Here is a structured summary of the NICE NG116 (2018, updated 2025) guidelines on acute stress reaction and PTSD.
NICE Guideline NG116: Post-Traumatic Stress Disorder (2018, updated 2025)
Definitions
Acute Stress Disorder (ASD) - a DSM-5 diagnosis applied in the first month after a traumatic event. Requires 9 or more symptoms across 5 categories: intrusion, negative mood, dissociation, avoidance, and arousal (symptoms must start or worsen after the event).
Acute Stress Reaction (ICD-11: QE84) - classified under ICD-11 as a normal reaction to an abnormal event, not a mental disorder. Symptoms are transient and expected to resolve without formal treatment.
Clinically important PTSD symptoms - symptoms that significantly impair functioning but don't reach full diagnostic threshold.
PTSD - symptoms persisting beyond 1 month. DSM-5 clusters: intrusion, avoidance, negative alterations in cognition/mood, hyperarousal.
Planning Treatment (1.6.1-1.6.3)
- Use a holistic approach - consider all contributing factors, past treatment history, and patient preferences.
- Provide information and support to enable informed choice.
- Where there is significant risk of harm to self or others, establish a risk management and safety plan (involving family/carers where appropriate) as part of initial treatment planning.
Within the First Month After Trauma
Active Monitoring (1.6.4)
- Consider active monitoring (watchful waiting) for adults with subthreshold PTSD symptoms within 1 month of trauma.
- Arrange follow-up within 1 month.
Do NOT offer (1.6.5)
- Do not offer psychologically-focused debriefing (e.g. Critical Incident Stress Debriefing) for prevention or treatment of PTSD - evidence shows it is ineffective and potentially harmful.
Adults with ASD or Clinically Important PTSD Symptoms within 1 Month (1.6.15)
- Offer individual trauma-focused CBT (TF-CBT) - this is the recommended first-line intervention. Specific modalities include:
- Cognitive processing therapy
- Cognitive therapy for PTSD
- Narrative exposure therapy
- Prolonged exposure therapy
Drug Treatment in the First Month (1.6.24)
- Do not offer drug treatments, including benzodiazepines, to prevent PTSD in adults.
Established PTSD (>1 month, or >3 months for EMDR)
Psychological Treatments - Adults (1.6.16-1.6.20)
Trauma-focused CBT (1.6.16-1.6.17)
- Offer individual TF-CBT to adults with PTSD or clinically important symptoms.
- Typically 8-12 sessions (more if multiple traumas).
- Delivered by trained practitioners with ongoing supervision.
- Must include:
- Psychoeducation about trauma reactions
- Strategies for managing arousal and flashbacks
- Safety planning
- Elaboration and processing of trauma memories
- Processing trauma-related emotions (shame, guilt, loss)
- Addressing trauma-related meanings for the individual
- Help to overcome avoidance
- Planning booster sessions (e.g. around trauma anniversaries)
EMDR (1.6.19-1.6.20)
- Offer EMDR to adults with PTSD who have presented more than 3 months after a non-combat-related trauma.
- Typically 8-12 sessions (more for multiple traumas).
- Must be based on a validated manual, delivered by trained practitioners.
- Delivered in a phased manner including: psychoeducation, managing distressing memories, identifying and treating target memories (often visual images), and promoting alternative positive beliefs.
Psychological Treatments - Children and Young People (1.6.6-1.6.13)
- Within 1 month of trauma: consider active monitoring or individual TF-CBT for those under 18 with ASD or clinically important symptoms.
- Group TF-CBT (1.6.7): consider for children aged 7-17 following large-scale shared trauma within the last month.
- Established PTSD in children (>3 months): offer TF-CBT as first-line (12 sessions for single event; longer for chronic/recurrent trauma).
- EMDR (1.6.13): consider for children aged 7-17 only if they do not respond to or engage with TF-CBT.
Drug Treatments - Adults (1.6.24-1.6.26)
| Recommendation | Detail |
|---|
| No drugs for prevention (1.6.24) | Do not offer any drug treatment (including benzodiazepines) to prevent PTSD. |
| Venlafaxine or SSRI (1.6.25) | Consider if the patient has a preference for drug treatment. Review regularly. Sertraline and paroxetine have UK marketing authorisation for PTSD; venlafaxine is off-label. |
| Antipsychotics (1.6.26) | Consider risperidone in addition to psychological therapies to manage symptoms if TF-CBT/EMDR have failed or are declined, and there are severe, ongoing symptoms. |
SSRIs with the best evidence in adults: fluoxetine, paroxetine, sertraline. Venlafaxine (SNRI) also supported.
Drug Treatments - Children and Young People (1.6.14)
- Pharmacotherapy is not recommended for PTSD in children and young people (very limited evidence).
- If comorbid disorders (depression, anxiety) require treatment, drugs may be considered to target those conditions specifically.
Key Practical Points
- Do not delay or withhold treatment because of ongoing court proceedings or compensation claims.
- Transitions between services: the referring team should not discharge the patient before a care plan is agreed in the new service.
- Involve family members and carers where appropriate, both to support the patient and to address their own needs as carers.
- Actively promote access to services - particularly for migrants, asylum seekers, and people with language or literacy needs.
- PTSD can occur after a wide range of traumatic events (road traffic accidents, assault, childbirth, natural disasters, combat, etc.). Assessment should be thorough and consider all trauma history.
Summary Table
| Scenario | Recommended Action |
|---|
| Subthreshold symptoms <1 month | Active monitoring, follow-up within 1 month |
| ASD / clinically important symptoms <1 month (adults) | Offer individual TF-CBT |
| ASD / clinically important symptoms <1 month (children) | Active monitoring or individual TF-CBT |
| Established PTSD >1 month (adults) | Offer TF-CBT (8-12 sessions) |
| Non-combat PTSD >3 months (adults) | Offer EMDR as alternative to TF-CBT |
| Established PTSD (children/young people) | TF-CBT first-line; EMDR if TF-CBT fails |
| Patient prefers medication (adults) | Sertraline/paroxetine (licensed) or venlafaxine (off-label) |
| Prevention of PTSD - drugs | Do NOT offer (including benzodiazepines) |
| Psychological debriefing | Do NOT offer |
Source:
NICE NG116 - Post-traumatic stress disorder (2018, updated 2025) | Maudsley Prescribing Guidelines in Psychiatry, 15th ed. | Kaplan & Sadock's Comprehensive Textbook of Psychiatry