Yes, calcium gluconate can be given through a UVC in a neonate, but only after confirming that the catheter tip is in a central position, ideally at the IVC-right atrial junction.

Do not infuse it through a low-lying or malpositioned UVC, especially if the tip is in the portal/hepatic circulation. Calcium extravasation or hypertonic infusion into the liver can cause severe hepatic injury or necrosis.

Use slow administration with cardiac monitoring, follow your NICU’s concentration/rate policy, and reassess line position before use. Neonatal hypocalcemia review specifically warns that a UVC tip in the portal vein can lead to hepatic necrosis with calcium administration.

Textbook support: Morgan and Mikhail's Clinical Anesthesiology, notes that UVC tips should not be in the liver to prevent hypertonicity-induced hepatic injury, and lists calcium gluconate for selected neonatal indications (p. 1665).