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Jaundice Pathology

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Here is what the PDF covers across 10 sections (~45 KB, A4, fully formatted with colored tables and section headers):

Section	Content
1. Bilirubin Metabolism	Formation (heme oxygenase → biliverdin reductase), albumin transport, hepatic uptake, UDPGT conjugation, MRP2 excretion, enterohepatic circulation
2. Measurement of Bilirubin	Van den Bergh reaction, direct/indirect fractions, reference values, delta bilirubin (biliprotein)
3. Classification of Jaundice	Prehepatic / Hepatic / Posthepatic with mechanisms and causes table; genetic conjugation disorders (Gilbert's, Crigler-Najjar I & II, Dubin-Johnson, Rotor)
4. Hepatocellular Jaundice	Viral hepatitis, alcoholic hepatitis, DILI, autoimmune hepatitis, Wilson disease; histological features; LFT pattern
5. Obstructive Jaundice	Extrahepatic vs intrahepatic causes; pathophysiology (acholic stools, pruritus, vitamin K deficiency, cholangitis); LFT pattern
6. Clinical Evaluation	History, physical exam findings (Courvoisier's sign, Charcot's triad), lab algorithm, imaging (USS, MRCP, ERCP, liver biopsy)
7. Neonatal Jaundice	Physiological vs pathological; biliary atresia; kernicterus; phototherapy
8. Differential Diagnosis	Side-by-side comparison table for all 3 types
9. Management	Obstructive (ERCP, PTC, UDCA), hepatocellular (antivirals, NAC, transplant), haemolytic, pruritus treatment
10. High-Yield Summary	18 key examination points including Courvoisier's law, Reynolds' pentad, delta bilirubin, vitamin K response test

Sources: Harrison's Principles of Internal Medicine (22nd ed., 2025) and Sleisenger & Fordtran's GI and Liver Disease.

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