Domperidone drops dose
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domperidone drops 1mg/ml dose pediatric adults
Domperidone Drops / Oral Suspension (1 mg/mL)
Adults & Adolescents (≥12 years, weighing ≥35 kg)
| Parameter | Detail |
|---|---|
| Dose | 10 mL (= 10 mg) per dose |
| Frequency | Up to 3 times daily (leave ≥8 hours between doses) |
| Max daily dose | 30 mL (30 mg)/day |
| When to take | 15-30 minutes before meals |
| Max duration | 7 days (without medical review) |
Pediatric Population (under 12 years)
Important regulatory update: Following a 2014 European review of cardiac risk, domperidone efficacy in children under 12 has not been established. The 1 mg/mL "paediatric" suspension (Motilium) was withdrawn from the market (effective September 2019 in several EU countries) due to lack of proven efficacy and cardiac safety concerns.
If used off-label in children (under medical supervision), the historical dose that was reviewed was:
- 0.25 mg/kg/dose, up to 3 times daily (maximum)
- This was reduced from a previous 0.25-0.5 mg/kg dose range specifically to lower cardiotoxicity risk
Special Populations
| Population | Adjustment |
|---|---|
| Renal impairment (severe) | Reduce frequency to once or twice daily; may need dose reduction |
| Hepatic impairment (mild) | No adjustment needed |
| Hepatic impairment (moderate/severe) | Contraindicated |
| Elderly (>60 years) | Use lowest effective dose - higher cardiac risk |
Key Safety Points
- Risk of serious ventricular arrhythmias / sudden cardiac death - higher risk in: age >60, doses >30 mg/day, concurrent QT-prolonging drugs or CYP3A4 inhibitors
- Contraindicated in QTc prolongation, electrolyte disturbances (hypokalemia, hyperkalemia, hypomagnesemia), bradycardia, congestive heart failure
- Contraindicated with strong CYP3A4 inhibitors (e.g., ketoconazole, fluconazole, erythromycin, clarithromycin)
- Use at the lowest effective dose for the shortest duration
Source: NHS Domperidone guidance | EMA SmPC (emc) | Sleisenger & Fordtran's GI and Liver Disease
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