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dermatology AND ultrasonography

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high frequency ultrasound dermatology indications technique Doppler review

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https://pmc.ncbi.nlm.nih.gov/articles/PMC8058126

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USG in Dermatology

Introduction

Ultrasonography (USG) is a non-invasive, radiation-free, real-time imaging modality used to assess skin, appendages, subcutaneous tissue, vessels, lymph nodes, and superficial soft-tissue lesions. In dermatology, high-frequency ultrasound (HFUS), usually using probes of 15-22 MHz or higher, is preferred because it provides high resolution of superficial structures. HFUS review

Principle

  • Ultrasound waves are emitted by a piezoelectric transducer.
  • Echoes reflected from tissues of differing acoustic impedance are converted into a grayscale image.
  • Higher frequency gives better resolution but lower tissue penetration.
  • B-mode provides structural imaging.
  • Colour/power Doppler demonstrates vascularity, helping assess inflammatory activity and tumour blood flow.

Frequency and penetration

Probe frequencyMain use
7-15 MHzSubcutis, deeper masses, muscles, regional lymph nodes
15-22 MHzRoutine dermatologic HFUS, dermis and superficial lesions
20-30 MHzEpidermis, dermis, superficial tumours
>30-50 MHzUltra-high-frequency USG, very superficial skin structures; very limited penetration

Normal sonographic appearance of skin

  • Epidermis: thin, echogenic entry echo.
  • Dermis: relatively echogenic band due to collagen.
  • Subcutaneous fat: hypoechoic lobules separated by echogenic fibrous septa.
  • Fascia: bright echogenic linear structure.
  • In photoaged skin, a subepidermal low-echogenic band (SLEB) may be seen.

Technique

  1. Use a high-frequency linear transducer with abundant gel.
  2. Examine lesion in two perpendicular planes.
  3. Avoid excess transducer pressure, as it may compress vessels and alter lesion dimensions.
  4. Assess:
    • Site and depth
    • Size in three dimensions
    • Margins and echogenicity
    • Relation to dermis, subcutis, fascia, muscle, or bone
    • Internal vascularity using colour/power Doppler
    • Regional lymph nodes when indicated
  5. Store images for serial comparison.

Indications / Applications

1. Skin tumours

  • Defines tumour thickness, depth, margins, and invasion into subcutis or deeper structures.
  • Assists in preoperative planning and selection of biopsy site.
  • Helps evaluate regional lymph nodes.
  • Useful in:
    • Melanoma
    • Basal cell carcinoma
    • Squamous cell carcinoma
    • Dermatofibrosarcoma protuberans (DFSP)
    • Cutaneous metastases
    • Cysts and benign soft-tissue tumours
Melanoma: HFUS can estimate Breslow thickness preoperatively and identify satellite lesions or suspicious nodes. A recent meta-analysis supports its value for preoperative cutaneous melanoma assessment, though histopathology remains the definitive standard (PMID: 38967397).
BCC: typically a hypoechoic lesion in the dermis with internal hyperechoic foci and increased Doppler vascularity. It helps define lateral and deep extent.

2. Inflammatory dermatoses

USG can demonstrate skin thickness, oedema, fibrosis, and vascularity.
  • Psoriasis: dermal thickening, hypoechoic dermis, increased Doppler flow in active plaques.
  • Atopic dermatitis: increased skin thickness and SLEB; useful for monitoring.
  • Morphea/systemic sclerosis: assesses dermal thickness and distinguishes active inflammatory disease from late fibrosis.
  • Lupus panniculitis and other panniculitides: evaluates depth and activity of inflammation.
  • Hidradenitis suppurativa: detects subclinical nodules, abscesses, fluid collections, and sinus tracts; useful for staging and treatment planning.
  • Cellulitis/abscess: differentiates diffuse inflammatory oedema from a drainable fluid collection.

3. Vascular lesions

  • Differentiates haemangioma, vascular malformation, and nonvascular masses.
  • Doppler assesses flow pattern, velocity, and vascularity.
  • Useful in planning treatment of haemangiomas and vascular malformations.

4. Hair and nail disorders

  • Assesses scalp thickness, follicles, perifollicular inflammation, and subcutaneous lesions.
  • Useful in evaluating nail-unit tumours, subungual exostosis, glomus tumour, cysts, and inflammatory nail disease.
  • Can detect nail-plate changes and increased vascularity in nail psoriasis.

5. Cosmetic and procedural dermatology

  • Determines depth and position of dermal fillers.
  • Detects filler-related nodules, granulomas, or vascular complications.
  • Assists in localization of foreign material and guides dissolution or intervention.
  • Evaluates skin thickness and subcutaneous fat in body-contouring procedures.

6. Procedure guidance

  • Guides aspiration/drainage of abscesses or cysts.
  • Helps choose an appropriate biopsy site in deep lesions.
  • Guides intralesional injections and localisation of foreign bodies.

Advantages

  • Non-invasive, painless, and radiation-free.
  • Portable and relatively inexpensive.
  • Real-time dynamic assessment.
  • Can be repeated for monitoring.
  • Shows lesion dimensions and depth before surgery.
  • Colour Doppler assesses vascularity and inflammatory activity.
  • Useful adjunct to clinical examination, dermoscopy, biopsy, and histopathology.

Limitations

  • Strongly operator-dependent.
  • High-frequency probes have limited penetration, hence are less useful for deep lesions.
  • Sonographic features may be nonspecific.
  • Cannot replace histopathology for definitive diagnosis of most tumours.
  • Air, thick crust, ulceration, calcification, and irregular surfaces can produce artefacts.
  • Limited standardisation of terminology, protocols, and diagnostic cut-offs.

Conclusion

HFUS with colour Doppler is a valuable adjunct in modern dermatology. It enables objective assessment of cutaneous lesion morphology, depth, vascularity, disease activity, and response to therapy. Its major roles are in skin tumours, hidradenitis suppurativa, inflammatory dermatoses, vascular lesions, nail disease, and cosmetic dermatology. It complements, but does not replace, clinical examination and histopathology.
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