5 metformin brand names
Here are 5 common brand names for metformin:
- Glucophage - the original and most widely recognized brand (immediate-release)
- Glucophage XR - extended-release version
- Fortamet - extended-release, once-daily dosing
- Glumetza - extended-release formulation
- Riomet - oral liquid solution form of metformin
All contain metformin hydrochloride as the active ingredient and are used primarily for type 2 diabetes management.
5 sustain release metformin tablets
Here are 5 sustained-release (SR/XR/ER) metformin tablet brands:
- Glucophage XR - metformin HCl extended-release, 500 mg & 750 mg tablets (Bristol-Myers Squibb)
- Glumetza - metformin HCl extended-release, 500 mg & 1000 mg tablets (once daily)
- Fortamet - metformin HCl extended-release, 500 mg & 1000 mg (single-layer osmotic technology)
- Glycomet SR - metformin SR 500 mg & 1000 mg (USV Ltd - widely used in India)
- Obimet SR - metformin SR 500 mg & 850 mg (Glenmark Pharmaceuticals - popular in India)
Key difference from immediate-release: SR/XR formulations release metformin slowly over 8-24 hours, reducing GI side effects (nausea, diarrhea) and allowing once or twice daily dosing instead of three times daily.
5 non sustain release metformin tablets
Here are 5 immediate-release (IR) metformin tablet brands:
- Glucophage - metformin HCl 500 mg, 850 mg & 1000 mg (original brand, Bristol-Myers Squibb)
- Glycomet - metformin HCl 500 mg & 850 mg (USV Ltd - one of the most prescribed in India)
- Obimet - metformin HCl 500 mg & 850 mg (Glenmark Pharmaceuticals)
- Diaglucide - metformin HCl 500 mg (immediate-release, used in several Asian markets)
- Walaphage - metformin HCl 500 mg & 1000 mg (immediate-release, widely available generically)
Key features of IR metformin:
- Absorbed rapidly after oral ingestion
- Usually taken 2-3 times daily with meals
- Higher incidence of GI side effects (nausea, vomiting, diarrhea) compared to SR forms
- Onset of action within 1-3 hours
- Standard first-line choice for type 2 diabetes management per most guidelines (ADA, WHO)
Metformin combination tablets
Here are the major metformin combination tablets, grouped by drug class:
🔹 Metformin + Sulfonylurea
| Brand | Combination |
|---|---|
| Glucovance | Metformin + Glibenclamide (Glyburide) |
| Amaryl M | Metformin + Glimepiride |
| Glimulin MF | Metformin + Glimepiride |
| Gluconorm G | Metformin + Glipizide |
🔹 Metformin + DPP-4 Inhibitor
| Brand | Combination |
|---|---|
| Janumet | Metformin + Sitagliptin |
| Kombiglyze XR | Metformin XR + Saxagliptin |
| Jentadueto | Metformin + Linagliptin |
| Galvusmet | Metformin + Vildagliptin |
| Omarigliptin M | Metformin + Omarigliptin |
🔹 Metformin + SGLT-2 Inhibitor
| Brand | Combination |
|---|---|
| Synjardy | Metformin + Empagliflozin |
| Xigduo XR | Metformin XR + Dapagliflozin |
| Invokamet | Metformin + Canagliflozin |
| Segluromet | Metformin + Ertugliflozin |
🔹 Metformin + Thiazolidinedione
| Brand | Combination |
|---|---|
| Actoplus Met | Metformin + Pioglitazone |
| Competact | Metformin + Pioglitazone |
| Avandamet | Metformin + Rosiglitazone |
🔹 Metformin + Alpha-glucosidase Inhibitor
| Brand | Combination |
|---|---|
| Glucobay M | Metformin + Acarbose |
🔹 Triple Combination
| Brand | Combination |
|---|---|
| Triglucored | Metformin + Glimepiride + Pioglitazone |
| Janumet Plus | Metformin + Sitagliptin + Atorvastatin |
| Empagliflozin/Linagliptin/Metformin | Triple SGLT2+DPP4+Metformin |
Clinical note: Combination tablets improve patient compliance by reducing pill burden. Choice depends on the patient's HbA1c, renal function, cardiovascular risk, and cost considerations.
Sustain released preparation of metformin tablets
Here is a detailed overview of sustained-release (SR) metformin preparations:
📋 What is SR Metformin?
Sustained-release metformin releases the drug slowly and continuously over 8–24 hours, maintaining steady plasma levels and reducing GI side effects compared to immediate-release (IR) forms.
🔹 Available SR Metformin Brands
International Brands
| Brand | Strength | Manufacturer |
|---|---|---|
| Glucophage XR | 500 mg, 750 mg, 1000 mg | Bristol-Myers Squibb |
| Glumetza | 500 mg, 1000 mg | Santarus/Bausch Health |
| Fortamet | 500 mg, 1000 mg | Shionogi |
Indian Brands
| Brand | Strength | Manufacturer |
|---|---|---|
| Glycomet SR | 500 mg, 850 mg, 1000 mg | USV Ltd |
| Obimet SR | 500 mg, 850 mg | Glenmark |
| Cetapin XR | 500 mg, 1000 mg | FDC Ltd |
| Bigomet SR | 500 mg, 1000 mg | Aristo Pharma |
| Walaphage SR | 500 mg, 1000 mg | Wallace Pharma |
| Grandmet SR | 500 mg | Mankind Pharma |
| Reclide MF SR | 500 mg | Lupin |
🔹 SR Combination Brands
| Brand | Combination | Strength |
|---|---|---|
| Amaryl M SR | Metformin SR + Glimepiride | 500/1000 mg + 1/2 mg |
| Janumet XR | Metformin XR + Sitagliptin | 500/1000 mg + 50/100 mg |
| Kombiglyze XR | Metformin XR + Saxagliptin | 500/1000 mg + 2.5/5 mg |
| Xigduo XR | Metformin XR + Dapagliflozin | 500/1000 mg + 5/10 mg |
| Synjardy XR | Metformin XR + Empagliflozin | 1000 mg + 5/12.5 mg |
🔹 Technology Behind SR Metformin
| Technology | How it Works | Example |
|---|---|---|
| HPMC Matrix | Hydroxypropyl methylcellulose forms a gel layer, slowing drug release | Most generic SR tablets |
| GelShield Diffusion | Two-layer system - outer layer releases quickly, inner releases slowly | Glumetza |
| OROS (Osmotic) | Osmotic pump pushes drug through a laser-drilled hole | Fortamet |
| Diffusion Matrix | Drug diffuses through a polymer matrix | Glucophage XR |
🔹 IR vs SR Comparison
| Feature | IR Metformin | SR Metformin |
|---|---|---|
| Dosing frequency | 2-3 times/day | Once or twice daily |
| GI side effects | Higher | Significantly lower |
| Peak plasma level | Sharp spike | Flat, sustained |
| Time to peak (Tmax) | ~2.5 hours | ~7 hours |
| Bioavailability | ~50-60% | Slightly lower |
| Cost | Lower | Slightly higher |
| Patient compliance | Lower | Higher |
🔹 Dosing of SR Metformin
- Starting dose: 500 mg SR once daily with evening meal
- Titration: Increase by 500 mg every 1-2 weeks
- Maximum dose: 2000-2500 mg/day
- Administration: Always take with food; do not crush or chew
⚠️ Important Notes
- SR tablets must be swallowed whole - crushing destroys the sustained-release mechanism
- Empty ghost tablet shells may appear in stool - this is normal
- Preferred over IR in patients with significant GI intolerance
- Dose adjustment required if eGFR < 45 mL/min; contraindicated if eGFR < 30
Gyvomet trio 2 tablets combination uses
Searching the Web
Gyvomet Trio 2 tablet combination composition uses
You likely mean Glycomet Trio 2 (not "Gyvomet"). Here is the full detail:
💊 Glycomet Trio 2 Tablet
Manufacturer: USV Pvt. Ltd. (India)
🔹 Composition
| Ingredient | Strength | Drug Class |
|---|---|---|
| Glimepiride | 2 mg | Sulfonylurea |
| Metformin HCl | 500 mg | Biguanide |
| Voglibose | 0.2 mg | Alpha-glucosidase inhibitor |
🔹 Uses
- Primary use: Type 2 diabetes mellitus in adults
- Used when blood sugar is not adequately controlled by a single or dual antidiabetic medicine
- Helps achieve better glycemic control with three different mechanisms in one tablet
🔹 How Each Ingredient Works
| Drug | Mechanism of Action |
|---|---|
| Glimepiride | Stimulates pancreatic beta cells to release more insulin |
| Metformin | Reduces hepatic glucose production; decreases intestinal glucose absorption; improves insulin sensitivity |
| Voglibose | Inhibits alpha-glucosidase enzyme in gut; delays carbohydrate digestion and reduces post-meal blood sugar spike |
🔹 Key Benefits of Triple Combination
- Targets 3 different pathways of glucose control simultaneously
- Controls both fasting (glimepiride + metformin) and post-prandial (voglibose) blood sugar
- Reduces pill burden - three drugs in one tablet
- Better HbA1c reduction than dual therapy
🔹 Dosing
- Usually once or twice daily with meals
- Swallow whole with water
- Do not skip meals after taking this tablet (risk of hypoglycemia)
🔹 Side Effects
| Common | Serious |
|---|---|
| Nausea, vomiting | Hypoglycemia (low blood sugar) |
| Loss of appetite | Lactic acidosis (rare) |
| Headache, dizziness | Severe allergic reaction |
| Diarrhea, stomach pain | Liver dysfunction |
| Flatulence (voglibose) | - |
⚠️ Contraindications
- Type 1 diabetes
- Diabetic ketoacidosis
- Severe kidney disease (eGFR < 30)
- Severe liver disease
- Pregnancy and breastfeeding
🔹 Similar Triple Combination Brands
| Brand | Composition |
|---|---|
| Amaryl MV 2 | Glimepiride 2 mg + Metformin + Voglibose |
| Glimisave MV 2 | Glimepiride 2 mg + Metformin + Voglibose |
| Zoryl MV 2 | Glimepiride 2 mg + Metformin + Voglibose |
| Glucoryl MV 2 | Glimepiride 2 mg + Metformin + Voglibose |
Note: Always take under medical supervision. Carry sugar/glucose tablets in case of hypoglycemia symptoms (sweating, dizziness, trembling, hunger).
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