Reading File
Finding Sources
Searching the Web
ranitidine oral solution syrup uses dosage NDMA safety 2026
Reading File
Finding Sources
Here is a full breakdown of what is in the image and everything you need to know about this medicine:
Ranidom-PD Syrup - Ranitidine Oral Solution IP
Brand: Ranidom-PD Syrup
Generic: Ranitidine Oral Solution IP
Manufacturer: Mankind Pharma (India)
Flavour: Peppermint
Volume: 100 mL
Status: Prescription (Rx) only
What is Ranitidine?
Ranitidine is an H2-receptor antagonist (H2 blocker). It works by competitively blocking histamine H2 receptors on gastric parietal cells, which reduces stomach acid secretion. It does not affect H1 receptors. The "PD" in the brand name typically denotes a paediatric/pediatric drops or syrup formulation suited for children.
What It Is Used For
- Duodenal and gastric ulcers (active treatment and maintenance of healing)
- Gastroesophageal reflux disease (GERD)
- Erosive esophagitis (treatment and maintenance)
- Pathological hypersecretory conditions such as Zollinger-Ellison syndrome
- Heartburn and acid indigestion
- Used in anesthesia settings to reduce risk of aspiration pneumonitis (by raising gastric pH before surgery)
Dosage
Adults:
- Active ulcer: 150 mg (10 mL of 15 mg/mL solution) twice daily, or 300 mg once at bedtime
- Maintenance: 150 mg at bedtime
- GERD/Erosive esophagitis: 150 mg twice daily
- Zollinger-Ellison: 150 mg twice daily, adjusted as needed (up to 6 g/day in severe cases)
Paediatric (1 month to 16 years):
- 2-4 mg/kg twice daily, maximum 300 mg/day (active ulcer)
- 2-4 mg/kg once daily, maximum 150 mg/day (maintenance)
- (per Fitzpatrick's Dermatology dosing table: 5-10 mg/kg/day divided in 2 doses)
Side Effects
From textbook sources (Fitzpatrick's Dermatology, 10th ed.):
| Category | Effects |
|---|---|
| CNS | Confusion, dizziness, drowsiness, headache |
| GI | Nausea, vomiting, diarrhea/constipation, abdominal pain, rare hepatitis |
| Cardiovascular | Alters parasympathetic/sympathetic balance; rapid IV injection (not applicable to oral syrup) can rarely cause hypotension, bradycardia, arrhythmias |
| Hematologic (rare) | Granulocytopenia, thrombocytopenia |
| Other | Does NOT cause gynecomastia (unlike cimetidine) |
Drug Interactions
Ranitidine has fewer drug interactions than cimetidine. However:
- Can reduce urinary excretion of procainamide and quinidine (raising their levels)
- Unlike cimetidine, it does NOT significantly inhibit hepatic microsomal enzymes (CYP450), so interactions with phenytoin, benzodiazepines, and warfarin are minimal
- Does not bind androgen receptors (no anti-androgenic effects)
Dose Adjustment
- Required in renal impairment (ranitidine is largely renally cleared)
- Use with caution in hepatic disease
Important Safety Notice - NDMA
The FDA (US) withdrew all ranitidine products from the market in April 2020 due to the presence of N-nitrosodimethylamine (NDMA), a probable human carcinogen, found in ranitidine products at unacceptable levels - and because NDMA levels increase over time and with temperature. However, ranitidine is still manufactured and prescribed in India (where Mankind Pharma operates), where regulatory decisions differ from the US FDA.
If you or a family member has been prescribed this, consult your prescribing doctor about whether a proton pump inhibitor (PPI) such as omeprazole or pantoprazole, or an H2 blocker like famotidine (which does NOT have the NDMA issue), would be an appropriate alternative.
Sources: Fitzpatrick's Dermatology (10th ed.), Katzung's Basic & Clinical Pharmacology (16th ed.), FDA NDMA recall notice, DailyMed prescribing information
This is a shared conversation. Sign in to Orris to start your own chat.