You are answering a USMLE-style medical question. Question: A 46-year-old man comes to the emergency department because of a 4-week history of fatigue and headache that have gotten progressively worse. He has allergic asthma treated with inhaled salbutamol. He immigrated to the USA from Thailand 9 years ago. He lives by himself and works as a waiter in a restaurant. He has had 6 lifetime male sexual partners and uses condoms inconsistently. He drinks 1–2 beers daily. His temperature is 38.2°C (100.8°F), pulse is 88/min, and blood pressure is 128/76 mm Hg. Examination of the mouth shows several white patches on the tongue and oral mucosa that can be easily scraped off with a tongue blade. On mental status examination, the patient is somnolent and has short-term memory deficits. The remainder of the examination shows no abnormalities. Laboratory studies show: Hemoglobin 13.6 g/dL Leukocyte count 9,600/mm3 Segmented neutrophils 80% Eosinophils 1% Lymphocytes 17% Monocytes 2% CD4+ T-lymphocytes 80/mm3 (Normal ≥ 500) Platelet count 328,000/mm3 Serum pH 7.36 Na+ 135 mEq/L Cl- 101 mEq/L K+ 4.8 mEq/L HCO3- 22 mEq/L Glucose 95 mg/dL Creatinine 0.9 mg/dL BUN 16 mg/dL Bilirubin, total 0.7 mg/dL AST 13 U/L ALT 15 U/L Erythrocyte sedimentation rate 10 mm/hour HIV test positive A lumbar puncture is performed and an opening pressure of 150 mm H2O is noted. Cerebrospinal fluid analysis shows a leukocyte count of 25/mm3 (60% lymphocytes), protein concentration of 52 mg/dL, and a glucose concentration of 37 mg/dL. India ink stain shows organisms with prominent capsules. Blood cultures are drawn. Which of the following is the most appropriate pharmacotherapy for this patient's neurological symptoms?" Options: A) Pyrimethamine, sulfadiazine, and folinic acid B) Amphotericin B and flucytosine C) Fluconazole D) Vancomycin and meropenem Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.

B
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