Inj amoxyclav according to weight
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amoxicillin clavulanate injection dose per kg weight pediatric adult
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https://medicalguidelines.msf.org/en/viewport/EssDr/english/…
Here is a comprehensive dosing guide for Injection Amoxicillin-Clavulanate (Co-Amoxiclav / Amoxyclav) by weight:
Inj. Amoxicillin-Clavulanate (Co-Amoxiclav) - Dose by Weight
Note: Doses are expressed in terms of the amoxicillin component. The standard IV vial contains 1000 mg amoxicillin + 200 mg clavulanic acid (5:1 ratio).
Adults and Children ≥ 40 kg
| Infection | Dose | Frequency |
|---|---|---|
| Mild-moderate (skin/soft tissue, respiratory) | 1 g | Every 8 hours |
| Severe / Necrotizing infections | 2 g | Every 8 hours |
| Upper genital tract infection | 1 g | Every 8 hours |
Children < 40 kg (Weight-based dosing)
| Age/Weight | Infection Type | Dose | Frequency |
|---|---|---|---|
| < 3 months | Mild/moderate (e.g., cellulitis) | 30 mg/kg | Every 12 hours |
| < 3 months | Necrotizing infections | 50 mg/kg | Every 12 hours |
| 3 months to < 40 kg | Mild/moderate (e.g., cellulitis, respiratory) | 20-30 mg/kg | Every 8 hours (max 3 g/day) |
| 3 months to < 40 kg | Severe/Necrotizing infections | 50 mg/kg | Every 8 hours (max 6 g/day) |
Administration
- Reconstitution: Dissolve each vial (1g/200mg) in 20 mL Water for Injection or 0.9% Normal Saline
- Slow IV bolus: Inject over 3 minutes
- IV infusion: Infuse over 30 minutes
- Dilution for infusion:
- Children < 20 kg: dilute in 5 mL/kg of 0.9% Normal Saline
- Children ≥ 20 kg and adults: dilute in 100 mL of 0.9% Normal Saline
- Do NOT dilute in glucose/dextrose solutions
- Do NOT mix with other drugs in the same syringe or infusion bag
Renal Dose Adjustment
| CrCl | Dose Adjustment |
|---|---|
| > 30 mL/min | No change |
| 10-30 mL/min | Reduce frequency to every 12 hours |
| < 10 mL/min | Reduce frequency to every 24 hours |
| Hemodialysis | Give supplemental dose during and after dialysis |
Duration of IV Therapy
| Indication | Duration |
|---|---|
| Erysipelas / Cellulitis | 7-10 days |
| Necrotizing fasciitis / Gas gangrene | 14 days |
| Postpartum genital infection | Based on clinical response |
Switch to oral co-amoxiclav (PO) as soon as clinically appropriate.
Key Precautions
- Contraindicated in penicillin allergy, history of co-amoxiclav-related hepatic disorder, and infectious mononucleosis
- Use with caution in cephalosporin allergy (cross-sensitivity), hepatic impairment, and severe renal impairment
- Avoid combining with methotrexate (increased toxicity)
- Safe in pregnancy and breastfeeding
Inj amoxyclav according to weight
Here is the complete dosing guide for Injection Amoxicillin-Clavulanate (Co-Amoxiclav / Amoxyclav) by weight, based on authoritative guidelines:
Inj. Amoxicillin-Clavulanate (Co-Amoxiclav) - Dose by Weight
Doses expressed in amoxicillin component. Standard IV vial: 1000 mg amoxicillin + 200 mg clavulanic acid (5:1 ratio).
Adults and Children ≥ 40 kg
| Infection | Dose | Frequency |
|---|---|---|
| Mild-moderate (skin, soft tissue, respiratory) | 1 g | Every 8 hours |
| Severe / Necrotizing infections | 2 g | Every 8 hours |
| Upper genital tract infection | 1 g | Every 8 hours |
Children < 40 kg (Weight-based dosing)
| Age / Weight | Infection Type | Dose | Frequency |
|---|---|---|---|
| < 3 months | Mild/moderate (e.g., cellulitis) | 30 mg/kg | Every 12 hours |
| < 3 months | Necrotizing infections | 50 mg/kg | Every 12 hours |
| 3 months to < 40 kg | Mild/moderate | 20-30 mg/kg | Every 8 hours (max 3 g/day) |
| 3 months to < 40 kg | Severe / Necrotizing | 50 mg/kg | Every 8 hours (max 6 g/day) |
Administration
- Reconstitution: Dissolve each 1 g vial in 20 mL of Water for Injection or 0.9% Normal Saline
- Slow IV bolus: Inject over 3 minutes
- IV infusion: Infuse over 30 minutes
- Dilution for infusion:
- Children < 20 kg: dilute in 5 mL/kg of 0.9% Normal Saline
- Children ≥ 20 kg and adults: dilute in 100 mL of 0.9% Normal Saline
- Do NOT dilute in glucose/dextrose solutions
- Do NOT mix with other drugs in the same syringe or infusion bag
Renal Dose Adjustment
| CrCl | Adjustment |
|---|---|
| > 30 mL/min | No change |
| 10-30 mL/min | Every 12 hours |
| < 10 mL/min | Every 24 hours |
| Hemodialysis | Supplemental dose during and after dialysis |
Treatment Duration
| Indication | Duration |
|---|---|
| Erysipelas / Cellulitis | 7-10 days |
| Necrotizing fasciitis / Gas gangrene | 14 days |
| Postpartum genital infection | Based on clinical response |
Switch to oral co-amoxiclav as soon as clinically appropriate.
Key Precautions
- Contraindicated in penicillin allergy, prior co-amoxiclav hepatic reaction, and infectious mononucleosis
- Caution in cephalosporin allergy (cross-sensitivity), hepatic impairment, and severe renal impairment
- Avoid with methotrexate (increases methotrexate toxicity)
- Safe in pregnancy and breastfeeding
Inj solumedrol according to weight
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methylprednisolone solumedrol injection dose per kg weight pediatric adult indications
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https://www.drugs.com/dosage/solu-medrol.html
Here is the complete dosing guide for Injection Solu-Medrol (Methylprednisolone Sodium Succinate) by weight and indication:
Inj. Solu-Medrol (Methylprednisolone) - Dose by Weight
Available vials: 40 mg, 125 mg, 500 mg, 1 g (as sodium succinate)
Adults (Fixed Dosing - Not Purely Weight-Based)
| Indication | Dose | Frequency / Notes |
|---|---|---|
| General / mild-moderate steroid-responsive conditions | 10-40 mg IV | Single or repeated doses |
| Severe / acute conditions | 40-125 mg IV | As needed |
| High-dose pulse (shock, life-threatening) | 30 mg/kg IV | Over ≥ 30 min; repeat every 4-6 hrs for up to 48 hrs |
| Acute spinal cord injury (NASCIS protocol) | 30 mg/kg IV bolus, then 5.4 mg/kg/hr infusion | Bolus over 15 min, wait 45 min, then infusion for 23 hrs |
| Status asthmaticus / severe asthma | 125 mg IV (or 1-2 mg/kg) | Every 6-8 hours |
| MS relapse (pulse therapy) | 500-1000 mg IV daily | For 3-5 days |
| Lupus nephritis (pulse) | 500-1000 mg IV daily | For 3 consecutive days |
| Transplant rejection / severe autoimmune | 500-1000 mg IV daily | For 3 days |
Pediatrics (Weight-Based Dosing)
| Indication | Dose | Frequency |
|---|---|---|
| General/mild steroid-responsive | 0.11-1.6 mg/kg/day | Divided every 6-8 hours (3-4 doses/day) |
| Asthma exacerbation (NHLBI) | 1-2 mg/kg/day | Single or divided doses; continue 3-10 days |
| Severe asthma / status asthmaticus | 2 mg/kg IV loading, then 0.5-1 mg/kg every 6 hrs | Until improvement |
| High-dose pulse (life-threatening/shock) | 30 mg/kg IV | Over ≥ 30 min; repeat every 4-6 hrs up to 48 hrs |
| Lupus nephritis (pulse) | 15 mg/kg/day IV | For 3 consecutive days |
| Spinal cord injury | Same as adult weight-based protocol | 30 mg/kg bolus then 5.4 mg/kg/hr x 23 hrs |
| Minimum pediatric dose | ≥ 0.5 mg/kg | Every 24 hours (do not go below this) |
Pediatric dosing is governed more by severity of condition and patient response than by age or body size alone.
Administration
| Route | Method | Rate |
|---|---|---|
| IV bolus (low-moderate doses) | Dilute in NS or D5W | Give over 3-15 minutes |
| IV infusion (high doses) | Dilute in 50-100 mL NS or D5W | Infuse over 30 minutes minimum |
| IM | Direct injection | For non-emergency use |
Warning: Rapid IV injection of large doses (> 500 mg in < 10 min) can cause cardiac arrhythmia or cardiac arrest. Always infuse high doses slowly over ≥ 30 minutes.
Renal / Hepatic Adjustment
- Renal impairment: No specific dose reduction required (not renally eliminated)
- Hepatic impairment: Use with caution; metabolism may be reduced - monitor response
Key Precautions
- Contraindicated in: systemic fungal infections, live vaccines, intrathecal use, premature infants (benzyl alcohol in some formulations), ITP (IM route)
- Caution in: diabetes, hypertension, peptic ulcer, osteoporosis, active infections, psychiatric disorders
- Do not stop abruptly after prolonged use - taper gradually
- Monitor: blood glucose, blood pressure, weight, serum potassium, infections
Quick Reference Summary
| Population | Standard Dose | High-Dose Pulse |
|---|---|---|
| Adult | 10-125 mg IV | 30 mg/kg IV over 30 min |
| Pediatric | 0.11-2 mg/kg/day divided | 30 mg/kg IV over 30 min (max varies) |
| Lupus (pediatric) | - | 15 mg/kg/day x 3 days |
| Minimum pediatric | 0.5 mg/kg/24 hrs | - |
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