Seizures explained
A seizure is a sudden, temporary change in brain function caused by abnormal, excessive electrical activity in brain cells. It may last seconds to a few minutes and can affect movement, awareness, sensation, behavior, speech, or memory.
A seizure is not always the dramatic shaking episode shown in media.
What can a seizure look like?
1. Focal seizures
These begin in one area of the brain.
- Focal aware seizure: the person remains conscious. They may experience a strange smell or taste, tingling, visual changes, fear, nausea, or involuntary twitching.
- Focal impaired-awareness seizure: the person is confused or unaware, may stare, smack their lips, pick at clothing, wander, or fail to respond. They often do not remember it afterward.
- A focal seizure can spread to both sides of the brain and become a bilateral tonic-clonic seizure.
2. Generalized seizures
These involve both sides of the brain from the start.
- Tonic-clonic seizure: loss of consciousness, body stiffening followed by rhythmic jerking, sometimes with tongue biting, loss of bladder control, and confusion or sleepiness afterward.
- Absence seizure: brief blank stare and interruption of activity, usually lasting only seconds. It can be mistaken for daydreaming.
- Myoclonic seizure: sudden, brief muscle jerks.
- Atonic seizure: sudden loss of muscle tone, causing head drops or falls.
The current broad classification into focal and generalized seizures is summarized by the
CDC seizure-type guidance.
Why do seizures happen?
Some occur because of a temporary trigger, called a provoked or acute symptomatic seizure. Examples include:
- Low blood sugar
- Low sodium or other metabolic disturbance
- High fever in young children
- Alcohol or drug intoxication or withdrawal
- Certain medicines or toxins
- Serious infection affecting the brain
- Recent head injury or stroke
An unprovoked seizure happens without a temporary, reversible trigger. It can be associated with genetic predisposition, old brain injury, stroke, brain tumor, previous brain infection, or sometimes no identifiable cause. Frameworks for Internal Medicine explains that head injury, stroke, tumors, and intracranial infection can leave a lasting predisposition to future seizures.
Seizure versus epilepsy
- Seizure: one event of abnormal brain electrical activity.
- Epilepsy: a condition in which a person has an ongoing tendency to have recurrent unprovoked seizures.
So, a single seizure does not automatically mean epilepsy. Epilepsy is usually diagnosed after two unprovoked seizures more than 24 hours apart, or after one unprovoked seizure when the estimated risk of recurrence is high. Frameworks for Internal Medicine notes a roughly 40% to 50% chance of recurrence over 2 to 8 years after a first unprovoked seizure.
What happens after a seizure?
The recovery phase is called the postictal period. The person may be confused, sleepy, have a headache, muscle soreness, difficulty speaking, or temporary weakness of one side of the body. This can last minutes to hours.
How is a first seizure assessed?
A clinician will ask a witness what happened before, during, and after the episode, review medical history, and look for triggers. Tests may include:
- Blood glucose and electrolytes
- Toxicology or infection testing when indicated
- EEG, which records brain electrical activity
- Brain MRI or CT in selected situations
The immediate priorities are airway, breathing, circulation, stopping recurrent seizures, and identifying dangerous causes such as infection, metabolic disturbance, or drug toxicity. Harrison’s Principles of Internal Medicine, 22nd ed., p. 3459.
Treatment
Treatment depends on the cause and seizure type:
- Correct a reversible trigger, such as low glucose or low sodium.
- A prolonged seizure may require urgent emergency medicines.
- Recurrent unprovoked seizures may be treated with an antiseizure medicine chosen for the individual seizure type and patient factors.
- Some people with medication-resistant epilepsy may be candidates for surgery, implanted neurostimulation, or dietary therapy under specialist care.
When it is an emergency
Call emergency services if a seizure:
- Lasts 5 minutes or more
- Occurs repeatedly without the person waking fully between episodes
- Is the person’s first known seizure
- Happens in water
- Causes injury or breathing problems
- Occurs during pregnancy or in someone with diabetes
For someone actively convulsing, protect them from injury, cushion the head, time the episode, turn them onto their side when safe, and do
not put anything in their mouth or hold them down. See the
CDC first-aid instructions.