mkdir -p /tmp/workspace/pneumonia-notes && ls /tmp/workspace/

cat << 'PYEOF' > /tmp/workspace/pneumonia-notes/generate_pdf.py from reportlab.lib.pagesizes import A4 from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle from reportlab.lib.units import cm from reportlab.lib import colors from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle, HRFlowable, ListFlowable, ListItem from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY doc = SimpleDocTemplate( "/tmp/workspace/pneumonia-notes/Pneumonia_Notes_10marks.pdf", pagesize=A4, rightMargin=2*cm, leftMargin=2*cm, topMargin=2*cm, bottomMargin=2*cm, title="Pneumonia - Simple Notes for 10 Marks", author="Robbins Pathology / Harsh Mohan Style" ) styles = getSampleStyleSheet() # Custom styles title_style = ParagraphStyle( 'TitleStyle', parent=styles['Title'], fontSize=20, textColor=colors.HexColor('#1a237e'), spaceAfter=6, fontName='Helvetica-Bold', alignment=TA_CENTER ) subtitle_style = ParagraphStyle( 'SubtitleStyle', parent=styles['Normal'], fontSize=10, textColor=colors.HexColor('#546e7a'), spaceAfter=4, fontName='Helvetica-Oblique', alignment=TA_CENTER ) h1_style = ParagraphStyle( 'H1Style', parent=styles['Heading1'], fontSize=13, textColor=colors.white, backColor=colors.HexColor('#1a237e'), spaceBefore=10, spaceAfter=4, fontName='Helvetica-Bold', leftIndent=-10, rightIndent=-10, borderPadding=(4, 8, 4, 8), ) h2_style = ParagraphStyle( 'H2Style', parent=styles['Heading2'], fontSize=11, textColor=colors.white, backColor=colors.HexColor('#283593'), spaceBefore=8, spaceAfter=3, fontName='Helvetica-Bold', borderPadding=(3, 6, 3, 6), ) h3_style = ParagraphStyle( 'H3Style', parent=styles['Heading3'], fontSize=10, textColor=colors.HexColor('#1a237e'), spaceBefore=6, spaceAfter=2, fontName='Helvetica-Bold', ) body_style = ParagraphStyle( 'BodyStyle', parent=styles['Normal'], fontSize=9.5, leading=14, spaceAfter=4, fontName='Helvetica', alignment=TA_JUSTIFY ) bullet_style = ParagraphStyle( 'BulletStyle', parent=styles['Normal'], fontSize=9.5, leading=13, spaceAfter=2, leftIndent=12, fontName='Helvetica', ) bold_bullet_style = ParagraphStyle( 'BoldBulletStyle', parent=styles['Normal'], fontSize=9.5, leading=13, spaceAfter=2, leftIndent=12, fontName='Helvetica-Bold', ) note_style = ParagraphStyle( 'NoteStyle', parent=styles['Normal'], fontSize=9, leading=12, backColor=colors.HexColor('#e8eaf6'), borderPadding=(4, 6, 4, 6), spaceAfter=6, fontName='Helvetica-Oblique', textColor=colors.HexColor('#1a237e') ) story = [] # ─── TITLE ──────────────────────────────────────────────────────────────────── story.append(Paragraph("PNEUMONIA", title_style)) story.append(Paragraph("Simple Notes for 10 Marks | Pathology (Harsh Mohan Style)", subtitle_style)) story.append(HRFlowable(width="100%", thickness=2, color=colors.HexColor('#1a237e'), spaceAfter=10)) # ─── DEFINITION ─────────────────────────────────────────────────────────────── story.append(Paragraph("1. DEFINITION", h1_style)) story.append(Spacer(1, 4)) story.append(Paragraph( "Pneumonia is defined as <b>any infection (inflammation) of the lung parenchyma</b>. " "It is a common and potentially serious condition, accounting for ~2.3% of all deaths in the United States.", body_style )) # ─── CLASSIFICATION ──────────────────────────────────────────────────────────── story.append(Paragraph("2. CLASSIFICATION", h1_style)) story.append(Spacer(1, 4)) # Table of classification class_data = [ [Paragraph('<b>Type</b>', bold_bullet_style), Paragraph('<b>Key Features</b>', bold_bullet_style)], [Paragraph('Community-Acquired Pneumonia (CAP)', bullet_style), Paragraph('Acquired from environment in healthy individuals', bullet_style)], [Paragraph('Hospital-Acquired (Nosocomial) Pneumonia', bullet_style), Paragraph('Acquired during hospital stay (>48 hrs after admission)', bullet_style)], [Paragraph('Healthcare-Associated Pneumonia', bullet_style), Paragraph('Recent hosp., nursing home, IV antibiotics within 90 days', bullet_style)], [Paragraph('Aspiration Pneumonia', bullet_style), Paragraph('Aspiration of gastric/oropharyngeal contents', bullet_style)], [Paragraph('Lobar Pneumonia', bullet_style), Paragraph('Consolidation of entire lobe (usually pneumococcal)', bullet_style)], [Paragraph('Bronchopneumonia (Lobular)', bullet_style), Paragraph('Patchy consolidation; multilobar, bilateral, basal', bullet_style)], [Paragraph('Atypical (Viral) Pneumonia', bullet_style), Paragraph('Interstitial pattern; Mycoplasma, viruses', bullet_style)], ] class_table = Table(class_data, colWidths=[8*cm, 9*cm]) class_table.setStyle(TableStyle([ ('BACKGROUND', (0, 0), (-1, 0), colors.HexColor('#1a237e')), ('TEXTCOLOR', (0, 0), (-1, 0), colors.white), ('FONTNAME', (0, 0), (-1, 0), 'Helvetica-Bold'), ('ROWBACKGROUNDS', (0, 1), (-1, -1), [colors.HexColor('#e8eaf6'), colors.white]), ('GRID', (0, 0), (-1, -1), 0.5, colors.HexColor('#9fa8da')), ('VALIGN', (0, 0), (-1, -1), 'MIDDLE'), ('TOPPADDING', (0, 0), (-1, -1), 4), ('BOTTOMPADDING', (0, 0), (-1, -1), 4), ])) story.append(class_table) # ─── ETIOLOGY ───────────────────────────────────────────────────────────────── story.append(Paragraph("3. ETIOLOGY / CAUSATIVE ORGANISMS", h1_style)) story.append(Spacer(1, 4)) etio_data = [ [Paragraph('<b>Type</b>', bold_bullet_style), Paragraph('<b>Common Organisms</b>', bold_bullet_style)], [Paragraph('CAP - Bacterial', bullet_style), Paragraph('<b>Streptococcus pneumoniae</b> (MC), H. influenzae, M. catarrhalis, S. aureus, Klebsiella pneumoniae', bullet_style)], [Paragraph('CAP - Atypical', bullet_style), Paragraph('Mycoplasma pneumoniae (children/young adults), Legionella pneumophila, Chlamydia', bullet_style)], [Paragraph('CAP - Viral', bullet_style), Paragraph('Influenza A & B, RSV, Metapneumovirus, Adenovirus, COVID-19', bullet_style)], [Paragraph('Hospital-Acquired', bullet_style), Paragraph('S. aureus (MRSA), Pseudomonas aeruginosa, Enterobacteriaceae', bullet_style)], [Paragraph('Special cases', bullet_style), Paragraph('Klebsiella - chronic alcoholics; Pseudomonas - cystic fibrosis, neutropenia; Legionella - transplant, comorbidities', bullet_style)], ] etio_table = Table(etio_data, colWidths=[5*cm, 12*cm]) etio_table.setStyle(TableStyle([ ('BACKGROUND', (0, 0), (-1, 0), colors.HexColor('#1a237e')), ('TEXTCOLOR', (0, 0), (-1, 0), colors.white), ('FONTNAME', (0, 0), (-1, 0), 'Helvetica-Bold'), ('ROWBACKGROUNDS', (0, 1), (-1, -1), [colors.HexColor('#e8eaf6'), colors.white]), ('GRID', (0, 0), (-1, -1), 0.5, colors.HexColor('#9fa8da')), ('VALIGN', (0, 0), (-1, -1), 'MIDDLE'), ('TOPPADDING', (0, 0), (-1, -1), 4), ('BOTTOMPADDING', (0, 0), (-1, -1), 4), ])) story.append(etio_table) # ─── PATHOGENESIS ───────────────────────────────────────────────────────────── story.append(Paragraph("4. PATHOGENESIS", h1_style)) story.append(Spacer(1, 4)) story.append(Paragraph("<b>Defense mechanisms impaired in pneumonia:</b>", h3_style)) defenses = [ "Loss/suppression of cough reflex (coma, anesthesia, drugs, neuromuscular disorders)", "Dysfunction of mucociliary apparatus (cigarette smoke, viral infection, immotile cilia syndrome)", "Accumulation of secretions (cystic fibrosis, bronchial obstruction)", "Impaired macrophage function (alcohol, tobacco, anoxia, O2 intoxication)", "Pulmonary congestion and edema", "Defects in innate immunity (neutrophil/complement defects) - leads to pyogenic bacterial infections", "Cell-mediated immune defects - leads to intracellular microbes (mycobacteria, P. jirovecii)", ] for item in defenses: story.append(Paragraph(f"• {item}", bullet_style)) story.append(Spacer(1, 4)) story.append(Paragraph( "<b>Important note:</b> Most bacterial pneumonias enter via respiratory tract. " "Hematogenous spread from another organ may also occur. " "Viral pneumonia predisposes to secondary bacterial superinfection ('flu condemns, and additional infection executes').", note_style )) # ─── MORPHOLOGY ─────────────────────────────────────────────────────────────── story.append(Paragraph("5. MORPHOLOGY", h1_style)) story.append(Spacer(1, 4)) story.append(Paragraph("A. LOBAR PNEUMONIA - 4 CLASSICAL STAGES", h2_style)) story.append(Spacer(1, 4)) # 4 stages table stages_data = [ [Paragraph('<b>Stage</b>', bold_bullet_style), Paragraph('<b>Gross Appearance</b>', bold_bullet_style), Paragraph('<b>Microscopic Features</b>', bold_bullet_style)], [ Paragraph('<b>Stage 1:\nCongestion</b>', bold_bullet_style), Paragraph('Lung: heavy, boggy, red', bullet_style), Paragraph('Vascular engorgement, intraalveolar edema fluid, few neutrophils; bacteria present', bullet_style) ], [ Paragraph('<b>Stage 2:\nRed Hepatization</b>', bold_bullet_style), Paragraph('Lobe: red, firm, airless, liver-like consistency', bullet_style), Paragraph('Massive confluent exudation; alveolar spaces filled with neutrophils, red cells, and fibrin', bullet_style) ], [ Paragraph('<b>Stage 3:\nGray Hepatization</b>', bold_bullet_style), Paragraph('Lobe: grayish-brown color', bullet_style), Paragraph('Progressive disintegration of red cells; fibrinopurulent exudate persists', bullet_style) ], [ Paragraph('<b>Stage 4:\nResolution</b>', bold_bullet_style), Paragraph('Lung: returns to normal (if no complications)', bullet_style), Paragraph('Enzymatic digestion of exudate → granular semifluid debris → resorbed/expectorated/phagocytosed by macrophages', bullet_style) ], ] stages_table = Table(stages_data, colWidths=[4*cm, 5.5*cm, 7.5*cm]) stages_table.setStyle(TableStyle([ ('BACKGROUND', (0, 0), (-1, 0), colors.HexColor('#283593')), ('TEXTCOLOR', (0, 0), (-1, 0), colors.white), ('FONTNAME', (0, 0), (-1, 0), 'Helvetica-Bold'), ('ROWBACKGROUNDS', (0, 1), (-1, -1), [colors.HexColor('#e3f2fd'), colors.white]), ('GRID', (0, 0), (-1, -1), 0.5, colors.HexColor('#90caf9')), ('VALIGN', (0, 0), (-1, -1), 'MIDDLE'), ('TOPPADDING', (0, 0), (-1, -1), 5), ('BOTTOMPADDING', (0, 0), (-1, -1), 5), ])) story.append(stages_table) story.append(Spacer(1, 6)) story.append(Paragraph("B. BRONCHOPNEUMONIA (Lobular Pneumonia)", h2_style)) story.append(Spacer(1, 4)) broncho_points = [ "Patchy consolidation; multilobar, bilateral, basal distribution (secretions gravitate to lower lobes)", "Gross: slightly elevated, dry, granular, gray-red to yellow lesions; poorly delimited margins", "Histology: neutrophil-rich exudate fills bronchi, bronchioles, and adjacent alveolar spaces", "May become confluent → mimics lobar consolidation", ] for p in broncho_points: story.append(Paragraph(f"• {p}", bullet_style)) story.append(Spacer(1, 4)) story.append(Paragraph("C. VIRAL / ATYPICAL PNEUMONIA", h2_style)) story.append(Spacer(1, 4)) viral_points = [ "Interstitial (not intraalveolar) pattern of inflammation", "Edema and inflammatory infiltrates in alveolar walls (lymphocytes, not neutrophils)", "Alveolar spaces relatively free of exudate", "Hyaline membrane formation in severe cases (similar to ARDS)", "Superimposed bacterial infection may cause ulcerative bronchitis and bacterial pneumonia", ] for p in viral_points: story.append(Paragraph(f"• {p}", bullet_style)) # ─── CLINICAL FEATURES ──────────────────────────────────────────────────────── story.append(Paragraph("6. CLINICAL FEATURES", h1_style)) story.append(Spacer(1, 4)) cf_data = [ [Paragraph('<b>Feature</b>', bold_bullet_style), Paragraph('<b>Bacterial Pneumonia</b>', bold_bullet_style), Paragraph('<b>Viral/Atypical Pneumonia</b>', bold_bullet_style)], [Paragraph('Onset', bullet_style), Paragraph('Abrupt, sudden', bullet_style), Paragraph('Gradual, insidious', bullet_style)], [Paragraph('Fever', bullet_style), Paragraph('High fever, shaking chills', bullet_style), Paragraph('Low-grade fever, headache, myalgia', bullet_style)], [Paragraph('Cough', bullet_style), Paragraph('Productive (mucopurulent/blood-tinged)', bullet_style), Paragraph('Dry/non-productive', bullet_style)], [Paragraph('Chest pain', bullet_style), Paragraph('Pleuritic pain, pleural friction rub', bullet_style), Paragraph('Usually absent', bullet_style)], [Paragraph('X-ray', bullet_style), Paragraph('Lobar: whole lobe opaque; Bronchopneumonia: focal opacities', bullet_style), Paragraph('Bilateral interstitial infiltrates', bullet_style)], [Paragraph('Sputum', bullet_style), Paragraph('Rusty sputum (pneumococcal); currant jelly (Klebsiella)', bullet_style), Paragraph('Scanty or absent', bullet_style)], ] cf_table = Table(cf_data, colWidths=[4*cm, 6*cm, 7*cm]) cf_table.setStyle(TableStyle([ ('BACKGROUND', (0, 0), (-1, 0), colors.HexColor('#1a237e')), ('TEXTCOLOR', (0, 0), (-1, 0), colors.white), ('FONTNAME', (0, 0), (-1, 0), 'Helvetica-Bold'), ('ROWBACKGROUNDS', (0, 1), (-1, -1), [colors.HexColor('#e8eaf6'), colors.white]), ('GRID', (0, 0), (-1, -1), 0.5, colors.HexColor('#9fa8da')), ('VALIGN', (0, 0), (-1, -1), 'MIDDLE'), ('TOPPADDING', (0, 0), (-1, -1), 4), ('BOTTOMPADDING', (0, 0), (-1, -1), 4), ])) story.append(cf_table) # ─── COMPLICATIONS ──────────────────────────────────────────────────────────── story.append(Paragraph("7. COMPLICATIONS", h1_style)) story.append(Spacer(1, 4)) comp_data = [ ["1.", "Lung abscess", "Tissue destruction/necrosis (especially pneumococcal, Klebsiella)"], ["2.", "Empyema", "Spread to pleural cavity → fibrinopurulent pleuritis"], ["3.", "Bacteremic dissemination", "Endocarditis, meningitis, pericarditis, suppurative arthritis, renal/splenic abscesses"], ["4.", "Organization of exudate", "Fibrous thickening, pleural adhesions"], ["5.", "Septicemia", "Especially with Pseudomonas - fulminant disease"], ] for row in comp_data: story.append(Paragraph(f"<b>{row[0]}. {row[1]}:</b> {row[2]}", bullet_style)) # ─── SPECIAL TYPES ──────────────────────────────────────────────────────────── story.append(Paragraph("8. SPECIAL TYPES OF PNEUMONIA", h1_style)) story.append(Spacer(1, 4)) story.append(Paragraph("<b>Aspiration Pneumonia:</b>", h3_style)) asp_pts = [ "Occurs in debilitated patients, stroke, vomiting, impaired gag reflex", "Mixed chemical (gastric acid) + bacterial (oral flora) etiology", "Often necrotizing; fulminant clinical course", "Complication: Lung abscess (common)", "Organisms: Aerobes more common than anaerobes; often polymicrobial", ] for p in asp_pts: story.append(Paragraph(f"• {p}", bullet_style)) story.append(Spacer(1, 4)) story.append(Paragraph("<b>Klebsiella Pneumonia:</b>", h3_style)) story.append(Paragraph("• Chronic alcoholics, malnourished; thick mucoid blood-tinged ('currant jelly') sputum", bullet_style)) story.append(Spacer(1, 4)) story.append(Paragraph("<b>Legionella Pneumonia (Legionnaires' Disease):</b>", h3_style)) leg_pts = [ "Organism flourishes in water-cooling towers, potable water (aerosolized)", "Common in cardiac, renal, immunologic, hematologic disease; organ transplants", "Fatality up to 50% in immunosuppressed", "Diagnosis: Urine Legionella antigen, PCR sputum, culture (gold standard, 3-5 days)", ] for p in leg_pts: story.append(Paragraph(f"• {p}", bullet_style)) story.append(Spacer(1, 4)) story.append(Paragraph("<b>Mycoplasma Pneumonia (Atypical/Walking Pneumonia):</b>", h3_style)) story.append(Paragraph("• Children and young adults; sporadic or epidemics in closed communities (schools, military, prisons)", bullet_style)) story.append(Paragraph("• Mild symptoms; dry cough; bilateral interstitial infiltrates on X-ray", bullet_style)) # ─── QUICK REVISION BOX ─────────────────────────────────────────────────────── story.append(Spacer(1, 6)) story.append(HRFlowable(width="100%", thickness=1.5, color=colors.HexColor('#1a237e'), spaceAfter=4)) story.append(Paragraph("QUICK REVISION: HIGH-YIELD MNEMONICS", h2_style)) story.append(Spacer(1, 4)) mnemonics = [ ("<b>MC cause of CAP:</b>", "Streptococcus pneumoniae (pneumococcus)"), ("<b>4 stages of lobar pneumonia:</b>", "Congestion → Red Hepatization → Gray Hepatization → Resolution"), ("<b>Klebsiella:</b>", "Chronic alcoholics + currant jelly sputum"), ("<b>Pseudomonas:</b>", "Cystic fibrosis + neutropenia + nosocomial"), ("<b>Mycoplasma:</b>", "Young adults + closed communities + atypical/walking pneumonia"), ("<b>Legionella:</b>", "Water cooling towers + urine antigen test"), ("<b>Complications mnemonic SEAL:</b>", "Suppurative arthritis, Empyema, Abscess (lung), Leptomeningitis (meningitis)"), ("<b>Aspiration pneumonia:</b>", "Debilitated/unconscious patients + necrotizing + lung abscess"), ("<b>Hospital-acquired:</b>", "S. aureus (MRSA) + Gram-negative rods (Pseudomonas, Enterobacteriaceae)"), ("<b>Viral pneumonia:</b>", "Interstitial pattern; predisposes to secondary bacterial infection"), ] for label, val in mnemonics: story.append(Paragraph(f"{label} {val}", bullet_style)) story.append(Spacer(1, 6)) story.append(Paragraph( "Source: Robbins, Cotran & Kumar - Pathologic Basis of Disease (10th Ed.) | Prepared in Harsh Mohan style", subtitle_style )) doc.build(story) print("PDF generated successfully!") PYEOF python3 /tmp/workspace/pneumonia-notes/generate_pdf.py