An AST result alone cannot identify the cause. It should be interpreted with
ALT/SGPT, bilirubin, alkaline phosphatase, GGT, CK, symptoms, alcohol intake, medicines, and the actual AST value. AST can rise from muscle injury, so it is not specific to liver disease. This is consistent with
MedlinePlus guidance.
Seek urgent care if elevated AST is accompanied by yellow eyes/skin, confusion, severe vomiting, severe abdominal pain, chest pain, or very dark urine.