supplements available. For sedentary use: