The newest major HIV treatment guidance I found is the
WHO updated clinical-management recommendations, published in December 2025. It updates global treatment, prevention of vertical transmission, and tuberculosis prevention guidance. WHO continues to recommend
dolutegravir-based ART as the preferred initial and subsequent treatment approach, and identifies
darunavir/ritonavir as the preferred protease-inhibitor option when one is needed.
WHO’s update summary provides the key changes.
For United States adult and adolescent care, the current NIH/HHS Adult and Adolescent ARV Guidelines were updated September 25, 2025. They recommend:
The NIH guideline site also lists later 2026 updates for
adult/adolescent opportunistic infections (May 28, 2026) and
pediatric HIV treatment (June 25, 2026). Its
guideline hub is the best U.S. source for current adult, pregnancy, child, and opportunistic-infection recommendations.
A recent independent practice guideline, the IAS-USA 2024 recommendations, published in 2025, similarly supports an initial regimen based on bictegravir or dolutegravir plus NRTIs, with long-acting injectable treatment as an option for selected people. Gandhi et al.,
JAMA 2025,
PMID 39616604. The 2025 European AIDS Clinical Society update likewise recommends tenofovir plus emtricitabine/lamivudine with dolutegravir, bictegravir, or doravirine, with dolutegravir plus lamivudine as a two-drug option in suitable patients. Ambrosioni et al.,
HIV Medicine 2026,
PMID 41088922.
These are clinician guidelines, not a substitute for an individual prescription. ART should be chosen with an HIV clinician after checking viral load, CD4 count, kidney/liver function, hepatitis B status, resistance results, current medicines, and pregnancy status.