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Heat Stroke and Its Management
Definition
Heat stroke is an acute, life-threatening emergency characterized by:
- Core body temperature > 40°C (104°F)
- Altered mental status (CNS dysfunction)
It is fatal if left untreated. The distinction between exertional and classic heat stroke is not clinically important - both require immediate cooling.
Types
| Feature | Classic (Non-Exertional) Heat Stroke (CHS) | Exertional Heat Stroke (EHS) |
|---|
| Who | Elderly, debilitated, chronically ill | Young, healthy athletes, military recruits |
| Cause | Prolonged heat exposure (heat waves) | Vigorous physical activity in heat |
| Sweating | Usually absent (anhidrosis) | Present in ~50% of cases |
| CVP | Usually elevated | Normal or low |
| Rhabdomyolysis | Rare | Common |
| Acid-base | Respiratory alkalosis | Lactic acidosis |
| Hypoglycemia | Less common | Common (increased glucose metabolism + hepatic damage) |
Pathophysiology
The body generates heat through metabolism and gains it from the environment. Normally, heat is dissipated by:
- Evaporation (sweating) - most effective mechanism
- Radiation
- Convection
- Conduction
When these mechanisms fail or are overwhelmed, core temperature rises. Above 40°C, cellular proteins denature, enzyme systems fail, and direct thermal injury occurs to the brain (cerebellum is especially sensitive), liver, kidneys, and vascular endothelium. This triggers a cascade of systemic organ damage.
Risk Factors / Predisposing Factors
Environmental:
- High ambient temperature and humidity
- Poor ventilation, no air conditioning
Individual:
- Extremes of age (elderly, young children)
- Obesity
- Dehydration
- Cardiovascular disease, diabetes, alcoholism
- Psychiatric illness
Medications that impair heat tolerance:
| Drug Class | Examples |
|---|
| Anticholinergics | Atropine, oxybutynin, scopolamine |
| Antipsychotics | All (impair sweating) |
| Diuretics | Furosemide, hydrochlorothiazide |
| Antidepressants | Tricyclics |
| Antihistamines | All |
| Sympathomimetics | Amphetamines, cocaine |
| Beta-blockers | Impair cardiac output response |
Clinical Features
Cardinal Signs (Must Know)
- Hyperthermia - core temperature > 40°C (104°F)
- Altered mental status - confusion, delirium, coma
CNS Manifestations (cerebellum most vulnerable)
- Irritability, confusion, bizarre behavior, combativeness
- Hallucinations
- Ataxia (early cerebellar sign)
- Seizures (very common, especially during cooling - up to 75% of patients)
- Decerebrate/decorticate posturing
- Hemiplegia, status epilepticus
- Coma
Cardiovascular
- Tachycardia (up to 180 bpm)
- Hypotension (low peripheral vascular resistance)
- High cardiac output (hyperdynamic state)
- Cardiac failure in severe cases
Respiratory
- Tachypnea
- Respiratory alkalosis (CHS)
- Pulmonary edema
Skin
- Hot, flushed
- Anhidrosis (dry skin) - classic presentation, but NOT universal
GI
- Nausea, vomiting
- Diarrhea (splanchnic vasoconstriction)
Diagnosis
Heat stroke is a clinical diagnosis - no single diagnostic test confirms it.
Diagnosis = core temperature > 40°C + altered mental status + history of heat exposure, after excluding other causes.
Investigations (to detect organ damage, not to diagnose)
| Test | Purpose |
|---|
| CBC | Thrombocytopenia, leukocytosis |
| BMP / Metabolic panel | Renal function, electrolytes (hypo/hypernatremia, hypokalemia) |
| ABG | Respiratory alkalosis (CHS), lactic acidosis (EHS) |
| Serum creatinine, BUN | Acute renal failure |
| CPK (Creatine Phosphokinase) | Rhabdomyolysis |
| Myoglobin (urine & serum) | Rhabdomyolysis |
| LFT (liver enzymes) | Hepatic injury (peak at 24-72 hours) |
| Coagulation profile | DIC - PT, aPTT, fibrinogen, D-dimer |
| Blood glucose | Hypoglycemia (especially EHS) |
| ECG | Arrhythmias, myocardial injury |
| CT head | To rule out intracerebral hemorrhage |
| Lumbar puncture | If meningitis/encephalitis cannot be excluded |
Differential Diagnosis
| Category | Conditions |
|---|
| Infections | Meningitis, encephalitis, sepsis, malaria, typhoid, tetanus |
| Neurologic | Hypothalamic hemorrhage/infarct, CVA, status epilepticus |
| Endocrine | Thyroid storm, pheochromocytoma, DKA |
| Toxicologic | Anticholinergic toxidrome, serotonin syndrome, malignant hyperthermia, NMS, cocaine overdose |
Management
Immediate Priority: COOL FIRST, TREAT COMPLICATIONS SECOND
"A delay in cooling increases the mortality rate." - Tintinalli's Emergency Medicine
Step 1: ABC Stabilization
- Airway - intubate if unconscious or airway at risk
- Breathing - supplemental O2, mechanical ventilation if needed
- Circulation - IV access x 2 large bore, continuous cardiac monitoring
- Disability - GCS assessment, pupil examination
- Remove from hot environment immediately
- Remove all clothing
Step 2: Rapid Cooling (Most Critical Intervention)
Target: Reduce core temperature to ≤ 39°C (102.2°F) as fast as possible
| Cooling Method | Technique | Notes |
|---|
| Evaporative cooling (Strongly Recommended) | Spray cool water (~15°C) over body + fan to enhance evaporation | Practical, well tolerated, readily available |
| Ice water immersion (Recommended) | Immerse undressed patient in ice water tub covering trunk & extremities | Most effective for EHS; difficult to monitor |
| Ice packs to neck, axillae, groin | Apply to areas of major vessels | Adjunct method; slower alone |
| Cold IV fluids | Infuse cold 0.9% saline | Adjunct |
| Endovascular cooling | Central cooling catheter | For refractory cases |
| Iced gastric/bladder lavage | Cold saline via NGT or urinary catheter | Rarely needed |
STOP cooling when temperature reaches 39°C to prevent hypothermic overshoot.
Antipyretics (paracetamol, aspirin) are NOT effective in heat stroke - the hypothalamus is not reset (unlike fever from infection). They should NOT be used.
Step 3: IV Fluids
- Start IV fluids to maintain urine output of 0.5-1 mL/kg/hr
- Use 0.9% Normal Saline
- Avoid over-hydration (pulmonary edema risk, especially CHS)
- Use invasive monitoring (CVP line) in elderly or those with cardiac disease
Step 4: Temperature Monitoring
- Use rectal thermometer (most reliable) or esophageal/urinary catheter thermometer
- Do NOT use oral or axillary thermometers
Step 5: Treat Complications
| Complication | Management |
|---|
| Seizures | Benzodiazepines (lorazepam/diazepam IV) first-line |
| Shivering during cooling | Short-acting benzodiazepines; phenothiazines (second-line) |
| Hypotension (if not responding to fluids) | Dopamine or dobutamine; avoid norepinephrine (causes vasoconstriction, impairs skin cooling) |
| Rhabdomyolysis | Aggressive IV fluids, alkalinize urine (sodium bicarbonate) |
| Acute renal failure | Fluids, hemodialysis if severe |
| DIC | Fresh frozen plasma (FFP), platelets |
| Hypoglycemia | 50% dextrose IV |
| Pulmonary edema | Positive pressure ventilation, diuretics cautiously |
Complications
Early Complications
- Hypotension
- Seizures / coma
- Rhabdomyolysis
- Oliguria
- Pulmonary edema
- Hypokalemia, hyper/hyponatremia
- Hypothermic overshoot or hyperthermic rebound
Late Complications
- Acute Renal Failure (from rhabdomyolysis + dehydration)
- DIC (Disseminated Intravascular Coagulation) - poor prognostic sign
- Hepatic dysfunction - enzyme elevation peaks 24-72 hrs (centrilobular necrosis)
- ARDS (Acute Respiratory Distress Syndrome)
- Myocardial injury
- Persistent neurologic deficits (cerebellar damage, dementia, hemiplegia)
- Intestinal ischemia / infarction
- Pancreatitis
Nursing Management
Immediate Priorities
- Remove patient from hot environment, to a cool, shaded area
- Remove all clothing
- Begin cooling immediately - do not wait for investigations
- Monitor core temperature continuously (rectal route)
- Establish two large-bore IV lines; draw blood for investigations
- Maintain airway - position, suction, oxygen
- Insert urinary catheter - monitor hourly urine output
Ongoing Nursing Care
- Neurological monitoring - GCS, pupil check every 15-30 min
- Vital signs every 15 min until stable
- Administer IV fluids as ordered; monitor for fluid overload
- Seizure precautions - padded side rails, suction available, anticonvulsants ready
- Skin care during cooling procedures
- Administer medications as prescribed
- Prevent hypothermic overshoot - stop cooling when temp reaches 39°C
- Monitor lab values - electrolytes, CPK, renal function, coagulation profile
- Psychological support to patient and family
- Patient education on heat illness prevention post-recovery
Prevention Education (Discharge Teaching)
- Avoid outdoor activity during peak heat hours (11 AM - 3 PM)
- Wear light, loose, light-colored clothing
- Stay well hydrated
- Never leave children/elderly in parked cars
- Acclimatize gradually to hot environments
- Review medications that impair heat tolerance
Prognosis / Poor Prognostic Factors
- Delay in cooling (most important factor)
- Lactic acidosis (especially in CHS)
- Advanced age
- Hypotension on arrival
- Altered coagulation / DIC
- Necessity for intubation on arrival
- Temperature > 41°C for prolonged time
- Renal failure
Heat Stroke vs. Heat Exhaustion (Quick Differentiation)
| Feature | Heat Exhaustion | Heat Stroke |
|---|
| Temperature | < 40°C | > 40°C |
| Mental status | Normal | Altered (CNS dysfunction) |
| Sweating | Present, profuse | Absent (CHS) or present (EHS) |
| Skin | Cool, clammy | Hot, flushed |
| Blood pressure | Low | Low |
| Urgency | Urgent | Life-threatening emergency |
| Treatment | Fluids, rest, cooling | Aggressive rapid cooling + ICU |
Sources: Tintinalli's Emergency Medicine (Comprehensive Study Guide); Rosen's Emergency Medicine (Concepts and Clinical Practice)