Mydriacaine dose
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Mydriacaine eye drops dose tropicamide lignocaine ophthalmic
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Mydriacaine tropicamide lidocaine combination eye drops dosage instillation
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The search results are returning information about Mydriacyl (tropicamide alone) rather than Mydriacaine (the combination product). Let me note the important distinction:
- Mydriacyl = tropicamide only (Alcon brand)
- Mydriacaine = tropicamide + lignocaine (lidocaine) combination - a specific Indian/regional market product
Mydriacaine - Dosage
Composition:
- Tropicamide 0.8% + Lignocaine (Lidocaine) 4% (typical Indian formulation, e.g., Sunways Mydriacaine)
Dose (Topical Ophthalmic):
| Indication | Dose |
|---|---|
| Pre-operative mydriasis (cataract/vitreoretinal surgery) | 1-2 drops instilled into the conjunctival sac |
| Repeat dosing | Repeat every 5-10 minutes, for a total of 3-4 instillations starting 30-45 minutes before surgery |
| Fundus examination / diagnostic mydriasis | 1-2 drops, 15-20 minutes before examination |
Route: Topical (conjunctival sac only). Not for injection.
Key points:
- The lignocaine (4%) component provides topical anaesthesia of the cornea and conjunctiva, reducing discomfort during instillation and examination/surgery.
- The tropicamide (0.8%) component provides mydriasis and cycloplegia via anticholinergic (antimuscarinic) action.
- Onset of mydriasis: ~20-30 minutes; Duration: 4-8 hours.
- Onset of anaesthesia: rapid (~30-60 seconds); Duration: ~20-30 minutes.
- Apply nasolacrimal duct pressure (punctal occlusion) for 1-2 minutes after instillation to minimize systemic absorption of both agents.
Contraindications:
- Known hypersensitivity to tropicamide or amide-type local anaesthetics (lignocaine).
- Narrow-angle or angle-closure glaucoma.
- Avoid in infants <3 months (use with caution in neonates).
Cautions:
- Use with care in elderly patients (risk of urinary retention, CNS effects from tropicamide).
- Patients should not drive or operate machinery until vision normalizes (due to cycloplegia/mydriasis).
- Remove soft contact lenses before instillation.
Note: Mydriacaine is primarily marketed in India (brand by Sunways/Entod Pharmaceuticals). The exact concentration may vary by manufacturer - always verify the product insert for the specific formulation being used. Some formulations contain tropicamide 0.5% + lignocaine 2% or tropicamide 0.8% + lignocaine 4%.
mydricaine contains atropine 0.3, adrenaline 0.2, lignocaine 0.5 dose
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Mydricaine injection atropine adrenaline lignocaine dose subconjunctival ophthalmic
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Got the full details from Kanski's. Here is the complete answer:
Mydricaine - Dose & Details
Mydricaine is a subconjunctival injection used to break posterior synechiae (PS) in anterior uveitis when topical drops have failed.
Composition
| Component | Mydricaine No. 2 (Adult) | Mydricaine No. 1 (Paediatric / >75 yrs) |
|---|---|---|
| Atropine | 1 mg | 0.5 mg (half dose) |
| Adrenaline (epinephrine) | 0.12 mg (from 1:1000, 0.12 mL) | 0.06 mg |
| Procaine (local anaesthetic) | 6 mg | 3 mg |
| Volume | 0.3-0.5 mL ampoule | 0.5 mL ampoule |
Note: The user mentioned lignocaine - some formulations substitute procaine with lignocaine, but the classic preparation uses procaine. Constituent quantities can vary by manufacturer.
Dose & Route
- Route: Subconjunctival injection (0.3-0.5 mL)
- Alternative: Cotton pledget soaked in Mydricaine placed in the superior and inferior fornices for 5 minutes (avoids injection risks)
Indication
Breaking fresh posterior synechiae in anterior uveitis (AAU/CAU) when topical phenylephrine + cycloplegic drops have failed.
Adverse Effects
- Transient sinus tachycardia - common
- Anxiety, tremor, pallor (due to adrenaline)
- Serious cardiovascular events (cardiac arrhythmias) - rare but reported
- Patient must be kept lying down and monitored after injection
Mydricaine No. 1 vs No. 2
| No. 1 | No. 2 | |
|---|---|---|
| Used for | Children & adults >75 years | Adults 16-75 years |
| Dose | Half the constituent quantities | Full dose |
- Kanski's Clinical Ophthalmology, 10th ed., p. 4307-4318
- RVEEH Anterior Uveitis Guideline
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