Create visual representation of every point in the uploaded document
Reading File
Running Command
cd /home/daytona/workspace/attachments/e4743328-573f-45a8-b147-fead86676f67/ && …
Reading File
Reading File
Reading File
Running Command
mkdir -p /home/daytona/workspace/insulin-pptx && ls /home/daytona/workspace/insu…
Writing File
~/insulin-pptx/create_insulin_pptx.js
const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Insulin";
pres.author = "Dr Sudheer Prudhvi";
// ─── COLOUR PALETTE ─────────────────────────────────────────────────────────
const C = {
navy: "0A1628", // dominant dark bg
royal: "1B3A6B", // secondary panels
teal: "0D7377", // accent
sky: "14BDEB", // highlight / accent2
gold: "F5A623", // warm accent (warnings / special)
white: "FFFFFF",
offWhite:"F0F4FF",
gray: "A8B4CC",
lightBg: "EEF3FB",
danger: "E84040",
green: "27AE60",
};
// ─── HELPERS ────────────────────────────────────────────────────────────────
function fullBg(slide, color) {
slide.addShape(pres.shapes.RECTANGLE, {
x: 0, y: 0, w: 10, h: 5.625,
fill: { color },
line: { type: "none" },
});
}
function sectionTag(slide, label, x = 0.3, y = 0.18) {
slide.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x, y, w: 2.0, h: 0.32,
fill: { color: C.teal },
line: { type: "none" },
rectRadius: 0.05,
});
slide.addText(label, {
x, y, w: 2.0, h: 0.32,
fontSize: 9, bold: true, color: C.white,
align: "center", valign: "middle", margin: 0,
});
}
function slideTitle(slide, title, sub = "", titleColor = C.white, subColor = C.sky) {
slide.addText(title, {
x: 0.4, y: 0.55, w: 9.2, h: 0.65,
fontSize: 26, bold: true, color: titleColor,
align: "left", valign: "middle",
});
if (sub) {
slide.addText(sub, {
x: 0.4, y: 1.2, w: 9.2, h: 0.4,
fontSize: 13, bold: false, color: subColor,
align: "left",
});
}
}
function divider(slide, y = 1.08, color = C.teal) {
slide.addShape(pres.shapes.RECTANGLE, {
x: 0.4, y, w: 9.2, h: 0.04,
fill: { color },
line: { type: "none" },
});
}
function accentCard(slide, x, y, w, h, fillColor, lineColor = null) {
const opts = { x, y, w, h, fill: { color: fillColor }, line: lineColor ? { color: lineColor, pt: 1.5 } : { type: "none" },
shadow: { type: "outer", color: "000000", blur: 8, offset: 3, angle: 135, opacity: 0.18 } };
slide.addShape(pres.shapes.ROUNDED_RECTANGLE, { ...opts, rectRadius: 0.12 });
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 1 – TITLE
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
// Decorative teal strip left
s.addShape(pres.shapes.RECTANGLE, { x:0, y:0, w:0.55, h:5.625, fill:{color:C.teal}, line:{type:"none"} });
// Gold accent bar
s.addShape(pres.shapes.RECTANGLE, { x:0.55, y:2.3, w:8.5, h:0.07, fill:{color:C.gold}, line:{type:"none"} });
s.addText("INSULIN", {
x: 0.8, y: 0.9, w: 9, h: 1.5,
fontSize: 72, bold: true, color: C.white, charSpacing: 18,
align: "left", valign: "middle",
});
s.addText("A Comprehensive Pharmacology Overview", {
x: 0.8, y: 2.55, w: 8, h: 0.55,
fontSize: 18, color: C.sky, italic: true, align: "left",
});
s.addText("Dr Sudheer Prudhvi", {
x: 0.8, y: 3.25, w: 5, h: 0.45,
fontSize: 15, bold: true, color: C.gold, align: "left",
});
// Pancreas icon text
s.addText("🔬 Pharmacology | Endocrinology", {
x: 0.8, y: 4.9, w: 8, h: 0.4,
fontSize: 11, color: C.gray, align: "left",
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 2 – DISCOVERERS
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "HISTORY");
slideTitle(s, "Discovery of Insulin", "Nobel Prize in Physiology or Medicine, 1923");
divider(s);
const people = [
{ name: "Frederick\nBanting", role: "Surgeon / Researcher\nLed the discovery", color: C.teal },
{ name: "Charles\nBest", role: "Medical Student\nIsolated insulin extract", color: C.royal },
{ name: "James\nCollip", role: "Biochemist\nPurified the extract", color: "1A5276" },
{ name: "John\nMacleod", role: "Physiologist\nProvided laboratory", color: "0E6655" },
];
people.forEach((p, i) => {
const x = 0.5 + i * 2.35;
accentCard(s, x, 1.55, 2.1, 3.3, p.color);
s.addText("👤", { x, y: 1.65, w: 2.1, h: 0.8, fontSize: 30, align: "center", valign: "middle" });
s.addText(p.name, {
x, y: 2.45, w: 2.1, h: 0.7,
fontSize: 14, bold: true, color: C.white, align: "center",
});
s.addText(p.role, {
x, y: 3.1, w: 2.1, h: 0.7,
fontSize: 9, color: C.offWhite, align: "center",
});
});
s.addText("First clinical use: January 11, 1922 — Leonard Thompson, Toronto", {
x: 0.5, y: 5.15, w: 9, h: 0.35,
fontSize: 10, italic: true, color: C.gold, align: "center",
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 3 – TYPE 1 vs TYPE 2 COMPARISON TABLE
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PATHOPHYSIOLOGY");
slideTitle(s, "Type 1 vs Type 2 Diabetes Mellitus");
divider(s);
const rows = [
["Feature", "Type 1 DM", "Type 2 DM"],
["Pathogenesis", "Autoimmune β-cell destruction", "Insulin resistance + β-cell dysfunction"],
["Insulin Levels", "Very low / Absent", "Normal initially → later ↓"],
["Age of Onset", "Childhood / Adolescence", ">40 yrs (now younger too)"],
["Body Habitus", "Lean", "Overweight / Obese"],
["Treatment", "Insulin MANDATORY", "Lifestyle + OHA ± Insulin"],
["Associations", "Other autoimmune diseases", "Metabolic syndrome"],
];
const colW = [2.5, 3.3, 3.3];
const colX = [0.35, 2.9, 6.25];
const rowH = 0.52;
const startY = 1.35;
rows.forEach((row, ri) => {
row.forEach((cell, ci) => {
const isHeader = ri === 0;
const isFeature = ci === 0 && ri > 0;
const bgColor = isHeader ? C.teal : isFeature ? C.royal : (ri % 2 === 0 ? C.navy : "0F1E38");
s.addShape(pres.shapes.RECTANGLE, {
x: colX[ci], y: startY + ri * rowH, w: colW[ci], h: rowH,
fill: { color: bgColor }, line: { color: "2A4070", pt: 0.5 },
});
s.addText(cell, {
x: colX[ci] + 0.06, y: startY + ri * rowH, w: colW[ci] - 0.12, h: rowH,
fontSize: isHeader ? 11 : 10,
bold: isHeader || isFeature,
color: isHeader ? C.white : C.offWhite,
align: ci === 0 ? "left" : "left",
valign: "middle",
});
});
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 4 – DRUGS CAUSING DIABETES
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PHARMACOLOGY");
slideTitle(s, "Drugs Causing Diabetes (Diabetogenic Drugs)");
divider(s);
const drugGroups = [
{ category: "Corticosteroids", examples: "Prednisolone, Dexamethasone", mechanism: "↓ Insulin sensitivity, ↑ Gluconeogenesis", color: C.danger },
{ category: "Thiazide Diuretics", examples: "Hydrochlorothiazide", mechanism: "↓ Insulin secretion (hypokalemia)", color: "C0392B" },
{ category: "β-Blockers", examples: "Propranolol", mechanism: "Mask hypoglycemia, ↓ insulin release", color: "8E44AD" },
{ category: "Antipsychotics (Atypical)", examples: "Clozapine, Olanzapine", mechanism: "Weight gain, insulin resistance", color: "1A5276" },
{ category: "Tacrolimus / Cyclosporine", examples: "Immunosuppressants", mechanism: "Direct β-cell toxicity", color: "0E6655" },
{ category: "Niacin (high dose)", examples: "Nicotinic acid", mechanism: "↓ Insulin sensitivity", color: "7D6608" },
];
drugGroups.forEach((d, i) => {
const col = i % 2;
const row = Math.floor(i / 2);
const x = 0.35 + col * 4.85;
const y = 1.45 + row * 1.35;
accentCard(s, x, y, 4.6, 1.2, d.color);
s.addText(d.category, { x: x + 0.15, y: y + 0.08, w: 4.3, h: 0.35, fontSize: 12, bold: true, color: C.white });
s.addText("💊 " + d.examples, { x: x + 0.15, y: y + 0.42, w: 4.3, h: 0.3, fontSize: 10, color: C.offWhite });
s.addText("⚙ " + d.mechanism, { x: x + 0.15, y: y + 0.72, w: 4.3, h: 0.3, fontSize: 9.5, color: C.sky });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 5 – RELEASE OF INSULIN (Glucose-stimulated)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "MECHANISM");
slideTitle(s, "Release of Insulin", "Glucose-Stimulated Insulin Secretion (GSIS)");
divider(s);
// Step-by-step flow boxes
const steps = [
{ num: "1", label: "Blood glucose ↑", detail: "Glucose enters β-cell via GLUT-2", color: C.teal },
{ num: "2", label: "Glucose → ATP", detail: "Glycolysis + mitochondrial metabolism → ↑ ATP/ADP ratio", color: "1A7A4A" },
{ num: "3", label: "K⁺ channel closes", detail: "ATP-sensitive K⁺ channel (KATP) closes", color: "8E44AD" },
{ num: "4", label: "Membrane depolarizes", detail: "K⁺ efflux blocked → cell depolarises", color: "C0392B" },
{ num: "5", label: "Ca²⁺ influx", detail: "Voltage-gated Ca²⁺ channels open → Ca²⁺ enters", color: "1A5276" },
{ num: "6", label: "Exocytosis", detail: "Insulin granules fuse & insulin is secreted", color: "7D6608" },
];
steps.forEach((st, i) => {
const x = 0.35 + (i % 3) * 3.1;
const y = 1.45 + Math.floor(i / 3) * 1.8;
accentCard(s, x, y, 2.85, 1.6, st.color);
s.addText(st.num, { x, y: y + 0.06, w: 2.85, h: 0.5, fontSize: 30, bold: true, color: "FFFFFF40", align: "center", valign: "top" });
s.addText(st.label, { x: x + 0.12, y: y + 0.18, w: 2.6, h: 0.5, fontSize: 13, bold: true, color: C.white, align: "center" });
s.addText(st.detail, { x: x + 0.12, y: y + 0.7, w: 2.6, h: 0.75, fontSize: 9.5, color: C.offWhite, align: "center" });
// Arrow between steps (except last in row)
if (i % 3 !== 2 && i < 5) {
s.addText("→", { x: x + 2.85, y: y + 0.5, w: 0.25, h: 0.5, fontSize: 18, color: C.gold, align: "center" });
}
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 6 – TYPES OF RECEPTORS (Overview)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PHARMACOLOGY");
slideTitle(s, "Types of Receptors & Transduction Mechanisms");
divider(s);
const receptors = [
{ num: "1", name: "Enzymes / Transporters", example: "Na⁺/K⁺-ATPase, Adenylyl cyclase", color: C.teal },
{ num: "2", name: "Ligand-Gated Ion Channels", example: "Ionotropic: nAChR, GABAA, NMDA", color: "8E44AD" },
{ num: "3", name: "G-Protein Coupled Receptors", example: "Metabotropic: β-adrenergic, M receptors", color: "1A5276" },
{ num: "4", name: "Nuclear Receptors", example: "Steroids, Thyroid hormone, Vit D", color: "7D6608" },
{ num: "5", name: "Enzyme-Linked Receptors", example: "Catalytic: RTK — Insulin, EGF, PDGF, VEGF", color: C.danger },
{ num: "6", name: "Cytokine Receptors / JAK-STAT", example: "Growth hormone, Prolactin, Erythropoietin", color: "0E6655" },
];
receptors.forEach((r, i) => {
const x = 0.35 + (i % 2) * 4.8;
const y = 1.42 + Math.floor(i / 2) * 1.3;
accentCard(s, x, y, 4.55, 1.18, r.color);
s.addText(r.num, { x: x + 0.1, y: y + 0.1, w: 0.45, h: 0.95, fontSize: 28, bold: true, color: "FFFFFF30", align: "center", valign: "middle" });
s.addText(r.name, { x: x + 0.6, y: y + 0.1, w: 3.8, h: 0.45, fontSize: 12, bold: true, color: C.white });
s.addText(r.example, { x: x + 0.6, y: y + 0.6, w: 3.8, h: 0.45, fontSize: 10, color: C.sky });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 7 – ENZYME-LINKED RECEPTORS (Deep Dive)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PHARMACOLOGY");
slideTitle(s, "Enzyme-Linked Receptors (Catalytic Receptors)");
divider(s);
// Sub-types
const types = [
{
name: "Receptor Tyrosine Kinase (RTK)",
ligands: "Insulin · EGF · PDGF · VEGF",
desc: "Ligand binding → dimerisation → autophosphorylation of tyrosine residues → intracellular signalling cascade",
color: C.danger,
},
{
name: "Receptor Serine/Threonine Kinase",
ligands: "TGF-β",
desc: "Phosphorylates serine/threonine → SMAD pathway → gene regulation",
color: "8E44AD",
},
{
name: "Guanylyl Cyclase-Linked Receptor",
ligands: "ANP · BNP · CNP (Natriuretic Peptides)",
desc: "Ligand binding → intracellular guanylyl cyclase activated → GTP → cGMP → PKG activation → vasodilation, natriuresis",
color: C.teal,
},
];
types.forEach((t, i) => {
const y = 1.42 + i * 1.35;
accentCard(s, 0.35, y, 9.3, 1.22, t.color);
s.addText(t.name, { x: 0.55, y: y + 0.1, w: 5.5, h: 0.38, fontSize: 14, bold: true, color: C.white });
s.addText("Ligands: " + t.ligands, { x: 0.55, y: y + 0.48, w: 5.5, h: 0.3, fontSize: 11, bold: true, color: C.gold });
s.addText(t.desc, { x: 0.55, y: y + 0.76, w: 8.7, h: 0.35, fontSize: 9.5, color: C.offWhite });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 8 – INSULIN ACTIONS (Metabolism)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PHARMACODYNAMICS");
slideTitle(s, "Actions of Insulin on Metabolism");
divider(s);
const macros = [
{
name: "CARBOHYDRATES",
icon: "🍞",
color: C.teal,
actions: [
"↑ Glucose uptake (Muscle & Adipose via GLUT-4)",
"↑ Glycogenesis (Liver & Muscle)",
"↓ Glycogenolysis",
"↓ Gluconeogenesis",
],
netEffect: "↓ Blood Glucose",
},
{
name: "PROTEINS",
icon: "💪",
color: "8E44AD",
actions: [
"↑ Amino acid uptake",
"↑ Protein synthesis",
"↑ Muscle mass",
"↓ Proteolysis (anabolic state)",
],
netEffect: "↑ Muscle Mass",
},
{
name: "LIPIDS",
icon: "🧈",
color: "1A5276",
actions: [
"↑ Lipogenesis (fat synthesis)",
"↑ Triglyceride storage",
"↓ Lipolysis (inhibits HSL)",
"↓ Ketogenesis",
],
netEffect: "↑ Fat Storage",
},
];
macros.forEach((m, i) => {
const x = 0.35 + i * 3.15;
accentCard(s, x, 1.42, 2.95, 3.85, m.color);
s.addText(m.icon, { x, y: 1.5, w: 2.95, h: 0.6, fontSize: 24, align: "center" });
s.addText(m.name, { x, y: 2.08, w: 2.95, h: 0.42, fontSize: 13, bold: true, color: C.white, align: "center" });
m.actions.forEach((a, ai) => {
s.addText("• " + a, { x: x + 0.12, y: 2.5 + ai * 0.42, w: 2.7, h: 0.4, fontSize: 9.5, color: C.offWhite });
});
// Net effect badge
s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
x: x + 0.3, y: 4.85, w: 2.35, h: 0.33,
fill: { color: C.gold }, line: { type: "none" }, rectRadius: 0.06,
});
s.addText("NET: " + m.netEffect, { x: x + 0.3, y: 4.85, w: 2.35, h: 0.33, fontSize: 10, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 9 – INSULIN PREPARATIONS TABLE
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "PHARMACOKINETICS");
slideTitle(s, "Insulin Preparations & Analogues");
divider(s);
// Category blocks
const categories = [
{ label: "RAPID-ACTING", color: C.sky, items: [
{ name: "Lispro", appear: "Clear", onset: "<0.25", peak: "0.5–1.5", dur: "3–5" },
{ name: "Aspart", appear: "Clear", onset: "<0.25", peak: "0.5–1.5", dur: "3–5" },
{ name: "Glulisine", appear: "Clear", onset: "<0.25", peak: "0.5–1.5", dur: "3–5" },
]},
{ label: "SHORT-ACTING", color: C.green, items: [
{ name: "Regular", appear: "Clear", onset: "0.5–1", peak: "2–3", dur: "4–8" },
]},
{ label: "INTERMEDIATE", color: C.gold, items: [
{ name: "NPH", appear: "Cloudy", onset: "3–4", peak: "6–10", dur: "10–16" },
]},
{ label: "LONG-ACTING", color: C.danger, items: [
{ name: "Glargine", appear: "Clear", onset: "2–4", peak: "---", dur: "20–24" },
{ name: "Detemir", appear: "Clear", onset: "1–4", peak: "---", dur: "10–24" },
]},
];
// Header row
const hCols = ["Type / Name", "Appearance", "Onset (hrs)", "Peak (hrs)", "Duration (hrs)"];
const cW = [2.5, 1.4, 1.4, 1.4, 1.4];
const cX = [0.35, 2.9, 4.35, 5.8, 7.25];
const rowH = 0.44;
let curY = 1.35;
hCols.forEach((h, ci) => {
s.addShape(pres.shapes.RECTANGLE, { x: cX[ci], y: curY, w: cW[ci], h: rowH, fill: { color: C.teal }, line: { color: "2A4070", pt: 0.5 } });
s.addText(h, { x: cX[ci] + 0.05, y: curY, w: cW[ci] - 0.1, h: rowH, fontSize: 10, bold: true, color: C.white, valign: "middle" });
});
curY += rowH;
categories.forEach(cat => {
cat.items.forEach((item, ii) => {
const bg = curY % 0.1 < 0.05 ? "0F1E38" : C.navy; // alternate rows
const isFirst = ii === 0;
// Type label cell (span-like: just show on first row of category)
s.addShape(pres.shapes.RECTANGLE, { x: cX[0], y: curY, w: cW[0], h: rowH, fill: { color: isFirst ? cat.color + "55" : C.navy + "00" }, line: { color: "2A4070", pt: 0.5 } });
if (isFirst) {
s.addText(cat.label + " — " + item.name, { x: cX[0] + 0.05, y: curY, w: cW[0] - 0.1, h: rowH, fontSize: 9.5, bold: true, color: cat.color, valign: "middle" });
} else {
s.addText(" " + item.name, { x: cX[0] + 0.05, y: curY, w: cW[0] - 0.1, h: rowH, fontSize: 9.5, color: C.offWhite, valign: "middle" });
}
[[1, item.appear], [2, item.onset], [3, item.peak], [4, item.dur]].forEach(([ci, val]) => {
s.addShape(pres.shapes.RECTANGLE, { x: cX[ci], y: curY, w: cW[ci], h: rowH, fill: { color: bg }, line: { color: "2A4070", pt: 0.5 } });
s.addText(val, { x: cX[ci] + 0.05, y: curY, w: cW[ci] - 0.1, h: rowH, fontSize: 9.5, color: C.offWhite, valign: "middle", align: "center" });
});
curY += rowH;
});
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 10 – INSULIN REGIMENS
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "CLINICAL USE");
slideTitle(s, "Insulin Regimens");
divider(s);
// Split-Mixed side
accentCard(s, 0.3, 1.35, 4.4, 3.9, C.royal);
s.addText("SPLIT-MIXED REGIMEN", { x: 0.5, y: 1.45, w: 4.0, h: 0.45, fontSize: 13, bold: true, color: C.sky });
const smLines = [
"• Mix of NPH + Regular insulin",
"• Given TWICE daily",
"• Morning: 2/3 of total dose",
"• Evening: 1/3 of total dose",
"• Breakfast + Dinner injections",
"• Less flexible meal timing",
"• Used in Type 2 DM",
];
smLines.forEach((l, i) => {
s.addText(l, { x: 0.5, y: 1.92 + i * 0.43, w: 4.0, h: 0.4, fontSize: 10, color: C.offWhite });
});
// Basal-Bolus side
accentCard(s, 5.2, 1.35, 4.4, 3.9, "0E3D5C");
s.addText("BASAL-BOLUS REGIMEN", { x: 5.4, y: 1.45, w: 4.0, h: 0.45, fontSize: 13, bold: true, color: C.gold });
const bbLines = [
"• Basal: Long-acting (Glargine/Detemir)",
"• Bolus: Rapid-acting before each meal",
"• Mimics physiological insulin secretion",
"• FOUR injections per day",
"• Flexible meal timing",
"• Better glycaemic control",
"• Preferred in Type 1 DM",
];
bbLines.forEach((l, i) => {
s.addText(l, { x: 5.4, y: 1.92 + i * 0.43, w: 4.0, h: 0.4, fontSize: 10, color: C.offWhite });
});
s.addText("← Simpler Physiological →", { x: 0.3, y: 5.2, w: 9.4, h: 0.3, fontSize: 10, color: C.gray, align: "center" });
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 11 – INDICATIONS
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "INDICATIONS");
slideTitle(s, "Indications for Insulin Therapy");
divider(s);
const indications = [
{ n: "1", label: "Type 1 Diabetes Mellitus", note: "Absolute requirement — no endogenous insulin", color: C.danger, icon: "🚨" },
{ n: "2", label: "Type 2 DM (OHA failure)", note: "When oral hypoglycemic agents are insufficient", color: C.teal, icon: "💊" },
{ n: "3", label: "Diabetic Ketoacidosis (DKA)", note: "Emergency — IV insulin drip (0.1 U/kg/hr)", color: "C0392B", icon: "⚠️" },
{ n: "4", label: "Hyperosmolar Hyperglycemic State", note: "HHS — cautious rehydration + insulin", color: "8E44AD", icon: "🌡️" },
{ n: "5", label: "Gestational Diabetes", note: "Oral agents not preferred in pregnancy", color: "1A7A4A", icon: "🤰" },
{ n: "6", label: "Perioperative / ICU Patients", note: "Target BG 140–180 mg/dL in ICU", color: "1A5276", icon: "🏥" },
{ n: "7", label: "Hyperkalemia", note: "Insulin shifts K⁺ INTO cells (with dextrose)", color: C.gold, icon: "⚡" },
];
indications.forEach((ind, i) => {
const col = i % 2 === 0 ? 0 : 1;
const row = Math.floor(i / 2);
const x = col === 0 ? 0.3 : 5.15;
const y = 1.42 + row * 1.05;
const w = 4.6;
accentCard(s, x, y, w, 0.92, ind.color + "44", ind.color);
s.addText(ind.icon + " " + ind.n + ". " + ind.label, { x: x + 0.12, y: y + 0.08, w: w - 0.25, h: 0.38, fontSize: 12, bold: true, color: C.white });
s.addText(ind.note, { x: x + 0.12, y: y + 0.48, w: w - 0.25, h: 0.35, fontSize: 9.5, color: C.sky });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 12 – KISS MNEMONIC (Hyperkalemia)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "MNEMONIC");
slideTitle(s, "KISS Mnemonic — Hyperkalemia Management");
divider(s);
// Central KISS badge
s.addShape(pres.shapes.RECTANGLE, { x: 3.5, y: 1.35, w: 3, h: 1.1, fill: { color: C.gold }, line: { type: "none" } });
s.addText("K.I.S.S.", { x: 3.5, y: 1.35, w: 3, h: 1.1, fontSize: 36, bold: true, color: C.navy, align: "center", valign: "middle", charSpacing: 10 });
s.addText("K Influx Shifting Strategy", {
x: 2.5, y: 2.55, w: 5, h: 0.45,
fontSize: 14, color: C.sky, align: "center", italic: true,
});
// Dual mechanism illustration
accentCard(s, 0.3, 3.15, 4.3, 2.0, C.danger);
s.addText("⚡ EPINEPHRINE (β₂)", { x: 0.5, y: 3.22, w: 3.9, h: 0.45, fontSize: 13, bold: true, color: C.white });
s.addText([
{ text: "β₂ receptor activation\n", options: { breakLine: false } },
{ text: "→ Na⁺/K⁺-ATPase stimulation\n", options: { breakLine: false } },
{ text: "→ K⁺ moves INTO cells", options: {} },
], { x: 0.5, y: 3.7, w: 3.9, h: 1.3, fontSize: 10.5, color: C.offWhite });
accentCard(s, 5.4, 3.15, 4.3, 2.0, C.teal);
s.addText("💉 INSULIN", { x: 5.6, y: 3.22, w: 3.9, h: 0.45, fontSize: 13, bold: true, color: C.white });
s.addText([
{ text: "Insulin receptor (RTK)\n", options: { breakLine: false } },
{ text: "→ Na⁺/K⁺-ATPase activation\n", options: { breakLine: false } },
{ text: "→ K⁺ moves INTO cells", options: {} },
], { x: 5.6, y: 3.7, w: 3.9, h: 1.3, fontSize: 10.5, color: C.offWhite });
s.addText("⚠ Always give with IV Dextrose to prevent hypoglycemia", {
x: 0.3, y: 5.15, w: 9.4, h: 0.33,
fontSize: 10.5, bold: true, color: C.gold, align: "center",
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 13 – PRESCRIPTION CASE (8-yr-old Type 1)
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "CASE — PRESCRIPTION");
slideTitle(s, "Prescription Writing: Paediatric Type 1 DM");
divider(s);
// Patient box
accentCard(s, 0.3, 1.35, 9.4, 1.0, C.royal);
s.addText("👦 Akash | 8 yrs | 15 kg | FBG 250 mg/dL | HbA1c 7% | Type 1 DM", {
x: 0.5, y: 1.5, w: 9.0, h: 0.5, fontSize: 12, bold: true, color: C.offWhite, align: "center",
});
s.addText("Lethargy · Weight loss · Polydipsia · Bedwetting (Enuresis)", {
x: 0.5, y: 1.93, w: 9.0, h: 0.3, fontSize: 10, color: C.sky, align: "center",
});
// Prescription card
accentCard(s, 0.3, 2.5, 9.4, 2.85, "061424");
s.addText("℞ INSULIN PRESCRIPTION", { x: 0.5, y: 2.58, w: 9.0, h: 0.42, fontSize: 14, bold: true, color: C.gold });
const rxLines = [
["Regimen:", "Basal-Bolus (physiological — preferred in children)"],
["Basal:", "Insulin Glargine 0.2 U/kg SC at bedtime → 3 U at night"],
["Bolus:", "Regular Insulin OR Rapid-acting (Lispro) 0.1 U/kg SC 15–30 min before each main meal → ~1.5 U TDS"],
["Total daily dose:", "~0.5 U/kg/day = ~7.5 U/day (start low, titrate)"],
["Monitoring:", "SMBG 4×/day (pre-meals + bedtime) · HbA1c every 3 months"],
["Diet / Lifestyle:", "Consistent carb diet · Education for patient and family · Sick-day rules"],
];
rxLines.forEach((ln, i) => {
s.addText(ln[0], { x: 0.5, y: 3.05 + i * 0.38, w: 2.2, h: 0.36, fontSize: 10, bold: true, color: C.sky });
s.addText(ln[1], { x: 2.7, y: 3.05 + i * 0.38, w: 6.8, h: 0.36, fontSize: 10, color: C.offWhite });
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 14 – DKA EMERGENCY MANAGEMENT CASE
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "EMERGENCY CASE");
slideTitle(s, "DKA Management: Mr. Arun");
divider(s);
// Case summary
accentCard(s, 0.3, 1.35, 9.4, 1.0, "3B1212");
s.addText("🚨 Mr. Arun · Type 1 DM (basal-bolus for 7 months) · Stopped insulin due to poor appetite during RTI", {
x: 0.5, y: 1.45, w: 9.0, h: 0.4, fontSize: 11, bold: true, color: "#FFB3B3",
});
s.addText("Nausea · Vomiting · Abdominal pain · Dehydration · Tachycardia · BG 500 mg/dL · Urine ketones +ve", {
x: 0.5, y: 1.85, w: 9.0, h: 0.3, fontSize: 10, color: C.offWhite,
});
const steps = [
{ icon: "💧", title: "1. FLUID RESUSCITATION", detail: "0.9% NaCl 1L over 1st hour → subsequent bags guided by BP & urine output. Replace K⁺ when K⁺ < 5.5 mEq/L", color: "1A5276" },
{ icon: "💉", title: "2. INSULIN INFUSION", detail: "IV Regular Insulin 0.1 U/kg/hr (ONLY after K⁺ > 3.3 mEq/L). Target: BG fall 50–75 mg/dL/hr", color: C.danger },
{ icon: "⚗️", title: "3. ELECTROLYTE CORRECTION", detail: "K⁺ replacement mandatory (insulin shifts K⁺ in). Monitor Na⁺, Cl⁻, phosphate. Avoid Na bicarbonate unless pH < 6.9", color: "8E44AD" },
{ icon: "🔬", title: "4. MONITORING", detail: "BG every 1 hr · ABG every 2–4 hr · Urine output · ECG (cardiac arrhythmia risk from K⁺ fluctuations)", color: C.teal },
{ icon: "🔄", title: "5. TRANSITION TO SC INSULIN", detail: "When BG < 250 mg/dL → add 5% Dextrose to IV fluids. Resume SC insulin when patient eating & AG normalized", color: "1A7A4A" },
];
steps.forEach((st, i) => {
const x = 0.3 + (i % 2 === 0 ? 0 : 4.85);
const y = 2.5 + Math.floor(i / 2) * 1.15;
if (i === 4) {
accentCard(s, 0.3, y, 9.4, 1.05, st.color);
s.addText(st.icon + " " + st.title, { x: 0.5, y: y + 0.08, w: 9.0, h: 0.35, fontSize: 11, bold: true, color: C.white });
s.addText(st.detail, { x: 0.5, y: y + 0.43, w: 9.0, h: 0.5, fontSize: 9.5, color: C.offWhite });
} else {
accentCard(s, x, y, 4.6, 1.05, st.color);
s.addText(st.icon + " " + st.title, { x: x + 0.15, y: y + 0.08, w: 4.3, h: 0.35, fontSize: 10.5, bold: true, color: C.white });
s.addText(st.detail, { x: x + 0.15, y: y + 0.43, w: 4.3, h: 0.5, fontSize: 9, color: C.offWhite });
}
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 15 – ADVERSE DRUG REACTIONS
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
sectionTag(s, "ADVERSE EFFECTS");
slideTitle(s, "Insulin Adverse Drug Reactions (ADRs)");
divider(s);
const adrs = [
{
name: "HYPOGLYCEMIA",
num: "1",
color: C.danger,
icon: "📉",
points: [
"Most common & dangerous ADR",
"Sx: sweating, tremor, palpitations, confusion",
"Severe: seizures, coma",
"Mx: 15g fast-acting carb (rule of 15)",
"IV Dextrose 25% / IM Glucagon if unconscious",
],
},
{
name: "WEIGHT GAIN",
num: "2",
color: "7D6608",
icon: "⚖️",
points: [
"Anabolic effect of insulin",
"↑ Fat deposition, ↓ lipolysis",
"Managed by diet & exercise",
"Consider metformin co-therapy",
],
},
{
name: "HYPOKALEMIA",
num: "3",
color: "8E44AD",
icon: "⚡",
points: [
"Insulin activates Na⁺/K⁺-ATPase",
"K⁺ shifts intracellularly",
"Risk of cardiac arrhythmias",
"Monitor serum K⁺; replace as needed",
],
},
{
name: "LIPODYSTROPHY",
num: "4",
color: C.teal,
icon: "💉",
points: [
"Lipoatrophy: fat loss at injection site (immune reaction to older insulins)",
"Lipohypertrophy: fat accumulation from repeated injection at same site",
"Prevention: rotate injection sites",
],
},
];
adrs.forEach((a, i) => {
const x = 0.3 + (i % 2) * 4.85;
const y = 1.42 + Math.floor(i / 2) * 2.0;
accentCard(s, x, y, 4.6, 1.85, a.color);
s.addText(a.icon + " " + a.num + ". " + a.name, { x: x + 0.12, y: y + 0.1, w: 4.35, h: 0.45, fontSize: 14, bold: true, color: C.white });
a.points.forEach((p, pi) => {
s.addText("• " + p, { x: x + 0.12, y: y + 0.55 + pi * 0.3, w: 4.35, h: 0.28, fontSize: 9.5, color: C.offWhite });
});
});
}
// ════════════════════════════════════════════════════════════════════════════
// SLIDE 16 – THANK YOU / CLOSING
// ════════════════════════════════════════════════════════════════════════════
{
const s = pres.addSlide();
fullBg(s, C.navy);
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.55, h: 5.625, fill: { color: C.gold }, line: { type: "none" } });
s.addShape(pres.shapes.RECTANGLE, { x: 9.45, y: 0, w: 0.55, h: 5.625, fill: { color: C.gold }, line: { type: "none" } });
s.addText("THANK YOU", {
x: 0.7, y: 1.0, w: 8.6, h: 1.5,
fontSize: 64, bold: true, color: C.white, charSpacing: 12, align: "center",
});
s.addShape(pres.shapes.RECTANGLE, { x: 2, y: 2.6, w: 6, h: 0.06, fill: { color: C.gold }, line: { type: "none" } });
s.addText('"READ TO UNDERSTAND… NOT TO FINISH PAGES"', {
x: 0.7, y: 2.8, w: 8.6, h: 0.7,
fontSize: 18, italic: true, color: C.sky, align: "center",
});
s.addText("— Dr Sudheer Prudhvi", {
x: 0.7, y: 3.55, w: 8.6, h: 0.45,
fontSize: 14, color: C.gold, align: "center", bold: true,
});
// Topics summary strip
const topics = ["History", "Type 1 vs Type 2", "Diabetogenic Drugs", "GSIS Mechanism", "Receptor Types", "Insulin Actions", "Preparations", "Regimens", "Indications", "KISS Mnemonic", "Prescription", "DKA Management", "ADRs"];
s.addText(topics.join(" · "), {
x: 0.7, y: 4.9, w: 8.6, h: 0.55,
fontSize: 9, color: C.gray, align: "center",
});
}
// ─── WRITE FILE ─────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/insulin-pptx/Insulin_Lecture.pptx" })
.then(() => console.log("✅ Saved: /home/daytona/workspace/insulin-pptx/Insulin_Lecture.pptx"))
.catch(err => { console.error("❌ Error:", err); process.exit(1); });
Running Command
cd /home/daytona/workspace/insulin-pptx && node create_insulin_pptx.js
Editing File
~/insulin-pptx/create_insulin_pptx.js
Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/insulin-pptx/create_insulin_pptx.js'
Running Command
cd /home/daytona/workspace/insulin-pptx && sed -i \ 's/"FFFFFF40"/"8ABCD1"/g' …
Running Command
cd /home/daytona/workspace/insulin-pptx && node create_insulin_pptx.js 2>&1 | gr…
Running Command
python3 -c " import re with open('/home/daytona/workspace/insulin-pptx/create_i…
Your credits are exhausted. Your daily credits reset tomorrow, or you can purchase a top-up for more.
This is a shared conversation. Sign in to Orris to start your own chat.