Ovulation, Fertilisation & Implantation — Comprehensive Reproductive Health Notes

ls /home/daytona/workspace/ 2>/dev/null || echo "workspace empty or missing"

mkdir -p /home/daytona/workspace/reproductive-health-pptx

~/reproductive-health-pptx/build.js

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

// ── Colour palette ──────────────────────────────────────────────
// Deep navy dominant + warm coral accent + soft lavender highlight
const C = {
  navy:     "0D1B2A",   // dominant background
  navyMid:  "1A2E45",   // card / panel background
  navyLight:"223354",   // lighter panel
  coral:    "E8503A",   // accent / heading bar
  corallg:  "F07A67",   // lighter coral for sub-headings
  gold:     "F5A623",   // data / highlight
  white:    "FFFFFF",
  off:      "D6E4F0",   // body text on dark bg
  slate:    "8BA7C4",   // muted text
  teal:     "2ABFBF",   // secondary accent (tables, icons)
};

// ── Image fetch helper ──────────────────────────────────────────
function fetchImages(urls) {
  const json = execSync(
    `node /home/daytona/skills/shared/scripts/fetch_images.js ${urls.map(u => `"${u}"`).join(" ")}`
  ).toString();
  return JSON.parse(json);
}

// Pre-fetch the three key diagrams used in the notes
const IMG_URLS = [
  "https://cdn.orris.care/cdss_images/9e9e325242f7f80ca26e1eb4bdfc1997008f88c8586a392e1d62c76ce021c264.png",  // hormonal cycle
  "https://cdn.orris.care/cdss_images/ea19901fe49dafcdfc83f44c2a624d54255962bafb5a3f6bf3b95f4c3410ae38.png",  // ovulation mechanism
  "https://cdn.orris.care/cdss_images/61f47b0929f1842175c20af1b4fd581ee6efb443b874f2f934f4d9fc23583ee4.png",  // fertilisation stages
];
console.log("Fetching images...");
const imgs = fetchImages(IMG_URLS);
const [imgCycle, imgOvMech, imgFert] = imgs;
console.log("Images fetched:", imgs.map(i => i.error || "OK"));

// ── Presentation setup ──────────────────────────────────────────
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Ovulation, Fertilisation & Implantation";
pres.author = "Reproductive Health Notes";

// ── Reusable helpers ────────────────────────────────────────────
function addSlideBg(slide) {
  slide.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.navy }, line: { color: C.navy }
  });
}

function addHeaderBar(slide, label) {
  // coral left accent stripe
  slide.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 0, w: 0.22, h: 5.625, fill: { color: C.coral }, line: { color: C.coral }
  });
  // topic label top-right pill
  slide.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 7.8, y: 0.18, w: 2.0, h: 0.36, fill: { color: C.coral }, line: { color: C.coral }, rectRadius: 0.05
  });
  slide.addText(label, {
    x: 7.8, y: 0.18, w: 2.0, h: 0.36, fontSize: 9, color: C.white, bold: true, align: "center", valign: "middle", margin: 0
  });
}

function sectionTitle(slide, title, subtitle) {
  slide.addText(title, {
    x: 0.5, y: 0.22, w: 7.1, h: 0.55, fontSize: 22, bold: true, color: C.white, align: "left", valign: "middle"
  });
  if (subtitle) {
    slide.addText(subtitle, {
      x: 0.5, y: 0.82, w: 7.1, h: 0.3, fontSize: 11, color: C.slate, align: "left", italic: true
    });
  }
}

function addDivider(slide, y) {
  slide.addShape(pres.shapes.RECTANGLE, {
    x: 0.5, y, w: 9.0, h: 0.025, fill: { color: C.corallg }, line: { color: C.corallg }
  });
}

function card(slide, x, y, w, h, color) {
  slide.addShape(pres.shapes.RECTANGLE, {
    x, y, w, h,
    fill: { color: color || C.navyMid },
    line: { color: C.navyLight, pt: 1 },
    shadow: { type: "outer", color: "000000", blur: 6, offset: 2, angle: 135, opacity: 0.2 }
  });
}

function bullets(slide, items, x, y, w, h, opts) {
  const o = opts || {};
  slide.addText(
    items.map((t, i) => ({ text: t, options: { bullet: { code: "25B8", color: o.bulletColor || C.teal }, breakLine: i < items.length - 1 } })),
    { x, y, w, h, fontSize: o.fontSize || 11.5, color: o.color || C.off, lineSpacingMultiple: 1.25 }
  );
}

// ════════════════════════════════════════════════════════════════
// SLIDE 1 — Cover
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  addSlideBg(s);

  // large coral accent block left
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.55, h: 5.625, fill: { color: C.coral }, line: { color: C.coral } });

  // decorative circle top-right
  s.addShape(pres.shapes.OVAL, { x: 7.8, y: -1.2, w: 3.5, h: 3.5, fill: { color: C.navyMid }, line: { color: C.navyLight, pt: 2 } });
  s.addShape(pres.shapes.OVAL, { x: 8.2, y: -0.8, w: 2.7, h: 2.7, fill: { color: C.navyLight }, line: { color: C.coral, pt: 1 } });

  s.addText("REPRODUCTIVE HEALTH", {
    x: 0.75, y: 1.15, w: 8.5, h: 0.5, fontSize: 13, bold: true, color: C.teal,
    charSpacing: 4, align: "left"
  });
  s.addText("Ovulation,\nFertilisation &\nImplantation", {
    x: 0.75, y: 1.65, w: 8.5, h: 2.1, fontSize: 36, bold: true, color: C.white, align: "left", lineSpacingMultiple: 1.1
  });
  s.addShape(pres.shapes.RECTANGLE, { x: 0.75, y: 3.8, w: 2.2, h: 0.06, fill: { color: C.coral }, line: { color: C.coral } });
  s.addText("Comprehensive Topic Summary  •  Three Modules", {
    x: 0.75, y: 3.95, w: 8.5, h: 0.35, fontSize: 11, color: C.slate, align: "left"
  });

  // module tags bottom
  const tags = ["MODULE 1 — OVULATION", "MODULE 2 — FERTILISATION", "MODULE 3 — IMPLANTATION"];
  tags.forEach((tag, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.75 + i * 3.05, y: 4.9, w: 2.85, h: 0.45, fill: { color: C.navyMid }, line: { color: C.teal, pt: 1 }, rectRadius: 0.06 });
    s.addText(tag, { x: 0.75 + i * 3.05, y: 4.9, w: 2.85, h: 0.45, fontSize: 8.5, bold: true, color: C.teal, align: "center", valign: "middle", margin: 0 });
  });
}

// ════════════════════════════════════════════════════════════════
// ── MODULE 1: OVULATION ──────────────────────────────────────
// ════════════════════════════════════════════════════════════════

// SLIDE 2 — Module 1 Section Title
{
  const s = pres.addSlide();
  addSlideBg(s);
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.navy }, line: { color: C.navy } });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 2.3, w: 10, h: 1.05, fill: { color: C.coral }, line: { color: C.coral } });
  s.addText("MODULE 1", { x: 0.6, y: 0.6, w: 8.8, h: 0.5, fontSize: 14, bold: true, color: C.teal, charSpacing: 5 });
  s.addText("OVULATION", { x: 0.6, y: 2.3, w: 8.8, h: 1.05, fontSize: 48, bold: true, color: C.white, align: "left", valign: "middle" });
  s.addText("Hormonal control • Follicular development • Mechanism of rupture • Corpus luteum", {
    x: 0.6, y: 3.55, w: 8.8, h: 0.4, fontSize: 12, color: C.off, italic: true
  });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 5.3, w: 10, h: 0.325, fill: { color: C.navyMid }, line: { color: C.navyMid } });
  s.addText("The Developing Human  •  Langman's Medical Embryology  •  Guyton & Hall", {
    x: 0, y: 5.3, w: 10, h: 0.325, fontSize: 8, color: C.slate, align: "center", valign: "middle"
  });
}

// SLIDE 3 — HPO Axis & Hormonal Events
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 1 — OVULATION");
  sectionTitle(s, "Hormonal Control — The HPO Axis", "Hypothalamic-Pituitary-Ovarian feedback loop drives the menstrual cycle");
  addDivider(s, 1.15);

  // Left: hormonal steps
  card(s, 0.32, 1.25, 4.6, 3.95, C.navyMid);
  s.addText("Key Hormonal Events", { x: 0.45, y: 1.3, w: 4.35, h: 0.38, fontSize: 12, bold: true, color: C.teal });
  bullets(s, [
    "GnRH (hypothalamus) → pulsatile release → drives FSH & LH",
    "FSH stimulates follicular development and estrogen production",
    "Rising estrogen → negative feedback initially suppresses FSH/LH",
    "Pre-ovulatory estrogen peak (≥200 pg/mL for ≥50 hrs) → positive feedback → LH surge",
    "LH rises 6–10× ; peaks ~16 hrs before ovulation",
    "FSH rises 2–3× synergistically with LH",
    "Ovulation occurs 24–36 hrs after LH peak",
    "Post-ovulation: corpus luteum secretes progesterone → prepares endometrium",
  ], 0.45, 1.72, 4.35, 3.3, { fontSize: 10.5 });

  // Right: diagram
  if (!imgCycle.error) {
    s.addImage({ data: imgCycle.base64, x: 5.2, y: 1.22, w: 4.55, h: 4.0 });
  }
  s.addText("Fig: Hormonal fluctuations & endometrial changes — The Developing Human", {
    x: 5.2, y: 5.26, w: 4.55, h: 0.2, fontSize: 6.5, color: C.slate, align: "center", italic: true
  });
}

// SLIDE 4 — Follicular Maturation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 1 — OVULATION");
  sectionTitle(s, "Follicular Maturation to Ovulation", "Sequential stages from primordial follicle to Graafian follicle");
  addDivider(s, 1.15);

  const stages = [
    ["Primordial", "Oocyte arrested in prophase I\nFlat granulosa cells around oocyte"],
    ["Primary", "Cuboidal granulosa cells\nZona pellucida forms"],
    ["Secondary (Antral)", "Fluid-filled antrum develops\nTheca interna & externa appear"],
    ["Mature Graafian", "Grows to ~25 mm\nLH surge → meiosis I completes\nOocyte arrested in metaphase II"],
  ];

  stages.forEach(([title, body], i) => {
    const x = 0.32 + i * 2.38;
    const isLast = i === 3;
    card(s, x, 1.28, 2.2, 3.65, isLast ? C.coral : C.navyMid);
    if (isLast) {
      s.addShape(pres.shapes.RECTANGLE, { x: x + 0.06, y: 1.34, w: 2.08, h: 0.44, fill: { color: "A83020" }, line: { color: "A83020" } });
    }
    s.addText(`${i + 1}. ${title}`, {
      x: x + 0.1, y: 1.34, w: 2.05, h: 0.44, fontSize: 10.5, bold: true,
      color: isLast ? C.white : C.gold, valign: "middle"
    });
    s.addText(body, {
      x: x + 0.1, y: 1.82, w: 2.0, h: 3.0, fontSize: 10, color: isLast ? "FFD9D3" : C.off,
      lineSpacingMultiple: 1.3
    });
  });

  // Arrow connectors between cards
  for (let i = 0; i < 3; i++) {
    const ax = 2.48 + i * 2.38;
    s.addText("▶", { x: ax, y: 2.75, w: 0.3, h: 0.3, fontSize: 12, color: C.teal, align: "center" });
  }

  // LH surge callout bottom
  card(s, 0.32, 5.05, 9.35, 0.46, "1A2E45");
  s.addText("⚡  LH surge triggers: Meiosis I completion  •  Metaphase II arrest  •  Collagenase ↑  •  Prostaglandins ↑  •  Follicle rupture", {
    x: 0.45, y: 5.05, w: 9.1, h: 0.46, fontSize: 10, color: C.gold, bold: true, valign: "middle"
  });
}

// SLIDE 5 — Mechanism of Follicle Rupture
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 1 — OVULATION");
  sectionTitle(s, "Mechanism of Follicle Rupture", "LH-driven cascade leading to oocyte expulsion");
  addDivider(s, 1.15);

  // Mechanism diagram (left)
  if (!imgOvMech.error) {
    s.addImage({ data: imgOvMech.base64, x: 0.32, y: 1.22, w: 3.5, h: 4.0 });
  }
  s.addText("Fig: Postulated mechanism of ovulation — Guyton & Hall", {
    x: 0.32, y: 5.26, w: 3.5, h: 0.2, fontSize: 6.5, color: C.slate, align: "center", italic: true
  });

  // Right: Step-by-step
  card(s, 4.1, 1.22, 5.6, 3.95, C.navyMid);
  s.addText("Step-by-Step Sequence", { x: 4.25, y: 1.28, w: 5.3, h: 0.38, fontSize: 12, bold: true, color: C.teal });

  const steps = [
    ["1", "Stigma", "Small avascular spot appears at apex of bulging follicle"],
    ["2", "Enzymatic", "Proteolytic enzymes (collagenase, MMP, plasmin) dissolve follicle capsule"],
    ["3", "Vascular", "Prostaglandins → vasodilation, hyperemia, plasma transudation into follicle"],
    ["4", "Swelling", "Follicle swells; stigma balloons outward then ruptures (~2 min)"],
    ["5", "Expulsion", "Oocyte-cumulus complex expelled: secondary oocyte + corona radiata + zona pellucida"],
    ["6", "Regulators", "MAPK3/1 (ERK1/2) signaling; smooth muscle in theca externa contracts"],
  ];
  steps.forEach(([num, label, desc], i) => {
    const y = 1.7 + i * 0.6;
    s.addShape(pres.shapes.OVAL, { x: 4.2, y: y + 0.04, w: 0.28, h: 0.28, fill: { color: C.coral }, line: { color: C.coral } });
    s.addText(num, { x: 4.2, y: y + 0.04, w: 0.28, h: 0.28, fontSize: 8, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(`${label}: `, { x: 4.55, y, w: 1.3, h: 0.36, fontSize: 10, bold: true, color: C.corallg, valign: "top" });
    s.addText(desc, { x: 5.7, y, w: 3.85, h: 0.36, fontSize: 10, color: C.off, valign: "top" });
  });
}

// SLIDE 6 — Corpus Luteum
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 1 — OVULATION");
  sectionTitle(s, "Corpus Luteum & Post-Ovulatory Events", "The ruptured follicle transforms; two possible outcomes");
  addDivider(s, 1.15);

  // Formation (left card)
  card(s, 0.32, 1.28, 4.3, 2.6, C.navyMid);
  s.addText("Formation & Function", { x: 0.45, y: 1.33, w: 4.1, h: 0.38, fontSize: 12, bold: true, color: C.teal });
  bullets(s, [
    "Granulosa + theca interna cells luteinize under LH",
    "Cells enlarge 2×, fill with lipid → yellow appearance",
    "Secretes progesterone (primary) and estrogen",
    "Progesterone → secretory endometrium for implantation",
    "Also raises basal body temperature (BBT) by 0.3–0.5°C",
  ], 0.45, 1.75, 4.1, 2.0, { fontSize: 10.5 });

  // Two outcomes (right)
  // No fertilisation
  card(s, 4.82, 1.28, 4.85, 1.2, "1A2E45");
  s.addShape(pres.shapes.RECTANGLE, { x: 4.82, y: 1.28, w: 4.85, h: 0.38, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  s.addText("❌  No Fertilisation", { x: 4.95, y: 1.28, w: 4.6, h: 0.38, fontSize: 11, bold: true, color: C.corallg, valign: "middle" });
  bullets(s, [
    "Corpus luteum involutes after 10–12 days",
    "Called corpus luteum of menstruation",
    "Becomes corpus albicans (white scar)",
    "Progesterone/estrogen fall → menstruation",
  ], 4.95, 1.7, 4.6, 0.8, { fontSize: 10 });

  // Fertilisation outcome
  card(s, 4.82, 2.6, 4.85, 1.28, "1A2E45");
  s.addShape(pres.shapes.RECTANGLE, { x: 4.82, y: 2.6, w: 4.85, h: 0.38, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  s.addText("✅  Fertilisation Occurs", { x: 4.95, y: 2.6, w: 4.6, h: 0.38, fontSize: 11, bold: true, color: C.teal, valign: "middle" });
  bullets(s, [
    "hCG (from syncytiotrophoblast) rescues corpus luteum",
    "Corpus luteum of pregnancy; hCG peaks at ~10 wks",
    "Maintains progesterone/estrogen for first 20 weeks",
    "Placenta takes over steroidogenesis thereafter",
  ], 4.95, 3.02, 4.6, 0.8, { fontSize: 10 });

  // Clinical bottom
  card(s, 0.32, 4.0, 9.35, 1.2, "1A2E45");
  s.addText("Clinical Notes", { x: 0.45, y: 4.05, w: 9.1, h: 0.35, fontSize: 10.5, bold: true, color: C.gold });
  bullets(s, [
    "Mittelschmerz — mid-cycle pain from peritoneal irritation by follicular fluid",
    "Anovulation — inadequate gonadotropins; treated with clomiphene citrate (risk: multiple gestation ×10)",
    "OCP — E+P suppress GnRH/FSH/LH → no dominant follicle → no ovulation",
  ], 0.45, 4.42, 9.1, 0.75, { fontSize: 10 });
}

// ════════════════════════════════════════════════════════════════
// ── MODULE 2: FERTILISATION ──────────────────────────────────
// ════════════════════════════════════════════════════════════════

// SLIDE 7 — Module 2 Section Title
{
  const s = pres.addSlide();
  addSlideBg(s);
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 2.3, w: 10, h: 1.05, fill: { color: C.teal }, line: { color: C.teal } });
  s.addText("MODULE 2", { x: 0.6, y: 0.6, w: 8.8, h: 0.5, fontSize: 14, bold: true, color: C.teal, charSpacing: 5 });
  s.addText("FERTILISATION", { x: 0.6, y: 2.3, w: 8.8, h: 1.05, fontSize: 42, bold: true, color: C.white, align: "left", valign: "middle" });
  s.addText("Sperm transport • Capacitation • Acrosome reaction • Three phases • Zygote formation", {
    x: 0.6, y: 3.55, w: 8.8, h: 0.4, fontSize: 12, color: C.off, italic: true
  });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 5.3, w: 10, h: 0.325, fill: { color: C.navyMid }, line: { color: C.navyMid } });
  s.addText("Langman's Medical Embryology  •  The Developing Human  •  Ganong's Review of Medical Physiology", {
    x: 0, y: 5.3, w: 10, h: 0.325, fontSize: 8, color: C.slate, align: "center", valign: "middle"
  });
}

// SLIDE 8 — Sperm Transport & Capacitation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 2 — FERTILISATION");
  sectionTitle(s, "Sperm Transport & Capacitation", "From ejaculation to the site of fertilisation in the ampulla");
  addDivider(s, 1.15);

  // Transport card
  card(s, 0.32, 1.28, 4.5, 2.5, C.navyMid);
  s.addText("Sperm Transport", { x: 0.45, y: 1.33, w: 4.25, h: 0.38, fontSize: 12, bold: true, color: C.teal });
  bullets(s, [
    "~200–300 million sperm deposited; only 300–500 reach ampulla",
    "~1% of sperm enter the cervix; survive many hours there",
    "Transport via uterine smooth muscle contractions (not sperm motility)",
    "Journey: cervix → isthmus: 30 min to 6 days",
    "At isthmus: sperm pause, become less motile",
    "At ovulation: cumulus cell chemoattractants re-activate sperm",
    "Oocyte viable for 12–24 hrs; sperm viable for up to 5–7 days",
  ], 0.45, 1.75, 4.25, 1.9, { fontSize: 10.5 });

  // Capacitation card
  card(s, 5.0, 1.28, 4.65, 2.5, C.navyMid);
  s.addText("Capacitation (~7 hours)", { x: 5.12, y: 1.33, w: 4.4, h: 0.38, fontSize: 12, bold: true, color: C.gold });
  bullets(s, [
    "Conditioning in the female reproductive tract (uterine tube epithelium)",
    "Glycoprotein coat + seminal plasma proteins removed from acrosomal plasma membrane",
    "Membrane destabilized → primed for acrosome reaction",
    "Only capacitated sperm can penetrate corona radiata",
    "Speeding to the ampulla confers NO advantage — capacitation must complete first",
  ], 5.12, 1.75, 4.4, 1.9, { fontSize: 10.5 });

  // Acrosome reaction
  card(s, 0.32, 3.9, 9.35, 1.38, C.navyMid);
  s.addText("Acrosome Reaction", { x: 0.45, y: 3.95, w: 9.1, h: 0.38, fontSize: 12, bold: true, color: C.corallg });
  s.addText("Triggered when capacitated sperm bind to ZP3 (zona pellucida glycoprotein). Outer acrosomal membrane fuses with plasma membrane → releases acrosomal enzymes: hyaluronidase (corona dispersal), acrosin (serine protease — zona lysis), esterase, neuraminidase. These digest a path through the zona pellucida.", {
    x: 0.45, y: 4.35, w: 9.1, h: 0.85, fontSize: 10.5, color: C.off, lineSpacingMultiple: 1.25
  });
}

// SLIDE 9 — Three Phases of Fertilisation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 2 — FERTILISATION");
  sectionTitle(s, "Three Phases of Fertilisation", "Sequential events from corona penetration to zygote formation");
  addDivider(s, 1.15);

  // Diagram left
  if (!imgFert.error) {
    s.addImage({ data: imgFert.base64, x: 0.32, y: 1.22, w: 3.35, h: 4.05 });
  }
  s.addText("Fig: A–E Fertilisation stages — The Developing Human", {
    x: 0.32, y: 5.3, w: 3.35, h: 0.2, fontSize: 6.5, color: C.slate, align: "center", italic: true
  });

  // Phase cards right
  const phases = [
    {
      num: "Phase 1", label: "Penetration of Corona Radiata",
      color: C.navyMid, accent: C.coral,
      points: ["Capacitated sperm pass freely through corona cells", "Hyaluronidase + tubal enzymes disperse follicular cells", "Sperm tail movements aid mechanical penetration"],
    },
    {
      num: "Phase 2", label: "Penetration of Zona Pellucida",
      color: C.navyMid, accent: C.gold,
      points: ["Acrosin + enzymes lyse zona, form a pathway", "Zona reaction: cortical granules release lysosomal enzymes", "Zona becomes impermeable → blocks polyspermy (primary block)"],
    },
    {
      num: "Phase 3", label: "Fusion of Plasma Membranes",
      color: C.navyMid, accent: C.teal,
      points: ["Posterior sperm head membrane fuses with oocyte membrane", "Sperm head + tail enter cytoplasm; sperm membrane stays on surface", "Oocyte responds: ① cortical/zona reaction ② meiosis II resumes → 2nd polar body + female pronucleus ③ metabolic activation"],
    },
  ];
  phases.forEach((p, i) => {
    const y = 1.22 + i * 1.35;
    card(s, 3.87, y, 5.78, 1.22, p.color);
    s.addShape(pres.shapes.RECTANGLE, { x: 3.87, y, w: 5.78, h: 0.38, fill: { color: C.navyLight }, line: { color: C.navyLight } });
    s.addText(`${p.num}: ${p.label}`, { x: 4.0, y, w: 5.5, h: 0.38, fontSize: 10.5, bold: true, color: p.accent, valign: "middle" });
    bullets(s, p.points, 4.0, y + 0.4, 5.5, 0.8, { fontSize: 9.5 });
  });
}

// SLIDE 10 — Pronuclei & Results of Fertilisation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 2 — FERTILISATION");
  sectionTitle(s, "Pronuclei, Syngamy & Results", "Formation of the zygote and significance of fertilisation");
  addDivider(s, 1.15);

  // Left: pronuclei steps
  card(s, 0.32, 1.28, 4.6, 2.95, C.navyMid);
  s.addText("Pronuclear Development → Zygote", { x: 0.45, y: 1.33, w: 4.35, h: 0.38, fontSize: 11.5, bold: true, color: C.teal });
  bullets(s, [
    "Sperm nucleus decondenses → male pronucleus (22+X or 22+Y)",
    "Oocyte completes meiosis II → female pronucleus (22+X) + 2nd polar body",
    "Both pronuclei are haploid; each replicates DNA independently",
    "Nuclear envelopes break down (syngamy)",
    "Chromosomes align on first mitotic spindle",
    "Centromeres split; sister chromatids move to opposite poles",
    "Deep cleavage furrow → 2-cell zygote (46 chromosomes, diploid)",
    "Total fertilisation duration: ~24 hours",
  ], 0.45, 1.74, 4.35, 2.4, { fontSize: 10 });

  // Right: results table
  card(s, 5.1, 1.28, 4.55, 2.95, C.navyMid);
  s.addText("Key Results of Fertilisation", { x: 5.22, y: 1.33, w: 4.3, h: 0.38, fontSize: 11.5, bold: true, color: C.gold });
  const results = [
    ["Diploid restoration", "46 chromosomes; new maternal-paternal combination"],
    ["Sex determination", "X sperm → 46,XX (♀); Y sperm → 46,XY (♂)"],
    ["Meiosis II completion", "Mature ovum + second polar body formed"],
    ["Cleavage initiation", "Metabolic activation → embryonic development begins"],
    ["Genetic variability", "Novel combination of parental chromosomes"],
  ];
  results.forEach(([key, val], i) => {
    const y = 1.75 + i * 0.48;
    s.addText(`${key}:`, { x: 5.22, y, w: 1.85, h: 0.38, fontSize: 9.5, bold: true, color: C.corallg, valign: "middle" });
    s.addText(val, { x: 7.1, y, w: 2.4, h: 0.38, fontSize: 9.5, color: C.off, valign: "middle" });
    if (i < results.length - 1)
      s.addShape(pres.shapes.RECTANGLE, { x: 5.22, y: y + 0.38, w: 4.3, h: 0.01, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  });

  // Polyspermy block summary
  card(s, 0.32, 4.35, 9.35, 0.95, "1A2E45");
  s.addText("Prevention of Polyspermy", { x: 0.45, y: 4.4, w: 9.1, h: 0.32, fontSize: 10.5, bold: true, color: C.corallg });
  s.addText("Primary block: Zona reaction (cortical granule release → zona modification → impermeable to further sperm).  Secondary: Cortical reaction modifies oocyte plasma membrane.", {
    x: 0.45, y: 4.74, w: 9.1, h: 0.5, fontSize: 10, color: C.off
  });
}

// ════════════════════════════════════════════════════════════════
// ── MODULE 3: IMPLANTATION ───────────────────────────────────
// ════════════════════════════════════════════════════════════════

// SLIDE 11 — Module 3 Section Title
{
  const s = pres.addSlide();
  addSlideBg(s);
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 2.3, w: 10, h: 1.05, fill: { color: C.gold }, line: { color: C.gold } });
  s.addText("MODULE 3", { x: 0.6, y: 0.6, w: 8.8, h: 0.5, fontSize: 14, bold: true, color: C.gold, charSpacing: 5 });
  s.addText("IMPLANTATION", { x: 0.6, y: 2.3, w: 8.8, h: 1.05, fontSize: 40, bold: true, color: C.navy, align: "left", valign: "middle" });
  s.addText("Blastocyst development • Endometrial receptivity • Stages of implantation • Trophoblast differentiation", {
    x: 0.6, y: 3.55, w: 8.8, h: 0.4, fontSize: 12, color: C.off, italic: true
  });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 5.3, w: 10, h: 0.325, fill: { color: C.navyMid }, line: { color: C.navyMid } });
  s.addText("Creasy & Resnik's Maternal-Fetal Medicine  •  The Developing Human  •  Langman's Medical Embryology", {
    x: 0, y: 5.3, w: 10, h: 0.325, fontSize: 8, color: C.slate, align: "center", valign: "middle"
  });
}

// SLIDE 12 — Pre-implantation Development
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 3 — IMPLANTATION");
  sectionTitle(s, "Pre-Implantation Development", "Zygote → Blastocyst: cleavage, compaction, and hatching");
  addDivider(s, 1.15);

  const timeline = [
    ["Day 0", "Zygote", "Fertilisation in ampulla; diploid (46 chr)"],
    ["Day 1–2", "2–4 Cell", "First cleavage divisions (cells = blastomeres)"],
    ["Day 3–4", "Morula", "16+ cells; compaction; enters uterine cavity"],
    ["Day 4–5", "Blastocyst", "Cavitation; zona pellucida hatching begins"],
    ["Day 6–7", "Hatched", "Zona shed; polar TE attaches to endometrium"],
  ];
  timeline.forEach(([day, stage, desc], i) => {
    const x = 0.32 + i * 1.88;
    card(s, x, 1.28, 1.76, 3.6, C.navyMid);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 1.28, w: 1.76, h: 0.42, fill: { color: i === 4 ? C.coral : C.navyLight }, line: { color: C.navyLight } });
    s.addText(day, { x, y: 1.28, w: 1.76, h: 0.42, fontSize: 9.5, bold: true, color: i === 4 ? C.white : C.teal, align: "center", valign: "middle", margin: 0 });
    s.addText(stage, { x: x + 0.08, y: 1.74, w: 1.6, h: 0.42, fontSize: 11.5, bold: true, color: i === 4 ? C.gold : C.corallg, align: "center" });
    s.addText(desc, { x: x + 0.08, y: 2.2, w: 1.6, h: 2.5, fontSize: 9.5, color: C.off, align: "center", lineSpacingMultiple: 1.3 });
    if (i < timeline.length - 1)
      s.addText("▶", { x: x + 1.76, y: 2.8, w: 0.12, h: 0.3, fontSize: 10, color: C.teal, align: "center" });
  });

  // Blastocyst structure
  card(s, 0.32, 4.98, 9.35, 0.5, C.navyMid);
  s.addText("Blastocyst Structure:  ", { x: 0.45, y: 4.98, w: 2.0, h: 0.5, fontSize: 10.5, bold: true, color: C.teal, valign: "middle" });
  s.addText("Trophectoderm (TE) — outer layer → placenta/membranes  |  Inner Cell Mass (ICM) — embryo proper  |  Blastocoel — fluid cavity  |  Polar TE — over ICM → initiates implantation", {
    x: 2.3, y: 4.98, w: 7.2, h: 0.5, fontSize: 10, color: C.off, valign: "middle"
  });
}

// SLIDE 13 — Endometrial Receptivity
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 3 — IMPLANTATION");
  sectionTitle(s, "Endometrial Receptivity — Window of Implantation", "Days 20–24 of a 28-day cycle; estrogen + progesterone priming required");
  addDivider(s, 1.15);

  // Left: key molecular mediators
  card(s, 0.32, 1.28, 5.0, 3.95, C.navyMid);
  s.addText("Key Molecular Mediators", { x: 0.45, y: 1.33, w: 4.75, h: 0.38, fontSize: 12, bold: true, color: C.teal });

  const meds = [
    ["HB-EGF", "Endometrial epithelium/pinopodia", "Critical attachment signal; binds ErbB1/ErbB4 on polar TE"],
    ["LIF", "Luminal epithelium", "Signals blastocyst and endometrium for receptivity"],
    ["IHH", "Epithelium", "Paracrine epithelial-stromal interaction"],
    ["HOXA10/11", "Stroma", "Crucial for decidualization"],
    ["HAND2", "Stroma", "Decidualization; suppresses epithelial differentiation"],
    ["BMP2", "Stroma", "Required for decidualization; embryo spacing"],
    ["WNT", "Endometrial epithelium", "Blastocyst attachment signaling"],
  ];
  meds.forEach(([factor, loc, role], i) => {
    const y = 1.75 + i * 0.49;
    s.addText(factor, { x: 0.45, y, w: 1.1, h: 0.38, fontSize: 9.5, bold: true, color: C.gold, valign: "middle" });
    s.addText(loc, { x: 1.58, y, w: 1.55, h: 0.38, fontSize: 8.5, color: C.slate, valign: "middle", italic: true });
    s.addText(role, { x: 3.16, y, w: 2.0, h: 0.38, fontSize: 8.5, color: C.off, valign: "middle" });
    if (i < meds.length - 1)
      s.addShape(pres.shapes.RECTANGLE, { x: 0.45, y: y + 0.38, w: 4.65, h: 0.01, fill: { color: C.navyLight }, line: { color: C.navyLight } });
  });

  // Right: hormone requirements + pinopodia
  card(s, 5.52, 1.28, 4.12, 1.8, C.navyMid);
  s.addText("Hormonal Requirements", { x: 5.65, y: 1.33, w: 3.85, h: 0.38, fontSize: 11.5, bold: true, color: C.corallg });
  bullets(s, [
    "Both E2 (estradiol) AND P4 (progesterone) are required",
    "E2 + P4 → HB-EGF expression on pinopodia",
    "Pinopodia appear only during implantation window",
    "Progesterone from corpus luteum drives decidualization",
  ], 5.65, 1.74, 3.85, 1.2, { fontSize: 10 });

  card(s, 5.52, 3.18, 4.12, 2.05, C.navyMid);
  s.addText("Pinopodia", { x: 5.65, y: 3.23, w: 3.85, h: 0.38, fontSize: 11.5, bold: true, color: C.gold });
  bullets(s, [
    "Finger-like projections on luminal endometrial surface",
    "Appear exclusively during the window of implantation",
    "Express HB-EGF in both soluble and membrane-bound forms",
    "HB-EGF receptors (ErbB1/ErbB4) on polar TE microvilli mediate first contact",
  ], 5.65, 3.65, 3.85, 1.45, { fontSize: 10 });
}

// SLIDE 14 — Three Stages of Implantation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 3 — IMPLANTATION");
  sectionTitle(s, "Three Stages of Implantation", "Apposition → Adhesion → Invasion; complete by Day 10–12");
  addDivider(s, 1.15);

  const stageData = [
    {
      num: "1", name: "Apposition",
      color: C.navyMid, accent: C.teal,
      points: ["Loose, initial contact of polar TE with luminal endometrium", "Typically on posterior uterine wall", "Reversible at this stage", "Blastocyst orientates ICM toward endometrium"],
    },
    {
      num: "2", name: "Adhesion",
      color: C.navyMid, accent: C.corallg,
      points: ["Firm, irreversible attachment", "HB-EGF (endometrium) binds ErbB1/ErbB4 (polar TE)", "TE integrins bind endometrial fibronectin/laminin", "LIF + blastocyst-to-endometrium cross-signals", "TE microvilli interdigitate with endometrial surface"],
    },
    {
      num: "3", name: "Invasion",
      color: C.navyMid, accent: C.gold,
      points: ["Polar TE cells break through endometrial epithelium", "Cytotrophoblast (CTB) shell forms around embryo", "CTB differentiates → primitive syncytiotrophoblast (STB)", "STB: invasive + secretory (begins hCG secretion)", "Embryo fully embedded by Day 10–12"],
    },
  ];
  stageData.forEach((st, i) => {
    const x = 0.32 + i * 3.18;
    card(s, x, 1.28, 3.0, 3.95, st.color);
    s.addShape(pres.shapes.OVAL, { x: x + 1.12, y: 1.34, w: 0.76, h: 0.76, fill: { color: st.accent }, line: { color: st.accent } });
    s.addText(st.num, { x: x + 1.12, y: 1.34, w: 0.76, h: 0.76, fontSize: 22, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
    s.addText(st.name, { x: x + 0.1, y: 2.2, w: 2.8, h: 0.42, fontSize: 13, bold: true, color: st.accent, align: "center" });
    bullets(s, st.points, x + 0.15, 2.65, 2.7, 2.45, { fontSize: 9.8 });
  });

  // Arrow connectors
  for (let i = 0; i < 2; i++) {
    s.addText("▶", { x: 3.27 + i * 3.18, y: 3.15, w: 0.3, h: 0.35, fontSize: 14, color: C.coral, align: "center" });
  }
}

// SLIDE 15 — Trophoblast Differentiation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 3 — IMPLANTATION");
  sectionTitle(s, "Trophoblast Differentiation & Decidualization", "Post-implantation: two lineages with distinct roles");
  addDivider(s, 1.15);

  // Central node: CTB
  card(s, 3.9, 1.28, 2.2, 0.68, C.coral);
  s.addText("CTB Progenitor Cell", { x: 3.9, y: 1.28, w: 2.2, h: 0.68, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  // Arrow down-left (STB)
  s.addText("↙", { x: 2.5, y: 1.95, w: 0.5, h: 0.5, fontSize: 20, color: C.teal, align: "center" });
  // Arrow down-right (EVT)
  s.addText("↘", { x: 7.0, y: 1.95, w: 0.5, h: 0.5, fontSize: 20, color: C.gold, align: "center" });

  // STB card
  card(s, 0.32, 2.5, 4.3, 2.7, C.navyMid);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.32, y: 2.5, w: 4.3, h: 0.4, fill: { color: C.teal }, line: { color: C.teal } });
  s.addText("Syncytiotrophoblast (STB)", { x: 0.32, y: 2.5, w: 4.3, h: 0.4, fontSize: 11, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
  bullets(s, [
    "Multi-nucleated; covers the placental surface",
    "Transport and endocrine functions throughout pregnancy",
    "Produces hCG, hPL, estrogens, progesterone",
    "hCG rescues corpus luteum; forms basis of pregnancy test",
    "Placenta takes over steroidogenesis by week 20",
  ], 0.45, 2.95, 4.05, 2.1, { fontSize: 10 });

  // EVT card
  card(s, 5.35, 2.5, 4.32, 2.7, C.navyMid);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.35, y: 2.5, w: 4.32, h: 0.4, fill: { color: C.gold }, line: { color: C.gold } });
  s.addText("Extravillous Cytotrophoblast (EVT)", { x: 5.35, y: 2.5, w: 4.32, h: 0.4, fontSize: 11, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
  bullets(s, [
    "iEVT: invades endometrial stroma + superficial 1/3 myometrium",
    "eEVT: invades arterioles → replaces endothelium → vascular remodeling",
    "Driven by hypoxia (HIF) + ASCL2 + WNT/β-catenin signaling",
    "Integrin switch: α6/β4 → α5/α1 (fibronectin receptors)",
    "MMP-9 and plasminogen activators enable stromal invasion",
  ], 5.48, 2.95, 4.05, 2.1, { fontSize: 10 });

  // Decidualization footer
  card(s, 0.32, 5.3, 9.35, 0.2, "1A2E45");
  s.addText("Decidualization: Stromal cells enlarge under progesterone influence → glycogen-rich decidua (HOXA10/11, HAND2, BMP2). Provides nutrition and immune tolerance for embryo.", {
    x: 0.45, y: 5.2, w: 9.1, h: 0.3, fontSize: 8.5, color: C.slate, valign: "middle"
  });
}

// SLIDE 16 — Clinical Correlates of Implantation
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "MODULE 3 — IMPLANTATION");
  sectionTitle(s, "Clinical Correlates of Implantation", "When implantation goes wrong — and ART solutions");
  addDivider(s, 1.15);

  const conditions = [
    {
      name: "Ectopic Pregnancy",
      color: C.coral,
      points: ["Implantation outside uterine cavity (most often fallopian tube)", "Risk factors: PID, tubal scarring, previous ectopic, IUD", "Life-threatening if tube ruptures → surgical/medical (methotrexate) management"],
    },
    {
      name: "Placenta Previa",
      color: C.gold,
      points: ["Implantation over or near internal cervical os", "Defect in embryo spacing mechanisms (BMP2 pathway)", "Painless antepartum haemorrhage; managed by C-section"],
    },
    {
      name: "Preeclampsia",
      color: C.teal,
      points: ["Defective eEVT vascular remodeling → high-resistance circulation", "Shallow EVT invasion; spiral arteries not adequately remodeled", "Associated with HB-EGF pathway defects; new-onset hypertension + proteinuria"],
    },
    {
      name: "Recurrent Miscarriage",
      color: C.corallg,
      points: ["Defects in HB-EGF/LIF signaling, decidualization, or EVT invasion", "Genetic (aneuploidies), anatomical, immunological or thrombophilic causes", "Investigated from ≥3 consecutive losses"],
    },
    {
      name: "IVF / ART",
      color: C.slate,
      points: ["Stimulated follicles → oocyte retrieval; fertilised in Petri dish", "4–8 cell or blastocyst stage transferred to uterus via catheter", "Excess embryos cryopreserved; multiple pregnancy risk monitored"],
    },
  ];

  conditions.forEach((c, i) => {
    const col = i < 3 ? 0 : 1;
    const row = i < 3 ? i : i - 3;
    const x = col === 0 ? 0.32 : 5.18;
    const y = 1.28 + row * 1.43;
    card(s, x, y, 4.62, 1.3, C.navyMid);
    s.addShape(pres.shapes.RECTANGLE, { x, y, w: 0.22, h: 1.3, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.name, { x: x + 0.32, y: y + 0.06, w: 4.2, h: 0.34, fontSize: 11, bold: true, color: c.color });
    bullets(s, c.points, x + 0.32, y + 0.42, 4.2, 0.85, { fontSize: 9.2 });
  });
}

// SLIDE 17 — Integrated Timeline
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "INTEGRATED SUMMARY");
  sectionTitle(s, "Integrated Timeline: Ovulation → Implantation", "Key events mapped to days relative to ovulation");
  addDivider(s, 1.15);

  const events = [
    { day: "−2 to −1", event: "LH Surge", desc: "6–10× rise; FSH also rises 2–3×", color: C.coral },
    { day: "Day 0", event: "Ovulation", desc: "Oocyte expelled; corpus luteum forms", color: C.corallg },
    { day: "Day 0–1", event: "Fertilisation", desc: "Capacitation → acrosome reaction → zygote in ampulla", color: C.gold },
    { day: "Day 2–4", event: "Cleavage", desc: "2-cell → morula; enters uterine cavity", color: C.teal },
    { day: "Day 4–5", event: "Blastocyst", desc: "Cavitation; zona hatching", color: C.slate },
    { day: "Day 6–7", event: "Implantation Begins", desc: "Polar TE adheres to endometrium (apposition → adhesion)", color: C.coral },
    { day: "Day 8–9", event: "Invasion", desc: "CTB shell; STB forms; hCG secretion starts", color: C.corallg },
    { day: "Day 10–12", event: "Fully Embedded", desc: "Embryo completely within endometrium", color: C.gold },
    { day: "~Day 28+", event: "Pregnancy Test +ve", desc: "hCG detectable in blood/urine", color: C.teal },
  ];

  // Timeline bar
  s.addShape(pres.shapes.RECTANGLE, { x: 0.5, y: 3.0, w: 9.0, h: 0.08, fill: { color: C.navyLight }, line: { color: C.navyLight } });

  events.forEach((ev, i) => {
    const x = 0.45 + i * 1.02;
    const above = i % 2 === 0;

    // dot on timeline
    s.addShape(pres.shapes.OVAL, { x: x + 0.2, y: 2.96, w: 0.18, h: 0.18, fill: { color: ev.color }, line: { color: ev.color } });

    if (above) {
      // card above timeline
      card(s, x, 1.28, 0.95, 1.6, C.navyMid);
      s.addShape(pres.shapes.RECTANGLE, { x, y: 1.28, w: 0.95, h: 0.28, fill: { color: ev.color }, line: { color: ev.color } });
      s.addText(ev.day, { x, y: 1.28, w: 0.95, h: 0.28, fontSize: 7, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
      s.addText(ev.event, { x: x + 0.05, y: 1.58, w: 0.85, h: 0.38, fontSize: 8.5, bold: true, color: ev.color, align: "center" });
      s.addText(ev.desc, { x: x + 0.04, y: 1.98, w: 0.88, h: 0.7, fontSize: 7, color: C.off, align: "center", lineSpacingMultiple: 1.2 });
      // connector line
      s.addShape(pres.shapes.RECTANGLE, { x: x + 0.45, y: 2.88, w: 0.02, h: 0.1, fill: { color: ev.color }, line: { color: ev.color } });
    } else {
      // card below timeline
      s.addShape(pres.shapes.RECTANGLE, { x: x + 0.45, y: 3.12, w: 0.02, h: 0.1, fill: { color: ev.color }, line: { color: ev.color } });
      card(s, x, 3.22, 0.95, 1.6, C.navyMid);
      s.addShape(pres.shapes.RECTANGLE, { x, y: 3.22, w: 0.95, h: 0.28, fill: { color: ev.color }, line: { color: ev.color } });
      s.addText(ev.day, { x, y: 3.22, w: 0.95, h: 0.28, fontSize: 7, bold: true, color: C.navy, align: "center", valign: "middle", margin: 0 });
      s.addText(ev.event, { x: x + 0.05, y: 3.52, w: 0.85, h: 0.38, fontSize: 8.5, bold: true, color: ev.color, align: "center" });
      s.addText(ev.desc, { x: x + 0.04, y: 3.92, w: 0.88, h: 0.7, fontSize: 7, color: C.off, align: "center", lineSpacingMultiple: 1.2 });
    }
  });
}

// SLIDE 18 — Hormone Summary Table
{
  const s = pres.addSlide();
  addSlideBg(s);
  addHeaderBar(s, "INTEGRATED SUMMARY");
  sectionTitle(s, "Key Hormones — Integrated Summary", "Role of each hormone across ovulation, fertilisation, and implantation");
  addDivider(s, 1.15);

  const rows = [
    ["GnRH", "Hypothalamus", "Pulsatile release drives FSH & LH secretion from anterior pituitary"],
    ["FSH", "Anterior pituitary", "Follicular development; estrogen production from granulosa cells"],
    ["LH", "Anterior pituitary", "Triggers ovulation (surge); corpus luteum maintenance"],
    ["Estradiol (E2)", "Granulosa / corpus luteum / STB", "Follicular growth; positive feedback → LH surge; endometrial proliferation; HB-EGF expression"],
    ["Progesterone (P4)", "Corpus luteum / STB", "Secretory endometrium; inhibits new follicle development; thermogenic (BBT); decidualization"],
    ["hCG", "Syncytiotrophoblast", "Rescues corpus luteum; maintains P4/E2 in early pregnancy; basis of pregnancy tests"],
    ["Inhibin", "Granulosa cells", "Suppresses FSH; dominant follicle selection"],
    ["Prostaglandins", "Follicular cells", "Follicular wall smooth muscle contraction; vasodilation; facilitate oocyte expulsion"],
  ];

  // Header row
  s.addShape(pres.shapes.RECTANGLE, { x: 0.32, y: 1.28, w: 9.35, h: 0.4, fill: { color: C.coral }, line: { color: C.coral } });
  const headers = ["Hormone", "Source", "Role"];
  const colW = [1.7, 2.5, 5.0];
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}

// SLIDE 19 — Summary & Sources
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  const takeaways = [
    "OVULATION is triggered by the LH surge (24–36 hrs prior); the secondary oocyte is arrested in metaphase II until fertilisation",
    "CORPUS LUTEUM is maintained by hCG after fertilisation; its progesterone output is critical for the first 20 weeks",
    "FERTILISATION occurs in the ampulla; requires capacitation (~7 hrs) + acrosome reaction; takes ~24 hours; restores diploidy and determines sex",
    "POLYSPERMY is prevented by the zona reaction (primary block) — cortical granules modify the zona pellucida immediately after sperm entry",
    "IMPLANTATION begins Day 6–7; requires a receptive endometrium (Days 20–24); HB-EGF/ErbB signaling mediates initial attachment",
    "TROPHOBLAST differentiates into STB (endocrine/transport) and EVT (iEVT invades stroma; eEVT remodels spiral arteries)",
    "Defective EVT invasion → preeclampsia; ectopic implantation → ectopic pregnancy — both are clinical emergencies",
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  s.addText("Sources: The Developing Human (Moore)  •  Langman's Medical Embryology  •  Guyton & Hall Medical Physiology  •  Creasy & Resnik's Maternal-Fetal Medicine  •  Berek & Novak's Gynecology", {
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// ── Write file ──────────────────────────────────────────────────
const outPath = "/home/daytona/workspace/reproductive-health-pptx/Ovulation_Fertilisation_Implantation.pptx";
pres.writeFile({ fileName: outPath }).then(() => {
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