alkasol syrup
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Alkasol syrup disodium hydrogen citrate uses dosage mechanism
Here is a complete overview of Alkasol Syrup:
Alkasol Syrup (Disodium Hydrogen Citrate)
Manufacturer: Stadmed Pvt. Ltd.
Salt/Composition: Disodium Hydrogen Citrate 1.4 g per 5 ml
Drug Class: Urinary Alkalizer / Drugs for Renal Calculi
Mechanism of Action
Disodium hydrogen citrate is metabolized in the body to sodium bicarbonate, which increases the pH (alkalinity) of urine. Alkaline urine:
- Dissolves uric acid and urate kidney stones
- Inhibits formation of new calcium oxalate and uric acid crystals
- Enhances the antibacterial activity of certain antibiotics (sulfonamides, fluoroquinolones) that work better in alkaline urine
- Relieves burning and discomfort during urination
Indications (Uses)
| Condition | Rationale |
|---|---|
| Urinary Tract Infections (UTIs) - cystitis, urethritis, pyelitis | Alkalizes urine, enhances antibiotic efficacy |
| Kidney stones (Urolithiasis) - uric acid/urate stones | Dissolves existing stones, prevents new ones |
| Gout | Promotes renal excretion of uric acid |
| Metabolic acidosis (mild, acute) | Acts as systemic alkalizer |
| Urinary discomfort/burning | Reduces acidic irritation of urinary mucosa |
Dosage
| Population | Dose |
|---|---|
| Adults | 15-30 ml (3-6 teaspoons), 3-4 times daily after meals, diluted in water/juice |
| Children | Only as directed by a pediatrician |
- Always dilute in a full glass of water or fruit juice
- Take after meals to reduce stomach upset
- Continue for the full prescribed duration
Side Effects
Common:
- Nausea, vomiting
- Diarrhea / loose stools (laxative effect at high doses)
- Stomach pain / gastric discomfort
- Weakness
Serious (rare):
- Hypernatremia (excess sodium, especially in cardiac/renal patients)
- Metabolic alkalosis (overdose)
- Aluminum toxicity if taken with aluminum-containing antacids
Contraindications
- Severe kidney disease / renal failure
- Hyperkalemia (if potassium-citrate formulation)
- Sodium-restricted diets (heart failure, hypertension)
- Known hypersensitivity to citrate salts
- Pregnancy and breastfeeding (safety not established - use only if clearly needed)
Drug Interactions
Alkasol can reduce blood levels and efficacy of drugs excreted more rapidly in alkaline urine:
- Tetracyclines - reduced absorption
- Lithium - increased renal excretion (reduced effect)
- Methotrexate - altered excretion
- Salicylates (aspirin) - increased excretion
- Chlorpropamide, methenamine - reduced efficacy
- Aluminum antacids - dangerous increase in aluminum absorption; avoid combination
Important Warnings
- Not a diuretic - it does not increase urine volume
- Not an antibiotic - for UTIs, it is used alongside antibiotics, not instead of them
- Patients with heart disease, liver disease, or kidney impairment should use with caution and medical supervision
- Monitor electrolytes in long-term use
Quick Tips
- Drink plenty of water (2-3 liters/day) while on Alkasol to help flush the urinary tract
- Do not self-medicate; dosage and duration depend on the condition being treated
- Common brand equivalents: Citralka (Pfizer), Cital, Oricitral, Alkacip
Disclaimer: This information is for educational purposes. Always follow your doctor's or pharmacist's instructions for your specific condition.
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