All details about epilepsy and seizure

Reading File

Epilepsy and seizure defination epidemiology pathophysiology investigation management treatment prevention all data with reference

Finding Sources
Searching PubMed

"epilepsy"[MeSH Terms] AND "seizures"[MeSH Terms]

Searching the Web

epilepsy seizure definition epidemiology pathophysiology management 2024 guidelines

Reading File
Finding Sources
Finding Sources
Reading File
Reading File
Finding Sources
Reading File
Finding Sources
Finding Sources
Reading File
Reading File
Finding Sources
Reading File
Finding Sources
Finding Sources
Reading File
Reading File
Reading File
Reading File
This is a comprehensive reference covering all aspects of epilepsy and seizures. Here is a quick orientation to the sections:

What's covered above:
SectionKey Content
1. DefinitionsILAE 2014 definition of epilepsy, seizure, status epilepticus
2. Epidemiology50 million globally, incidence/prevalence data, age patterns
3. EtiologyStructural, genetic, metabolic, immune, infectious, unknown
4. ClassificationILAE 2017 focal vs. generalized; all seizure subtypes with descriptions
5. PathophysiologyExcitation/inhibition imbalance, PDS, channelopathies, hippocampal sclerosis, genetics
6. Clinical PresentationAuras by localization, tonic-clonic phases, postictal features
7. InvestigationsEEG, MRI protocol, blood tests, LP, genetic/autoimmune workup
8. Management/TreatmentAcute first aid → Status epilepticus protocol → Chronic ASMs (full table) → Surgery → VNS/RNS/DBS → Ketogenic diet
9. Drug-induced seizuresMetabolic causes; ineffectiveness of ASMs if underlying cause not treated
10. PreventionPrimary, secondary, tertiary prevention strategies
11. Special populationsPregnancy, elderly, children
12. Prognosis70% seizure-free; pharmacoresistance; surgical outcomes; SUDEP
13. References15 authoritative references (textbooks + ILAE + AAN + PubMed)

Give uper all information in ppt

Reading File
Reading File
Reading File
Running Command

ls -la /home/daytona/workspace/

Running Command

mkdir -p /home/daytona/workspace/epilepsy-ppt

Writing File

~/epilepsy-ppt/epilepsy.js

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Epilepsy and Seizures - Complete Clinical Reference";
pres.author = "Orris Medical";

// ─── COLOR PALETTE ──────────────────────────────────────────────
const C = {
  darkBlue:   "0A1628",  // dominant dark bg
  midBlue:    "1A3A5C",  // card/panel bg
  accentTeal: "00B4D8",  // heading accent / highlight
  accentGold: "F4A261",  // sub-accent
  white:      "FFFFFF",
  lightGray:  "E8EFF6",
  textLight:  "D0E4F7",
  textDark:   "0A1628",
  red:        "E63946",
  green:      "2DC653",
  orange:     "F4A261",
};

// ─── HELPERS ────────────────────────────────────────────────────
function darkSlide(slide) {
  slide.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.darkBlue }, line: { color: C.darkBlue } });
}
function sectionBar(slide, title) {
  slide.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.72, fill: { color: C.midBlue }, line: { color: C.midBlue } });
  slide.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.72, w: 10, h: 0.06, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
  slide.addText(title, { x: 0.35, y: 0.08, w: 9.3, h: 0.55, fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", margin: 0 });
}
function card(slide, x, y, w, h, color) {
  color = color || C.midBlue;
  slide.addShape(pres.shapes.ROUNDED_RECTANGLE, { x, y, w, h, fill: { color }, line: { color }, rectRadius: 0.12, shadow: { type: "outer", color: "000000", blur: 8, offset: 3, angle: 135, opacity: 0.2 } });
}
function accentLine(slide, x, y, w) {
  slide.addShape(pres.shapes.RECTANGLE, { x, y, w, h: 0.04, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
}

// ═══════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  // Left accent bar
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.12, h: 5.625, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
  // Brain icon placeholder (circle)
  s.addShape(pres.shapes.ELLIPSE, { x: 7.1, y: 0.7, w: 2.5, h: 2.5, fill: { color: C.midBlue }, line: { color: C.accentTeal, pt: 2 } });
  s.addText("🧠", { x: 7.1, y: 0.7, w: 2.5, h: 2.5, fontSize: 72, align: "center", valign: "middle" });
  // Main title
  s.addText("EPILEPSY", { x: 0.5, y: 0.7, w: 6.3, h: 1.1, fontSize: 52, bold: true, color: C.white, fontFace: "Calibri", margin: 0 });
  s.addText("& SEIZURES", { x: 0.5, y: 1.75, w: 6.3, h: 0.9, fontSize: 40, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  accentLine(s, 0.5, 2.75, 5.5);
  s.addText("Complete Clinical Reference", { x: 0.5, y: 2.88, w: 6.3, h: 0.5, fontSize: 18, color: C.textLight, fontFace: "Calibri", margin: 0 });
  s.addText("Definition  •  Epidemiology  •  Pathophysiology  •  Classification\nInvestigation  •  Management  •  Treatment  •  Prevention", {
    x: 0.5, y: 3.5, w: 9.2, h: 0.85, fontSize: 13, color: C.accentGold, fontFace: "Calibri", align: "left", margin: 0
  });
  s.addText("Sources: Adams & Victor | Bradley & Daroff | Katzung | WHO 2024 | ILAE 2017", {
    x: 0.5, y: 5.05, w: 9.2, h: 0.4, fontSize: 10, color: "7A9CC0", fontFace: "Calibri", margin: 0
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 2 — CONTENTS
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Contents");
  const topics = [
    ["01", "Definitions"],
    ["02", "Epidemiology"],
    ["03", "Etiology"],
    ["04", "Classification of Seizures"],
    ["05", "Pathophysiology"],
    ["06", "Clinical Presentation"],
    ["07", "Investigations"],
    ["08", "Management & Treatment"],
    ["09", "Antiseizure Medications"],
    ["10", "Non-Pharmacological Treatment"],
    ["11", "Prevention & Prognosis"],
    ["12", "References"],
  ];
  const cols = [topics.slice(0, 6), topics.slice(6)];
  cols.forEach((col, ci) => {
    col.forEach((t, i) => {
      const x = ci === 0 ? 0.35 : 5.2;
      const y = 0.95 + i * 0.74;
      card(s, x, y, 4.6, 0.62, C.midBlue);
      s.addText(t[0], { x: x + 0.12, y: y + 0.1, w: 0.5, h: 0.42, fontSize: 13, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
      s.addText(t[1], { x: x + 0.7, y: y + 0.1, w: 3.7, h: 0.42, fontSize: 13, color: C.white, fontFace: "Calibri", margin: 0 });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 3 — DEFINITIONS
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "01 | Definitions");
  // Seizure card
  card(s, 0.35, 0.92, 9.3, 1.32, "102040");
  s.addText("SEIZURE", { x: 0.55, y: 0.98, w: 3, h: 0.38, fontSize: 15, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  s.addText(
    "A transient event of signs/symptoms due to abnormal, excessive, and hypersynchronous neuronal activity in the brain. May manifest as involuntary movements, altered consciousness, sensory disturbance, autonomic phenomena, or psychic symptoms.",
    { x: 0.55, y: 1.35, w: 9.0, h: 0.78, fontSize: 12, color: C.textLight, fontFace: "Calibri", margin: 0 }
  );
  // Epilepsy card
  card(s, 0.35, 2.38, 9.3, 1.62, "102040");
  s.addText("EPILEPSY  (ILAE 2014 Definition)", { x: 0.55, y: 2.44, w: 8.8, h: 0.38, fontSize: 15, bold: true, color: C.accentGold, fontFace: "Calibri", margin: 0 });
  s.addText([
    { text: "A disease of the brain defined by any ONE of:\n", options: { bold: true, color: C.white, breakLine: false } },
    { text: "1.  At least two unprovoked (or reflex) seizures > 24 hours apart\n", options: { color: C.textLight } },
    { text: "2.  One unprovoked seizure + ≥60% probability of recurrence over next 10 years\n", options: { color: C.textLight } },
    { text: "3.  Diagnosis of an epilepsy syndrome", options: { color: C.textLight } },
  ], { x: 0.55, y: 2.85, w: 9.0, h: 1.05, fontSize: 12, fontFace: "Calibri", margin: 0 });
  // Status card
  card(s, 0.35, 4.12, 9.3, 0.85, "1A0A0A");
  s.addText("STATUS EPILEPTICUS", { x: 0.55, y: 4.17, w: 3.5, h: 0.38, fontSize: 14, bold: true, color: C.red, fontFace: "Calibri", margin: 0 });
  s.addText("Prolonged seizures (>5 min) or repeated seizures without recovery between episodes. Life-threatening emergency.", {
    x: 0.55, y: 4.53, w: 9.0, h: 0.35, fontSize: 12, color: C.textLight, fontFace: "Calibri", margin: 0
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 4 — EPIDEMIOLOGY
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "02 | Epidemiology");
  const stats = [
    { val: "50M",   label: "People worldwide\nhave epilepsy",        col: C.accentTeal },
    { val: "80%",   label: "Cases in low/middle-\nincome countries",  col: C.accentGold },
    { val: "70%",   label: "Can be seizure-free\nif treated",         col: C.green },
    { val: "3×",    label: "Higher premature\ndeath risk",            col: C.red },
  ];
  stats.forEach((st, i) => {
    const x = 0.35 + i * 2.35;
    card(s, x, 0.88, 2.15, 1.55, C.midBlue);
    s.addText(st.val, { x, y: 0.98, w: 2.15, h: 0.72, fontSize: 36, bold: true, color: st.col, fontFace: "Calibri", align: "center", margin: 0 });
    s.addText(st.label, { x, y: 1.65, w: 2.15, h: 0.68, fontSize: 11, color: C.textLight, fontFace: "Calibri", align: "center", margin: 0 });
  });
  const rows = [
    ["Annual incidence (US)", "~44 new cases per 100,000 persons/year"],
    ["Lifetime prevalence (US)", "~3% lifetime risk of receiving an epilepsy diagnosis"],
    ["Active epilepsy prevalence", "~0.8% of the general population"],
    ["Age of onset peaks", "Early childhood (first year of life) and after age 60"],
    ["First seizure lifetime risk", "~9% of all people will have at least one seizure in their lifetime"],
    ["Treatment gap (low-income)", "Up to 75% of patients receive no treatment"],
    ["Most common cause after 60", "Cerebrovascular disease"],
  ];
  rows.forEach((r, i) => {
    const y = 2.6 + i * 0.42;
    const bg = i % 2 === 0 ? "0D2136" : "0A1628";
    s.addShape(pres.shapes.RECTANGLE, { x: 0.35, y, w: 9.3, h: 0.42, fill: { color: bg }, line: { color: bg } });
    s.addText(r[0], { x: 0.45, y: y + 0.05, w: 3.5, h: 0.32, fontSize: 11.5, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
    s.addText(r[1], { x: 4.05, y: y + 0.05, w: 5.5, h: 0.32, fontSize: 11.5, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 5 — ETIOLOGY
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "03 | Etiology");
  const cats = [
    { title: "Structural", color: "1A5276", items: ["Hippocampal/mesial temporal sclerosis", "Cortical dysplasia & malformations", "Tumors (primary or metastatic)", "Cerebrovascular disease (leading cause >60yr)", "Traumatic brain injury", "Encephalitis / meningitis"] },
    { title: "Genetic", color: "1A4731", items: ["SCN1A mutation → Dravet syndrome", "KCNQ2/3 → Benign neonatal epilepsy", "CHRNA4 → Nocturnal frontal lobe epilepsy", "Monozygotic twin concordance: 70%", "Familial incidence: 5-10% of primary epilepsies", "Polygenic contributions common"] },
    { title: "Metabolic", color: "4A1942", items: ["Hypoglycemia, hyponatremia, hypocalcemia", "Hypomagnesemia, hypernatremia", "Renal failure (uremia)", "Hepatic encephalopathy, thyrotoxicosis", "Porphyria", "Alcohol/BZD withdrawal"] },
    { title: "Immune / Infectious", color: "4A2E0A", items: ["Anti-NMDAR, anti-LGI1, anti-CASPR2", "Autoimmune encephalitis", "Neurocysticercosis (global leading cause)", "Cerebral malaria, HIV", "Bacterial meningitis", "Viral encephalitis"] },
  ];
  cats.forEach((c, i) => {
    const x = 0.18 + i * 2.45;
    card(s, x, 0.88, 2.28, 4.55, c.color);
    s.addText(c.title, { x: x + 0.1, y: 0.94, w: 2.08, h: 0.38, fontSize: 13, bold: true, color: C.accentTeal, fontFace: "Calibri", align: "center", margin: 0 });
    accentLine(s, x + 0.1, 1.34, 2.08);
    c.items.forEach((item, j) => {
      s.addText([{ text: "• ", options: { color: C.accentGold } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.1, y: 1.42 + j * 0.52, w: 2.1, h: 0.5, fontSize: 10.5, fontFace: "Calibri", margin: 0
      });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 6 — CLASSIFICATION (ILAE 2017)
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "04 | Classification of Seizures (ILAE 2017)");
  // Focal
  card(s, 0.25, 0.88, 3.05, 4.5, "0D2545");
  s.addText("FOCAL ONSET", { x: 0.35, y: 0.94, w: 2.85, h: 0.38, fontSize: 14, bold: true, color: C.accentTeal, fontFace: "Calibri", align: "center", margin: 0 });
  s.addText("(formerly Partial)", { x: 0.35, y: 1.28, w: 2.85, h: 0.28, fontSize: 10, color: "7A9CC0", fontFace: "Calibri", align: "center", margin: 0 });
  accentLine(s, 0.45, 1.6, 2.65);
  const focalItems = [
    ["Focal Aware", "Simple partial — consciousness preserved; aura, Jacksonian march"],
    ["Focal Impaired", "Complex partial — consciousness impaired; automatisms"],
    ["Focal → Bilateral", "Formerly 'secondarily generalized'; starts focal, spreads bilaterally"],
  ];
  focalItems.forEach((f, i) => {
    s.addText(f[0], { x: 0.38, y: 1.72 + i * 1.05, w: 2.72, h: 0.3, fontSize: 11.5, bold: true, color: C.accentGold, fontFace: "Calibri", margin: 0 });
    s.addText(f[1], { x: 0.38, y: 2.02 + i * 1.05, w: 2.72, h: 0.65, fontSize: 10.5, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
  // Generalized
  card(s, 3.6, 0.88, 4.05, 4.5, "0D2545");
  s.addText("GENERALIZED ONSET", { x: 3.7, y: 0.94, w: 3.85, h: 0.38, fontSize: 14, bold: true, color: C.accentGold, fontFace: "Calibri", align: "center", margin: 0 });
  s.addText("(both hemispheres from onset)", { x: 3.7, y: 1.28, w: 3.85, h: 0.28, fontSize: 10, color: "7A9CC0", fontFace: "Calibri", align: "center", margin: 0 });
  accentLine(s, 3.75, 1.6, 3.75);
  const genItems = [
    ["Tonic-Clonic (Grand Mal)", "LOC → tonic stiffening → clonic jerking; <3 min; postictal confusion"],
    ["Absence (Petit Mal)", "4-20 sec staring; no postictal state; 3 Hz spike-wave; onset 5-7 yr"],
    ["Myoclonic", "Brief (<100 ms) muscle jerks; juvenile myoclonic epilepsy, Dravet"],
    ["Atonic (Drop Attacks)", "Sudden loss of muscle tone; Lennox-Gastaut syndrome"],
    ["Epileptic Spasms", "Sudden flexion/extension; West syndrome (infantile spasms)"],
  ];
  genItems.forEach((g, i) => {
    s.addText(g[0], { x: 3.72, y: 1.72 + i * 0.8, w: 3.8, h: 0.28, fontSize: 11, bold: true, color: C.white, fontFace: "Calibri", margin: 0 });
    s.addText(g[1], { x: 3.72, y: 2.0 + i * 0.8, w: 3.8, h: 0.5, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
  // Unknown
  card(s, 7.85, 0.88, 1.9, 4.5, "1A2A1A");
  s.addText("UNKNOWN ONSET", { x: 7.92, y: 0.94, w: 1.76, h: 0.38, fontSize: 11, bold: true, color: C.green, fontFace: "Calibri", align: "center", margin: 0 });
  accentLine(s, 7.95, 1.35, 1.7);
  s.addText("Seizure onset cannot be determined from available information.", {
    x: 7.92, y: 1.45, w: 1.76, h: 1.0, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0
  });
  s.addText("UNCLASSIFIED", { x: 7.92, y: 2.7, w: 1.76, h: 0.32, fontSize: 10, bold: true, color: C.green, fontFace: "Calibri", align: "center", margin: 0 });
  s.addText("Insufficient information or unusual presentation.", { x: 7.92, y: 3.1, w: 1.76, h: 0.8, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0 });
  s.addText("Source: ILAE 2017 Operational Classification", { x: 0.35, y: 5.25, w: 9.3, h: 0.28, fontSize: 9, color: "607080", fontFace: "Calibri", margin: 0 });
}

// ═══════════════════════════════════════════════════════
// SLIDE 7 — PATHOPHYSIOLOGY
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "05 | Pathophysiology");
  card(s, 0.25, 0.88, 9.5, 1.05, "0D2136");
  s.addText("Core Mechanism:", { x: 0.42, y: 0.94, w: 2.2, h: 0.38, fontSize: 13, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  s.addText("Sudden imbalance between excitation (glutamate ↑) and inhibition (GABA ↓) in cortical neuronal networks → Excessive, abnormal, synchronous discharge", {
    x: 2.65, y: 0.94, w: 7.0, h: 0.9, fontSize: 12, color: C.white, fontFace: "Calibri", margin: 0
  });
  const pathCards = [
    { title: "PDS — Paroxysmal Depolarization Shift", color: "152A40", text: "Large sustained neuronal depolarization with burst of action potentials, followed by hyperpolarization. In normal tissue, inhibitory surround contains the discharge. When inhibition fails → seizure spreads." },
    { title: "Ion Channel Dysfunction", color: "152A40", text: "Persistent Na+ currents (SCN1A mutation = Dravet), T-type Ca²+ channels (absence seizures via thalamocortical loops), voltage-gated K+ channel dysfunction (KCNQ2/3 = benign neonatal epilepsy)." },
    { title: "Hippocampal Sclerosis", color: "152A40", text: "Neuronal loss in CA1 sector (Sommer sector) + gliosis. Most common substrate in temporal lobe epilepsy. Detected by MRI. Surgical resection achieves 70% seizure freedom." },
    { title: "Consequences of Chronic Seizures", color: "1A1A0A", text: "Accelerated cortical thinning (neurodegeneration), hippocampal atrophy, memory/cognitive impairment, SUDEP risk (Sudden Unexpected Death in Epilepsy)." },
  ];
  pathCards.forEach((pc, i) => {
    const col = i < 2 ? 0 : 1;
    const row = i < 2 ? i : i - 2;
    const x = 0.25 + col * 4.88;
    const y = 2.1 + row * 1.62;
    card(s, x, y, 4.65, 1.48, pc.color);
    s.addText(pc.title, { x: x + 0.15, y: y + 0.1, w: 4.35, h: 0.32, fontSize: 12, bold: true, color: C.accentGold, fontFace: "Calibri", margin: 0 });
    s.addText(pc.text, { x: x + 0.15, y: y + 0.45, w: 4.35, h: 0.92, fontSize: 10.5, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 8 — CLINICAL PRESENTATION
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "06 | Clinical Presentation");
  // Left: Phases
  card(s, 0.25, 0.88, 4.7, 4.55, "0D2136");
  s.addText("Tonic-Clonic Seizure Phases", { x: 0.38, y: 0.95, w: 4.44, h: 0.35, fontSize: 13, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  accentLine(s, 0.38, 1.33, 4.44);
  const phases = [
    { phase: "PRODROME", desc: "Hours before: irritability, apathy, or ecstasy (not the aura itself)", col: "7A9CC0" },
    { phase: "AURA", desc: "Initial focal seizure; olfactory (mesial temporal), visual (occipital), déjà vu (temporal), fear/formed hallucinations (amygdalo-hippocampal)", col: C.accentGold },
    { phase: "TONIC PHASE", desc: "Sudden cry, loss of consciousness, tonic extension of limbs (~10-30 sec)", col: C.red },
    { phase: "CLONIC PHASE", desc: "Rhythmic jerking, tongue biting, incontinence (~1-2 min)", col: C.orange },
    { phase: "POSTICTAL", desc: "Confusion, headache, fatigue, Todd's paresis (transient focal weakness)", col: C.green },
  ];
  phases.forEach((p, i) => {
    s.addText(p.phase, { x: 0.38, y: 1.42 + i * 0.76, w: 1.5, h: 0.28, fontSize: 10, bold: true, color: p.col, fontFace: "Calibri", margin: 0 });
    s.addText(p.desc, { x: 0.38, y: 1.7 + i * 0.76, w: 4.44, h: 0.42, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
  // Right: Aura localization table
  card(s, 5.2, 0.88, 4.55, 4.55, "0D2136");
  s.addText("Aura → Seizure Focus Localization", { x: 5.32, y: 0.95, w: 4.3, h: 0.35, fontSize: 13, bold: true, color: C.accentGold, fontFace: "Calibri", margin: 0 });
  accentLine(s, 5.32, 1.33, 4.3);
  const auras = [
    ["Somatosensory", "Contralateral post-rolandic"],
    ["Visual (unformed)", "Occipital cortex"],
    ["Olfactory", "Mesial temporal"],
    ["Gustatory", "Insula"],
    ["Auditory", "Heschl gyri"],
    ["Déjà vu / dreamy state", "Temporal lobe"],
    ["Fear / formed hallucination", "Amygdalo-hippocampal"],
    ["Vertigo", "Superior temporal"],
    ["Automatisms", "Temporal / frontal"],
  ];
  auras.forEach((a, i) => {
    const bg = i % 2 === 0 ? "112030" : "0D1A28";
    s.addShape(pres.shapes.RECTANGLE, { x: 5.32, y: 1.42 + i * 0.36, w: 4.3, h: 0.36, fill: { color: bg }, line: { color: bg } });
    s.addText(a[0], { x: 5.38, y: 1.46 + i * 0.36, w: 2.1, h: 0.28, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0 });
    s.addText(a[1], { x: 7.5, y: 1.46 + i * 0.36, w: 2.08, h: 0.28, fontSize: 10, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 9 — INVESTIGATIONS
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "07 | Investigations");
  const invCols = [
    {
      title: "EEG (Most Important)",
      color: "0D2545",
      accentC: C.accentTeal,
      items: [
        "Interictal EEG: epileptiform discharges (spikes, sharp waves)",
        "3 Hz spike-wave → Childhood Absence Epilepsy",
        "Hypsarrhythmia → West Syndrome (Infantile Spasms)",
        "Centrotemporal spikes → BECTS",
        "Video-EEG: gold standard for presurgical evaluation",
        "Continuous EEG: after paralytics in ICU for non-convulsive status",
      ]
    },
    {
      title: "Neuroimaging",
      color: "0D2545",
      accentC: C.accentGold,
      items: [
        "MRI brain (epilepsy protocol) — preferred",
        "Detects hippocampal sclerosis, cortical dysplasia, tumors",
        "Sequences: T1 volumetric, FLAIR, T2, DWI, gadolinium",
        "CT brain: acute hemorrhage, trauma, MRI unavailable",
      ]
    },
    {
      title: "Blood Tests",
      color: "0D2545",
      accentC: C.green,
      items: [
        "Glucose, electrolytes (Na⁺, Ca²⁺, Mg²⁺), BUN, creatinine",
        "LFTs, TFTs, FBC",
        "Toxicology screen (alcohol, drugs, bupropion, tramadol)",
        "ASM drug levels if on treatment",
        "Pregnancy test in women of childbearing age",
      ]
    },
    {
      title: "Other Investigations",
      color: "0D2545",
      accentC: C.red,
      items: [
        "LP: if CNS infection suspected (NOT during active seizure)",
        "Autoimmune panel: anti-NMDAR, anti-LGI1, anti-CASPR2",
        "Genetic testing: whole exome for suspected genetic epilepsy",
        "Neuropsychological testing: cognitive/memory lateralization",
        "PET, SPECT, intracranial EEG for presurgical planning",
      ]
    },
  ];
  invCols.forEach((col, i) => {
    const x = 0.18 + i * 2.46;
    card(s, x, 0.88, 2.28, 4.55, col.color);
    s.addText(col.title, { x: x + 0.1, y: 0.94, w: 2.08, h: 0.38, fontSize: 11, bold: true, color: col.accentC, fontFace: "Calibri", align: "center", margin: 0 });
    accentLine(s, x + 0.1, 1.34, 2.08);
    col.items.forEach((item, j) => {
      s.addText([{ text: "• ", options: { color: col.accentC } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.12, y: 1.42 + j * 0.58, w: 2.06, h: 0.54, fontSize: 10, fontFace: "Calibri", margin: 0
      });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 10 — STATUS EPILEPTICUS MANAGEMENT
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "08 | Status Epilepticus — Emergency Management");
  const steps = [
    { time: "0-5 min", title: "STABILIZE", color: "1A2E4A", textC: C.accentTeal, items: ["ABCs: Airway, Breathing, Circulation", "O₂, cardiac monitor, pulse oximetry, capnography", "Large-bore IV access + bedside glucose", "IV Normal Saline (NOT glucose — incompatible with phenytoin)", "Labs: BMP, Ca²⁺, Mg²⁺, lactate, toxicology, drug levels", "Treat hypoglycemia; monitor temperature"] },
    { time: "5-20 min", title: "BENZODIAZEPINES (1st Line)", color: "1A2E1A", textC: C.green, items: ["IV Lorazepam 2-4 mg (preferred; duration 12-24 h)", "IM Midazolam 10 mg (if no IV access; non-inferior)", "IV Diazepam 5-10 mg (faster onset; shorter duration)", "Goal: terminate seizure activity immediately"] },
    { time: "20-40 min", title: "2nd LINE AEDs", color: "2E2A10", textC: C.accentGold, items: ["Fosphenytoin IV 20 mg/kg (preferred over phenytoin)", "Valproate IV 20-40 mg/kg", "Levetiracetam IV 60 mg/kg (up to 4.5 g)", "Lacosamide IV 200-400 mg"] },
    { time: ">40-60 min", title: "REFRACTORY — ICU", color: "2E1010", textC: C.red, items: ["Intubation + general anesthesia", "Propofol IV infusion OR Midazolam infusion OR Pentobarbital", "Continuous EEG monitoring (mandatory post-paralytics)", "Do NOT perform LP during active status epilepticus", "CT/MRI once seizures controlled"] },
  ];
  steps.forEach((st, i) => {
    const x = 0.18 + i * 2.45;
    card(s, x, 0.88, 2.28, 4.55, st.color);
    s.addShape(pres.shapes.RECTANGLE, { x: x + 0.1, y: 0.94, w: 2.08, h: 0.25, fill: { color: st.textC }, line: { color: st.textC } });
    s.addText(st.time, { x: x + 0.1, y: 0.94, w: 2.08, h: 0.25, fontSize: 10, bold: true, color: C.darkBlue, fontFace: "Calibri", align: "center", margin: 0 });
    s.addText(st.title, { x: x + 0.1, y: 1.23, w: 2.08, h: 0.36, fontSize: 11, bold: true, color: st.textC, fontFace: "Calibri", align: "center", margin: 0 });
    accentLine(s, x + 0.1, 1.61, 2.08);
    st.items.forEach((item, j) => {
      s.addText([{ text: "► ", options: { color: st.textC } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.12, y: 1.7 + j * 0.5, w: 2.06, h: 0.47, fontSize: 10, fontFace: "Calibri", margin: 0
      });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 11 — ANTISEIZURE MEDICATIONS TABLE
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "09 | Antiseizure Medications (ASMs)");
  // Table header
  const headers = ["Drug (Generic)", "Trade Name", "Adult Dose", "Half-Life", "Target Level", "Main Use"];
  const widths = [1.9, 1.2, 1.55, 0.9, 1.0, 3.12];
  let xOff = 0.18;
  headers.forEach((h, i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: xOff, y: 0.88, w: widths[i], h: 0.38, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
    s.addText(h, { x: xOff + 0.05, y: 0.9, w: widths[i] - 0.1, h: 0.34, fontSize: 10, bold: true, color: C.darkBlue, fontFace: "Calibri", margin: 0 });
    xOff += widths[i];
  });
  const rows = [
    ["Valproic Acid", "Depakote", "1,000-3,000 mg/d", "6-15 h", "50-100 µg/mL", "GTC, Absence, Myoclonic — broad spectrum"],
    ["Phenytoin", "Dilantin", "300-400 mg/d", "12-36 h", "10-20 µg/mL", "Focal, GTC"],
    ["Carbamazepine", "Tegretol", "600-1,200 mg/d", "14-25 h", "4-12 µg/mL", "Focal seizures"],
    ["Oxcarbazepine", "Trileptal", "900-2,400 mg/d", "1-5 h", "—", "Focal seizures"],
    ["Lamotrigine", "Lamictal", "300-500 mg/d", "15-60 h", "2-7 µg/mL", "Focal, Absence, GTC — broad spectrum"],
    ["Levetiracetam", "Keppra", "500-3,000 mg/d", "6-8 h", "—", "Focal, GTC — broad spectrum"],
    ["Ethosuximide", "Zarontin", "750-1,500 mg/d", "20-60 h", "50-100 µg/mL", "Absence seizures ONLY"],
    ["Lacosamide", "Vimpat", "300-400 mg/d", "13 h", "—", "Focal seizures"],
    ["Topiramate", "Topamax", "400 mg/d", "20-30 h", "—", "Focal, GTC"],
    ["Phenobarbital", "Luminal", "90-200 mg/d", "40-120 h", "15-40 µg/mL", "GTC, Focal (older agent)"],
  ];
  rows.forEach((row, ri) => {
    const bg = ri % 2 === 0 ? "0D1E30" : "0A1628";
    xOff = 0.18;
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: xOff, y: 1.28 + ri * 0.4, w: widths[ci], h: 0.4, fill: { color: bg }, line: { color: bg } });
      const textColor = ci === 0 ? C.white : ci === 5 ? C.accentTeal : C.textLight;
      s.addText(cell, { x: xOff + 0.05, y: 1.31 + ri * 0.4, w: widths[ci] - 0.1, h: 0.34, fontSize: 9.5, color: textColor, fontFace: "Calibri", margin: 0 });
      xOff += widths[ci];
    });
  });
  s.addText("⚠  Never use carbamazepine/oxcarbazepine for absence/myoclonic seizures — may worsen them.", {
    x: 0.18, y: 5.27, w: 9.6, h: 0.28, fontSize: 10, color: C.red, fontFace: "Calibri", bold: true, margin: 0
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 12 — MECHANISMS OF ACTION
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "09b | Mechanisms of Action of ASMs");
  const mechs = [
    { title: "Na⁺ Channel Blockade", color: "0D2545", drugs: "Phenytoin, Carbamazepine,\nOxcarbazepine, Lamotrigine,\nLacosamide", text: "Reduces sustained high-frequency neuronal firing by blocking voltage-gated sodium channels in their inactivated state. Effective for focal and tonic-clonic seizures." },
    { title: "GABA Enhancement", color: "1A2E1A", drugs: "Benzodiazepines, Barbiturates,\nValproate, Vigabatrin,\nClobazam", text: "Potentiates GABAergic inhibition. BZDs and barbiturates act on GABA-A receptor. Valproate increases GABA synthesis/reduces catabolism. Vigabatrin irreversibly inhibits GABA-T." },
    { title: "T-type Ca²⁺ Channel Block", color: "2E2A10", drugs: "Ethosuximide, Valproate", text: "Specifically targets thalamocortical circuits underlying absence seizures. T-type calcium channels generate rhythmic 3 Hz spike-wave activity; their blockade abolishes absence seizures." },
    { title: "SV2A Modulation", color: "2E1010", drugs: "Levetiracetam, Brivaracetam", text: "Binds synaptic vesicle protein 2A — unique mechanism not shared by other ASMs. Reduces neurotransmitter release from presynaptic terminals." },
    { title: "AMPA Receptor Antagonism", color: "1A1A30", drugs: "Perampanel", text: "Non-competitive AMPA glutamate receptor antagonist. Reduces glutamate-mediated excitation. Approved for focal and generalized tonic-clonic seizures." },
    { title: "HCN Channel Modulation", color: "1A2040", drugs: "Lamotrigine, Gabapentin,\nPregabalin", text: "Gabapentin/pregabalin bind α2δ subunit of voltage-gated Ca²+ channels, reducing excitatory neurotransmitter release." },
  ];
  mechs.forEach((m, i) => {
    const col = i % 3;
    const row = Math.floor(i / 3);
    const x = 0.18 + col * 3.27;
    const y = 0.9 + row * 2.24;
    card(s, x, y, 3.1, 2.1, m.color);
    s.addText(m.title, { x: x + 0.12, y: y + 0.1, w: 2.86, h: 0.32, fontSize: 11.5, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
    s.addText(m.drugs, { x: x + 0.12, y: y + 0.44, w: 2.86, h: 0.48, fontSize: 9.5, color: C.accentGold, fontFace: "Calibri", italic: true, margin: 0 });
    s.addText(m.text, { x: x + 0.12, y: y + 0.96, w: 2.86, h: 1.0, fontSize: 10, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 13 — NON-PHARMACOLOGICAL TREATMENT
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "10 | Non-Pharmacological Treatment");
  const nonPharm = [
    {
      title: "Epilepsy Surgery",
      icon: "🔬",
      color: "0D2545",
      textC: C.accentTeal,
      items: [
        "For pharmacoresistant epilepsy (failed ≥2 ASMs)",
        "Temporal lobectomy: 70% seizure-free",
        "Extratemporal resection: lower success",
        "Lesionectomy: curative for structural lesions",
        "Presurgical: Video-EEG, MRI, neuropsychology, PET, SPECT",
      ]
    },
    {
      title: "Neuromodulation",
      icon: "⚡",
      color: "1A2E1A",
      textC: C.green,
      items: [
        "VNS (Vagus Nerve Stimulator): open-loop; refractory focal seizures + LGS",
        "RNS (Responsive Neurostimulator): closed-loop intracranial device",
        "DBS (Deep Brain Stimulation): bilateral anterior thalamic nuclei",
        "All three devices approved for drug-refractory epilepsy",
      ]
    },
    {
      title: "Ketogenic Diet",
      icon: "🥑",
      color: "2E2A10",
      textC: C.accentGold,
      items: [
        "High fat, low carbohydrate, controlled protein",
        "First-line for GLUT1 deficiency syndrome",
        "Especially effective: myoclonic epilepsies, infantile spasms,",
        "Dravet syndrome, tuberous sclerosis, LGS",
        "Benefits both children and adults (Chen et al., 2023)",
      ]
    },
    {
      title: "Immunotherapy",
      icon: "💉",
      color: "2E1010",
      textC: C.red,
      items: [
        "For autoimmune/paraneoplastic epilepsy",
        "1st line: Corticosteroids, IVIG, Plasmapheresis",
        "2nd line: Rituximab, Mycophenolate, Azathioprine",
        "ACTH or Vigabatrin for West syndrome",
      ]
    },
  ];
  nonPharm.forEach((np, i) => {
    const x = 0.18 + i * 2.45;
    card(s, x, 0.88, 2.28, 4.55, np.color);
    s.addText(np.icon + " " + np.title, { x: x + 0.1, y: 0.94, w: 2.08, h: 0.38, fontSize: 11, bold: true, color: np.textC, fontFace: "Calibri", align: "center", margin: 0 });
    accentLine(s, x + 0.1, 1.34, 2.08);
    np.items.forEach((item, j) => {
      s.addText([{ text: "• ", options: { color: np.textC } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.12, y: 1.42 + j * 0.62, w: 2.06, h: 0.58, fontSize: 10, fontFace: "Calibri", margin: 0
      });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 14 — PREVENTION
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "11 | Prevention");
  const prevLevels = [
    {
      level: "PRIMARY PREVENTION",
      subtitle: "Avoiding the first seizure",
      color: "0D2545",
      textC: C.accentTeal,
      items: [
        "Prevent/treat CNS infections promptly",
        "Prevention of head trauma (helmets, seat belts)",
        "Good prenatal care (prevent birth injuries, HIE)",
        "Control cardiovascular risk factors → prevent stroke",
        "Avoid precipitants: sleep deprivation, alcohol excess",
        "Lead/heavy metal poisoning prevention (children)",
      ]
    },
    {
      level: "SECONDARY PREVENTION",
      subtitle: "Preventing seizure recurrence",
      color: "1A2E1A",
      textC: C.green,
      items: [
        "After 2 unprovoked seizures: ASM strongly recommended",
        "After 1 seizure + high recurrence risk: start ASM",
        "(structural lesion, epileptiform EEG, prior brain injury)",
        "AAN 2015 guideline (reaffirmed Feb 2024)",
        "Febrile seizures: prophylactic ASMs NOT routinely recommended",
        "Medication adherence: most important factor for seizure control",
      ]
    },
    {
      level: "TERTIARY PREVENTION",
      subtitle: "Reducing the impact of chronic epilepsy",
      color: "2E2A10",
      textC: C.accentGold,
      items: [
        "Regular follow-up, medication optimization",
        "SUDEP awareness: nocturnal supervision, detection devices",
        "Driving restriction counseling (seizure-free period required)",
        "Rescue benzodiazepines: intranasal midazolam, diastat",
        "Mental health support (anxiety/depression 2-3x higher)",
        "Seizure action plans for patients and caregivers",
      ]
    },
  ];
  prevLevels.forEach((pl, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 0.88, 3.1, 4.55, pl.color);
    s.addText(pl.level, { x: x + 0.1, y: 0.94, w: 2.9, h: 0.35, fontSize: 12, bold: true, color: pl.textC, fontFace: "Calibri", align: "center", margin: 0 });
    s.addText(pl.subtitle, { x: x + 0.1, y: 1.3, w: 2.9, h: 0.28, fontSize: 10, color: "7A9CC0", fontFace: "Calibri", italic: true, align: "center", margin: 0 });
    accentLine(s, x + 0.1, 1.6, 2.9);
    pl.items.forEach((item, j) => {
      s.addText([{ text: "• ", options: { color: pl.textC } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.12, y: 1.68 + j * 0.52, w: 2.88, h: 0.48, fontSize: 10, fontFace: "Calibri", margin: 0
      });
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 15 — SPECIAL POPULATIONS & PROGNOSIS
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "11b | Special Populations & Prognosis");
  // Special populations
  const pops = [
    { title: "Pregnancy", color: "1A2545", textC: C.accentTeal, items: ["Continue ASMs — uncontrolled seizures risk fetal hypoxia", "Valproate: highest teratogenicity — avoid if alternatives exist", "Lamotrigine / Levetiracetam: relatively safer", "Folic acid supplementation mandatory pre-conception"] },
    { title: "Elderly", color: "1A2545", textC: C.accentGold, items: ["Most common new-onset cause: cerebrovascular disease", "Drug interactions + polypharmacy hazards increased", "Enzyme-inducing ASMs accelerate bone metabolism", "Start low, go slow — increased drug sensitivity"] },
    { title: "Children", color: "1A2545", textC: C.green, items: ["Wide variety of age-specific syndromes", "West, Dravet, LGS, CAE, BECTS", "Many benign childhood epilepsies remit spontaneously", "ACTH/Vigabatrin first-line for infantile spasms"] },
  ];
  pops.forEach((p, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 0.9, 3.1, 2.6, p.color);
    s.addText(p.title, { x: x + 0.12, y: 0.96, w: 2.86, h: 0.32, fontSize: 13, bold: true, color: p.textC, fontFace: "Calibri", align: "center", margin: 0 });
    accentLine(s, x + 0.12, 1.3, 2.86);
    p.items.forEach((item, j) => {
      s.addText([{ text: "• ", options: { color: p.textC } }, { text: item, options: { color: C.textLight } }], {
        x: x + 0.15, y: 1.38 + j * 0.5, w: 2.8, h: 0.46, fontSize: 10, fontFace: "Calibri", margin: 0
      });
    });
  });
  // Prognosis
  card(s, 0.2, 3.68, 9.6, 1.72, "0D1E30");
  s.addText("Prognosis", { x: 0.35, y: 3.74, w: 2.5, h: 0.34, fontSize: 14, bold: true, color: C.accentTeal, fontFace: "Calibri", margin: 0 });
  accentLine(s, 0.35, 4.1, 9.3);
  const progItems = [
    "~70% of patients achieve seizure freedom with appropriate treatment",
    "~30% develop pharmacoresistance",
    "After 2 failed ASM trials: only ~5-10% respond to further medications",
    "Temporal lobectomy: 50-70% achieve long-term seizure freedom",
    "SUDEP risk: ~1/1,000 person-years in general epilepsy; up to 1/150 in severe drug-resistant epilepsy",
  ];
  progItems.forEach((item, i) => {
    const x = i < 3 ? 0.35 : 5.2;
    const y = i < 3 ? 4.18 + i * 0.38 : 4.18 + (i - 3) * 0.38;
    s.addText([{ text: "✓  ", options: { color: C.green } }, { text: item, options: { color: C.textLight } }], {
      x, y, w: 4.6, h: 0.35, fontSize: 10.5, fontFace: "Calibri", margin: 0
    });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 16 — REFERENCES
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "12 | References");
  const refs = [
    "1.  Adams and Victor's Principles of Neurology, 12th Ed. — Chapter 15: Epilepsy and Other Seizure Disorders",
    "2.  Bradley and Daroff's Neurology in Clinical Practice — Chapter 100: Seizures and Epilepsy Definitions",
    "3.  Katzung's Basic and Clinical Pharmacology, 16th Ed. — Chapter 24: Antiseizure Medications",
    "4.  Tintinalli's Emergency Medicine: A Comprehensive Study, 9th Ed. — Chapter 171: Treatment of Status Epilepticus",
    "5.  Eric Kandel's Principles of Neural Science, 6th Ed. — Seizure Focus and Surgical Treatment",
    "6.  Harriet Lane Handbook, 23rd Ed. — Status Epilepticus Treatment Guidelines",
    "7.  Fisher RS et al. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia 2014; 55(4):475-482",
    "8.  Scheffer IE et al. ILAE classification of the epilepsies. Epilepsia 2017; 58(4):512-521",
    "9.  WHO Epilepsy Fact Sheet, February 2024",
    "10. AAN/AES Practice Guideline: Management of an Unprovoked First Seizure in Adults. Neurology 2015; 84(16):1705. Reaffirmed Feb 2024",
    "11. Pressler RM et al. Treatment of seizures in the neonate: ILAE Task Force. Epilepsia 2023 Oct [PMID: 37655702]",
    "12. Chu H et al. Antiseizure medications for idiopathic generalized epilepsies. J Neurol 2023 [PMID: 37378757]",
    "13. Chen S et al. Ketogenic Diet and Multiple Health Outcomes: Umbrella Review. Nutrients 2023 [PMID: 37836444]",
    "14. NAEC 2023 Guidelines for Specialized Epilepsy Centers. Neurology 2024 Feb",
    "15. Hauser WA, Annegers JF. Epidemiology of epilepsy. Textbook of Epilepsy, 1992",
  ];
  refs.forEach((r, i) => {
    const col = i < 8 ? 0 : 1;
    const row = i < 8 ? i : i - 8;
    const x = col === 0 ? 0.3 : 5.15;
    const y = 0.96 + row * 0.56;
    s.addText(r, { x, y, w: 4.65, h: 0.5, fontSize: 9.5, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════
// SLIDE 17 — CLOSING
// ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.12, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 5.505, w: 10, h: 0.12, fill: { color: C.accentTeal }, line: { color: C.accentTeal } });
  s.addText("KEY TAKEAWAYS", { x: 1, y: 0.4, w: 8, h: 0.5, fontSize: 20, bold: true, color: C.accentTeal, fontFace: "Calibri", align: "center", margin: 0 });
  accentLine(s, 2, 0.95, 6);
  const takeaways = [
    ["50 million people", "worldwide have epilepsy; 80% in low/middle-income countries"],
    ["ILAE 2014 definition", "requires ≥2 unprovoked seizures or 1 seizure with ≥60% recurrence risk"],
    ["Core mechanism", "is glutamate excess + GABA deficit → excessive synchronized neuronal discharge"],
    ["EEG + MRI", "are the cornerstone investigations for all seizure presentations"],
    ["Monotherapy first", "achieves seizure control in ~2/3 of patients; pharmacoresistance in ~30%"],
    ["Status epilepticus", "lorazepam → fosphenytoin/levetiracetam → anesthesia within 30 minutes"],
    ["Surgery, VNS, RNS/DBS", "and ketogenic diet are options for drug-refractory epilepsy"],
    ["Prevention", "addresses primary (avoid first seizure), secondary (prevent recurrence), tertiary (reduce impact)"],
  ];
  takeaways.forEach((t, i) => {
    const bg = i % 2 === 0 ? "0D1E30" : "0A1628";
    s.addShape(pres.shapes.RECTANGLE, { x: 0.4, y: 1.08 + i * 0.54, w: 9.2, h: 0.52, fill: { color: bg }, line: { color: bg } });
    s.addText(t[0] + ": ", { x: 0.52, y: 1.12 + i * 0.54, w: 2.2, h: 0.4, fontSize: 11, bold: true, color: C.accentGold, fontFace: "Calibri", margin: 0 });
    s.addText(t[1], { x: 2.72, y: 1.12 + i * 0.54, w: 6.76, h: 0.4, fontSize: 11, color: C.textLight, fontFace: "Calibri", margin: 0 });
  });
}

// ─── WRITE FILE ─────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/epilepsy-ppt/Epilepsy_and_Seizures.pptx" })
  .then(() => console.log("SUCCESS: /home/daytona/workspace/epilepsy-ppt/Epilepsy_and_Seizures.pptx"))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });
Running Command

cd /home/daytona/workspace/epilepsy-ppt && node epilepsy.js

Running Command

node -e "const p = require('pptxgenjs'); const pres = new p(); console.log(Object.keys(pres.shapes).filter(k => k.includes('RECT') || k.includes('ELLIP') || k.includes('OVAL') || k.includes('ROUND')));"

Editing File

~/epilepsy-ppt/epilepsy.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/epilepsy-ppt/epilepsy.js'
Running Command

cd /home/daytona/workspace/epilepsy-ppt && node epilepsy.js

The presentation is ready! Here is your download link:

Epilepsy and Seizures

Presentation · PPTX


What's inside - 17 slides with a dark professional medical theme:
SlideContent
1Title slide
2Contents / outline
3Definitions (Seizure, Epilepsy ILAE 2014, Status Epilepticus)
4Epidemiology (stat cards + full data table)
5Etiology (4 column cards: Structural / Genetic / Metabolic / Immune-Infectious)
6Classification of Seizures - ILAE 2017 (Focal / Generalized / Unknown)
7Pathophysiology (PDS, ion channels, hippocampal sclerosis, chronic consequences)
8Clinical Presentation (seizure phases + aura localization table)
9Investigations (EEG, MRI, blood tests, other workup)
10Status Epilepticus Emergency Protocol (4-step timeline)
11Antiseizure Medications full table (10 drugs with doses, half-life, target levels)
12Mechanisms of Action (6 drug classes)
13Non-Pharmacological Treatment (Surgery, VNS/RNS/DBS, Ketogenic Diet, Immunotherapy)
14Prevention (Primary / Secondary / Tertiary)
15Special Populations + Prognosis
1615 References (textbooks + ILAE + AAN + PubMed PMIDs)
17Key Takeaways closing slide
This is a shared conversation. Sign in to Orris to start your own chat.