Q: Cardinal signs of fatty liver Q: Quick answer A: Fatty liver is often asymptomatic. When signs are present, the cardinal clinical finding is: - Hepatomegaly: enlarged, smooth, usually non-tender liver - Mild right upper abdominal discomfort or fullness - Fatigue or malaise - In more advanced disease: features of chronic liver disease, such as jaundice, ascites, pedal edema, spider angiomas, or splenomegaly On ultrasound, typical signs are a bright echogenic liver, increased liver-kidney contrast, and poor visualization of deep hepatic vessels/diaphragm.