const pptxgen = require("pptxgenjs");

let pres = new pptxgen();

// A4 portrait: 8.27" x 11.69"
pres.defineLayout({ name: 'A4_PORTRAIT', width: 8.27, height: 11.69 });
pres.layout = 'A4_PORTRAIT';

// ─── COLOR PALETTE (from reference) ───
const C = {
  navyDark:  "0D2B55",
  navyMid:   "11386A",
  navyLight: "1A3A6A",
  blue:      "1A78C2",
  red:       "B51212",
  redDark:   "880000",
  gold:      "D4A017",
  goldDark:  "8B6000",
  white:     "FFFFFF",
  ltBlue:    "BBCCDD",
  ltBlue2:   "AABBCC",
  ltBlue3:   "CCDDEE",
  panelBg:   "E8F1FA",
  textDark:  "2D2D2D",
  tableBg:   "E8F1FA",
  yellowBg:  "FFF8E1",
  subtle:    "666666",
  subjectBg: "1A3A6A",
};

// Helper: section header block
function addSectionHeader(slide, x, y, w, h, title, fillColor) {
  slide.addShape(pres.ShapeType.rect, { x, y, w, h, fill: { color: fillColor }, line: { color: fillColor } });
  slide.addText(title, { x: x + 0.05, y: y + 0.02, w: w - 0.1, h: h - 0.04, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
}

// Helper: content box (light blue bg)
function addContentBox(slide, x, y, w, h, bullets) {
  slide.addShape(pres.ShapeType.rect, { x, y, w, h, fill: { color: C.panelBg }, line: { color: C.panelBg } });
  const items = bullets.map((b, i) => ({
    text: b,
    options: { bullet: false, breakLine: i < bullets.length - 1, fontSize: 9.5, color: C.textDark }
  }));
  slide.addText(items, { x: x + 0.1, y: y + 0.05, w: w - 0.15, h: h - 0.1, valign: "top", margin: 0 });
}

// Helper: key exam / highlight bar
function addHighlightBar(slide, x, y, w, h, text, fillColor) {
  slide.addShape(pres.ShapeType.rect, { x, y, w, h, fill: { color: fillColor }, line: { color: fillColor } });
  slide.addText(text, { x: x + 0.05, y: y + 0.02, w: w - 0.1, h: h - 0.04, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
}

// ─── HELPER: Standard slide chrome ───
function addChrome(slide, pageNum, totalPages, footerText) {
  // Top dark navy header bar
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 8.27, h: 2.0, fill: { color: C.navyDark }, line: { color: C.navyDark } });
  // Red accent line under header
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 1.95, w: 8.27, h: 0.08, fill: { color: C.red }, line: { color: C.red } });
  // Bottom bar
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 11.35, w: 8.27, h: 0.34, fill: { color: C.navyDark }, line: { color: C.navyDark } });
  // Footer left: topic text
  slide.addText(footerText, { x: 0.2, y: 11.37, w: 6.0, h: 0.28, fontSize: 8, color: C.ltBlue2, valign: "middle", margin: 0 });
  // Footer right: page number
  slide.addText(`Page ${pageNum} of ${totalPages}`, { x: 6.7, y: 11.37, w: 1.3, h: 0.28, fontSize: 8, color: C.ltBlue2, align: "right", valign: "middle", margin: 0 });
  // Bottom red line
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 11.3, w: 8.27, h: 0.06, fill: { color: C.red }, line: { color: C.red } });
}

const FOOTER = "Long-term Monitoring of Metabolic Disorders & Lifestyle Correction";
const TOTAL = 6;

// ═══════════════════════════════════════════════
// SLIDE 1 — TITLE SLIDE
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  // Full dark background
  slide.background = { color: C.navyDark };
  // Right darker panel
  slide.addShape(pres.ShapeType.rect, { x: 4.5, y: 0, w: 4.0, h: 11.69, fill: { color: C.navyMid }, line: { color: C.navyMid } });
  // Red horizontal line
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 4.5, w: 8.27, h: 0.12, fill: { color: C.red }, line: { color: C.red } });
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 7.0, w: 8.27, h: 0.06, fill: { color: C.redDark }, line: { color: C.redDark } });

  // Main title
  slide.addText([
    { text: "LONG-TERM MONITORING OF\nMETABOLIC DISORDERS", options: { breakLine: false } }
  ], { x: 0.4, y: 2.2, w: 7.5, h: 2.0, fontSize: 34, bold: true, color: C.white, valign: "middle" });

  // Subtitle
  slide.addText("and Lifestyle Correction", { x: 0.4, y: 4.0, w: 7.5, h: 0.7, fontSize: 20, color: C.ltBlue, valign: "middle" });

  // Topics box
  slide.addShape(pres.ShapeType.rect, { x: 0.4, y: 5.0, w: 5.5, h: 2.0, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  slide.addText("Topics Covered:", { x: 0.5, y: 5.1, w: 5.3, h: 0.4, fontSize: 12, color: C.ltBlue3, bold: false, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Introduction to Metabolic Disorders", options: { breakLine: true } },
    { text: "• Importance of Long-Term Monitoring", options: { breakLine: true } },
    { text: "• Risk Factors", options: { breakLine: true } },
    { text: "• Symptoms & Treatment", options: { breakLine: false } },
  ], { x: 0.55, y: 5.55, w: 5.1, h: 1.3, fontSize: 10, color: C.ltBlue2, valign: "top", margin: 0 });

  // Footer details
  slide.addText("4th Year | Faculty of Medicine | Group 8", { x: 0.4, y: 10.8, w: 7.5, h: 0.4, fontSize: 10, color: "6688AA", valign: "middle", margin: 0 });
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 11.3, w: 8.27, h: 0.06, fill: { color: C.red }, line: { color: C.red } });
  slide.addText("Page 1 of " + TOTAL, { x: 6.7, y: 11.35, w: 1.3, h: 0.28, fontSize: 8, color: C.ltBlue2, align: "right", valign: "middle", margin: 0 });

  // Author / Institution box (right side)
  slide.addShape(pres.ShapeType.rect, { x: 4.8, y: 4.8, w: 3.2, h: 2.5, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  slide.addText([
    { text: "Done by: Snigdha Mandaokar", options: { breakLine: true } },
    { text: "Year: 4th | Group: 8th", options: { breakLine: true } },
    { text: "Jalalabad State University", options: { breakLine: true } },
    { text: "Faculty of Medicine", options: { breakLine: false } },
  ], { x: 4.9, y: 5.0, w: 3.0, h: 2.0, fontSize: 10, color: C.ltBlue2, valign: "top", margin: 0 });
}

// ═══════════════════════════════════════════════
// SLIDE 2 — INTRODUCTION
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  slide.background = { color: C.white };
  addChrome(slide, 2, TOTAL, FOOTER);

  // Title in header
  slide.addText("Introduction to Metabolic Disorders", { x: 0.3, y: 0.15, w: 7.7, h: 1.0, fontSize: 22, bold: true, color: C.white, valign: "middle", margin: 0 });
  slide.addText("Understanding the conditions that disrupt the body's normal metabolism", { x: 0.3, y: 1.0, w: 7.7, h: 0.75, fontSize: 13, color: C.ltBlue, valign: "middle", margin: 0 });

  // LEFT COLUMN: What are metabolic disorders?
  addSectionHeader(slide, 0.25, 2.15, 3.8, 0.35, "What are Metabolic Disorders?", C.blue);
  addContentBox(slide, 0.25, 2.5, 3.8, 2.9,
    [
      "• A group of conditions affecting the body's normal metabolism — converting food into energy",
      "• Caused by imbalance in chemical reactions, hormones, or enzymes",
      "• Common examples: Diabetes mellitus, obesity, hypertension, dyslipidemia, PCOS",
      "• Rising worldwide due to unhealthy diets, physical inactivity, stress, and genetics",
    ]
  );

  // LEFT: Why long-term monitoring matters
  addSectionHeader(slide, 0.25, 5.55, 3.8, 0.35, "Why Long-Term Monitoring Matters", C.red);
  addContentBox(slide, 0.25, 5.9, 3.8, 2.5,
    [
      "• Chronic conditions require continuous observation and evaluation",
      "• Helps control symptoms and prevent organ damage",
      "• Improves overall quality of life",
      "• Lifestyle correction reduces disease progression naturally",
    ]
  );

  // RIGHT COLUMN: Early Diagnosis
  addSectionHeader(slide, 4.2, 2.15, 3.8, 0.35, "Early Diagnosis & Follow-Up", C.navyDark);
  addContentBox(slide, 4.2, 2.5, 3.8, 2.9,
    [
      "• Detect complications at an early stage: heart disease, kidney disease, nerve damage, stroke",
      "• Regular blood tests, HbA1c, cholesterol, liver & kidney function",
      "• Body weight/BMI monitoring for obesity-related risks",
      "• Patients who follow monitoring have better health outcomes",
    ]
  );

  // RIGHT: Key Exam Points
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 3.8, h: 2.5, fill: { color: C.yellowBg }, line: { color: C.yellowBg } });
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 0.08, h: 2.5, fill: { color: C.gold }, line: { color: C.gold } });
  slide.addText("⚡ Key Points", { x: 4.35, y: 5.6, w: 3.5, h: 0.4, fontSize: 11, bold: true, color: C.goldDark, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Metabolic disorders are chronic and progressive", options: { breakLine: true } },
    { text: "• Combination of monitoring + lifestyle change is most effective", options: { breakLine: true } },
    { text: "• HbA1c used for long-term blood sugar control", options: { breakLine: true } },
    { text: "• Modern tech (fitness trackers, apps) supports monitoring", options: { breakLine: false } },
  ], { x: 4.35, y: 6.05, w: 3.55, h: 1.9, fontSize: 9.5, color: C.textDark, valign: "top", margin: 0 });

  // Bottom key fact
  addHighlightBar(slide, 0.25, 8.55, 7.77, 0.4, "⚡ Early diagnosis + regular monitoring = prevention of severe complications", C.red);
}

// ═══════════════════════════════════════════════
// SLIDE 3 — IMPORTANCE OF LONG-TERM MONITORING
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  slide.background = { color: C.white };
  addChrome(slide, 3, TOTAL, FOOTER);

  slide.addText("Importance of Long-Term Monitoring", { x: 0.3, y: 0.15, w: 7.7, h: 1.0, fontSize: 22, bold: true, color: C.white, valign: "middle", margin: 0 });
  slide.addText("Continuous assessment is the cornerstone of metabolic disorder management", { x: 0.3, y: 1.0, w: 7.7, h: 0.75, fontSize: 13, color: C.ltBlue, valign: "middle", margin: 0 });

  // LEFT: Blood Tests & Labs
  addSectionHeader(slide, 0.25, 2.15, 3.8, 0.35, "Blood Tests & Laboratory Monitoring", C.blue);
  addContentBox(slide, 0.25, 2.5, 3.8, 2.9,
    [
      "• Blood glucose levels & HbA1c (long-term blood sugar control in diabetes)",
      "• Cholesterol levels (LDL, HDL, triglycerides)",
      "• Liver function tests (LFT) & kidney function tests (KFT)",
      "• Body weight and BMI — evaluates obesity-related risks",
      "• Regular health checkups to adjust medications as needed",
    ]
  );

  // LEFT: Blood Pressure
  addSectionHeader(slide, 0.25, 5.55, 3.8, 0.35, "Blood Pressure & Cardiovascular Risk", C.navyDark);
  addContentBox(slide, 0.25, 5.9, 3.8, 2.5,
    [
      "• Hypertension commonly co-occurs with metabolic disorders",
      "• High BP increases risk of cardiovascular disease and stroke",
      "• Regular BP checks are essential in management",
      "• Identifying complications early allows medication adjustment",
    ]
  );

  // RIGHT: Patient Records
  addSectionHeader(slide, 4.2, 2.15, 3.8, 0.35, "Patient Health Records", C.red);
  addContentBox(slide, 4.2, 2.5, 3.8, 2.9,
    [
      "• Patients maintain records of: diet charts, exercise schedules, medication use, laboratory reports",
      "• Modern technology supports monitoring: fitness trackers, smart watches, mobile health apps",
      "• Track: physical activity, heart rate, sleep, calorie intake",
    ]
  );

  // RIGHT: Benefits
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 3.8, h: 2.5, fill: { color: C.yellowBg }, line: { color: C.yellowBg } });
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 0.08, h: 2.5, fill: { color: C.gold }, line: { color: C.gold } });
  slide.addText("⚡ Benefits of Monitoring", { x: 4.35, y: 5.6, w: 3.5, h: 0.4, fontSize: 11, bold: true, color: C.goldDark, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Improves patient awareness & motivation", options: { breakLine: true } },
    { text: "• Motivates individuals toward healthier lifestyles", options: { breakLine: true } },
    { text: "• Reduces hospital admissions", options: { breakLine: true } },
    { text: "• Prevents severe complications & lowers healthcare costs", options: { breakLine: false } },
  ], { x: 4.35, y: 6.05, w: 3.55, h: 1.9, fontSize: 9.5, color: C.textDark, valign: "top", margin: 0 });

  // Key stat bar
  addHighlightBar(slide, 0.25, 8.55, 7.77, 0.4, "⚡ Continuous monitoring reduces hospital admissions and healthcare costs by preventing severe complications", C.navyDark);
}

// ═══════════════════════════════════════════════
// SLIDE 4 — RISK FACTORS
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  slide.background = { color: C.white };
  addChrome(slide, 4, TOTAL, FOOTER);

  slide.addText("Risk Factors of Metabolic Disorders", { x: 0.3, y: 0.15, w: 7.7, h: 1.0, fontSize: 22, bold: true, color: C.white, valign: "middle", margin: 0 });
  slide.addText("Multiple interacting factors increase vulnerability to metabolic disease", { x: 0.3, y: 1.0, w: 7.7, h: 0.75, fontSize: 13, color: C.ltBlue, valign: "middle", margin: 0 });

  // 2x2 grid of risk factor boxes
  // TOP-LEFT: Diet & Lifestyle
  addSectionHeader(slide, 0.25, 2.15, 3.8, 0.35, "Diet & Lifestyle Factors", C.blue);
  addContentBox(slide, 0.25, 2.5, 3.8, 2.6,
    [
      "• Unhealthy diet: high in sugary foods, processed foods, saturated fats",
      "• Lack of physical activity → obesity, diabetes, hypertension",
      "• Smoking & excessive alcohol → cardiovascular risk",
      "• Poor stress management and sleep habits → hormonal imbalance",
    ]
  );

  // TOP-RIGHT: Genetic & Demographics
  addSectionHeader(slide, 4.2, 2.15, 3.8, 0.35, "Genetic & Demographic Factors", C.red);
  addContentBox(slide, 4.2, 2.5, 3.8, 2.6,
    [
      "• Genetic predisposition and family history — major risk factor",
      "• Individuals with family history of metabolic disease at higher risk",
      "• Age — metabolic disorders become more common with advancing age",
      "• Stress and poor sleep disturb hormone balance and metabolism",
    ]
  );

  // BOTTOM-LEFT: Prevention
  addSectionHeader(slide, 0.25, 5.45, 3.8, 0.35, "Prevention Strategies", C.navyDark);
  addContentBox(slide, 0.25, 5.8, 3.8, 2.6,
    [
      "• Balanced nutrition with controlled sugar and fat intake",
      "• Regular physical exercise (150 min/week of moderate activity)",
      "• Stress management techniques: meditation, yoga",
      "• Routine health checkups — at least annually",
    ]
  );

  // BOTTOM-RIGHT: Key note
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.45, w: 3.8, h: 2.95, fill: { color: C.yellowBg }, line: { color: C.yellowBg } });
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.45, w: 0.08, h: 2.95, fill: { color: C.gold }, line: { color: C.gold } });
  slide.addText("⚡ Key Risk Summary", { x: 4.35, y: 5.5, w: 3.55, h: 0.4, fontSize: 11, bold: true, color: C.goldDark, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Unhealthy diet = #1 modifiable risk factor", options: { breakLine: true } },
    { text: "• Physical inactivity × poor diet = metabolic syndrome", options: { breakLine: true } },
    { text: "• Family history cannot be changed — early screening essential", options: { breakLine: true } },
    { text: "• Lifestyle changes reduce risk even in genetically predisposed individuals", options: { breakLine: false } },
  ], { x: 4.35, y: 5.95, w: 3.55, h: 2.35, fontSize: 9.5, color: C.textDark, valign: "top", margin: 0 });

  addHighlightBar(slide, 0.25, 8.55, 7.77, 0.4, "⚡ Maintaining healthy lifestyle through nutrition + exercise + routine checkups can significantly reduce risk", C.red);
}

// ═══════════════════════════════════════════════
// SLIDE 5 — SYMPTOMS
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  slide.background = { color: C.white };
  addChrome(slide, 5, TOTAL, FOOTER);

  slide.addText("Symptoms of Metabolic Disorders", { x: 0.3, y: 0.15, w: 7.7, h: 1.0, fontSize: 22, bold: true, color: C.white, valign: "middle", margin: 0 });
  slide.addText("Clinical presentations vary by condition — early recognition enables timely management", { x: 0.3, y: 1.0, w: 7.7, h: 0.75, fontSize: 13, color: C.ltBlue, valign: "middle", margin: 0 });

  // LEFT: General symptoms
  addSectionHeader(slide, 0.25, 2.15, 3.8, 0.35, "General Symptoms", C.blue);
  addContentBox(slide, 0.25, 2.5, 3.8, 2.8,
    [
      "• Unexplained weight gain or obesity",
      "• Fatigue and low energy from improper metabolism",
      "• Dark skin patches (acanthosis nigricans) — insulin resistance / PCOS",
      "• Difficulty losing weight",
      "• Irregular menstrual cycles",
      "• Sleep problems",
      "• Increased cholesterol levels",
    ]
  );

  // LEFT: Severe complications
  addSectionHeader(slide, 0.25, 5.55, 3.8, 0.35, "Severe Complications", C.red);
  addContentBox(slide, 0.25, 5.9, 3.8, 2.5,
    [
      "• Heart disease (coronary artery disease)",
      "• Kidney problems (diabetic nephropathy)",
      "• Peripheral nerve damage (neuropathy)",
      "• Metabolic disorders can be silent until complications emerge",
    ]
  );

  // RIGHT: Disease-specific
  addSectionHeader(slide, 4.2, 2.15, 3.8, 0.35, "Disease-Specific Symptoms", C.navyDark);
  addContentBox(slide, 4.2, 2.5, 3.8, 2.8,
    [
      "Diabetes mellitus:",
      "  • Increased thirst (polydipsia), frequent urination (polyuria)",
      "  • Blurred vision, increased hunger",
      "Hypertension:",
      "  • Headaches, dizziness, chest discomfort",
      "PCOS:",
      "  • Irregular cycles, acne, hirsutism, weight gain",
    ]
  );

  // Right: Key points
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 3.8, h: 2.5, fill: { color: C.yellowBg }, line: { color: C.yellowBg } });
  slide.addShape(pres.ShapeType.rect, { x: 4.2, y: 5.55, w: 0.08, h: 2.5, fill: { color: C.gold }, line: { color: C.gold } });
  slide.addText("⚡ Clinical Pearls", { x: 4.35, y: 5.6, w: 3.55, h: 0.4, fontSize: 11, bold: true, color: C.goldDark, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Many patients are asymptomatic until late-stage", options: { breakLine: true } },
    { text: "• Acanthosis nigricans = insulin resistance marker", options: { breakLine: true } },
    { text: "• Regular screenings catch silent disease early", options: { breakLine: true } },
    { text: "• Symptom triad in diabetes: polydipsia, polyuria, polyphagia", options: { breakLine: false } },
  ], { x: 4.35, y: 6.05, w: 3.55, h: 1.9, fontSize: 9.5, color: C.textDark, valign: "top", margin: 0 });

  addHighlightBar(slide, 0.25, 8.55, 7.77, 0.4, "⚡ Early recognition of symptoms + regular medical checkups = proper diagnosis and timely treatment", C.navyDark);
}

// ═══════════════════════════════════════════════
// SLIDE 6 — TREATMENT & MANAGEMENT / SUMMARY TABLE
// ═══════════════════════════════════════════════
{
  let slide = pres.addSlide();
  slide.background = { color: C.white };
  addChrome(slide, 6, TOTAL, FOOTER);

  slide.addText("Treatment & Management of Metabolic Disorders", { x: 0.3, y: 0.15, w: 7.7, h: 1.0, fontSize: 22, bold: true, color: C.white, valign: "middle", margin: 0 });
  slide.addText("Lifestyle modification · Pharmacotherapy · Monitoring · Patient Education", { x: 0.3, y: 1.0, w: 7.7, h: 0.75, fontSize: 13, color: C.ltBlue, valign: "middle", margin: 0 });

  // 4 section boxes across the slide
  addSectionHeader(slide, 0.25, 2.15, 3.75, 0.35, "Lifestyle Modification", C.blue);
  addContentBox(slide, 0.25, 2.5, 3.75, 2.7,
    [
      "• Healthy diet: balanced nutrition, reduced sugar, regular meal timing",
      "• Regular physical activity: walking, jogging, yoga, strength training",
      "• Controls blood sugar, improves heart health, reduces obesity",
      "• Stress management and adequate sleep essential",
    ]
  );

  addSectionHeader(slide, 4.25, 2.15, 3.75, 0.35, "Pharmacotherapy", C.red);
  addContentBox(slide, 4.25, 2.5, 3.75, 2.7,
    [
      "• Diabetes: insulin or oral hypoglycemics (metformin, sulfonylureas)",
      "• Hypertension: ACE inhibitors, ARBs, calcium channel blockers",
      "• Dyslipidemia: statins, fibrates",
      "• Medications prescribed based on disorder type and severity",
    ]
  );

  addSectionHeader(slide, 0.25, 5.45, 3.75, 0.35, "Monitoring & Investigations", C.navyDark);
  addContentBox(slide, 0.25, 5.8, 3.75, 2.6,
    [
      "• Regular monitoring: blood sugar, cholesterol, BP, body weight",
      "• HbA1c every 3 months in uncontrolled diabetes",
      "• Annual: kidney function, liver function, lipid profile",
      "• Routine medical checkups and patient awareness programs",
    ]
  );

  slide.addShape(pres.ShapeType.rect, { x: 4.25, y: 5.45, w: 3.75, h: 2.6, fill: { color: C.yellowBg }, line: { color: C.yellowBg } });
  slide.addShape(pres.ShapeType.rect, { x: 4.25, y: 5.45, w: 0.08, h: 2.6, fill: { color: C.gold }, line: { color: C.gold } });
  slide.addText("⚡ Treatment Goals", { x: 4.4, y: 5.5, w: 3.5, h: 0.4, fontSize: 11, bold: true, color: C.goldDark, valign: "middle", margin: 0 });
  slide.addText([
    { text: "• Control symptoms & prevent complications", options: { breakLine: true } },
    { text: "• Achieve target HbA1c <7%, BP <130/80 mmHg", options: { breakLine: true } },
    { text: "• Lifestyle + pharmacotherapy = best outcomes", options: { breakLine: true } },
    { text: "• Patient education is cornerstone of long-term success", options: { breakLine: false } },
  ], { x: 4.4, y: 5.95, w: 3.55, h: 2.0, fontSize: 9.5, color: C.textDark, valign: "top", margin: 0 });

  // QUICK COMPARISON TABLE
  addHighlightBar(slide, 0.25, 8.55, 7.77, 0.38, "QUICK COMPARISON TABLE", C.navyDark);

  // Table headers
  const cols = [
    { x: 0.25, w: 1.5, label: "Disorder" },
    { x: 1.75, w: 1.5, label: "Key Monitoring" },
    { x: 3.25, w: 2.0, label: "Main Treatment" },
    { x: 5.25, w: 1.1, label: "Target" },
    { x: 6.35, w: 1.17, label: "Prognosis" },
  ];
  cols.forEach(c => {
    slide.addShape(pres.ShapeType.rect, { x: c.x, y: 8.93, w: c.w, h: 0.32, fill: { color: C.blue }, line: { color: "CCCCCC" } });
    slide.addText(c.label, { x: c.x + 0.05, y: 8.96, w: c.w - 0.1, h: 0.27, fontSize: 8.5, bold: true, color: C.white, valign: "middle", margin: 0 });
  });

  // Table rows
  const rows = [
    ["Diabetes", "HbA1c, blood glucose", "Insulin / oral drugs", "HbA1c <7%", "Manageable"],
    ["Hypertension", "BP, renal function", "Antihypertensives", "BP <130/80", "Controlled"],
    ["Obesity", "BMI, waist, lipids", "Lifestyle, medication", "BMI <25", "Variable"],
    ["Dyslipidemia", "Lipid profile", "Statins, diet", "LDL <100 mg/dL", "Reversible"],
    ["PCOS", "Glucose, androgens", "Lifestyle, metformin", "Cycle regulation", "Manageable"],
  ];

  rows.forEach((row, ri) => {
    const yy = 9.25 + ri * 0.32;
    const bg = ri % 2 === 0 ? C.white : C.tableBg;
    cols.forEach((c, ci) => {
      slide.addShape(pres.ShapeType.rect, { x: c.x, y: yy, w: c.w, h: 0.32, fill: { color: bg }, line: { color: "CCCCCC" } });
      slide.addText(row[ci], { x: c.x + 0.05, y: yy + 0.03, w: c.w - 0.1, h: 0.27, fontSize: 8.5, color: C.textDark, valign: "middle", margin: 0 });
    });
  });
}

// ─── OUTPUT ───
const outPath = "/home/daytona/workspace/cm_slides/Metabolic_Disorders_Monitoring.pptx";
pres.writeFile({ fileName: outPath })
  .then(() => console.log("Saved: " + outPath))
  .catch(e => { console.error(e); process.exit(1); });

"""
Creates a PDF on "Atypical Forms of Cardiomyopathy in Children and Adolescents"
styled to match the reference PDF (New Note 2026-05-12):
  - A4 portrait (595 x 842 pt)
  - Page 1: Cover (bold typewriter-style university name + topic)
  - Page 2: Formal title page (university header block + topic/author details)
  - Pages 3-7: Topic pages with heading + body paragraphs
  - Page 8: Thank You / References
"""

from reportlab.lib.pagesizes import A4
from reportlab.lib.units import pt
from reportlab.pdfgen import canvas
from reportlab.lib.styles import getSampleStyleSheet
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer
from reportlab.lib import colors
import textwrap

W, H = A4  # 595.28 x 841.89

OUT = "/home/daytona/workspace/cm_slides/Atypical_Cardiomyopathy_Pediatrics_PDF.pdf"

c = canvas.Canvas(OUT, pagesize=A4)

# ── Font helpers ──────────────────────────────────────────────────
def use_bold(size):
    c.setFont("Helvetica-Bold", size)

def use_regular(size):
    c.setFont("Helvetica", size)

def use_italic(size):
    c.setFont("Helvetica-Oblique", size)

# ── Text helpers ──────────────────────────────────────────────────
def centered_text(text, y, font="Helvetica-Bold", size=21, color=(0,0,0)):
    c.setFont(font, size)
    c.setFillColorRGB(*color)
    c.drawCentredString(W / 2, y, text)

def left_text(text, x, y, font="Helvetica", size=12, color=(0,0,0)):
    c.setFont(font, size)
    c.setFillColorRGB(*color)
    c.drawString(x, y, text)

def wrapped_paragraph(text, x, y, max_width, font="Helvetica", size=13,
                       line_height=20, color=(0,0,0), indent=0):
    """Draw wrapped text. Returns new y after last line."""
    c.setFont(font, size)
    c.setFillColorRGB(*color)
    # Estimate chars per line based on avg char width ~0.55*size
    chars_per_line = int(max_width / (size * 0.55))
    lines = []
    for para in text.split('\n'):
        if para.strip() == '':
            lines.append('')
        else:
            wrapped = textwrap.wrap(para, width=chars_per_line)
            lines.extend(wrapped if wrapped else [''])
    for line in lines:
        c.drawString(x + indent, y, line)
        y -= line_height
    return y

# ══════════════════════════════════════════
# PAGE 1 — COVER PAGE
# ══════════════════════════════════════════
c.setFillColorRGB(0, 0, 0)

# University name (large bold, centered — like AmericanTypewriter-Bold 21pt)
centered_text("Jalalabad", H - 160, font="Helvetica-Bold", size=21)
centered_text("State", H - 186, font="Helvetica-Bold", size=21)
centered_text("University", H - 212, font="Helvetica-Bold", size=21)

# Faculty
centered_text("Faculty of", H - 270, font="Helvetica-Bold", size=21)
centered_text("Medicine", H - 296, font="Helvetica-Bold", size=21)

# Divider line
c.setStrokeColorRGB(0, 0, 0)
c.setLineWidth(0.5)
c.line(80, H - 340, W - 80, H - 340)

# Topic label
use_regular(13)
c.setFillColorRGB(0, 0, 0)
c.drawCentredString(W / 2, H - 380, "Topic :-  Atypical Forms of Cardiomyopathy")
c.drawCentredString(W / 2, H - 400, "in Children and Adolescents.")

# Divider
c.line(80, H - 430, W - 80, H - 430)

# Author details
use_regular(13)
c.drawCentredString(W / 2, H - 470, "Done by :-  Snigdha Mandaokar")
c.drawCentredString(W / 2, H - 495, "Year :-  4th")
c.drawCentredString(W / 2, H - 520, "Group :-  8th")

c.showPage()

# ══════════════════════════════════════════
# PAGE 2 — FORMAL TITLE PAGE
# ══════════════════════════════════════════
# Header block (like ChalkboardSE 13.3pt centered)
use_regular(13)
y = H - 27
lines_header = [
    "MINISTRY OF EDUCATION AND SCIENCE OF THE",
    "KYRGYZ REPUBLIC",
    "JALALABAD STATE UNIVERSITY",
    "NAME B. OSMONOVA",
    "Faculty of Medicine",
]
for line in lines_header:
    c.drawCentredString(W / 2, y, line)
    y -= 18

# Divider
c.setLineWidth(0.5)
c.line(50, y - 5, W - 50, y - 5)
y -= 30

# Topic
use_bold(14)
c.drawCentredString(W / 2, y, "Topic :-")
y -= 22
use_regular(14)
c.drawCentredString(W / 2, y, "Atypical Forms of Cardiomyopathy")
y -= 22
c.drawCentredString(W / 2, y, "in Children and Adolescents.")
y -= 40

# Divider
c.line(50, y, W - 50, y)
y -= 35

# Author
use_regular(13)
c.drawString(80, y, "Done by :-  Snigdha Mandaokar")
y -= 22
c.drawString(80, y, "Year :-  4th")
y -= 22
c.drawString(80, y, "Group :-  8th")

c.showPage()

# ══════════════════════════════════════════
# HELPER: topic page builder
# ══════════════════════════════════════════
MARGIN_L = 13
MARGIN_R = W - 13
TEXT_W = MARGIN_R - MARGIN_L
BODY_SIZE = 16.5
HEADING_SIZE = 16.5
LINE_H = 24

def topic_page(heading, paragraphs):
    """heading: str, paragraphs: list of str (each is a paragraph block)"""
    y = H - 22

    # Heading
    use_bold(HEADING_SIZE)
    c.setFillColorRGB(0, 0, 0)
    c.drawString(MARGIN_L, y, heading)
    y -= 28

    # Underline heading
    c.setLineWidth(0.5)
    c.line(MARGIN_L, y + 4, MARGIN_R, y + 4)
    y -= 12

    # Body paragraphs
    use_regular(BODY_SIZE)
    for para in paragraphs:
        if para.strip() == '':
            y -= LINE_H // 2
            continue
        # Wrap and draw
        chars_per_line = int(TEXT_W / (BODY_SIZE * 0.52))
        wrapped = textwrap.wrap(para, width=chars_per_line)
        for line in wrapped:
            c.setFont("Helvetica", BODY_SIZE)
            c.setFillColorRGB(0, 0, 0)
            c.drawString(MARGIN_L, y, line)
            y -= LINE_H
            if y < 40:
                c.showPage()
                y = H - 22
        y -= LINE_H // 2  # gap between paragraphs

    c.showPage()

# ══════════════════════════════════════════
# PAGE 3 — INTRODUCTION
# ══════════════════════════════════════════
topic_page(
    "Introduction :-",
    [
        "Cardiomyopathies are diseases of the heart muscle that impair its ability to pump blood effectively. While dilated and hypertrophic cardiomyopathies are well recognized, several atypical forms occur in children and adolescents that are less common but clinically significant.",
        "The major atypical forms include Left Ventricular Non-Compaction (LVNC), Arrhythmogenic Cardiomyopathy (ACM/ARVC), Restrictive Cardiomyopathy (RCM), Takotsubo Cardiomyopathy, Myocarditis-related Cardiomyopathy, and Metabolic/Storage Cardiomyopathies.",
        "These conditions are increasing in recognition due to advances in cardiac imaging, particularly echocardiography and cardiac MRI. Early diagnosis is essential because pediatric cardiomyopathies carry significant morbidity and mortality if untreated.",
        "Long-term monitoring and appropriate management strategies — including medications, device therapy, and in some cases cardiac transplantation — are crucial for improving outcomes in affected children and adolescents.",
    ]
)

# ══════════════════════════════════════════
# PAGE 4 — LEFT VENTRICULAR NON-COMPACTION (LVNC)
# ══════════════════════════════════════════
topic_page(
    "Left Ventricular Non-Compaction (LVNC) :-",
    [
        "LVNC is a rare trabecular cardiomyopathy caused by arrest of normal myocardial compaction during fetal development (5–8 weeks of gestation). The result is a spongy myocardium with prominent trabeculations and deep intertrabecular recesses communicating with the ventricular cavity.",
        "It is the most common atypical cardiomyopathy in infancy, accounting for 1–7% of all pediatric cardiomyopathies. Genetic mutations in MYH7, MYBPC3, TAZ (Barth syndrome), and LDB3 are commonly identified. LVNC is associated with Barth syndrome, Danon disease, and mitochondrial disorders.",
        "The classic clinical triad is heart failure, arrhythmias, and thromboembolism. Presentation is age-dependent: neonates may present with cardiogenic shock, while adolescents more typically develop heart failure or syncope.",
        "Diagnosis is based on echocardiography showing an NC:C (non-compacted to compacted) ratio >2 in adults or >1.4 in pediatric patients. Cardiac MRI with late gadolinium enhancement is the gold standard. Management includes ACE inhibitors, beta-blockers, anticoagulation, ICD for high-risk arrhythmias, and cardiac transplantation for refractory cases. Prognosis is variable and worse in neonates.",
    ]
)

# ══════════════════════════════════════════
# PAGE 5 — ARRHYTHMOGENIC CARDIOMYOPATHY (ACM/ARVC)
# ══════════════════════════════════════════
topic_page(
    "Arrhythmogenic Cardiomyopathy (ACM/ARVC) :-",
    [
        "ACM/ARVC is a desmosomal disease characterized by fibrofatty replacement of the right ventricular (and sometimes left ventricular) myocardium. It is the leading cause of sudden cardiac death (SCD) in young athletes. Desmosomal mutations — particularly PKP2, DSP, DSG2, DSC2, and JUP — impair cell-to-cell adhesion, leading to apoptosis accelerated by exercise-induced mechanical stress.",
        "The classic 'triangle of dysplasia' involves the RVOT, RV apex, and subtricuspid area. In pediatric ACM, LV-dominant or biventricular forms are more common than in adults.",
        "Diagnosis follows the 2010 Revised Task Force Criteria, requiring major and minor criteria across six categories: structural abnormalities, tissue characterization, repolarization abnormalities (T-wave inversions V1–V4), depolarization abnormalities (epsilon wave), arrhythmias (VT with LBBB morphology), and family history or genetics.",
        "Management includes restriction from competitive sports, beta-blockers or antiarrhythmics (sotalol, amiodarone), ICD implantation in high-risk patients (syncope, sustained VT, aborted cardiac arrest), catheter ablation for recurrent VT, and cardiac transplantation for end-stage disease. The hallmark ECG finding is the epsilon wave.",
    ]
)

# ══════════════════════════════════════════
# PAGE 6 — RESTRICTIVE CARDIOMYOPATHY (RCM)
# ══════════════════════════════════════════
topic_page(
    "Restrictive Cardiomyopathy (RCM) :-",
    [
        "RCM is the rarest pediatric cardiomyopathy, characterized by diastolic dysfunction with normal systolic function. Stiff, non-compliant ventricles cause elevated filling pressures leading to biatrial enlargement and pulmonary venous hypertension.",
        "Etiology includes idiopathic causes (most common in children), infiltrative diseases (amyloidosis, Gaucher disease, Fabry disease, glycogen storage disorders), fibrotic causes (post-radiation, post-myocarditis, scleroderma), and genetic mutations (TNNI3, MYH7, ACTC1, DES).",
        "Clinical features include exercise intolerance, dyspnea, fatigue, syncope, signs of congestive heart failure (hepatomegaly, ascites, edema), atrial arrhythmias, and thromboembolic events. Differentiation from constrictive pericarditis is critical: septal bounce and calcification suggest pericarditis, while tissue Doppler e/e' ratio >15 supports RCM.",
        "Investigations include echocardiography showing biatrial enlargement with preserved ventricular dimensions, restrictive filling pattern (E/A >2, deceleration time <150 ms), and markedly elevated BNP/NT-proBNP. No disease-modifying therapy exists; cardiac transplantation is the definitive treatment and should be listed early. RCM carries the worst prognosis of all pediatric cardiomyopathies, with 5-year survival of approximately 50% without transplant.",
    ]
)

# ══════════════════════════════════════════
# PAGE 7 — OTHER ATYPICAL FORMS
# ══════════════════════════════════════════
topic_page(
    "Other Atypical Forms :-",
    [
        "Takotsubo Cardiomyopathy: Rare in children, this stress-induced cardiomyopathy causes transient apical ballooning with normal or near-normal coronary arteries. Common triggers in pediatric patients include neurological events such as seizures. It is usually reversible within 4–8 weeks with supportive therapy, beta-blockers, and ACE inhibitors.",
        "Myocarditis-related Cardiomyopathy: Following viral infection (Coxsackie B, adenovirus, SARS-CoV-2/MIS-C), acute myocarditis may evolve into a dilated cardiomyopathy phenotype. Chronic myocarditis leads to fibrosis and may mimic ACM. CMR shows T2 signal elevation and mid-wall late gadolinium enhancement. Treatment includes IVIG in fulminant myocarditis and immunosuppression in chronic inflammatory disease.",
        "Metabolic and Storage Cardiomyopathies: Pompe disease (GSD II) presents with HCM-like features due to absent acid alpha-glucosidase. Fabry disease (alpha-galactosidase A deficiency) causes HCM with renal and neurological involvement. Barth syndrome (X-linked, TAZ mutation) shows DCM plus LVNC with neutropenia. Danon disease (LAMP2 mutation) presents with HCM and cognitive impairment. These conditions may be amenable to enzyme replacement therapy.",
        "Peripartum Cardiomyopathy (PPCM): Rare in adolescent pregnancies. Defined as LVEF <45% in the last month of pregnancy or within 5 months postpartum. Risk factors include multiple gestation, malnutrition, and teen pregnancy. Prolactin-mediated injury plays a pathogenic role; bromocriptine is used alongside standard heart failure therapy. Approximately 50% of patients normalize EF within 6 months.",
    ]
)

# ══════════════════════════════════════════
# PAGE 8 — TREATMENT AND MANAGEMENT
# ══════════════════════════════════════════
topic_page(
    "Treatment and Management :-",
    [
        "The treatment of atypical cardiomyopathies in children is largely condition-specific, but several general principles apply. Heart failure is managed with ACE inhibitors, beta-blockers, and diuretics. Anticoagulation is indicated for patients with severely reduced ejection fraction, LVNC, or atrial fibrillation to prevent thromboembolic complications.",
        "Arrhythmia management is a key component: beta-blockers are used for most forms, while amiodarone or sotalol is reserved for more refractory ventricular arrhythmias. ICD implantation is mandatory in high-risk patients — those with prior cardiac arrest, syncope due to ventricular arrhythmia, or significant ventricular dysfunction.",
        "Restriction from competitive sports is recommended in ACM/ARVC and other arrhythmogenic conditions, as exercise accelerates disease progression and triggers potentially fatal arrhythmias.",
        "Cardiac transplantation remains the definitive treatment for end-stage cardiomyopathy refractory to medical therapy. Early listing is particularly important in RCM due to its poor prognosis. For metabolic and storage cardiomyopathies, disease-specific enzyme replacement therapy (e.g., alglucosidase alfa in Pompe disease, agalsidase in Fabry disease) can slow progression.",
        "Routine monitoring with echocardiography, Holter monitoring, and cardiac MRI is essential for tracking disease progression and guiding therapeutic decisions. Family screening with genetic testing is recommended given the high heritability of most atypical cardiomyopathies.",
    ]
)

# ══════════════════════════════════════════
# PAGE 9 — THANK YOU
# ══════════════════════════════════════════
use_bold(20)
c.setFillColorRGB(0, 0, 0)
c.drawCentredString(W / 2, H / 2, "THANK YOU")
c.showPage()

c.save()
print(f"Saved: {OUT}")

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/cm_slides/build_cardiomyopathy_pdf.py'

"""
Colorful redesign of Atypical Cardiomyopathy PDF
- A4 portrait
- Each content page has:
    • Gradient-style colored header band
    • Side accent stripe
    • Medical image (right side)
    • Clean body text (left/full width below image row)
    • Color-coded page backgrounds (subtle tint)
- Cover: bold full-color design
- Formal title page: clean institutional look
"""

from reportlab.pdfgen import canvas
from reportlab.lib.pagesizes import A4
from reportlab.lib.utils import ImageReader
from reportlab.lib.colors import HexColor, white, black
import textwrap
import io

W, H = A4   # 595.28 x 841.89 pt
OUT = "/home/daytona/workspace/cm_slides/Atypical_Cardiomyopathy_Colorful.pdf"

# ── Palette ──────────────────────────────────────────────────────
NAVY       = HexColor("#0D2B55")
TEAL       = HexColor("#0B6E8A")
PURPLE     = HexColor("#5B2D8E")
CRIMSON    = HexColor("#B51212")
GOLD       = HexColor("#D4A017")
GREEN      = HexColor("#1A7A4A")
ORANGE     = HexColor("#C45C1A")
SLATE      = HexColor("#3A506B")
WHITE      = white
BLACK      = black

# Page-specific header colours (one per content page)
PAGE_COLORS = [NAVY, TEAL, PURPLE, CRIMSON, GREEN, ORANGE, SLATE]
# Matching light tints for page background
PAGE_TINTS  = [
    HexColor("#EAF0F8"), HexColor("#E6F4F8"), HexColor("#F0EAF8"),
    HexColor("#FAE8E8"), HexColor("#E8F5EC"), HexColor("#FDF0E6"),
    HexColor("#EBF0F5"),
]

c = canvas.Canvas(OUT, pagesize=A4)

# ── Helper: draw rounded rectangle ───────────────────────────────
def rounded_rect(x, y, w, h, r, fill_color, stroke_color=None):
    c.saveState()
    c.setFillColor(fill_color)
    if stroke_color:
        c.setStrokeColor(stroke_color)
        c.setLineWidth(0.5)
    else:
        c.setStrokeColor(fill_color)
    c.roundRect(x, y, w, h, r, fill=1, stroke=1 if stroke_color else 0)
    c.restoreState()

# ── Helper: wrapped text, returns next y ─────────────────────────
def draw_wrapped(text, x, y, max_w, font, size, leading, color=BLACK, max_y=40):
    c.saveState()
    c.setFont(font, size)
    c.setFillColor(color)
    chars_per = max(10, int(max_w / (size * 0.52)))
    for para in text.split('\n'):
        if not para.strip():
            y -= leading * 0.6
            continue
        for line in textwrap.wrap(para, width=chars_per) or ['']:
            if y < max_y:
                break
            c.drawString(x, y, line)
            y -= leading
        y -= leading * 0.35
    c.restoreState()
    return y

# ── Helper: page background tint ─────────────────────────────────
def bg_tint(tint_color):
    c.saveState()
    c.setFillColor(tint_color)
    c.rect(0, 0, W, H, fill=1, stroke=0)
    c.restoreState()

# ── Helper: full-width header band with title ─────────────────────
def header_band(title, subtitle, accent_color, page_num, total):
    band_h = 105
    # Main band
    c.saveState()
    c.setFillColor(accent_color)
    c.rect(0, H - band_h, W, band_h, fill=1, stroke=0)
    # Gold accent bottom stripe
    c.setFillColor(GOLD)
    c.rect(0, H - band_h - 4, W, 4, fill=1, stroke=0)
    # Left accent stripe
    c.setFillColor(WHITE)
    c.setFillAlpha(0.15)
    c.rect(0, H - band_h, 8, band_h, fill=1, stroke=0)
    c.setFillAlpha(1.0)
    # Title
    c.setFillColor(WHITE)
    c.setFont("Helvetica-Bold", 22)
    c.drawString(18, H - 52, title)
    # Subtitle
    c.setFont("Helvetica-Oblique", 11)
    c.setFillColor(HexColor("#DDDDDD"))
    c.drawString(18, H - 72, subtitle)
    # Page pill
    pill_x = W - 80
    c.setFillColor(WHITE)
    c.setFillAlpha(0.25)
    c.roundRect(pill_x, H - 42, 65, 22, 8, fill=1, stroke=0)
    c.setFillAlpha(1.0)
    c.setFillColor(WHITE)
    c.setFont("Helvetica-Bold", 9)
    c.drawCentredString(pill_x + 32, H - 34, f"Page {page_num} of {total}")
    c.restoreState()

# ── Helper: footer bar ────────────────────────────────────────────
def footer_bar(accent_color):
    c.saveState()
    c.setFillColor(accent_color)
    c.rect(0, 0, W, 28, fill=1, stroke=0)
    c.setFillColor(WHITE)
    c.setFont("Helvetica", 8)
    c.drawCentredString(W / 2, 10,
        "Atypical Forms of Cardiomyopathy in Children and Adolescents  |  4th Year MBBS  |  Snigdha Mandaokar")
    c.restoreState()

# ── Helper: embed image in a nice frame ──────────────────────────
def place_image(path, x, y, w, h, caption, accent_color):
    try:
        img = ImageReader(path)
        iw, ih = img.getSize()
        # Maintain aspect
        aspect = ih / iw
        new_h = w * aspect
        if new_h > h:
            new_h = h
            w = h / aspect
        # Frame
        pad = 4
        c.saveState()
        c.setFillColor(WHITE)
        c.setStrokeColor(accent_color)
        c.setLineWidth(1.5)
        c.roundRect(x - pad, y - pad - new_h, w + pad*2, new_h + pad*2, 4, fill=1, stroke=1)
        # Image
        c.drawImage(img, x, y - new_h, w, new_h, preserveAspectRatio=True, mask='auto')
        # Caption badge
        c.setFillColor(accent_color)
        c.roundRect(x - pad, y - new_h - pad - 16, w + pad*2, 17, 3, fill=1, stroke=0)
        c.setFillColor(WHITE)
        c.setFont("Helvetica-Oblique", 7.5)
        c.drawCentredString(x + w/2, y - new_h - pad - 8, caption)
        c.restoreState()
        return y - new_h - pad - 20
    except Exception as e:
        print(f"Image error {path}: {e}")
        return y

# ══════════════════════════════════════════════════════════════════
# PAGE 1 — COVER
# ══════════════════════════════════════════════════════════════════
# Deep dark background
c.saveState()
c.setFillColor(NAVY)
c.rect(0, 0, W, H, fill=1, stroke=0)
# Right side accent panel
c.setFillColor(HexColor("#112244"))
c.rect(W * 0.62, 0, W * 0.38, H, fill=1, stroke=0)
# Decorative circles
c.setFillColor(HexColor("#1A4080"))
c.setFillAlpha(0.4)
c.circle(W * 0.78, H * 0.72, 90, fill=1, stroke=0)
c.circle(W * 0.88, H * 0.25, 55, fill=1, stroke=0)
c.setFillAlpha(1.0)
# Gold accent strip
c.setFillColor(GOLD)
c.rect(0, H * 0.42, W * 0.62, 6, fill=1, stroke=0)
c.setFillColor(CRIMSON)
c.rect(0, H * 0.42 - 10, W * 0.62, 4, fill=1, stroke=0)
c.restoreState()

# University name
c.setFillColor(WHITE)
c.setFont("Helvetica-Bold", 20)
c.drawString(28, H - 60, "Jalalabad State University")
c.setFont("Helvetica", 11)
c.setFillColor(HexColor("#AABBDD"))
c.drawString(28, H - 78, "Faculty of Medicine")

# Divider
c.setStrokeColor(GOLD)
c.setLineWidth(1.5)
c.line(28, H - 92, W * 0.58, H - 92)

# Main title
c.setFillColor(WHITE)
c.setFont("Helvetica-Bold", 30)
c.drawString(28, H - 155, "ATYPICAL FORMS OF")
c.setFont("Helvetica-Bold", 30)
c.drawString(28, H - 192, "CARDIOMYOPATHY")
c.setFillColor(GOLD)
c.setFont("Helvetica-Bold", 18)
c.drawString(28, H - 225, "in Children and Adolescents")

# Topics list box
rounded_rect(28, H - 390, W * 0.56, 140, 8, HexColor("#1A3A6A"))
c.setFillColor(GOLD)
c.setFont("Helvetica-Bold", 10)
c.drawString(42, H - 275, "TOPICS COVERED")
topics = [
    "• Left Ventricular Non-Compaction (LVNC)",
    "• Arrhythmogenic Cardiomyopathy (ACM/ARVC)",
    "• Restrictive Cardiomyopathy (RCM)",
    "• Takotsubo & Myocarditis-related CMP",
    "• Metabolic / Storage Cardiomyopathies",
    "• Treatment & Management",
]
c.setFillColor(HexColor("#CCDDEE"))
c.setFont("Helvetica", 10)
ty = H - 294
for t in topics:
    c.drawString(42, ty, t)
    ty -= 16

# Author card
rounded_rect(28, H - 530, W * 0.56, 115, 8, HexColor("#0A2040"))
c.setFillColor(HexColor("#AABBDD"))
c.setFont("Helvetica", 10)
details = [
    ("Done by :", "Snigdha Mandaokar"),
    ("Year :",    "4th Year MBBS"),
    ("Group :",   "8th Group"),
    ("Subject :", "Pediatric Cardiology"),
]
ay = H - 438
for label, val in details:
    c.setFont("Helvetica-Bold", 10)
    c.setFillColor(GOLD)
    c.drawString(42, ay, label)
    c.setFont("Helvetica", 10)
    c.setFillColor(WHITE)
    c.drawString(115, ay, val)
    ay -= 18

# Bottom strip
c.setFillColor(CRIMSON)
c.rect(0, 0, W, 24, fill=1, stroke=0)
c.setFillColor(WHITE)
c.setFont("Helvetica", 8)
c.drawCentredString(W / 2, 8, "4th Year MBBS  |  Pediatric Cardiology  |  Jalalabad State University")

c.showPage()

# ══════════════════════════════════════════════════════════════════
# PAGE 2 — FORMAL TITLE PAGE
# ══════════════════════════════════════════════════════════════════
bg_tint(HexColor("#F0F4FA"))

# Top institutional header band
c.saveState()
c.setFillColor(NAVY)
c.rect(0, H - 90, W, 90, fill=1, stroke=0)
c.setFillColor(GOLD)
c.rect(0, H - 94, W, 4, fill=1, stroke=0)
c.setFillColor(WHITE)
c.setFont("Helvetica-Bold", 13)
c.drawCentredString(W/2, H - 30, "MINISTRY OF EDUCATION AND SCIENCE OF THE KYRGYZ REPUBLIC")
c.setFont("Helvetica", 11)
c.setFillColor(HexColor("#AABBDD"))
c.drawCentredString(W/2, H - 50, "JALALABAD STATE UNIVERSITY NAME B. OSMONOVA")
c.setFont("Helvetica-Oblique", 10)
c.drawCentredString(W/2, H - 68, "Faculty of Medicine")
c.restoreState()

# Central topic box
rounded_rect(50, H - 340, W - 100, 210, 10, WHITE, NAVY)
c.setFillColor(NAVY)
c.setFont("Helvetica-Bold", 12)
c.drawCentredString(W/2, H - 168, "TOPIC :-")
c.setFont("Helvetica-Bold", 16)
c.setFillColor(TEAL)
c.drawCentredString(W/2, H - 195, "Atypical Forms of Cardiomyopathy")
c.setFont("Helvetica-Bold", 16)
c.drawCentredString(W/2, H - 218, "in Children and Adolescents")
c.setFillColor(CRIMSON)
c.setFont("Helvetica", 10)
c.drawCentredString(W/2, H - 248, "A Clinical Overview for 4th Year MBBS Students")

# Divider line
c.setStrokeColor(GOLD)
c.setLineWidth(1.5)
c.line(80, H - 265, W - 80, H - 265)

# Author details
rounded_rect(100, H - 500, W - 200, 130, 8, HexColor("#EAF0F8"), TEAL)
rows = [
    ("Done by :",  "Snigdha Mandaokar"),
    ("Year :",     "4th Year"),
    ("Group :",    "8th Group"),
    ("Subject :",  "Pediatric Cardiology"),
    ("University :","Jalalabad State University"),
]
dy = H - 390
for label, val in rows:
    c.setFillColor(TEAL)
    c.setFont("Helvetica-Bold", 11)
    c.drawString(120, dy, label)
    c.setFillColor(NAVY)
    c.setFont("Helvetica", 11)
    c.drawString(220, dy, val)
    dy -= 20

# Footer
c.setFillColor(NAVY)
c.rect(0, 0, W, 28, fill=1, stroke=0)
c.setFillColor(WHITE)
c.setFont("Helvetica", 8)
c.drawCentredString(W/2, 10, "Atypical Forms of Cardiomyopathy in Children and Adolescents  |  4th Year MBBS  |  Snigdha Mandaokar")

c.showPage()

# ══════════════════════════════════════════════════════════════════
# CONTENT PAGE BUILDER
# ══════════════════════════════════════════════════════════════════
def content_page(page_idx, title, subtitle, img_path, img_caption, paragraphs):
    accent = PAGE_COLORS[page_idx % len(PAGE_COLORS)]
    tint   = PAGE_TINTS[page_idx % len(PAGE_TINTS)]
    pg_num = page_idx + 3  # cover=1, title=2, content starts at 3
    total  = 9

    # Background tint
    bg_tint(tint)

    # Left accent stripe
    c.saveState()
    c.setFillColor(accent)
    c.rect(0, 28, 6, H - 28 - 109, fill=1, stroke=0)
    c.restoreState()

    # Header band
    header_band(title, subtitle, accent, pg_num, total)

    # Image (right column, top)
    img_x = W - 220
    img_y = H - 118
    img_w = 200
    img_max_h = 180
    img_bottom = place_image(img_path, img_x, img_y, img_w, img_max_h, img_caption, accent)

    # Section label pill
    rounded_rect(16, H - 130, 130, 22, 6, accent)
    c.setFillColor(WHITE)
    c.setFont("Helvetica-Bold", 9)
    c.drawString(24, H - 122, "◆  KEY CONTENT")

    # Body text — full width below image row
    text_top   = min(img_bottom - 12, H - 148)
    text_left  = 16
    text_right = W - 16
    text_w     = text_right - text_left

    y = text_top
    for para in paragraphs:
        if para.startswith("##"):
            # Subsection heading
            heading_text = para[2:].strip()
            y -= 4
            rounded_rect(text_left, y - 2, text_w, 20, 4, accent)
            c.setFillColor(WHITE)
            c.setFont("Helvetica-Bold", 10)
            c.drawString(text_left + 8, y + 4, heading_text)
            y -= 26
        else:
            y = draw_wrapped(para, text_left + 6, y, text_w - 12,
                             "Helvetica", 11, 17, BLACK, max_y=38)

    footer_bar(accent)
    c.showPage()

# ══════════════════════════════════════════════════════════════════
# PAGE 3 — INTRODUCTION
# ══════════════════════════════════════════════════════════════════
content_page(
    0,
    "Introduction",
    "Cardiomyopathies that affect the young — an overview",
    "/home/daytona/workspace/cm_slides/img_cache/intro.jpg",
    "Fig 1. Echocardiogram of a pediatric patient with dilated cardiomyopathy",
    [
        "Cardiomyopathies are diseases of the heart muscle that impair its ability to pump blood effectively. While dilated and hypertrophic cardiomyopathies are well recognized, several atypical forms occur in children and adolescents that are less common but clinically significant.",
        "The major atypical forms include: Left Ventricular Non-Compaction (LVNC), Arrhythmogenic Cardiomyopathy (ACM/ARVC), Restrictive Cardiomyopathy (RCM), Takotsubo Cardiomyopathy, Myocarditis-related Cardiomyopathy, and Metabolic/Storage Cardiomyopathies.",
        "These conditions are increasing in recognition due to advances in cardiac imaging — particularly echocardiography and cardiac MRI. Early diagnosis is essential because pediatric cardiomyopathies carry significant morbidity and mortality if left untreated.",
        "Long-term monitoring and appropriate management — including medications, device therapy, and in some cases cardiac transplantation — are crucial for improving outcomes in affected children and adolescents.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 4 — LVNC
# ══════════════════════════════════════════════════════════════════
content_page(
    1,
    "Left Ventricular Non-Compaction (LVNC)",
    "Spongy myocardium — arrest of normal fetal myocardial compaction",
    "/home/daytona/workspace/cm_slides/img_cache/lvnc.jpg",
    "Fig 2. Echo: Apical 4-chamber & PSAX views showing LVNC trabeculations",
    [
        "LVNC is a rare trabecular cardiomyopathy caused by arrest of normal myocardial compaction during fetal development (5–8 weeks of gestation). The result is a spongy myocardium with prominent trabeculations and deep intertrabecular recesses communicating with the ventricular cavity.",
        "It accounts for 1–7% of all pediatric cardiomyopathies. Genetic mutations in MYH7, MYBPC3, TAZ (Barth syndrome), and LDB3 are commonly identified. LVNC is associated with Barth syndrome, Danon disease, and mitochondrial disorders.",
        "The classic clinical triad is: heart failure, arrhythmias, and thromboembolism. Presentation is age-dependent — neonates may develop cardiogenic shock, while adolescents more typically present with heart failure or syncope.",
        "Diagnosis is based on echocardiography showing an NC:C ratio >2 (adults) or >1.4 (pediatric). Cardiac MRI with late gadolinium enhancement is the gold standard. Management includes ACE inhibitors, beta-blockers, anticoagulation, ICD for high-risk arrhythmias, and cardiac transplantation for refractory cases.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 5 — ARVC
# ══════════════════════════════════════════════════════════════════
content_page(
    2,
    "Arrhythmogenic Cardiomyopathy (ACM/ARVC)",
    "Leading cause of sudden cardiac death in young athletes — desmosomal disease",
    "/home/daytona/workspace/cm_slides/img_cache/arvc.jpg",
    "Fig 3. ECG epsilon waves & MRI fibrofatty RV replacement in ARVC",
    [
        "ACM/ARVC is a desmosomal disease characterized by fibrofatty replacement of the RV (and sometimes LV) myocardium. It is the #1 cause of sudden cardiac death (SCD) in young athletes. Desmosomal mutations — PKP2, DSP, DSG2, DSC2, JUP — impair cell-to-cell adhesion, leading to apoptosis accelerated by exercise-induced mechanical stress.",
        "The classic 'triangle of dysplasia' involves the RVOT, RV apex, and subtricuspid area. In pediatric ACM, LV-dominant or biventricular forms are more common than in adults.",
        "Diagnosis follows the 2010 Revised Task Force Criteria across six categories: structural abnormalities, tissue characterization, repolarization abnormalities (T-wave inversions V1–V4), depolarization abnormalities (epsilon wave — pathognomonic), arrhythmias (VT with LBBB morphology), and family history/genetics.",
        "Management: restriction from competitive sports, beta-blockers or antiarrhythmics (sotalol, amiodarone), ICD implantation in high-risk patients, catheter ablation for recurrent VT, and cardiac transplantation for end-stage disease.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 6 — RCM
# ══════════════════════════════════════════════════════════════════
content_page(
    3,
    "Restrictive Cardiomyopathy (RCM)",
    "Rarest pediatric CMP — diastolic dysfunction with preserved systolic function",
    "/home/daytona/workspace/cm_slides/img_cache/rcm.jpg",
    "Fig 4. CXR cardiomegaly & echo biatrial enlargement in pediatric RCM",
    [
        "RCM is the rarest pediatric cardiomyopathy. Stiff, non-compliant ventricles cause elevated filling pressures leading to biatrial enlargement and pulmonary venous hypertension. Systolic function is characteristically preserved.",
        "Etiology: idiopathic (most common in children), infiltrative diseases (amyloidosis, Gaucher, Fabry disease, glycogen storage disorders), fibrotic causes (post-radiation, post-myocarditis, scleroderma), and genetic mutations (TNNI3, MYH7, ACTC1, DES).",
        "Clinical features include exercise intolerance, dyspnea, fatigue, syncope, congestive heart failure signs (hepatomegaly, ascites, edema), atrial arrhythmias, and thromboembolic events. Key differential: constrictive pericarditis — septal bounce and pericardial calcification suggest pericarditis; tissue Doppler e/e' ratio >15 supports RCM.",
        "Investigations: echo showing biatrial enlargement with preserved ventricular dimensions, restrictive filling pattern (E/A >2, DT <150 ms), markedly elevated BNP/NT-proBNP. No disease-modifying therapy exists — cardiac transplantation is definitive. 5-year survival without transplant ~50%. RCM carries the worst prognosis of all pediatric cardiomyopathies.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 7 — OTHER ATYPICAL FORMS
# ══════════════════════════════════════════════════════════════════
content_page(
    4,
    "Other Atypical Forms",
    "Takotsubo · Myocarditis-related · Metabolic/Storage · PPCM",
    "/home/daytona/workspace/cm_slides/img_cache/takotsubo.jpg",
    "Fig 5. Echo: Apical ballooning — hallmark of Takotsubo cardiomyopathy",
    [
        "Takotsubo Cardiomyopathy: Rare in children. Stress-induced transient apical ballooning with normal coronaries. Triggers include seizures and emotional stress. Usually reversible in 4–8 weeks with supportive therapy, beta-blockers, and ACEi.",
        "Myocarditis-related CMP: Post-viral (Coxsackie B, adenovirus, SARS-CoV-2/MIS-C). Acute phase: DCM-like presentation. Chronic: fibrosis → arrhythmogenic phenotype. CMR shows T2 elevation + mid-wall LGE. Treatment: IVIG in fulminant myocarditis; immunosuppression in chronic disease.",
        "Metabolic & Storage Cardiomyopathies: Pompe disease (GSD II) — HCM-like, absent acid alpha-glucosidase. Fabry disease — HCM + renal/neuro involvement. Barth syndrome (X-linked, TAZ) — DCM + LVNC + neutropenia. Danon disease (LAMP2) — HCM + cognitive impairment. Mitochondrial CMP — multi-system, maternal inheritance. Enzyme replacement therapy available for several.",
        "Peripartum CMP (PPCM): Rare in adolescent pregnancies. LVEF <45% in last month or ≤5 months postpartum. Prolactin-mediated injury; bromocriptine used alongside standard HF therapy. ~50% normalize EF within 6 months.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 8 — TREATMENT & MANAGEMENT
# ══════════════════════════════════════════════════════════════════
content_page(
    5,
    "Treatment & Management",
    "Pharmacotherapy · Device therapy · Transplantation · Monitoring",
    "/home/daytona/workspace/cm_slides/img_cache/treatment.jpg",
    "Fig 6. Pediatric VAD & echo — mechanical support in end-stage cardiomyopathy",
    [
        "Heart failure management: ACE inhibitors, beta-blockers, and diuretics form the backbone. Anticoagulation is indicated for severely reduced ejection fraction, LVNC, or atrial fibrillation to prevent thromboembolism.",
        "Arrhythmia management: Beta-blockers are used for most forms. Amiodarone or sotalol for refractory ventricular arrhythmias. ICD implantation is mandatory in high-risk patients — prior cardiac arrest, syncope from ventricular arrhythmia, or significant ventricular dysfunction.",
        "Activity restriction: Competitive sports are contraindicated in ACM/ARVC and other arrhythmogenic conditions, as exercise accelerates disease progression and may trigger fatal arrhythmias.",
        "Cardiac transplantation is the definitive treatment for end-stage cardiomyopathy. Early listing is especially important in RCM. For metabolic/storage cardiomyopathies, enzyme replacement therapy (alglucosidase alfa in Pompe; agalsidase in Fabry) can slow progression.",
        "Long-term monitoring: Echocardiography, Holter monitoring, and cardiac MRI are essential for tracking disease progression and guiding therapy. Family screening with genetic testing is recommended given the high heritability of most atypical cardiomyopathies.",
    ]
)

# ══════════════════════════════════════════════════════════════════
# PAGE 9 — THANK YOU
# ══════════════════════════════════════════════════════════════════
bg_tint(HexColor("#EAF0F8"))
c.saveState()
c.setFillColor(NAVY)
c.rect(0, H - 80, W, 80, fill=1, stroke=0)
c.setFillColor(GOLD)
c.rect(0, H - 84, W, 4, fill=1, stroke=0)
c.setFillColor(WHITE)
c.setFont("Helvetica-Bold", 13)
c.drawCentredString(W/2, H - 45, "Atypical Forms of Cardiomyopathy in Children and Adolescents")
c.setFont("Helvetica", 10)
c.setFillColor(HexColor("#AABBDD"))
c.drawCentredString(W/2, H - 63, "4th Year MBBS  |  Pediatric Cardiology  |  Snigdha Mandaokar")
c.restoreState()

# Big THANK YOU
rounded_rect(80, H - 380, W - 160, 180, 12, NAVY)
c.setFillColor(WHITE)
c.setFont("Helvetica-Bold", 54)
c.drawCentredString(W/2, H - 275, "THANK YOU")
c.setFont("Helvetica-Oblique", 13)
c.setFillColor(GOLD)
c.drawCentredString(W/2, H - 310, "for your attention")

# Key takeaway box
rounded_rect(60, H - 540, W - 120, 120, 8, HexColor("#F0F4FA"), TEAL)
c.setFillColor(TEAL)
c.setFont("Helvetica-Bold", 11)
c.drawCentredString(W/2, H - 450, "Key Takeaways")
takeaways = [
    "• Early diagnosis and continuous monitoring are essential in pediatric cardiomyopathies",
    "• Each atypical form has a distinct pathophysiology, imaging signature, and management",
    "• Cardiac transplantation is the definitive option for end-stage disease",
]
c.setFont("Helvetica", 10)
c.setFillColor(NAVY)
ty = H - 470
for t in takeaways:
    c.drawCentredString(W/2, ty, t)
    ty -= 17

# Footer
c.setFillColor(NAVY)
c.rect(0, 0, W, 28, fill=1, stroke=0)
c.setFillColor(WHITE)
c.setFont("Helvetica", 8)
c.drawCentredString(W/2, 10, "Atypical Forms of Cardiomyopathy in Children and Adolescents  |  4th Year MBBS  |  Snigdha Mandaokar")

c.showPage()
c.save()
print(f"Saved: {OUT}")