Connective Tissue - Short Notes

const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Connective Tissue - Short Notes";
pres.author = "Orris Medical";

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// ══════════════════════════════════════════════════════════════
// SLIDE 1: TITLE
// ══════════════════════════════════════════════════════════════
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  s.addText("Connective Tissue", { x: 1.5, y: 1.2, w: 8, h: 1.0, fontSize: 46, bold: true, color: C.white, fontFace: "Calibri", charSpacing: 1 });
  s.addText("Types  •  Classification  •  Cells  •  ECM  •  Functions", { x: 1.5, y: 2.4, w: 8, h: 0.6, fontSize: 18, color: C.light, fontFace: "Calibri", italic: true });
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  s.addText("Histology Short Notes", { x: 1.5, y: 3.3, w: 7, h: 0.5, fontSize: 14, color: C.grey, fontFace: "Calibri", align: "left" });
  s.addText("Based on Junqueira's Basic Histology & Pawlina's Histology Atlas", { x: 1.5, y: 3.75, w: 7, h: 0.4, fontSize: 11, color: C.grey, fontFace: "Calibri", italic: true });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 2: OVERVIEW – What is Connective Tissue?
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "What is Connective Tissue?");

  // left text block
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  s.addText([
    { text: "Definition", options: { bold: true, color: C.teal, breakLine: true, fontSize: 16 } },
    { text: "CT cells are widely separated, with intercellular spaces filled by ECM. The ECM — not the cells — defines CT identity.", options: { color: C.dark, fontSize: 13, breakLine: true } },
    { text: " ", options: { breakLine: true } },
    { text: "Origin", options: { bold: true, color: C.teal, breakLine: true, fontSize: 16 } },
    { text: "Nearly all CT derives from Mesoderm via Mesenchyme.\nException: Head CT from Neural Crest Cells (ectoderm).", options: { color: C.dark, fontSize: 13, breakLine: true } },
    { text: " ", options: { breakLine: true } },
    { text: "Key Concept", options: { bold: true, color: C.teal, breakLine: true, fontSize: 16 } },
    { text: "Classification is based on:\n• ECM composition & organization\n• Cell types present\n• Function of the tissue", options: { color: C.dark, fontSize: 13 } },
  ], { x: 0.45, y: 1.0, w: 4.1, h: 4.1, fontFace: "Calibri", valign: "top" });

  // right: 4-function diagram (quadrant boxes)
  const funcs = [
    { label: "Physical Support", icon: "🔩", color: C.teal },
    { label: "Immunity & Defense", icon: "🛡️", color: C.accent },
    { label: "Nutrient Diffusion", icon: "💧", color: C.green },
    { label: "Wound Repair", icon: "🩹", color: C.gold },
  ];
  s.addText("Core Functions", { x: 5.0, y: 0.85, w: 4.6, h: 0.4, fontSize: 15, bold: true, color: C.teal, fontFace: "Calibri", align: "center" });
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  // bottom note
  s.addText("CT forms the supportive STROMA of organs, surrounding the functional PARENCHYMA", {
    x: 0.25, y: 5.1, w: 9.5, h: 0.38, fontSize: 11, color: C.grey, italic: true, fontFace: "Calibri", align: "center"
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 3: CLASSIFICATION OVERVIEW (tree diagram)
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Classification of Connective Tissue");

  // Root node
  card(s, 3.5, 0.88, 3.0, 0.65, C.navy);
  s.addText("CONNECTIVE TISSUE", { x: 3.5, y: 0.88, w: 3.0, h: 0.65, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });

  // 3 main branches
  const branches = [
    { label: "Embryonic CT", color: C.purple, x: 0.3, bx: 0.3, by: 2.1 },
    { label: "CT Proper", color: C.teal, x: 3.5, bx: 3.5, by: 2.1 },
    { label: "Specialized CT", color: C.accent, x: 6.7, bx: 6.7, by: 2.1 },
  ];

  // vertical stem
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    // vertical lines from bar to branch
    s.addShape(pres.shapes.RECTANGLE, { x: b.bx + 1.47, y: 2.09, w: 0.02, h: 0.02, fill: { color: C.grey }, line: { color: C.grey } });
  });

  // Sub-types under Embryonic
  const eSubs = ["Mesenchyme", "Mucous CT\n(Wharton's Jelly)"];
  eSubs.forEach((t, i) => {
    card(s, 0.15 + i * 1.55, 3.05, 1.4, 0.7, C.softBg);
    s.addText(t, { x: 0.15 + i * 1.55, y: 3.05, w: 1.4, h: 0.7, fontSize: 10, color: C.purple, fontFace: "Calibri", align: "center", valign: "middle", bold: true });
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  s.addShape(pres.shapes.RECTANGLE, { x: 0.84, y: 2.71, w: 0.02, h: 0.34, fill: { color: C.purple }, line: { color: C.purple } });
  s.addShape(pres.shapes.RECTANGLE, { x: 0.84, y: 3.04, w: 2.41, h: 0.02, fill: { color: C.purple }, line: { color: C.purple } });

  // Sub-types under CT Proper
  const pSubs = ["Loose\n(Areolar)", "Dense\nIrregular", "Dense\nRegular"];
  pSubs.forEach((t, i) => {
    card(s, 3.15 + i * 1.15, 3.05, 1.05, 0.7, C.softBg);
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  // Sub-types under Specialized
  const sSubs = ["Cartilage", "Bone", "Blood", "Adipose", "Reticular"];
  sSubs.forEach((t, i) => {
    const col = i % 2 === 0 ? C.softBg : C.offW;
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}

// ══════════════════════════════════════════════════════════════
// SLIDE 4: EMBRYONIC CT
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Embryonic Connective Tissue");

  // left: Mesenchyme
  card(s, 0.25, 0.9, 4.55, 4.35, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.25, y: 0.9, w: 4.55, h: 0.42, fill: { color: C.purple }, line: { color: C.purple }, rectRadius: 0.08 });
  s.addText("🔬  Mesenchyme", { x: 0.35, y: 0.9, w: 4.35, h: 0.42, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
  s.addText([
    { text: "Origin: ", options: { bold: true, color: C.purple } },
    { text: "Mesoderm (+ Neural Crest in head)\n", options: { color: C.dark } },
    { text: "Cells: ", options: { bold: true, color: C.purple } },
    { text: "Small spindle-shaped, uniform; linked by gap junctions; form 3D network\n", options: { color: C.dark } },
    { text: "Matrix: ", options: { bold: true, color: C.purple } },
    { text: "Viscous ground substance; sparse fine collagen & reticular fibers\n", options: { color: C.dark } },
    { text: "Location: ", options: { bold: true, color: C.purple } },
    { text: "Early embryo (mesodermal layer)\n", options: { color: C.dark } },
    { text: "Significance: ", options: { bold: true, color: C.purple } },
    { text: "Stem/progenitor cells → ALL adult CT types, muscle, vascular & urogenital systems", options: { color: C.dark } },
  ], { x: 0.4, y: 1.38, w: 4.2, h: 3.7, fontSize: 12, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.3 });

  // right: Mucous CT
  card(s, 5.05, 0.9, 4.55, 4.35, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.05, y: 0.9, w: 4.55, h: 0.42, fill: { color: C.tealL }, line: { color: C.tealL }, rectRadius: 0.08 });
  s.addText("💧  Mucous (Mucoid) CT", { x: 5.15, y: 0.9, w: 4.35, h: 0.42, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
  s.addText([
    { text: "Also called: ", options: { bold: true, color: C.teal } },
    { text: "Mucoid CT / Wharton's Jelly\n", options: { color: C.dark } },
    { text: "Cells: ", options: { bold: true, color: C.teal } },
    { text: "Large fibroblasts, randomly arranged\n", options: { color: C.dark } },
    { text: "Matrix: ", options: { bold: true, color: C.teal } },
    { text: "Very loose ECM; highly viscous; rich in hyaluronan; wisps of sparse collagen\n", options: { color: C.dark } },
    { text: "Location: ", options: { bold: true, color: C.teal } },
    { text: "Fetal umbilical cord\n", options: { color: C.dark } },
    { text: "Function: ", options: { bold: true, color: C.teal } },
    { text: "Supports and cushions umbilical blood vessels; protects from compression", options: { color: C.dark } },
  ], { x: 5.2, y: 1.38, w: 4.2, h: 3.7, fontSize: 12, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.3 });

  // note at bottom
  s.addText("Both types are transient — mesenchyme gives rise to all adult connective tissues", {
    x: 0.5, y: 5.18, w: 9.0, h: 0.3, fontSize: 11, italic: true, color: C.grey, fontFace: "Calibri", align: "center"
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 5: CT PROPER (with comparison diagram)
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Connective Tissue Proper");

  const types = [
    {
      title: "Loose (Areolar) CT",
      color: C.green,
      icon: "🌱",
      points: [
        "Many cell types (fibroblasts, macrophages, mast cells, plasma cells)",
        "Loosely arranged collagen + elastic fibers",
        "Abundant ground substance",
        "Supports microvasculature & nerves",
        "Acts as immune defense frontier",
        "Location: Lamina propria of GI tract, beneath epithelia, around blood vessels",
      ]
    },
    {
      title: "Dense Irregular CT",
      color: C.gold,
      icon: "🔀",
      points: [
        "Mostly fibroblasts; few other cells",
        "Thick collagen fibers in RANDOM arrangement",
        "Little ground substance",
        "Resists forces from multiple directions",
        "Location: Dermis, organ capsules (kidney, liver, spleen), submucosa of GI tract",
      ]
    },
    {
      title: "Dense Regular CT",
      color: C.teal,
      icon: "➡️",
      points: [
        "Almost entirely parallel collagen bundles",
        "Aligned fibroblasts (tendinocytes)",
        "Minimal ground substance",
        "Resists strong forces in ONE direction",
        "Location: Tendons, ligaments, aponeuroses, corneal stroma",
      ]
    },
  ];

  types.forEach((t, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 0.9, 3.1, 4.55, C.white);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 0.9, w: 3.1, h: 0.45, fill: { color: t.color }, line: { color: t.color } });
    s.addText(`${t.icon}  ${t.title}`, { x: x + 0.1, y: 0.9, w: 2.9, h: 0.45, fontSize: 12, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
    const bullets = t.points.map((p, j) => ({
      text: p,
      options: { bullet: { code: "25CF", color: t.color }, color: C.dark, fontSize: 11, breakLine: j < t.points.length - 1, paraSpaceAfter: 4 }
    }));
    s.addText(bullets, { x: x + 0.15, y: 1.42, w: 2.8, h: 3.9, fontFace: "Calibri", valign: "top" });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 6: SPECIALIZED CT
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Specialized Connective Tissue");

  const scts = [
    { name: "Cartilage", color: C.teal,   icon: "🦴", feature: "Large water-rich matrix\n(hyaluronan aggregates)", cell: "Chondrocyte", func: "Structural support; low-friction surfaces" },
    { name: "Bone",      color: C.accent,  icon: "🦷", feature: "Mineralized matrix\n(Ca²⁺ + phosphate + collagen)", cell: "Osteocyte", func: "Rigid support; mineral reservoir" },
    { name: "Blood",     color: C.purple,  icon: "🩸", feature: "Fluid ECM = Plasma\n(protein-rich)", cell: "RBC, WBC, Platelets", func: "O₂ transport; immunity; homeostasis" },
    { name: "Adipose",   color: C.gold,    icon: "🔵", feature: "Cells dominate (not ECM)\nLipid droplets inside adipocytes", cell: "Adipocyte", func: "Energy storage; hormone secretion" },
    { name: "Reticular", color: C.green,   icon: "🕸️", feature: "Delicate collagen III\n(reticulin) 3D network", cell: "Reticular cell", func: "Stroma of bone marrow, liver, lymph nodes" },
  ];

  scts.forEach((t, i) => {
    const row = Math.floor(i / 3);
    const col = i % 3;
    const x = 0.2 + col * 3.27;
    const y = 0.92 + row * 2.35;
    const w = i >= 3 ? 4.65 : 3.1;
    const xAdj = i === 3 ? 0.55 : (i === 4 ? 5.25 : x);
    card(s, xAdj, y, w, 2.1, C.white);
    // header
    s.addShape(pres.shapes.RECTANGLE, { x: xAdj, y, w, h: 0.4, fill: { color: t.color }, line: { color: t.color } });
    s.addText(`${t.icon}  ${t.name}`, { x: xAdj + 0.1, y, w: w - 0.2, h: 0.4, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
    s.addText([
      { text: "Key Feature: ", options: { bold: true, color: t.color } },
      { text: t.feature + "\n", options: { color: C.dark } },
      { text: "Cell: ", options: { bold: true, color: t.color } },
      { text: t.cell + "\n", options: { color: C.dark } },
      { text: "Function: ", options: { bold: true, color: t.color } },
      { text: t.func, options: { color: C.dark } },
    ], { x: xAdj + 0.15, y: y + 0.45, w: w - 0.3, h: 1.55, fontSize: 11, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.3 });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 7: CELLS OF CONNECTIVE TISSUE
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Cells of Connective Tissue");

  // Two-column: Resident vs Wandering
  // Left: Resident cells header
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.2, y: 0.9, w: 4.55, h: 0.42, fill: { color: C.teal }, line: { color: C.teal }, rectRadius: 0.05 });
  s.addText("🏠  RESIDENT (Fixed) Cells", { x: 0.3, y: 0.9, w: 4.35, h: 0.42, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });

  const residentCells = [
    { name: "Fibroblast / Fibrocyte", color: C.teal, desc: "Major CT cell. Synthesizes & maintains ECM (collagen, elastic fibers, ground substance). Fibroblast = active; Fibrocyte = inactive." },
    { name: "Adipocyte", color: C.gold, desc: "Stores triglycerides in intracellular lipid droplets. Secretes hormones (leptin, adiponectin) regulating energy homeostasis." },
    { name: "Mast Cell", color: C.accent, desc: "Bone marrow precursor. Granules: histamine, heparin, leukotrienes. Mediates allergy & inflammatory reactions." },
    { name: "Reticular Cell", color: C.green, desc: "Produces collagen III (reticulin) fibers. Forms 3D stroma scaffold of lymphoid organs." },
  ];

  residentCells.forEach((c, i) => {
    card(s, 0.2, 1.38 + i * 1.0, 4.55, 0.88, C.white);
    s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.38 + i * 1.0, w: 0.14, h: 0.88, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.name, { x: 0.4, y: 1.38 + i * 1.0, w: 4.2, h: 0.33, fontSize: 12, bold: true, color: c.color, fontFace: "Calibri", valign: "middle" });
    s.addText(c.desc, { x: 0.4, y: 1.71 + i * 1.0, w: 4.2, h: 0.55, fontSize: 10.5, color: C.dark, fontFace: "Calibri", valign: "top" });
  });

  // Right: Wandering cells header
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 5.05, y: 0.9, w: 4.7, h: 0.42, fill: { color: C.accent }, line: { color: C.accent }, rectRadius: 0.05 });
  s.addText("🚶  WANDERING (Transient) Cells", { x: 5.15, y: 0.9, w: 4.5, h: 0.42, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });

  const wandCells = [
    { name: "Macrophage", color: C.purple, desc: "From blood monocytes. Phagocytosis of pathogens/debris. ECM turnover. Antigen presentation to lymphocytes." },
    { name: "Plasma Cell", color: C.tealL, desc: "From B lymphocytes. Short-lived. Secretes specific antibodies (immunoglobulins). Abundant RER (clock-face nucleus)." },
    { name: "Neutrophil", color: C.gold, desc: "First-line defense. Phagocytosis of bacteria. Arrive early in acute inflammation. Multi-lobed nucleus." },
    { name: "Eosinophil", color: C.green, desc: "Anti-parasitic. Modulates allergic reactions. Contains large eosinophilic granules. Bi-lobed nucleus." },
    { name: "Lymphocyte", color: C.accent, desc: "Immune surveillance. T cells (cell-mediated) & B cells (humoral immunity). Small, round nucleus." },
  ];

  wandCells.forEach((c, i) => {
    card(s, 5.05, 1.38 + i * 0.82, 4.7, 0.72, C.white);
    s.addShape(pres.shapes.RECTANGLE, { x: 5.05, y: 1.38 + i * 0.82, w: 0.14, h: 0.72, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.name, { x: 5.25, y: 1.38 + i * 0.82, w: 4.35, h: 0.28, fontSize: 11.5, bold: true, color: c.color, fontFace: "Calibri", valign: "middle" });
    s.addText(c.desc, { x: 5.25, y: 1.66 + i * 0.82, w: 4.35, h: 0.44, fontSize: 10.5, color: C.dark, fontFace: "Calibri", valign: "top" });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 8: FIBROBLAST & ECM SYNTHESIS (process diagram)
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "ECM Synthesis: Collagen Production by Fibroblast");

  const steps = [
    { label: "1. Transcription\n& Translation", sub: "Fibroblast nucleus\n→ mRNA → Ribosomes", color: C.teal },
    { label: "2. Hydroxylation\nin RER", sub: "Pro + Lys hydroxylated\n(needs Vit C)", color: C.tealL },
    { label: "3. Procollagen\nTriple Helix", sub: "3 α-chains form\nright-handed helix", color: C.purple },
    { label: "4. Secretion\n(Exocytosis)", sub: "Golgi → secretory\nvesicles", color: C.gold },
    { label: "5. Cleavage\nof Ends", sub: "Procollagen peptidases\nremove N & C ends", color: C.accent },
    { label: "6. Collagen\nFibril Assembly", sub: "Molecules aggregate;\ncross-linked by Lys/Hylys", color: C.green },
  ];

  steps.forEach((st, i) => {
    const x = 0.2 + (i % 3) * 3.27;
    const y = i < 3 ? 1.0 : 3.05;
    card(s, x, y, 3.0, 1.78, C.white);
    s.addShape(pres.shapes.ELLIPSE, { x: x + 1.1, y: y + 0.1, w: 0.8, h: 0.55, fill: { color: st.color }, line: { color: st.color } });
    s.addText(`${i + 1}`, { x: x + 1.1, y: y + 0.1, w: 0.8, h: 0.55, fontSize: 18, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
    s.addText(st.label, { x: x + 0.1, y: y + 0.68, w: 2.8, h: 0.55, fontSize: 12, bold: true, color: st.color, fontFace: "Calibri", align: "center" });
    s.addText(st.sub, { x: x + 0.1, y: y + 1.2, w: 2.8, h: 0.5, fontSize: 10, color: C.dark, fontFace: "Calibri", align: "center" });
    // arrow right (within row)
    if (i % 3 < 2) {
      arrowRight(s, x + 3.05, y + 0.74);
    }
  });
  // arrow down between rows
  s.addShape(pres.shapes.DOWN_ARROW, { x: 4.7, y: 2.78, w: 0.6, h: 0.28, fill: { color: C.teal }, line: { color: C.teal } });

  s.addText("Final result: Collagen fibrils with characteristic 68 nm banding pattern → bundled into collagen fibers", {
    x: 0.3, y: 5.15, w: 9.4, h: 0.3, fontSize: 11, color: C.grey, italic: true, fontFace: "Calibri", align: "center"
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 9: COLLAGEN TYPES
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Collagen Types – Key Fibers of ECM");

  // Left: collagen hierarchy diagram
  s.addText("Structural Hierarchy", { x: 0.3, y: 0.9, w: 3.2, h: 0.38, fontSize: 13, bold: true, color: C.teal, fontFace: "Calibri", align: "center" });
  const hierarchy = [
    { label: "Triple Helix\n(tropocollagen)\n300 nm × 1.5 nm", color: C.teal, y: 1.35 },
    { label: "Collagen\nFibril\n(cross-linked)", color: C.tealL, y: 2.35 },
    { label: "Collagen\nFiber", color: C.purple, y: 3.35 },
    { label: "Collagen\nBundle", color: C.navy, y: 4.25 },
  ];
  hierarchy.forEach((h, i) => {
    const hw = 2.8 - i * 0.3;
    const hx = 0.3 + (i * 0.15);
    card(s, hx, h.y, hw, 0.78, C.white);
    s.addShape(pres.shapes.RECTANGLE, { x: hx, y: h.y, w: hw, h: 0.18, fill: { color: h.color }, line: { color: h.color } });
    s.addText(h.label, { x: hx, y: h.y + 0.2, w: hw, h: 0.52, fontSize: 10.5, color: h.color, bold: true, fontFace: "Calibri", align: "center", valign: "middle" });
    if (i < hierarchy.length - 1) {
      s.addShape(pres.shapes.DOWN_ARROW, { x: hx + hw / 2 - 0.15, y: h.y + 0.78, w: 0.3, h: 0.2, fill: { color: h.color }, line: { color: h.color } });
    }
  });
  s.addText("68 nm banding\nvisible on EM", { x: 0.35, y: 2.08, w: 1.5, h: 0.35, fontSize: 9, color: C.grey, italic: true, fontFace: "Calibri" });

  // Right: collagen types table
  s.addText("Key Collagen Types", { x: 3.6, y: 0.9, w: 6.1, h: 0.38, fontSize: 13, bold: true, color: C.teal, fontFace: "Calibri", align: "center" });

  const colTypes = [
    { type: "Type I",   loc: "Skin, bone, tendons, ligaments", note: "Most abundant; forms thick fibers" },
    { type: "Type II",  loc: "Cartilage", note: "Fine fibrils; high tensile strength in matrix" },
    { type: "Type III", loc: "Reticular fibers (lymph nodes, liver, BM)", note: "Collagen III = reticulin; stains with silver" },
    { type: "Type IV",  loc: "Basement membranes", note: "Does NOT form fibrils; forms sheets" },
    { type: "Type VII", loc: "Dermo-epidermal junction", note: "Anchoring fibrils; lost in Epidermolysis bullosa" },
  ];
  const rowColors = [C.softBg, C.white, C.softBg, C.white, C.softBg];
  // header
  s.addShape(pres.shapes.RECTANGLE, { x: 3.6, y: 1.35, w: 6.1, h: 0.38, fill: { color: C.navy }, line: { color: C.navy } });
  s.addText([
    { text: "Type", options: { bold: true, color: C.white } },
    { text: "    Location", options: { bold: true, color: C.light } },
    { text: "                        Key Note", options: { bold: true, color: C.gold } },
  ], { x: 3.65, y: 1.35, w: 6.0, h: 0.38, fontSize: 11, fontFace: "Calibri", valign: "middle" });

  colTypes.forEach((ct, i) => {
    const ry = 1.73 + i * 0.72;
    s.addShape(pres.shapes.RECTANGLE, { x: 3.6, y: ry, w: 6.1, h: 0.7, fill: { color: rowColors[i] }, line: { color: C.light } });
    s.addText(ct.type, { x: 3.65, y: ry, w: 0.95, h: 0.7, fontSize: 11.5, bold: true, color: C.teal, fontFace: "Calibri", valign: "middle", align: "center" });
    s.addText(ct.loc, { x: 4.65, y: ry, w: 2.7, h: 0.7, fontSize: 10.5, color: C.dark, fontFace: "Calibri", valign: "middle" });
    s.addText(ct.note, { x: 7.4, y: ry, w: 2.2, h: 0.7, fontSize: 10, color: C.grey, fontFace: "Calibri", valign: "middle", italic: true });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 10: ELASTIC & RETICULAR FIBERS
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Elastic & Reticular Fibers");

  // Elastic
  card(s, 0.2, 0.9, 4.6, 4.4, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.9, w: 4.6, h: 0.42, fill: { color: C.gold }, line: { color: C.gold } });
  s.addText("🌀  Elastic Fibers", { x: 0.3, y: 0.9, w: 4.4, h: 0.42, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });

  s.addText([
    { text: "Composition:\n", options: { bold: true, color: C.gold, breakLine: true } },
    { text: "• Elastin core (amorphous protein)\n• Fibrillin microfibrils (scaffold for elastin)\n", options: { color: C.dark, breakLine: true } },
    { text: "Property:\n", options: { bold: true, color: C.gold, breakLine: true } },
    { text: "• Stretch up to 150% then recoil\n• Rich in hydrophobic amino acids (Gly, Val, Ala, Pro)\n", options: { color: C.dark, breakLine: true } },
    { text: "Staining:\n", options: { bold: true, color: C.gold, breakLine: true } },
    { text: "• Orcein or Weigert's stain (NOT H&E)\n", options: { color: C.dark, breakLine: true } },
    { text: "Locations:\n", options: { bold: true, color: C.gold, breakLine: true } },
    { text: "• Lung parenchyma (allows lung expansion)\n• Elastic arteries (aorta, pulmonary)\n• Skin (dermis)\n• Ligamentum flavum & nuchae\n• Vocal cords", options: { color: C.dark } },
  ], { x: 0.35, y: 1.4, w: 4.3, h: 3.75, fontSize: 12, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.25 });

  // Reticular
  card(s, 5.1, 0.9, 4.6, 4.4, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.1, y: 0.9, w: 4.6, h: 0.42, fill: { color: C.green }, line: { color: C.green } });
  s.addText("🕸️  Reticular Fibers", { x: 5.2, y: 0.9, w: 4.4, h: 0.42, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });

  s.addText([
    { text: "Composition:\n", options: { bold: true, color: C.green, breakLine: true } },
    { text: "• Collagen TYPE III\n• Also called reticulin\n", options: { color: C.dark, breakLine: true } },
    { text: "Structure:\n", options: { bold: true, color: C.green, breakLine: true } },
    { text: "• Thin, delicate fibers\n• Form 3D network (not bundles)\n", options: { color: C.dark, breakLine: true } },
    { text: "Staining:\n", options: { bold: true, color: C.green, breakLine: true } },
    { text: "• Silver impregnation stain\n  (fibers appear BLACK / argyrophilic)\n", options: { color: C.dark, breakLine: true } },
    { text: "Locations (organ stroma):\n", options: { bold: true, color: C.green, breakLine: true } },
    { text: "• Bone marrow (hemopoietic stroma)\n• Liver sinusoids\n• Lymph nodes & spleen\n• Pancreas, adrenal glands", options: { color: C.dark } },
  ], { x: 5.25, y: 1.4, w: 4.3, h: 3.75, fontSize: 12, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.25 });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 11: GROUND SUBSTANCE & ECM
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Ground Substance – ECM Components");

  // Left: GAGs
  card(s, 0.2, 0.88, 4.55, 4.5, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.88, w: 4.55, h: 0.42, fill: { color: C.teal }, line: { color: C.teal } });
  s.addText("Glycosaminoglycans (GAGs)", { x: 0.3, y: 0.88, w: 4.35, h: 0.42, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
  s.addText([
    { text: "Long unbranched polysaccharide chains\nHighly hydrophilic — attract & trap water\n\n", options: { color: C.dark, breakLine: true } },
    { text: "Types:\n", options: { bold: true, color: C.teal, breakLine: true } },
    { text: "• Hyaluronic acid (hyaluronan)", options: { bold: true, color: C.dark, breakLine: true } },
    { text: "  - Non-sulfated; most abundant GAG\n  - Forms viscous hydrated gel\n  - Key in joint fluid & embryonic matrix\n", options: { color: C.dark, breakLine: true } },
    { text: "• Chondroitin sulfate ", options: { bold: true, color: C.dark } },
    { text: "— cartilage, bone\n", options: { color: C.dark, breakLine: true } },
    { text: "• Heparan sulfate ", options: { bold: true, color: C.dark } },
    { text: "— BM, cell surfaces\n", options: { color: C.dark, breakLine: true } },
    { text: "• Dermatan sulfate ", options: { bold: true, color: C.dark } },
    { text: "— skin, blood vessels\n", options: { color: C.dark, breakLine: true } },
    { text: "• Keratan sulfate ", options: { bold: true, color: C.dark } },
    { text: "— cartilage, cornea", options: { color: C.dark } },
  ], { x: 0.35, y: 1.36, w: 4.2, h: 3.9, fontSize: 11.5, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.2 });

  // Right: Proteoglycans + Adhesive glycoproteins
  card(s, 5.05, 0.88, 4.7, 2.15, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.05, y: 0.88, w: 4.7, h: 0.42, fill: { color: C.purple }, line: { color: C.purple } });
  s.addText("Proteoglycans", { x: 5.15, y: 0.88, w: 4.5, h: 0.42, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
  s.addText([
    { text: "= Core protein + covalently attached GAG chains\nForm huge aggregates (e.g. aggrecan in cartilage)\n", options: { color: C.dark, breakLine: true } },
    { text: "Function: ", options: { bold: true, color: C.purple } },
    { text: "Hydration reservoir; resist compressive forces; bind growth factors; regulate cell signaling", options: { color: C.dark } },
  ], { x: 5.2, y: 1.36, w: 4.4, h: 1.6, fontSize: 11.5, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.2 });

  card(s, 5.05, 3.15, 4.7, 2.23, C.white);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.05, y: 3.15, w: 4.7, h: 0.42, fill: { color: C.accent }, line: { color: C.accent } });
  s.addText("Multiadhesive Glycoproteins", { x: 5.15, y: 3.15, w: 4.5, h: 0.42, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
  s.addText([
    { text: "Fibronectin: ", options: { bold: true, color: C.accent } },
    { text: "Attaches cells to collagen & fibrin. Important in wound healing & cell migration.\n\n", options: { color: C.dark, breakLine: true } },
    { text: "Laminin: ", options: { bold: true, color: C.accent } },
    { text: "Major component of basement membranes. Anchors epithelial cells to basal lamina. Binds type IV collagen & integrins.", options: { color: C.dark } },
  ], { x: 5.2, y: 3.63, w: 4.4, h: 1.65, fontSize: 11.5, fontFace: "Calibri", valign: "top", lineSpacingMultiple: 1.2 });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 12: ECM FUNCTIONS (visual summary)
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Functions of the ECM");

  const funcs = [
    { title: "Structural Support", icon: "🏗️", color: C.teal, desc: "Fibers (collagen, elastic, reticular) provide tensile strength, elasticity, and 3D framework" },
    { title: "Hydration", icon: "💧", color: C.tealL, desc: "GAGs attract water → maintains tissue hydration and turgor pressure" },
    { title: "Metabolite Diffusion", icon: "⚡", color: C.gold, desc: "ECM acts as medium for O₂, CO₂, nutrients, and metabolites to diffuse between blood and cells" },
    { title: "Molecular Sieve", icon: "🔬", color: C.purple, desc: "Filters movement of cells & molecules — acts as a selective barrier" },
    { title: "Cell Adhesion", icon: "🔗", color: C.accent, desc: "Fibronectin & Laminin bind integrins on cells, anchoring them to the ECM" },
    { title: "Cell Signaling", icon: "📡", color: C.green, desc: "ECM sequesters growth factors (FGFs, TGF-β); proteoglycans regulate their release and activity" },
  ];

  funcs.forEach((f, i) => {
    const col = i % 3;
    const row = Math.floor(i / 3);
    const x = 0.3 + col * 3.2;
    const y = 0.95 + row * 2.3;
    card(s, x, y, 3.0, 2.1, C.white);
    // icon circle
    s.addShape(pres.shapes.ELLIPSE, { x: x + 1.1, y: y + 0.08, w: 0.8, h: 0.8, fill: { color: f.color }, line: { color: f.color } });
    s.addText(f.icon, { x: x + 1.1, y: y + 0.08, w: 0.8, h: 0.8, fontSize: 20, align: "center", valign: "middle" });
    s.addText(f.title, { x: x + 0.1, y: y + 0.95, w: 2.8, h: 0.42, fontSize: 12, bold: true, color: f.color, fontFace: "Calibri", align: "center" });
    s.addText(f.desc, { x: x + 0.15, y: y + 1.38, w: 2.7, h: 0.62, fontSize: 10.5, color: C.dark, fontFace: "Calibri", align: "center", valign: "top" });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 13: SUMMARY TABLE
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  contentBg(s);
  slideTitle(s, "Quick Reference Summary");

  const rows = [
    { cat: "Embryonic CT", sub: "Mesenchyme\nMucoid CT", cells: "Undiff. mesenchymal\nFibroblasts", ecm: "Sparse collagen\nHyaluronan-rich", fn: "Precursor to all adult CT" },
    { cat: "Loose CT", sub: "Areolar", cells: "Fibroblasts, Macrophages\nMast cells, Plasma cells", ecm: "Loosely arranged collagen\n+ elastic fibers + GS", fn: "Support, immune defense\ndiffusion medium" },
    { cat: "Dense Irregular CT", sub: "Dense CT Proper", cells: "Mostly fibroblasts", ecm: "Thick random collagen\nbundles; little GS", fn: "Resist multidirectional\nforces; protect organs" },
    { cat: "Dense Regular CT", sub: "Dense CT Proper", cells: "Aligned fibroblasts\n(tendinocytes)", ecm: "Parallel collagen\nbundles", fn: "Resist force in\none direction" },
    { cat: "Specialized CT", sub: "Bone / Cartilage\nBlood / Adipose / Reticular", cells: "Osteocytes / Chondrocytes\nRBC, WBC / Adipocytes", ecm: "Mineralized / Hyaluronan\nPlasma / Lipid / Reticulin", fn: "Rigid support / Cushion\nTransport / Energy / Stroma" },
  ];

  // header
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.88, w: 9.6, h: 0.4, fill: { color: C.navy }, line: { color: C.navy } });
  const headers = ["CT Type", "Subtype", "Cells", "ECM", "Function"];
  const hx = [0.25, 2.15, 4.0, 6.1, 8.0];
  const hw = [1.85, 1.8, 2.05, 1.85, 1.75];
  headers.forEach((h, i) => {
    s.addText(h, { x: hx[i], y: 0.88, w: hw[i], h: 0.4, fontSize: 11, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
  });

  const rColors = [C.softBg, C.white, C.softBg, C.white, C.softBg];
  rows.forEach((r, i) => {
    const ry = 1.28 + i * 0.84;
    s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: ry, w: 9.6, h: 0.82, fill: { color: rColors[i] }, line: { color: C.light } });
    const rowVals = [r.cat, r.sub, r.cells, r.ecm, r.fn];
    rowVals.forEach((rv, j) => {
      s.addText(rv, { x: hx[j] + 0.05, y: ry + 0.04, w: hw[j] - 0.1, h: 0.74, fontSize: 10, color: C.dark, fontFace: "Calibri", valign: "middle", align: "center" });
    });
  });
}

// ══════════════════════════════════════════════════════════════
// SLIDE 14: CLOSING SLIDE
// ══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkBg(s);
  s.addShape(pres.shapes.ELLIPSE, { x: 7.5, y: -0.8, w: 3.5, h: 3.5, fill: { color: C.teal, transparency: 85 }, line: { color: C.teal, transparency: 85 } });
  s.addShape(pres.shapes.ELLIPSE, { x: -0.8, y: 3.5, w: 3, h: 3, fill: { color: C.tealL, transparency: 88 }, line: { color: C.tealL, transparency: 88 } });
  s.addShape(pres.shapes.RECTANGLE, { x: 3.5, y: 2.45, w: 3, h: 0.06, fill: { color: C.gold }, line: { color: C.gold } });
  s.addText("Key Takeaways", { x: 1.0, y: 0.8, w: 8, h: 0.75, fontSize: 34, bold: true, color: C.white, fontFace: "Calibri", align: "center" });
  const takeaways = [
    "ECM — not cells — defines CT identity",
    "All CT derives from mesenchyme (mesoderm)",
    "Classification: Embryonic → CT Proper → Specialized",
    "Fibroblast = master producer of ECM",
    "Collagen (strength) + Elastic (recoil) + Reticular (scaffold)",
    "Ground substance = GAGs + Proteoglycans + Adhesive glycoproteins",
  ];
  takeaways.forEach((t, i) => {
    s.addText([
      { text: "✓  ", options: { color: C.gold, bold: true } },
      { text: t, options: { color: C.white } },
    ], { x: 1.5, y: 1.75 + i * 0.58, w: 7, h: 0.5, fontSize: 14, fontFace: "Calibri", valign: "middle" });
  });
  s.addText("Sources: Junqueira's Basic Histology 17e | Pawlina's Histology: A Text and Atlas", {
    x: 1.5, y: 5.2, w: 7, h: 0.3, fontSize: 10, color: C.grey, italic: true, fontFace: "Calibri", align: "center"
  });
}

// ─── WRITE FILE ─────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/connective-tissue-pptx/Connective_Tissue_Notes.pptx" })
  .then(() => console.log("✅ Done: Connective_Tissue_Notes.pptx"))
  .catch(e => { console.error("Error:", e); process.exit(1); });

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Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/connective-tissue-pptx/make_pptx.js'