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1. Definition - Diagnostic criteria (≥10% clonal plasma cells + M protein + myeloma-defining event)

2. Epidemiology - ~30,000 new cases/year in the US, median age 70, higher incidence in males and people of African descent; IgG (60%) is the most common M-protein type

3. Pathogenesis - IgH translocations involving cyclin D genes, IL-6 as a key growth factor, RANKL-mediated osteoclast activation, simultaneous osteoblast suppression, and mechanisms of renal injury (Bence Jones cast nephropathy, amyloid deposits, hypercalcemia)

4. Clinical Features (CRAB) - Hypercalcemia, Renal insufficiency, Anemia, Bone lesions, plus additional features like neuropathy, hyperviscosity, and amyloidosis

5. Diagnosis - Laboratory workup (SPEP, immunofixation, free light chains, 24-hr urine), bone marrow biopsy findings, and imaging modalities (skeletal survey vs. CT vs. MRI vs. PET-CT)

6. Staging - Revised ISS (R-ISS) with criteria and median OS per stage; high-risk cytogenetics (del17p, t(4;14), t(14;16))

7. Treatment - Induction regimens (VRd, Dara-VRd), ASCT for eligible patients, lenalidomide maintenance; a full drug class table covering proteasome inhibitors, IMiDs, anti-CD38 antibodies, CAR-T therapy, and bispecific antibodies; supportive care

8. Complications - Management of hypercalcemia, AKI, spinal cord compression, infections, and neuropathy

9. Prognosis & Monitoring - Response categories from sCR to PD, MRD negativity as a prognostic marker

10. Spectrum of Plasma Cell Disorders - Side-by-side comparison of MGUS, Smoldering MM, and Active MM

Sources: Goldman-Cecil Medicine, Robbins & Kumar Basic Pathology, Textbook of Family Medicine, Bradley & Daroff's Neurology, and IMWG consensus criteria.

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