Syp pedicloryl pedia dose and use
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Pedicloryl pedia syrup chloral hydrate pediatric dose uses India
Here is a complete reference for Syp. Pedicloryl Pedia (Chloral Hydrate Syrup):
Syp. Pedicloryl Pedia - Chloral Hydrate Syrup
Composition: Chloral Hydrate 200 mg / 5 mL (some brands: 250 mg/5 mL)
Uses (Indications)
- Procedural sedation - before minor procedures (EEG, MRI, audiometry, ophthalmic exam, dental procedures) in young children
- Short-term hypnotic - sleep induction in children
- Pre-operative sedation - 30-60 minutes before surgery
- Sedation in PICU/NICU - for mechanically ventilated infants (less common now)
Pediatric Dosing
| Indication | Dose | Timing |
|---|---|---|
| Procedural sedation | 50-75 mg/kg orally | 30-60 min before procedure |
| Hypnotic (sleep) | 25-50 mg/kg orally | At bedtime |
| Pre-op sedation | 25-50 mg/kg orally | 30 min before |
| ICU sedation (repeat dosing) | 10-50 mg/kg every 6-8 hrs | As needed |
Maximum single dose:
- Infants and young children: 1,000 mg (1 g)
- Older children: up to 2,000 mg (2 g)
If needed, a half-repeat dose may be given 30 minutes after the first if sedation is inadequate.
Age Restrictions
- Under 2 years: Use with caution - safety not well established; start at lowest dose
- Preterm neonates: Start at lower end (10 mg/kg); monitor for at least 24 hours post-dose due to slow elimination
How to Give
- Mix with milk or juice to improve palatability (it is bitter)
- Dilute the syrup 1:3 to 1:5 with water to reduce gastric irritation if needed
- Give 30-60 minutes before the procedure/bedtime
Contraindications
- Severe hepatic impairment (extensively liver-metabolized)
- Significant renal impairment / renal failure (CrCl < 48 mL/min)
- Severe cardiac disease
- Known hypersensitivity to chloral hydrate
Important Safety Points
- Not for long-term use - short-term only (less than 2 weeks)
- Monitor for respiratory depression, apnea, bradycardia, hypotension especially in neonates
- Can cause QT prolongation - caution in electrolyte imbalances
- Has a narrow therapeutic window - toxic dose in children can be as low as 1.5 g
- Reduce dose in mild hepatic or renal impairment
Side Effects
- Drowsiness, ataxia, nausea, vomiting
- CNS/respiratory depression (dose-dependent)
- Residual agitation possible for several hours after dosing
- Cardiac arrhythmias (at toxic doses)
Bottom line for practice: For procedural sedation in a child, give 50-75 mg/kg orally 30-60 minutes before the procedure, with a maximum of 1 g per dose in young children. Always have resuscitation equipment available and monitor vitals throughout.
Tab drotaverin ped dose
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drotaverine tablet pediatric dose children mg/kg
Tab. Drotaverine HCl - Pediatric Dosing
Each tablet = 40 mg (standard strength)
Dose by Age
| Age Group | Dose | Frequency |
|---|---|---|
| 1-6 years | 10-20 mg (¼ to ½ tablet) | 1-2 times daily |
| 6-12 years | 20-40 mg (½ to 1 tablet) | 2-3 times daily |
| > 12 years | 40-80 mg (1-2 tablets) | 2-3 times daily (adult dose) |
Maximum daily dose:
- 6-12 years: 80 mg/day
-
12 years: 160 mg/day
Note: No clinical studies established dosing in children under 6 years; use only under medical supervision if necessary.
Uses in Children
- Smooth muscle spasms of the GI tract (gastric spasm, intestinal/colonic spasm, IBS)
- Recurrent abdominal pain - a randomized controlled trial (PMID 26499007) showed drotaverine reduced abdominal pain episodes significantly in children aged 4-12 years
- Biliary/renal colic (adjunct)
- Pyloric spasm
- Dysmenorrhea (adolescent girls)
- Spastic constipation
Contraindications
- Severe renal or hepatic insufficiency
- Cardiac insufficiency (low output syndrome)
- Hypersensitivity to drotaverine
- Hypotension - use with caution
Key Points
- Drotaverine is a PDE4 inhibitor - causes smooth muscle relaxation without anticholinergic side effects
- No cardiac toxicity or hypotensive risk at therapeutic doses (advantage over other antispasmodics)
- Generally well tolerated; adverse effects are rare
- Tablet contains lactose - avoid in galactose intolerance
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