National immunization schedule with dose route

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India national immunization schedule 2025 dose route site age

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https://ima-india.org/ima/pdfdata/Immunization_Schedule_CHAR…

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National Immunization Schedule - India

There are two parallel schedules used in India:

National Immunization Schedule (NIS) / Universal Immunization Programme (UIP) - Government of India, free at all public health centres
IAP (Indian Academy of Pediatrics) / IMA Schedule - Recommended comprehensive schedule (includes additional vaccines)

Part A: UIP / National Immunization Schedule (Government of India)

Beneficiary	Age	Vaccine	Dose	Route	Site
Infants	At Birth	BCG	0.1 mL (neonates: 0.05 mL)	Intradermal (ID)	Left upper arm
		bOPV-0 (zero dose)	2 drops	Oral	Mouth
		Hepatitis B (birth dose)	0.5 mL	IM	Left anterolateral thigh
	6 Weeks	bOPV-1	2 drops	Oral	Mouth
		Pentavalent-1 (DPT+HepB+Hib)	0.5 mL	IM	Anterolateral thigh
		fIPV-1 (fractional IPV)	0.1 mL	Intradermal (ID)	Right anterolateral thigh
		RVV-1 (Rotavirus)	5 drops	Oral	Mouth
		PCV-1	0.5 mL	IM	Anterolateral thigh
	10 Weeks	bOPV-2	2 drops	Oral	Mouth
		Pentavalent-2	0.5 mL	IM	Anterolateral thigh
		RVV-2	5 drops	Oral	Mouth
	14 Weeks	bOPV-3	2 drops	Oral	Mouth
		Pentavalent-3	0.5 mL	IM	Anterolateral thigh
		fIPV-2	0.1 mL	ID	Right anterolateral thigh
		RVV-3	5 drops	Oral	Mouth
		PCV-2	0.5 mL	IM	Anterolateral thigh
	9-11 Months	MR-1 (Measles-Rubella)	0.5 mL	SC	Right upper arm
		JE-1 (Japanese Encephalitis)	0.5 mL	SC	Right upper arm
		PCV Booster	0.5 mL	IM	Anterolateral thigh
		fIPV-3	0.1 mL	ID	Right anterolateral thigh
		Vitamin A (1st dose)	1 lakh IU (1 mL)	Oral	Mouth
Children	16-23 Months	MR-2	0.5 mL	SC	Right upper arm
		JE-2	0.5 mL	SC	Right upper arm
		DPT Booster-1	0.5 mL	IM	Anterolateral thigh
		bOPV Booster	2 drops	Oral	Mouth
		Vitamin A (2nd-9th dose, every 6 months up to 5 yrs)	2 lakh IU (1 mL)	Oral	Mouth
	5-6 Years	DPT Booster-2	0.5 mL	IM	Upper arm
	10 Years	Td	0.5 mL	IM	Upper arm
	16 Years	Td	0.5 mL	IM	Upper arm
Pregnant Women	At registration / 1st ANC	Td-1	0.5 mL	IM	Upper arm
	4 weeks after Td-1	Td-2	0.5 mL	IM	Upper arm
	(If previously vaccinated within 3 yrs)	Td Booster	0.5 mL	IM	Upper arm

Key notes:

Pentavalent = DPT + Hepatitis B + Hib (5-in-1 vaccine)

fIPV = fractional dose Inactivated Polio Vaccine (1/5th of full dose) given intradermally

JE vaccine is part of NIS in endemic states (UP, Bihar, West Bengal, Assam, Karnataka, etc.)

Td replaced TT in India's NIS

Part B: IAP / IMA Comprehensive Schedule (0-18 Years)

Age	Vaccine	Dose	Route	Site	Remarks
Birth	BCG	0.05 mL	ID	Left upper arm	Within 24-72 h
	OPV-0	2 drops	Oral	-	Before hospital discharge
	Hep B-0	0.5 mL	IM	Left thigh	Mandatory before discharge
6 Weeks	DTwP/DTaP-1	0.5 mL	IM	Anterolateral thigh	Use combination vaccines
	Hib-1	0.5 mL	IM	Anterolateral thigh
	IPV-1	0.5 mL	IM	Anterolateral thigh
	Hep B-1	0.5 mL	IM	Anterolateral thigh
	PCV10/13-1	0.5 mL	IM	Anterolateral thigh
	Rota-1	0.5-2 mL	Oral	Squirt toward buccal mucosa	Do not give after 16 weeks
10 Weeks	DTwP/DTaP-2	0.5 mL	IM	Anterolateral thigh
	Hib-2	0.5 mL	IM	Anterolateral thigh
	IPV-2	0.5 mL	IM	Anterolateral thigh
	Hep B-2	0.5 mL	IM	Anterolateral thigh
	PCV10/13-2	0.5 mL	IM	Anterolateral thigh
	Rota-2	0.5-2 mL	Oral	Buccal mucosa	2 doses for RV1
14 Weeks	DTwP/DTaP-3	0.5 mL	IM	Anterolateral thigh
	Hib-3	0.5 mL	IM	Anterolateral thigh
	IPV-3	0.5 mL	IM	Anterolateral thigh
	Hep B-3	0.5 mL	IM	Anterolateral thigh
	PCV10/13-3	0.5 mL	IM	Anterolateral thigh
	Rota-3	0.5-2 mL	Oral	Buccal mucosa	RV5/RV116E (3 doses)
6 Months	Hep B	0.5 mL	IM	-	If following 0, 1, 6 month schedule
	OPV-1	2 drops	Oral	-
	IIV-1 (Influenza)	0.25 mL	IM	-	High-risk groups
7 Months	IIV-2 (Influenza)	0.25 mL	IM	-	2nd dose if first given at 6 months
9 Months	OPV-2	2 drops	Oral	-
	MMR-1 / MR	0.5 mL	SC	Right upper arm	After 270 completed days
	Meningococcal-1	0.5 mL	IM	-	High-risk groups
10 Months	Typhoid Conjugate (TCV)-1	0.5 mL	IM	-	≥1 month gap after MMR
12 Months	Hepatitis A-1 (killed or live)	0.5 mL	IM (killed) or SC (live)	-	Single dose if live vaccine
	JE-1	0.25 mL	IM	-	Endemic areas, <3 years
	Cholera	-	Oral	-	Hyperendemic/outbreak areas
13 Months	JE-2	0.25 mL	IM	-	Endemic areas
15 Months	MMR-2	0.5 mL	SC	-
	Varicella-1	0.5 mL	SC	-
15-18 Months	PCV Booster	0.5 mL	IM	-
16-18 Months	DTwP/DTaP Booster-1	0.5 mL	IM	-	Combination vaccines preferred
	IPV Booster	0.5 mL	IM	-
	Hib Booster	0.5 mL	IM	-
18 Months	Hepatitis A-2 (killed)	0.5 mL	IM	-	2nd dose only for killed vaccine
2 Years	TCV-2 or Typhoid polysaccharide	0.5 mL	IM	Upper arm
	Meningococcal-2	0.5 mL	IM	-	Single dose if first dose at/after 2 yrs
4-6 Years	DTwP/DTaP/Tdap (Booster-2)	0.5 mL	IM	Upper arm
	OPV-3 (up to 5 years)	2 drops	Oral	-
	MMR-3	0.5 mL	SC	-
	Varicella-2	0.5 mL	SC	-	Min 3 months after first dose
9 Years+ (girls)	HPV	0.5 mL	IM	Upper arm	2 doses (6 months apart) if started before 15th birthday; 3 doses if started at/after 15 yrs
10 Years	Td / Tdap	0.5 mL	IM	Upper arm
16 Years	Td	0.5 mL	IM	Upper arm

Route Summary (Quick Reference)

Route	Vaccines
Intradermal (ID)	BCG (0.05-0.1 mL), fIPV (0.1 mL)
Oral	OPV, Rotavirus, Cholera, Vitamin A
Subcutaneous (SC)	MMR, Varicella, Hepatitis A (live), JE (some formulations)
Intramuscular (IM)	Hep B, DPT/DTwP/DTaP, Pentavalent, IPV (full dose), Hib, PCV, TCV, Typhoid, Meningococcal, HPV, Td, IIV (influenza)

Special Notes

Pentavalent replaces separate DPT + Hep B + Hib in the government UIP - do not give all three separately if pentavalent is used
fIPV (fractional IPV): Given ID in the anterolateral thigh at 6 and 14 weeks + 9 months under UIP as an effective dose-sparing strategy
BCG dose: 0.05 mL in neonates, 0.1 mL in children >1 month
Rotavirus: First dose must not be given after 16 weeks; last dose not after 8 months (varies by brand)
JE vaccine: Included in UIP only in endemic states
HPV: Included in NIS for girls 9-14 years in India (government program expanding state by state)

Sources: NIS - Government of India UIP; IAP/IMA Immunization Schedule Chart; Park's Textbook of Preventive and Social Medicine, 26th ed.

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