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Brachial Plexus Block - Complete Teaching Guide
Sources: Miller's Anesthesia 10e, Morgan & Mikhail's Clinical Anesthesiology 7e
1. Anatomy of the Brachial Plexus
The brachial plexus arises from ventral rami of C5-T1. It is organized into a memorable sequence:
Roots → Trunks → Divisions → Cords → Branches ("Randy Travis Drinks Cold Beer")
| Level | Components | Location |
|---|
| Roots | C5, C6, C7, C8, T1 | Between anterior & middle scalene muscles |
| Trunks | Superior (C5+C6), Middle (C7), Inferior (C8+T1) | Interscalene space → cephaloposterior to subclavian artery |
| Divisions | Anterior + posterior (from each trunk, 6 total) | Posterior to midportion of clavicle |
| Cords | Lateral, Posterior, Medial | Named relative to 2nd part of axillary artery |
| Branches | Terminal nerves | Lateral border of pectoralis minor |
Terminal nerve origins:
- Lateral cord → musculocutaneous nerve + lateral head of median nerve
- Medial cord → ulnar nerve + medial head of median nerve + medial antebrachial/brachial cutaneous nerves
- Posterior cord → axillary nerve + radial nerve
Cutaneous distribution:
2. The Four Main Approaches
The approach chosen depends on the surgical site. As you go more distal on the plexus, shoulder coverage is lost but ulnar coverage improves.
| Approach | Level Blocked | Best Indications | Notable Coverage Gap |
|---|
| Interscalene | Roots/upper & middle trunks | Shoulder, proximal humerus | C8-T1 (ulnar nerve) often spared |
| Supraclavicular | Distal trunk / proximal division | Elbow, forearm, hand | Suprascapular nerve (unreliable) |
| Infraclavicular | Cords | Elbow, forearm, hand (complete) | None - most complete coverage |
| Axillary | Terminal nerves | Hand, wrist, forearm | Musculocutaneous + intercostobrachial nerves spared |
3. Interscalene Block (ISB)
Indication
Shoulder surgery and proximal humerus procedures in patients without significant pulmonary disease.
Anatomy target
Superior and middle trunks, lying between the anterior scalene (AS) and middle scalene (MS) muscles - the classic "stoplight" sign on ultrasound (3 hypoechoic circles).
US-Guided Technique
- Patient supine, head turned away from operative side
- High-frequency linear probe placed at supraclavicular fossa, then traced cranially until trunks are visible between scalene muscles
- Needle advanced in-plane or out-of-plane (out-of-plane avoids the long thoracic and dorsal scapular nerves within the middle scalene belly)
- Volume: 10-15 mL; as low as 5 mL associated with decreased diaphragmatic paresis
- For surgical anesthesia: 20-30 mL commonly used
Complications (memorize these - high-yield)
| Complication | Frequency | Notes |
|---|
| Phrenic nerve block (hemidiaphragmatic paralysis) | ~100% | Reduces ipsilateral lung function ~25%; absolute contraindication with contralateral phrenic palsy or severe COPD |
| Horner's syndrome | Common | Stellate ganglion spread |
| Recurrent laryngeal nerve palsy | Common | Transient hoarseness |
| Vertebral artery injection | Rare but serious | |
| Subarachnoid/epidural injection | Rare | Needle directed medially |
Key rule: Bilateral interscalene blocks are always contraindicated. Phrenic nerve blockade is virtually inevitable with ISB.
4. Supraclavicular Block
Indication
Operations on the elbow, forearm, and hand. Historically called the "spinal of the arm" - rapid onset, dense reliable blockade because the plexus is most compact here (distal trunk / proximal division level).
Ultrasound Technique
- Patient supine, head turned 30° to contralateral side
- Linear high-frequency transducer in supraclavicular fossa, angled slightly toward thorax
- Identify subclavian artery in short-axis; plexus appears as a "cluster of grapes" cephalolateral to the artery, above the first rib
- Needle advanced in-plane from lateral to medial; avoid directing medially (pneumothorax risk)
- LA deposited around the plexus cluster; carefully trace cranially and caudally to ensure lower trunk is included (prevents ulnar sparing)
Complications
- Pneumothorax - most feared (risk reduced but not eliminated with ultrasound)
- Phrenic nerve palsy - ~50% of patients; apply same precautions as ISB
- Horner's syndrome
- Subclavian artery puncture
Note: Supraclavicular perineural catheters provide inferior analgesia compared with infraclavicular catheters and are more prone to displacement with movement.
5. Infraclavicular Block
Indication
Complete brachial plexus anesthesia for elbow, forearm, and hand. Best site for perineural catheter placement (stable, minimal displacement).
Anatomy target
The three cords (medial, lateral, posterior) in relation to the 2nd part of the axillary artery, deep to pectoralis major and minor.
Ultrasound Technique (Lateral Sagittal / Paracoracoid approach)
- Arm abducted to 90° (externallyrotates humeral head, retracts clavicle, straightens neurovascular bundle)
- Probe placed below and medial to coracoid process in sagittal orientation
- Axillary artery visible in short-axis, deep to pec major and minor
- Target: posterior to the axillary artery - 30-40 mL single injection produces complete block without needing to visualize all three cords
- Costoclavicular approach alternative: cords clustered lateral to 1st part of axillary artery - faster onset but higher pneumothorax risk
Complications
- Deeper block = decreased needle tip visibility (steep needle angles required)
- Pneumothorax (lower risk than supraclavicular)
- No phrenic nerve block - advantage over interscalene and supraclavicular
6. Axillary Block
Indication
Procedures on the hand, wrist, and forearm. Safest approach (no risk of pneumothorax or phrenic nerve palsy).
Critical anatomy - nerves ALREADY diverged at this level:
- Musculocutaneous nerve has already branched off (found between coracobrachialis heads or between coracobrachialis and biceps - must be separately blocked)
- Intercostobrachial nerve (T2) is always spared - causes tourniquet discomfort
- Musculocutaneous nerve = lateral antebrachial cutaneous nerve distally; must be blocked for lateral forearm coverage
Ultrasound Technique
- Patient supine, arm abducted 90° or hand placed behind head
- High-frequency linear probe in axilla - identify axillary artery and vein in cross-section
- Median (anteromedial), ulnar (posteromedial), and radial (posterolateral) nerves surround the artery
- Multiple injection technique - each nerve must be targeted individually (fascial separations exist between them)
- 5-10 mL around each nerve; musculocutaneous nerve blocked separately in coracobrachialis muscle
Key Limitations
- Axilla is a poor site for catheters - inferior analgesia vs. infraclavicular, increased infection and dislodgement risk
- Upper arm and shoulder not covered
- Requires more needle passes than other approaches
7. Lung-Sparing (Phrenic-Sparing) Alternatives for Shoulder
When shoulder surgery is needed in patients with pulmonary disease, newer targeted approaches include:
- Superior trunk block - targets the superior trunk (C5+C6) just proximal to the suprascapular nerve branch; noninferior pain scores vs. ISB with less hemidiaphragmatic paralysis
- Anterior suprascapular nerve block - LA deposited deep to omohyoid, shallow to prevertebral fascia; 5-15 mL; volumes >15 mL risk phrenic spread
8. Local Anesthetics Commonly Used
| Agent | Concentration | Onset | Duration |
|---|
| Ropivacaine | 0.5-0.75% | Moderate | Long (12-18h) |
| Bupivacaine | 0.25-0.5% | Slow-moderate | Long (12-18h) |
| Lidocaine | 1.5-2% | Fast | Intermediate (4-8h) |
| Mepivacaine | 1.5% | Moderate | Intermediate (4-8h) |
Epinephrine 1:200,000-1:400,000 may be added to prolong duration and serve as an intravascular injection marker.
9. General Complications (All Approaches)
| Complication | Prevention |
|---|
| Intravascular injection / LAST | Aspiration before injection; inject in increments; use epinephrine marker |
| Nerve injury | Avoid intraneural injection; stop if high resistance or pain on injection |
| Infection | Strict asepsis; monitor catheters |
| Hematoma | Respect anticoagulation guidelines (ASRA) |
Persistent neuropathic symptoms are more common after brachial plexus blocks than lower extremity blocks. Mechanisms include local ischemia, vasoconstrictors, neurotoxicity, or direct trauma.
10. Quick Reference: "Which Block for Which Surgery?"
| Surgical Site | Preferred Approach |
|---|
| Shoulder / rotator cuff | Interscalene (or superior trunk block if lung-sparing needed) |
| Proximal humerus / shoulder | Interscalene |
| Elbow (distal humerus / forearm) | Supraclavicular or Infraclavicular |
| Forearm / wrist / hand | Infraclavicular (best completeness + catheter) or Axillary |
| Hand only | Axillary (simple, safe) |
| Tourniquet analgesia | Intercostobrachial (T2) block supplement for any approach |
Key High-Yield Points to Remember
- The brachial plexus lies in a fascial sheath derived from prevertebral fascia - this is why a single injection at the right level can block the entire plexus
- Phrenic nerve palsy is inevitable with ISB and occurs in ~50% with supraclavicular block; it is absent with infraclavicular and axillary blocks
- The inferior trunk (C8-T1 / ulnar distribution) is the most commonly missed segment - check coverage explicitly
- Supraclavicular = most compact point of plexus = fastest onset, densest block
- Infraclavicular = best for catheters; axillary = safest (no pleural or phrenic risk)
- The intercostobrachial nerve (T2) is never blocked by any brachial plexus approach - it must be separately blocked for tourniquet tolerance
- Miller's Anesthesia 10e, Chapter 42 - Regional Anesthesia of the Upper Extremity
- Morgan & Mikhail's Clinical Anesthesiology 7e, Chapter 46 - Peripheral Nerve Blocks