Can you help me with making a presentation for seminar on CRISPR cas 9 in biochemistry 1st year mbbs
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CRISPR Cas9 MBBS Seminar
Presentation · PPTX
What's in the deck (12 slides)
| # | Slide | Highlights |
|---|---|---|
| 1 | Title Slide | Dark navy + electric teal design; Nobel Prize callout |
| 2 | Outline | All 10 topics listed with numbered cards |
| 3 | History & Discovery | Timeline from 1987 E. coli discovery → 2023 FDA approval |
| 4 | Bacterial Immune System | 3-phase process (Adaptation → crRNA biogenesis → Interference) |
| 5 | Molecular Components | Cas9 domains (RuvC, HNH, PAM) vs sgRNA structure, side-by-side |
| 6 | Mechanism of Action | 6-step process: guide design → PAM recognition → R-loop → DSB |
| 7 | NHEJ vs HDR | Dual card layout comparing both repair pathways with clinical relevance |
| 8 | Medical Applications | 4 categories: Haematology, Oncology, Infectious Disease, Metabolic/Neuro |
| 9 | Limitations | 6 challenges: off-targets, delivery, mosaicism, HDR inefficiency, immunogenicity, cost |
| 10 | Ethics | Germline editing (He Jiankui scandal), Access & Equity, Consent issues |
| 11 | Future & FDA Approvals | CASGEVY approval details, pipeline drugs, next-gen tools (Base/Prime editing) |
| 12 | Key Takeaways | 5 numbered summary points |
Sources used:
- Harper's Illustrated Biochemistry 32e (Table 39-2)
- Schwartz's Principles of Surgery 11e (Chapter 15, pp. 533-536)
- Tietz Textbook of Laboratory Medicine 7e (Chapter 67)
- PubMed: Tyumentseva 2023, Laurent 2024, Singh 2024, Cetin 2025
- CRISPR Medicine News (June 2025 - CASGEVY 5.5-year follow-up data)
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Here's your brand new version:
CRISPR Cas9 v2 MBBS
Presentation · PPTX
What's completely new in v2
Design: Dark forest green background + lime green accents + Trebuchet MS font. Left edge lime bar on every content slide. Cards use colour-coded side bands instead of full-colour headers.
Structure - 13 slides (vs 12 before):
| # | Slide | What's new |
|---|---|---|
| 1 | Title | CRISPR in giant 88pt type with simulated DNA helix animation dots |
| 2 | What is CRISPR? | NEW — Colour-blocked CRISPR acronym breakdown + Origin vs Why it Matters cards |
| 3 | Timeline | Redesigned as alternating above/below horizontal timeline (infographic style) |
| 4 | Bacterial Immunity | 3-phase process with connecting arrows between phase cards |
| 5 | Molecular Components | Central scissor diagram with Cas9 and sgRNA flanking cards |
| 6 | Mechanism | 6-step flow in 2 columns with down-arrows between steps |
| 7 | NHEJ vs HDR | DSB at centre, arrows branching left (NHEJ) and right (HDR) |
| 8 | Delivery Methods | NEW dedicated slide — 6 delivery methods as pro/con cards |
| 9 | Applications | Full-width CASGEVY approved banner + 4 domain cards |
| 10 | Limitations | Left colour-band cards with warning icons |
| 11 | Ethics | He Jiankui red alert banner + 3 pillar cards |
| 12 | Future Tools | 4 next-gen CRISPR tools + clinical pipeline table |
| 13 | Summary | Lime header + 5 numbered takeaways with dividers |
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