const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

// ── Colour palette ──────────────────────────────────────────────────────────
const DARK_BG   = "0D1B2A";   // deep navy   (dominant ~65 %)
const MID_BG    = "1B2A3A";   // slate navy  (card / panel fills)
const ACCENT    = "2EC4B6";   // teal        (titles, rules, icons)
const LIGHT_TXT = "E8F4F8";   // near-white
const MUTED_TXT = "A8C8D4";   // cool grey-blue
const GOLD      = "F4A261";   // warm gold   (callout highlight, ≤1 per slide)

// ── Typography ──────────────────────────────────────────────────────────────
const FONT = "Arial";
const T_TITLE  = 28;
const T_HEAD   = 24;
const T_BODY   = 18;
const T_SMALL  = 16;
const T_TAG    = 13;

// ── Image URLs ───────────────────────────────────────────────────────────────
const IMG_URLS = {
  tinea_composite : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_154b24b17aad789e04602e59d7dc231e6d6b2846636a638daf089b39e9e28c1f.jpg",
  tinea_capitis   : "https://cdn.orris.care/cdss_images/DermNetNZ_1760031386862_489e0d14-6366-4e73-82ef-d806cf9124dd.jpg",
  koh_hyphae      : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_b287ff1a1f0fddab8b51710d103849b604f279d981cc9c1b3ae501b193e6c4c0.jpg",
  koh_hyphae2     : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_b287ff1a1f0fddab8b51710d103849b604f279d981cc9c1b3ae501b193e6c4c0.jpg",
  koh_real        : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_b287ff1a1f0fddab8b51b0d103849b604f279d981cc9c1b3ae501b193e6c4c0.jpg",
  candida_oral    : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_174cdd5a05e9c760c847cb6310e852f49bf410da3df9f7ec100fb386e96770e3.jpg",
  candida_nails   : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_f2c2c06efd13b0722e54922b1986071befc1820b4d3bf0d31b769327686d9ccf.jpg",
  onychomycosis   : "https://cdn.orris.care/cdss_images/DermNetNZ_1760033825500_6adc27e4-2c65-40f5-bab1-283655813570.jpg",
  onychomycosis2  : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_7e641d3620836e7101f0dbfc1b54fd1a117c2ebd20017205baf856160fd65010.jpg",
  wood_lamp       : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_e23f9ccf524263e9a11b921befe120bcf45b573bde1f5bcc20edcbbfac3b66b9.jpg",
  sda_culture     : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_db9c0ad8bd45562837ac78d7155078b6c917b7d93c7f66c89a6f4e579220530e.jpg",
  koh_scraping    : "https://cdn.orris.care/cdss_images/pmc_clinical_VQA_72c2361ba9c0a2de01eeab4b700e96219608fb53b5ba600f4f879a35c22394e1.jpg",
};

// ── Fetch all images as base64 ────────────────────────────────────────────────
console.log("Downloading images …");
const urlList = Object.values(IMG_URLS);
let imgData = {};
try {
  const raw = execSync(
    `node /home/daytona/skills/shared/scripts/fetch_images.js ${urlList.map(u => `"${u}"`).join(" ")}`,
    { maxBuffer: 100 * 1024 * 1024 }
  ).toString();
  const arr = JSON.parse(raw);
  const keys = Object.keys(IMG_URLS);
  keys.forEach((k, i) => {
    imgData[k] = arr[i] && arr[i].base64 ? arr[i].base64 : null;
  });
} catch(e) {
  console.error("Image fetch error:", e.message);
}
console.log("Images fetched:", Object.keys(imgData).filter(k => imgData[k]).length, "/", Object.keys(imgData).length);

// ── Helper: safe image add (skips if null) ────────────────────────────────────
function addImg(slide, key, opts) {
  if (imgData[key]) {
    slide.addImage({ data: imgData[key], ...opts });
  }
}

// ── Helper: dark background ────────────────────────────────────────────────
function darkBg(slide) {
  slide.addShape("rect", { x: 0, y: 0, w: 10, h: 5.625, fill: { color: DARK_BG }, line: { color: DARK_BG } });
}

// ── Helper: slide title bar ────────────────────────────────────────────────
function titleBar(slide, text) {
  // top accent strip
  slide.addShape("rect", { x: 0, y: 0, w: 10, h: 0.65, fill: { color: MID_BG }, line: { color: MID_BG } });
  slide.addShape("rect", { x: 0, y: 0, w: 0.07, h: 0.65, fill: { color: ACCENT }, line: { color: ACCENT } });
  slide.addText(text, {
    x: 0.2, y: 0, w: 9.6, h: 0.65,
    fontSize: T_HEAD, fontFace: FONT, bold: true, color: ACCENT,
    valign: "middle", margin: 0
  });
}

// ── Helper: footer ────────────────────────────────────────────────────────
function footer(slide, label) {
  slide.addShape("rect", { x: 0, y: 5.35, w: 10, h: 0.275, fill: { color: MID_BG }, line: { color: MID_BG } });
  slide.addText("Clinical & Laboratory Diagnosis of Fungal Diseases of Skin & Appendages", {
    x: 0.2, y: 5.35, w: 7.5, h: 0.275,
    fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, valign: "middle", margin: 0
  });
  if (label) {
    slide.addText(label, {
      x: 7.7, y: 5.35, w: 2.1, h: 0.275,
      fontSize: T_TAG, fontFace: FONT, color: ACCENT, align: "right", valign: "middle", margin: 0
    });
  }
}

// ── Helper: bullet list ────────────────────────────────────────────────────
function bullets(items, fontSize) {
  return items.map((t, i) => ({
    text: t,
    options: { bullet: { code: "2022" }, breakLine: i < items.length - 1, fontSize: fontSize || T_BODY }
  }));
}

// ─────────────────────────────────────────────────────────────────────────────
// BUILD PRESENTATION
// ─────────────────────────────────────────────────────────────────────────────
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title  = "Clinical and Laboratory Diagnosis of Fungal Diseases of Skin & Appendages";

// ─── SLIDE 1 — TITLE ─────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);

  // decorative teal rectangle left side
  s.addShape("rect", { x: 0, y: 0, w: 0.18, h: 5.625, fill: { color: ACCENT }, line: { color: ACCENT } });

  // background composite image (right half, faded)
  addImg(s, "tinea_composite", { x: 4.6, y: 0, w: 5.4, h: 5.625, transparency: 55 });

  // dark overlay gradient-like rectangle over image
  s.addShape("rect", { x: 4.6, y: 0, w: 5.4, h: 5.625, fill: { color: DARK_BG, transparency: 30 }, line: { color: DARK_BG } });

  // Course badge
  s.addShape("rect", { x: 0.35, y: 0.3, w: 4.0, h: 0.38, fill: { color: ACCENT }, line: { color: ACCENT } });
  s.addText("Medical Immunology", {
    x: 0.35, y: 0.3, w: 4.0, h: 0.38,
    fontSize: T_TAG + 1, fontFace: FONT, bold: true, color: DARK_BG,
    align: "center", valign: "middle", margin: 0
  });

  // Title
  s.addText("Clinical and Laboratory\nDiagnosis of Fungal Diseases\nAffecting the Skin and Its Appendages", {
    x: 0.35, y: 0.85, w: 5.8, h: 2.3,
    fontSize: 22, fontFace: FONT, bold: true, color: LIGHT_TXT,
    valign: "top", margin: 0
  });

  // Teal rule
  s.addShape("rect", { x: 0.35, y: 3.2, w: 3.2, h: 0.06, fill: { color: ACCENT }, line: { color: ACCENT } });

  // Student info
  const infoItems = [
    { text: "Presented by: ", opts: { bold: true, color: ACCENT } },
    { text: "Zeel Kathiriya", opts: { color: LIGHT_TXT } },
    { text: "\nGroup: ", opts: { bold: true, color: ACCENT } },
    { text: "11  |  Semester: ", opts: { color: LIGHT_TXT } },
    { text: "4", opts: { color: LIGHT_TXT } },
    { text: "\nInstructor: ", opts: { bold: true, color: ACCENT } },
    { text: "Duyshenkulova Marina", opts: { color: LIGHT_TXT } },
  ];
  s.addText(infoItems.map(i => ({ text: i.text, options: { ...i.opts, fontSize: T_BODY, fontFace: FONT } })), {
    x: 0.35, y: 3.35, w: 5.8, h: 1.9,
    valign: "top", margin: 0
  });
}

// ─── SLIDE 2 — TABLE OF CONTENTS ─────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Table of Contents");
  footer(s, "Slide 2");

  const topics = [
    "01 — Aim & Objectives",
    "02 — Overview of Fungal Diseases of Skin & Appendages",
    "03 — Dermatophytosis (Tinea Infections)",
    "04 — Candidiasis of Skin & Nails",
    "05 — Clinical Diagnosis Methods",
    "06 — Laboratory Diagnosis — Direct Microscopy",
    "07 — Laboratory Diagnosis — Culture & Identification",
    "08 — Molecular & Serological Methods",
    "09 — Antifungal Treatment Overview",
    "10 — Conclusion",
    "11 — References",
  ];

  topics.forEach((t, i) => {
    const col = i < 6 ? 0 : 1;
    const row = i < 6 ? i : i - 6;
    const x = col === 0 ? 0.4 : 5.2;
    const y = 0.85 + row * 0.71;
    s.addShape("rect", { x, y: y - 0.02, w: 4.5, h: 0.52, fill: { color: MID_BG }, line: { color: MID_BG } });
    s.addShape("rect", { x, y: y - 0.02, w: 0.06, h: 0.52, fill: { color: ACCENT }, line: { color: ACCENT } });
    s.addText(t, {
      x: x + 0.12, y: y - 0.02, w: 4.38, h: 0.52,
      fontSize: T_SMALL, fontFace: FONT, color: LIGHT_TXT,
      valign: "middle", margin: 4
    });
  });
}

// ─── SLIDE 3 — AIM & OBJECTIVES ──────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Aim & Objectives");
  footer(s, "Slide 3");

  // Aim box
  s.addShape("rect", { x: 0.35, y: 0.8, w: 9.3, h: 0.75, fill: { color: MID_BG }, line: { color: ACCENT, pt: 1.5 } });
  s.addText([
    { text: "AIM: ", options: { bold: true, color: GOLD } },
    { text: "To understand the clinical features and laboratory methods used for diagnosis of superficial and cutaneous fungal diseases affecting the skin and its appendages.", options: { color: LIGHT_TXT } }
  ], { x: 0.45, y: 0.8, w: 9.1, h: 0.75, fontSize: T_BODY, fontFace: FONT, valign: "middle" });

  // Objectives
  s.addText("OBJECTIVES", {
    x: 0.35, y: 1.7, w: 4.0, h: 0.38,
    fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: ACCENT, margin: 0
  });

  const objs = [
    "Classify fungal diseases by affected structure (epidermis, hair, nails)",
    "Describe clinical presentations of tinea and candida infections",
    "Explain direct microscopy (KOH mount) and its interpretation",
    "Describe fungal culture on Sabouraud Dextrose Agar (SDA)",
    "Outline molecular and serological diagnostic methods",
    "Identify Wood lamp and dermoscopy as clinical adjuncts",
    "Summarise antifungal treatment principles",
  ];
  s.addText(bullets(objs, T_BODY - 1), {
    x: 0.45, y: 2.1, w: 5.7, h: 3.1,
    fontFace: FONT, color: LIGHT_TXT, valign: "top"
  });

  // image right side
  addImg(s, "tinea_capitis", { x: 6.3, y: 1.6, w: 3.4, h: 3.6,
    shadow: { type: "outer", color: "000000", blur: 8, offset: 3, angle: 135, opacity: 0.4 } });
  s.addText("Tinea capitis — scalp dermatophytosis", {
    x: 6.3, y: 5.18, w: 3.4, h: 0.25,
    fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, align: "center", margin: 0
  });
}

// ─── SLIDE 4 — OVERVIEW ──────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Overview: Fungal Diseases of Skin & Appendages");
  footer(s, "Slide 4");

  // Three category boxes
  const cats = [
    { title: "Superficial Mycoses", color: ACCENT,
      items: ["Affect only outer keratin layer", "No host immune response", "e.g. Pityriasis versicolor"] },
    { title: "Cutaneous Mycoses", color: GOLD,
      items: ["Invade stratum corneum, hair & nails", "Dermatophytes: Trichophyton,\nMicrosporum, Epidermophyton", "Cause tinea infections"] },
    { title: "Subcutaneous Mycoses", color: "E76F51",
      items: ["Below epidermis / dermis", "Trauma-inoculated", "e.g. Sporotrichosis, Mycetoma"] },
  ];
  cats.forEach((c, i) => {
    const x = 0.25 + i * 3.22;
    s.addShape("rect", { x, y: 0.8, w: 3.0, h: 3.8, fill: { color: MID_BG }, line: { color: c.color, pt: 1.5 } });
    s.addShape("rect", { x, y: 0.8, w: 3.0, h: 0.45, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.title, {
      x, y: 0.8, w: 3.0, h: 0.45,
      fontSize: T_SMALL, fontFace: FONT, bold: true, color: DARK_BG,
      align: "center", valign: "middle", margin: 0
    });
    s.addText(bullets(c.items, T_SMALL), {
      x: x + 0.1, y: 1.3, w: 2.8, h: 3.1,
      fontFace: FONT, color: LIGHT_TXT, valign: "top"
    });
  });

  // composite image below
  addImg(s, "tinea_composite", { x: 0.25, y: 4.65, w: 9.5, h: 0.75, transparency: 20 });
  s.addShape("rect", { x: 0.25, y: 4.65, w: 9.5, h: 0.75, fill: { color: DARK_BG, transparency: 45 }, line: { color: DARK_BG } });
  s.addText("Spectrum of tinea infections — composite clinical presentations (a: capitis  b: faciei  c-e: corporis  f: cruris  g-h: pedis  i: unguium)", {
    x: 0.35, y: 4.67, w: 9.3, h: 0.72,
    fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, valign: "middle", align: "center"
  });
}

// ─── SLIDE 5 — DERMATOPHYTOSIS ───────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Dermatophytosis — Tinea Infections");
  footer(s, "Slide 5");

  // Left text
  s.addText("Causative Agents", {
    x: 0.35, y: 0.78, w: 4.8, h: 0.38,
    fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: GOLD, margin: 0
  });
  s.addText(bullets([
    "Trichophyton spp. (most common: T. rubrum, T. tonsurans)",
    "Microsporum spp. (M. canis — zoophilic)",
    "Epidermophyton floccosum (skin & nails only)",
  ], T_SMALL - 1), {
    x: 0.45, y: 1.15, w: 4.6, h: 1.1,
    fontFace: FONT, color: LIGHT_TXT, valign: "top"
  });

  s.addText("Clinical Forms", {
    x: 0.35, y: 2.28, w: 4.8, h: 0.38,
    fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: GOLD, margin: 0
  });
  const forms = [
    ["Tinea capitis",   "Scalp; alopecia, scaling; common in children"],
    ["Tinea corporis",  "Body; annular erythematous plaque, central clearing"],
    ["Tinea pedis",     "Feet (\"athlete's foot\"); interdigital maceration"],
    ["Tinea unguium",   "Nails; onychomycosis — dystrophy, hyperkeratosis"],
    ["Tinea cruris",    "Groin; well-demarcated pruritic patches"],
    ["Tinea faciei",    "Face; erythematous scaly plaque"],
  ];
  forms.forEach(([title, desc], i) => {
    const y = 2.7 + i * 0.39;
    s.addShape("rect", { x: 0.35, y, w: 4.7, h: 0.35, fill: { color: MID_BG }, line: { color: MID_BG } });
    s.addShape("rect", { x: 0.35, y, w: 0.06, h: 0.35, fill: { color: ACCENT }, line: { color: ACCENT } });
    s.addText([
      { text: title + " — ", options: { bold: true, color: ACCENT, fontSize: T_SMALL - 1 } },
      { text: desc, options: { color: LIGHT_TXT, fontSize: T_SMALL - 1 } }
    ], { x: 0.45, y, w: 4.6, h: 0.35, fontFace: FONT, valign: "middle" });
  });

  // Image — composite tinea
  addImg(s, "tinea_composite", { x: 5.3, y: 0.78, w: 4.4, h: 4.6,
    shadow: { type: "outer", color: "000000", blur: 8, offset: 3, angle: 135, opacity: 0.4 } });
  s.addText("Composite: Tinea capitis, corporis, pedis, unguium", {
    x: 5.3, y: 5.3, w: 4.4, h: 0.22,
    fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, align: "center", margin: 0
  });
}

// ─── SLIDE 6 — CANDIDIASIS ────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Candidiasis of Skin & Nails");
  footer(s, "Slide 6");

  s.addText("Causative Agent: Candida albicans (most common), C. tropicalis, C. parapsilosis", {
    x: 0.35, y: 0.8, w: 9.3, h: 0.5,
    fontSize: T_BODY - 1, fontFace: FONT, color: MUTED_TXT, valign: "middle"
  });

  const forms = [
    { h: "Cutaneous Candidiasis", b: ["Skin folds — intertriginous areas", "Satellite pustules at margins", "Erythematous macerated patches", "Risk factors: obesity, diabetes, moisture"] },
    { h: "Onychomycosis (Candida)", b: ["Paronychia — nail fold inflammation", "White/yellow nail discolouration", "Proximal subungual pattern", "Chronic mucocutaneous candidiasis"] },
    { h: "Oral Candidiasis (Thrush)", b: ["White curd-like pseudomembranous plaques", "Underlying erythematous mucosa", "Seen in immunocompromised / infants", "Angular cheilitis variant"] },
  ];

  forms.forEach((f, i) => {
    const x = 0.25 + i * 3.22;
    s.addShape("rect", { x, y: 1.35, w: 3.0, h: 2.75, fill: { color: MID_BG }, line: { color: ACCENT, pt: 1 } });
    s.addShape("rect", { x, y: 1.35, w: 3.0, h: 0.42, fill: { color: ACCENT }, line: { color: ACCENT } });
    s.addText(f.h, { x, y: 1.35, w: 3.0, h: 0.42, fontSize: T_TAG + 2, fontFace: FONT, bold: true, color: DARK_BG, align: "center", valign: "middle", margin: 0 });
    s.addText(bullets(f.b, T_SMALL - 1), { x: x + 0.1, y: 1.8, w: 2.8, h: 2.25, fontFace: FONT, color: LIGHT_TXT, valign: "top" });
  });

  // Images row
  addImg(s, "candida_nails", { x: 0.25, y: 4.18, w: 3.0, h: 1.12,
    shadow: { type: "outer", color: "000000", blur: 6, offset: 2, angle: 135, opacity: 0.4 } });
  addImg(s, "onychomycosis", { x: 3.47, y: 4.18, w: 3.0, h: 1.12,
    shadow: { type: "outer", color: "000000", blur: 6, offset: 2, angle: 135, opacity: 0.4 } });
  addImg(s, "candida_oral", { x: 6.72, y: 4.18, w: 3.0, h: 1.12,
    shadow: { type: "outer", color: "000000", blur: 6, offset: 2, angle: 135, opacity: 0.4 } });

  ["CMC — nail & paronychia", "Onychomycosis (tinea unguium)", "Oral thrush (pseudomembranous)"].forEach((t, i) => {
    const x = 0.25 + i * 3.22;
    s.addText(t, { x, y: 5.3, w: 3.0, h: 0.22, fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, align: "center", margin: 0 });
  });
}

// ─── SLIDE 7 — CLINICAL DIAGNOSIS ─────────────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Clinical Diagnosis Methods");
  footer(s, "Slide 7");

  // Wood lamp image - left
  addImg(s, "wood_lamp", { x: 0.25, y: 0.78, w: 3.8, h: 3.0,
    shadow: { type: "outer", color: "000000", blur: 8, offset: 3, angle: 135, opacity: 0.4 } });
  s.addText("Wood lamp: blue-green fluorescence in Microsporum tinea capitis", {
    x: 0.25, y: 3.82, w: 3.8, h: 0.35,
    fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, align: "center", margin: 0
  });

  // Right text content
  const methods = [
    {
      title: "Wood Lamp (UV 365 nm)",
      pts: ["Microsporum spp. → apple-green / blue-green fluorescence", "Performed in dark room", "Trichophyton spp. — usually non-fluorescent", "Quick non-invasive bedside screen"]
    },
    {
      title: "Dermoscopy",
      pts: ["Comma / corkscrew hairs → tinea capitis", "Spiked pattern / longitudinal striae → onychomycosis", "Non-invasive magnified examination"]
    },
    {
      title: "Clinical Pattern Recognition",
      pts: ["Annular plaque with central clearing → tinea corporis", "Satellite pustules → cutaneous candidiasis", "Nail dystrophy + subungual hyperkeratosis → onychomycosis"]
    },
  ];

  let yy = 0.78;
  methods.forEach(m => {
    s.addText(m.title, { x: 4.3, y: yy, w: 5.4, h: 0.38, fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: GOLD, margin: 0 });
    s.addText(bullets(m.pts, T_SMALL - 1), { x: 4.4, y: yy + 0.38, w: 5.3, h: 0.92, fontFace: FONT, color: LIGHT_TXT, valign: "top" });
    yy += 1.35;
  });
}

// ─── SLIDE 8 — DIRECT MICROSCOPY (KOH) ───────────────────────────────────────
{
  const s = pres.addSlide();
  darkBg(s);
  titleBar(s, "Laboratory Diagnosis — Direct Microscopy (KOH Mount)");
  footer(s, "Slide 8");

  // Text left
  const steps = [
    "Collect skin scrapings, nail clippings, or hair",
    "Place specimen on glass slide",
    "Add 10–20% KOH solution (± DMSO for faster clearing)",
    "Gently heat or wait 15–30 min to digest keratin",
    "Cover-slip and examine under 10× and 40× objectives",
  ];
  s.addText("Procedure", { x: 0.35, y: 0.78, w: 4.8, h: 0.38, fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: GOLD, margin: 0 });
  s.addText(bullets(steps, T_SMALL - 1), { x: 0.45, y: 1.15, w: 4.7, h: 1.7, fontFace: FONT, color: LIGHT_TXT, valign: "top" });

  s.addText("Microscopic Findings", { x: 0.35, y: 2.95, w: 4.8, h: 0.38, fontSize: T_SMALL + 1, fontFace: FONT, bold: true, color: GOLD, margin: 0 });
  const findings = [
    "Dermatophytes: septate branching hyphae",
    "Candida: pseudohyphae + budding yeast",
    "Malassezia (PV): \"spaghetti and meatballs\" pattern",
    "Hair invasion: ectothrix or endothrix patterns",
    "Sensitivity: ~70–80%; specificity ~80–95%",
  ];
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}

// ─── SLIDE 9 — CULTURE & IDENTIFICATION ──────────────────────────────────────
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  titleBar(s, "Laboratory Diagnosis — Culture & Identification");
  footer(s, "Slide 9");

  // Left content
  const cultureInfo = [
    { h: "Sabouraud Dextrose Agar (SDA)", pts: ["Acidic pH (5.6) — suppresses bacteria", "Low-nutrient — selective for fungi", "Incubate 25–28 °C for 2–4 weeks", "Add cycloheximide + chloramphenicol (dermatophyte isolation)"] },
    { h: "Macroscopic Colony Morphology", pts: ["Trichophyton rubrum — white, powdery; red-wine pigment (reverse)", "Microsporum canis — fluffy, yellowish (reverse)", "Epidermophyton floccosum — khaki, suede-like"] },
    { h: "Microscopic Identification", pts: ["Lactophenol cotton blue (LPCB) staining", "Trichophyton — micro- and macroconidia, spiral hyphae", "Microsporum — large, spindle-shaped rough macroconidia", "Candida — germ tube test in serum (C. albicans)"] },
  ];

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  });

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  s.addText("SDA culture + LPCB microscopy — Microsporum gypseum", { x: 5.4, y: 5.08, w: 4.3, h: 0.3, fontSize: T_TAG, fontFace: FONT, color: MUTED_TXT, align: "center", margin: 0 });
}

// ─── SLIDE 10 — MOLECULAR & SEROLOGICAL ──────────────────────────────────────
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  darkBg(s);
  titleBar(s, "Molecular & Serological Diagnostic Methods");
  footer(s, "Slide 10");

  const cards = [
    {
      title: "PCR / Molecular Methods",
      color: ACCENT,
      pts: [
        "Species-level identification of dermatophytes",
        "ITS region sequencing (gold standard for identification)",
        "Pan-dermatophyte PCR from nail / hair",
        "Faster than culture — results in 24–48 h",
        "Detects mixed infections & resistant strains",
      ]
    },
    {
      title: "MALDI-TOF Mass Spectrometry",
      color: GOLD,
      pts: [
        "Rapid protein fingerprint identification",
        "Used on cultured colonies",
        "High accuracy for Candida & dermatophytes",
        "Cost-effective for high-throughput labs",
        "Replaces biochemical tests in many labs",
      ]
    },
    {
      title: "Serology & Histology",
      color: "E76F51",
      pts: [
        "Anti-Candida antibodies (immunocompromised)",
        "PAS stain on nail biopsy — hyphae stain red",
        "GMS (Grocott) — black fungal elements",
        "Biopsy indicated when culture fails",
        "Sensitivity of PAS nail biopsy ~85–90%",
      ]
    },
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  const rows = [
    ["KOH Mount",   "Minutes",  "~75%",  "No",  "Very Low"],
    ["Culture",     "2–4 wk",   "~85%",  "Yes", "Low"],
    ["PCR/ITS",     "24–48 h",  "~95%",  "Yes", "High"],
    ["MALDI-TOF",   "Minutes",  "~95%",  "Yes", "Medium"],
    ["PAS Biopsy",  "1–2 days", "~87%",  "No",  "Medium"],
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    });
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}

// ─── SLIDE 11 — ANTIFUNGAL TREATMENT ─────────────────────────────────────────
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  titleBar(s, "Antifungal Treatment Overview");
  footer(s, "Slide 11");

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    {
      h: "Topical Antifungals",
      items: ["Clotrimazole, Miconazole — tinea corporis/cruris/pedis", "Terbinafine cream — tinea pedis, corporis", "Ciclopirox nail lacquer — mild onychomycosis", "Nystatin — cutaneous candidiasis"]
    },
    {
      h: "Systemic Antifungals",
      items: ["Terbinafine (oral) — dermatophyte onychomycosis, tinea capitis", "Itraconazole — Candida, non-dermatophyte molds", "Fluconazole — candidiasis, tinea capitis", "Griseofulvin — tinea capitis (paediatric first-line)"]
    },
    {
      h: "Treatment Duration",
      items: ["Tinea corporis/cruris/pedis: 2–6 weeks", "Tinea capitis: 6–8 weeks (systemic required)", "Onychomycosis (fingernails): 6 weeks–3 months", "Onychomycosis (toenails): 3–6 months or longer"]
    },
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// ─── SLIDE 12 — CONCLUSION ────────────────────────────────────────────────────
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  titleBar(s, "Conclusion");
  footer(s, "Slide 12");

  const pts = [
    "Fungal diseases of skin and appendages are classified into superficial, cutaneous, and subcutaneous mycoses.",
    "Dermatophytes (Trichophyton, Microsporum, Epidermophyton) are the most frequent causative agents of tinea infections.",
    "Candida albicans causes cutaneous candidiasis, paronychia, and oral thrush — especially in immunocompromised hosts.",
    "KOH direct microscopy is the fastest, most accessible laboratory method — demonstrating hyphae or pseudohyphae.",
    "Culture on SDA remains the gold standard for species identification and antifungal susceptibility testing.",
    "Molecular methods (PCR, ITS sequencing, MALDI-TOF) offer rapid, accurate identification in complex or resistant cases.",
    "Wood lamp, dermoscopy, and clinical pattern recognition are valuable non-invasive adjuncts.",
    "Treatment choice depends on disease site, causative organism, and severity — ranging from topical to long-term systemic antifungals.",
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// ─── SLIDE 13 — REFERENCES ────────────────────────────────────────────────────
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  titleBar(s, "References");
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  const refs = [
    "1. Murray, P.R., Rosenthal, K.S., Pfaller, M.A. (2021). Medical Microbiology (9th ed.). Elsevier.",
    "2. Brooks, G.F., Carroll, K.C., Butel, J.S. et al. (2022). Jawetz, Melnick & Adelberg's Medical Microbiology (28th ed.). McGraw-Hill.",
    "3. Havlickova, B., Czaika, V.A., Friedrich, M. (2008). Epidemiological trends in skin mycoses worldwide. Mycoses, 51(Suppl 4):2–15.",
    "4. Aly, R. (1994). Ecology and epidemiology of dermatophyte infections. J Am Acad Dermatol, 31(3):S21–S25.",
    "5. Ameen, M. (2010). Epidemiology of superficial fungal infections. Clin Dermatol, 28(2):197–201.",
    "6. Nenoff, P., Krüger, C., Ginter-Hanselmayer, G., Tietz, H.J. (2014). Mycology — an update. Part 1: Dermatomycoses. J Dtsch Dermatol Ges, 12(3):188–210.",
    "7. Gupta, A.K., Cooper, E.A. (2008). Update in antifungal therapy of dermatophytosis. Mycopathologia, 166(5–6):353–367.",
    "8. Rezusta, A. et al. (2011). Current application of MALDI-TOF MS identification of dermatophytes. Med Mycol, 50(5):541–545.",
  ];

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// ─── WRITE FILE ───────────────────────────────────────────────────────────────
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