Here is a complete, textbook-based guide to the management of tonsillitis:
Management of Tonsillitis
1. Supportive (Symptomatic) Treatment - First Line for All Cases
The primary management of acute tonsillitis is symptomatic:
- Analgesics - Paracetamol (acetaminophen) and/or NSAIDs to relieve pain and fever
- Hydration - Encourage adequate fluid intake
- Saline gargles - Soothing for throat pain
- Wait for symptoms to resolve; most cases (both viral and bacterial) resolve quickly without antibiotics
(Scott-Brown's Otorhinolaryngology Head & Neck Surgery, Bailey and Love's Short Practice of Surgery)
2. Antibiotics - When to Use
Antibiotics shorten the illness and reduce the risk of complications (rheumatic fever, glomerulonephritis, peritonsillar abscess). Start antibiotics:
- If no improvement within 48-72 hours
- Or immediately if the disease is clinically severe at presentation
| Drug | Role |
|---|
| Benzyl-penicillin (Penicillin G) / Penicillin V (phenoxymethylpenicillin) | Drug of choice - no resistance reported for GABHS |
| Amoxicillin | Comparable efficacy; preferred in children (better taste of suspension) |
| 10-day oral course | Recommended for complete pharyngeal eradication |
| Benzathine penicillin IM (single dose) | Equally effective alternative |
| Clarithromycin / 1st-generation cephalosporins | For penicillin-allergic patients |
| Clindamycin | For macrolide-resistant GABHS in penicillin-allergic patients |
Important: Ampicillin must be avoided if infectious mononucleosis (EBV/glandular fever) is suspected - it causes a rash in ~90% of such patients. Amoxicillin causes rash in ~30% of EBV cases.
(Tintinalli's Emergency Medicine; Scott-Brown's Otorhinolaryngology; Bailey & Love)
3. Corticosteroids
- In severe cases, corticosteroids (oral or IM) - in addition to antibiotics - expedite resolution of pain and throat swelling
- Particularly useful when there is significant tonsillar swelling threatening the airway (e.g., in infectious mononucleosis)
(Scott-Brown's Otorhinolaryngology Head & Neck Surgery)
4. Infectious Mononucleosis Tonsillitis (Special Case)
- High-dose IV penicillin or cephalosporins for hospitalized patients
- Avoid ampicillin/amoxicillin
- Corticosteroids if airway compromise or severe swallowing difficulty
- Antiviral (acyclovir) - debatable; consider only in severe cases
5. Complications to Watch For
| Complication | Action |
|---|
| Peritonsillar abscess (Quinsy) | IV penicillin or cephalosporin + needle aspiration / incision and drainage |
| Rheumatic fever | Treat GABHS promptly with penicillin |
| Glomerulonephritis | Antibiotic treatment; note: antibiotics may not prevent glomerulonephritis |
| Parapharyngeal abscess / septicaemia | Hospital admission, IV antibiotics, surgical drainage |
6. Surgical Treatment - Tonsillectomy
Indicated when medical management is insufficient. Standard criteria (the Paradise criteria):
- 7 or more episodes in 1 year, OR
- 5 or more per year for 2 consecutive years, OR
- 3 or more per year for 3 consecutive years
- > 2 weeks of school/work missed in 1 year
- Tonsillar hypertrophy causing airway obstruction or sleep apnea
- Peritonsillar abscess (recurrent)
- Suspicion of malignancy
- Diphtheria carrier state
- Recurrent tonsillitis causing febrile seizures
Morbidity: post-op hemorrhage in ~2-4%; mortality 1 in 25,000.
(K.J. Lee's Essential Otolaryngology)
Summary in brief:
- Mild/early: rest, analgesics, hydration, saline gargles
- Bacterial / no improvement in 48-72h: Penicillin V or amoxicillin x 10 days
- Severe / hospitalized: IV penicillin + steroids
- Penicillin allergy: cephalosporin or clarithromycin
- Recurrent / obstructive: tonsillectomy