A detailed medical flowchart/diagram titled "PRE-ECLAMPSIA: Pathophysiology & Management" with multiple connected sections. TOP SECTION - "NORMAL vs PRE-ECLAMPSIA": Two parallel columns. Left (green): Arachidonic acid → Cyclo-oxygenase → PGI2 (Prostacyclin) → Vasodilation↑, Platelet aggregation↓, Uteroplacental blood flow↑; Also VEGF + Nitric Oxide → Vascular refractoriness; Angiotensinase (Placenta) inhibits Angiotensin-II. Right (red): Arachidonic acid → TXA2 (Thromboxane) + Antiangiogenic factors (sFlt-1, Endoglin) + Oxidative stress (ROS, Lipid peroxides) + Cytokines (TNF-α, IL-6) + Angiotensin-II (unchecked). CENTER CORE - Bold red box: "ENDOTHELIAL DYSFUNCTION + VASOSPASM" with arrow from Pre-Eclampsia column. From ENDOTHELIAL DYSFUNCTION, downward branches to 5 colored organ boxes: 1. Orange "KIDNEYS": Glomerular endotheliosis → ↓GFR 25% → Oliguria → Proteinuria (50-60% albumin, 10-15% α-globulin) → Bilateral renal cortical necrosis (severe). 2. Purple "BRAIN": Vasospasm + cerebral edema → Seizures (Eclampsia) → PRES (Posterior Reversible Encephalopathy Syndrome) - bilateral occipital vasogenic edema on T2 MRI → Headache, Visual changes, Blindness. 3. Blue "LIVER": Periportal hemorrhagic necrosis → Subcapsular hematoma → HELLP Syndrome: H=Hemolysis + EL=Elevated LFTs (AST/ALT >70, LDH >600) + LP=Low Platelets (<100,000/mm³). 4. Yellow "PLACENTA/UTERUS": Failed cytotrophoblast invasion beyond decidua-myometrial junction → Spiral arteries retain musculoelastic media → ↓Uteroplacental flow → IUGR + Fetal jeopardy. 5. Pink "BLOOD VESSELS": Intense vasospasm → Vasa vasorum impaired → Endothelial injury → Edema (capillary leak) + Pleural effusions + Pulmonary edema. BOTTOM LEFT - Green box "PROTEINURIA MECHANISM": Spasm afferent arterioles → Anoxic endothelial damage → Glomerular endotheliosis → ↑Capillary permeability → Protein leakage. BOTTOM RIGHT - Blue box "MANAGEMENT": Antiseizure: Magnesium sulfate; Delivery (Cesarean); Corticosteroids (<34 wks); Platelet transfusion if <50,000; ICU monitoring; Expectant if <34 wks (bed rest, albumin infusion, steroids). BOTTOM CENTER - Red box "COMPLICATIONS": Maternal: Abruptio placentae, DIC, Acute renal failure, ARDS, Subcapsular liver hematoma, Death; Perinatal: Prematurity, RDS, Sepsis, Death. Use clean medical diagram style with color-coded boxes, clear arrows showing cause→effect relationships, small icons for each organ, white background, easy to read fonts.