Create a summary document on myeloma diagnosis and staging I can share

Create a summary document on myeloma diagnosis and staging I can share with colleagues

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Create a summary document on multiple myeloma diagnosis and staging I can share with colleagues

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"multiple myeloma" AND "diagnosis" AND "staging"

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Multiple Myeloma Diagnosis Staging

Word Document · DOCX

Here's what the document covers across 10 sections with colour-coded tables and formatted headings:

Section	Content
1. Overview & Epidemiology	Incidence, demographics, racial disparities (US 2024 data)
2. Pathogenesis	Molecular drivers (IgH translocations, IL-6, RANKL), bone/renal/immune consequences
3. Disease Spectrum	MGUS → SMM → Active MM → Plasmacytoma with clear management cues
4. Diagnostic Criteria	Full IMWG 2014 criteria: CRAB criteria table + SLiM biomarker table
5. Diagnostic Workup	Bone marrow (IHC/flow), paraprotein studies (SPEP, SIFE, FLC), labs, imaging (WBLDCT, PET-CT, MRI)
6. Staging	ISS table, R-ISS table (current standard), cytogenetic risk stratification by FISH/DNA sequencing
7. Smoldering MM Risk	3-factor risk model; progression thresholds
8. Clinical Features	System-by-system table with frequency data
9. Differential Diagnosis	MGUS, Waldenström's, AL amyloidosis, bone mets, POEMS, plasmacytoma
10. Response Criteria	IMWG response categories from sCR → MRD-negative → PD

Sources: Harrison's 22E (2025), Goldman-Cecil Medicine, Robbins Pathology, Tietz Lab Medicine, plus the 2025 IMS/IMWG high-risk consensus (PMID 40489728) and 2024 EANM PET-CT guidelines (PMID 39207486).

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